YNL318C / HXT14

Protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL318C / HXT14

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:3.28|P-value:2.67E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:3.45|P-value:1.36E-4 ID:SGTC_199|Compound:4063-0024|FD-Score:4.00|P-value:1.23E-5 ID:SGTC_354|Compound:2783-3500|FD-Score:-3.75|P-value:5.56E-5 ID:SGTC_391|Compound:gliotoxin|FD-Score:4.08|P-value:8.71E-6 ID:SGTC_425|Compound:3825-7017|FD-Score:2.95|P-value:9.14E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:2.98|P-value:8.15E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:3.29|P-value:2.57E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.12|P-value:4.85E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.57|P-value:7.35E-7 ID:SGTC_1240|Compound:0356-0016|FD-Score:4.74|P-value:3.10E-7 ID:SGTC_1266|Compound:0828-0227|FD-Score:-3.18|P-value:5.48E-4 ID:SGTC_1403|Compound:3909-7815|FD-Score:3.87|P-value:2.25E-5 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:4.14|P-value:6.31E-6 ID:SGTC_1629|Compound:st005085|FD-Score:-3.16|P-value:5.83E-4 ID:SGTC_1657|Compound:st012939|FD-Score:3.21|P-value:3.46E-4 ID:SGTC_1835|Compound:st008666|FD-Score:3.80|P-value:3.11E-5 ID:SGTC_1956|Compound:st077085|FD-Score:3.18|P-value:3.83E-4 ID:SGTC_2105|Compound:5350118|FD-Score:-3.96|P-value:2.22E-5 ID:SGTC_2335|Compound:9018011|FD-Score:3.58|P-value:7.77E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:5.52|P-value:3.39E-9 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.49|P-value:1.15E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.07|P-value:9.00E-6 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-3.14|P-value:6.32E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.61|P-value:6.96E-5 ID:SGTC_3326|Compound:9140064|FD-Score:3.75|P-value:3.89E-5 ID:SGTC_3340|Compound:9146634|FD-Score:3.26|P-value:2.82E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:3.28|P-value:2.67E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:3.45|P-value:1.36E-4 ID:SGTC_199|Compound:4063-0024|FD-Score:4.00|P-value:1.23E-5 ID:SGTC_354|Compound:2783-3500|FD-Score:-3.75|P-value:5.56E-5 ID:SGTC_391|Compound:gliotoxin|FD-Score:4.08|P-value:8.71E-6 ID:SGTC_425|Compound:3825-7017|FD-Score:2.95|P-value:9.14E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:2.98|P-value:8.15E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:3.29|P-value:2.57E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.12|P-value:4.85E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.57|P-value:7.35E-7 ID:SGTC_1240|Compound:0356-0016|FD-Score:4.74|P-value:3.10E-7 ID:SGTC_1266|Compound:0828-0227|FD-Score:-3.18|P-value:5.48E-4 ID:SGTC_1403|Compound:3909-7815|FD-Score:3.87|P-value:2.25E-5 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:4.14|P-value:6.31E-6 ID:SGTC_1629|Compound:st005085|FD-Score:-3.16|P-value:5.83E-4 ID:SGTC_1657|Compound:st012939|FD-Score:3.21|P-value:3.46E-4 ID:SGTC_1835|Compound:st008666|FD-Score:3.80|P-value:3.11E-5 ID:SGTC_1956|Compound:st077085|FD-Score:3.18|P-value:3.83E-4 ID:SGTC_2105|Compound:5350118|FD-Score:-3.96|P-value:2.22E-5 ID:SGTC_2335|Compound:9018011|FD-Score:3.58|P-value:7.77E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:5.52|P-value:3.39E-9 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.49|P-value:1.15E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.07|P-value:9.00E-6 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-3.14|P-value:6.32E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.61|P-value:6.96E-5 ID:SGTC_3326|Compound:9140064|FD-Score:3.75|P-value:3.89E-5 ID:SGTC_3340|Compound:9146634|FD-Score:3.26|P-value:2.82E-4

Top fitness defect scores for YNL318C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2567 aureobasidin a 5.52 60.0 nM 3.39E-9 53 1.74E-8
2 SGTC_1240 0356-0016 4.74 42.1 µM 3.10E-7 mitochondrial response to ROS 19 1.08E-6
3 SGTC_1134 3477-0009 4.57 42.5 µM 7.35E-7 29 2.38E-6
4 SGTC_1576 erythromycin ethylsuccinate 4.14 23.2 µM 6.31E-6 18 1.70E-5
5 SGTC_391 gliotoxin 4.08 8.3 µM 8.71E-6 55 2.29E-5
6 SGTC_2617 dihydrotanshinone i 4.07 20.8 µM 9.00E-6 copper-dependent oxidative stress 42 2.36E-5
7 SGTC_199 4063-0024 4.00 41.6 µM 1.23E-5 5 3.15E-5
8 SGTC_1403 3909-7815 3.87 62.9 µM 2.25E-5 18 5.45E-5
9 SGTC_1835 st008666 3.80 49.2 µM 3.11E-5 26 7.32E-5
10 SGTC_3326 9140064 3.75 16.4 µM 3.89E-5 25 9.00E-5
11 SGTC_2634 4'-methoxyflavone 3.61 100.0 µM 6.96E-5 41 1.53E-4
12 SGTC_2335 9018011 3.58 154.2 µM 7.77E-5 36 1.69E-4
13 SGTC_2583 asiatic acid 3.49 100.0 µM 1.15E-4 53 2.42E-4
14 SGTC_167 3672-0051 3.45 66.2 µM 1.36E-4 58 2.82E-4
15 SGTC_1012 4112-3522 3.29 18.0 µM 2.57E-4 44 5.06E-4
16 SGTC_7 0192-1582 3.28 4.2 µM 2.67E-4 101 5.23E-4
17 SGTC_3340 9146634 3.26 11.1 µM 2.82E-4 34 5.51E-4
18 SGTC_1657 st012939 3.21 43.4 µM 3.46E-4 30 6.63E-4
19 SGTC_1956 st077085 3.18 54.0 µM 3.83E-4 49 7.27E-4
20 SGTC_1103 duloxetine 3.12 36.1 µM 4.85E-4 68 9.03E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.264 8.22E-55 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.176 8.35E-25 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
0.169 8.67E-23 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.125 4.38E-13 YDR118W APC4 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to the nucleus increases upon DNA replication stress
0.117 1.04E-11 YPR004C AIM45 hom Putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochondrial genome loss; may have a role in oxidative stress response
0.114 3.43E-11 YBR110W ALG1 het Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog
0.107 4.57E-10 YBR288C APM3 hom Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway
0.105 1.20E-9 YER180C ISC10 hom Protein required for sporulation, transcript is induced 7.5 hours after induction of meiosis, expected to play significant role in the formation of reproductive cells
0.101 4.55E-9 YMR211W DML1 het Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family
0.100 5.91E-9 YFL036W RPO41 hom Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.096 2.75E-8 YJR033C RAV1 hom Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate
0.093 5.97E-8 YER013W PRP22 het DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes
0.093 7.77E-8 YPL062W_d YPL062W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation
0.092 8.87E-8 YMR199W CLN1 hom G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
0.091 1.32E-7 YGL168W HUR1 hom Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene