YNL327W / EGT2

Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL327W / EGT2

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.19|P-value:6.03E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:3.15|P-value:6.93E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:3.09|P-value:8.67E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.69|P-value:8.90E-5 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.87|P-value:4.18E-5 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.06|P-value:9.52E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-5.01|P-value:1.18E-7 ID:SGTC_517|Compound:1365-0151|FD-Score:3.98|P-value:2.53E-5 ID:SGTC_585|Compound:0kpi-0023|FD-Score:3.22|P-value:5.40E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:3.52|P-value:1.71E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:3.28|P-value:4.27E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:3.43|P-value:2.48E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:3.48|P-value:2.00E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.21|P-value:5.67E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:3.24|P-value:4.93E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:4.43|P-value:3.32E-6 ID:SGTC_1128|Compound:3448-9350|FD-Score:4.65|P-value:1.11E-6 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.17|P-value:6.46E-4 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.28|P-value:4.40E-4 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.10|P-value:8.32E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:-3.33|P-value:2.92E-4 ID:SGTC_1702|Compound:st027038|FD-Score:3.33|P-value:3.59E-4 ID:SGTC_1733|Compound:st037357|FD-Score:4.13|P-value:1.33E-5 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:4.12|P-value:1.37E-5 ID:SGTC_2029|Compound:5175081|FD-Score:3.49|P-value:1.93E-4 ID:SGTC_2114|Compound:5491910|FD-Score:3.45|P-value:2.30E-4 ID:SGTC_2148|Compound:5546263|FD-Score:3.34|P-value:3.51E-4 ID:SGTC_2238|Compound:6671620|FD-Score:4.34|P-value:4.88E-6 ID:SGTC_2338|Compound:7999974|FD-Score:3.27|P-value:4.43E-4 ID:SGTC_2401|Compound:5128683|FD-Score:-3.20|P-value:4.57E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.15|P-value:6.99E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-5.97|P-value:3.92E-10 ID:SGTC_2514|Compound:salinomycin|FD-Score:4.10|P-value:1.50E-5 ID:SGTC_2515|Compound:chrysin|FD-Score:4.83|P-value:4.43E-7 ID:SGTC_2517|Compound:totarol|FD-Score:-3.22|P-value:4.26E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:-4.24|P-value:6.05E-6 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-4.42|P-value:2.55E-6 ID:SGTC_2629|Compound:bisabolol|FD-Score:4.69|P-value:9.08E-7 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-3.87|P-value:3.27E-5 ID:SGTC_2725|Compound:haloperidol|FD-Score:-3.04|P-value:8.22E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:3.53|P-value:1.69E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:-3.34|P-value:2.81E-4 ID:SGTC_2805|Compound:7950783|FD-Score:-5.87|P-value:7.28E-10 ID:SGTC_2809|Compound:7964133|FD-Score:-3.00|P-value:9.42E-4 ID:SGTC_2938|Compound:9059746|FD-Score:4.13|P-value:1.35E-5 ID:SGTC_2954|Compound:9074818|FD-Score:4.75|P-value:6.72E-7 ID:SGTC_2956|Compound:9076196|FD-Score:3.67|P-value:9.72E-5 ID:SGTC_2958|Compound:9077254|FD-Score:4.57|P-value:1.64E-6 ID:SGTC_3030|Compound:9087619|FD-Score:-3.15|P-value:5.56E-4 ID:SGTC_3041|Compound:9091929|FD-Score:3.19|P-value:6.03E-4 ID:SGTC_3107|Compound:9121808|FD-Score:-3.32|P-value:2.93E-4 ID:SGTC_3175|Compound:9106517|FD-Score:3.61|P-value:1.23E-4 ID:SGTC_3204|Compound:9114183|FD-Score:-3.55|P-value:1.24E-4 ID:SGTC_3208|Compound:9114115|FD-Score:5.66|P-value:3.91E-9 ID:SGTC_6|Compound:0844-0013|FD-Score:3.19|P-value:6.03E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:3.15|P-value:6.93E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:3.09|P-value:8.67E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.69|P-value:8.90E-5 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.87|P-value:4.18E-5 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.06|P-value:9.52E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-5.01|P-value:1.18E-7 ID:SGTC_517|Compound:1365-0151|FD-Score:3.98|P-value:2.53E-5 ID:SGTC_585|Compound:0kpi-0023|FD-Score:3.22|P-value:5.40E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:3.52|P-value:1.71E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:3.28|P-value:4.27E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:3.43|P-value:2.48E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:3.48|P-value:2.00E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.21|P-value:5.67E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:3.24|P-value:4.93E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:4.43|P-value:3.32E-6 ID:SGTC_1128|Compound:3448-9350|FD-Score:4.65|P-value:1.11E-6 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.17|P-value:6.46E-4 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.28|P-value:4.40E-4 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.10|P-value:8.32E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:-3.33|P-value:2.92E-4 ID:SGTC_1702|Compound:st027038|FD-Score:3.33|P-value:3.59E-4 ID:SGTC_1733|Compound:st037357|FD-Score:4.13|P-value:1.33E-5 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:4.12|P-value:1.37E-5 ID:SGTC_2029|Compound:5175081|FD-Score:3.49|P-value:1.93E-4 ID:SGTC_2114|Compound:5491910|FD-Score:3.45|P-value:2.30E-4 ID:SGTC_2148|Compound:5546263|FD-Score:3.34|P-value:3.51E-4 ID:SGTC_2238|Compound:6671620|FD-Score:4.34|P-value:4.88E-6 ID:SGTC_2338|Compound:7999974|FD-Score:3.27|P-value:4.43E-4 ID:SGTC_2401|Compound:5128683|FD-Score:-3.20|P-value:4.57E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.15|P-value:6.99E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-5.97|P-value:3.92E-10 ID:SGTC_2514|Compound:salinomycin|FD-Score:4.10|P-value:1.50E-5 ID:SGTC_2515|Compound:chrysin|FD-Score:4.83|P-value:4.43E-7 ID:SGTC_2517|Compound:totarol|FD-Score:-3.22|P-value:4.26E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:-4.24|P-value:6.05E-6 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-4.42|P-value:2.55E-6 ID:SGTC_2629|Compound:bisabolol|FD-Score:4.69|P-value:9.08E-7 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-3.87|P-value:3.27E-5 ID:SGTC_2725|Compound:haloperidol|FD-Score:-3.04|P-value:8.22E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:3.53|P-value:1.69E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:-3.34|P-value:2.81E-4 ID:SGTC_2805|Compound:7950783|FD-Score:-5.87|P-value:7.28E-10 ID:SGTC_2809|Compound:7964133|FD-Score:-3.00|P-value:9.42E-4 ID:SGTC_2938|Compound:9059746|FD-Score:4.13|P-value:1.35E-5 ID:SGTC_2954|Compound:9074818|FD-Score:4.75|P-value:6.72E-7 ID:SGTC_2956|Compound:9076196|FD-Score:3.67|P-value:9.72E-5 ID:SGTC_2958|Compound:9077254|FD-Score:4.57|P-value:1.64E-6 ID:SGTC_3030|Compound:9087619|FD-Score:-3.15|P-value:5.56E-4 ID:SGTC_3041|Compound:9091929|FD-Score:3.19|P-value:6.03E-4 ID:SGTC_3107|Compound:9121808|FD-Score:-3.32|P-value:2.93E-4 ID:SGTC_3175|Compound:9106517|FD-Score:3.61|P-value:1.23E-4 ID:SGTC_3204|Compound:9114183|FD-Score:-3.55|P-value:1.24E-4 ID:SGTC_3208|Compound:9114115|FD-Score:5.66|P-value:3.91E-9

Top fitness defect scores for YNL327W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3208 9114115 5.66 49.5 µM 3.91E-9 13 7.49E-9
2 SGTC_2515 chrysin 4.83 20.8 µM 4.43E-7 RPP1 & pyrimidine depletion 2 6.97E-7
3 SGTC_2954 9074818 4.75 52.7 µM 6.72E-7 23 1.04E-6
4 SGTC_2629 bisabolol 4.69 100.0 µM 9.08E-7 12 1.39E-6
5 SGTC_1128 3448-9350 4.65 235.0 µM 1.11E-6 16 1.68E-6
6 SGTC_2958 9077254 4.57 16.7 µM 1.64E-6 15 2.45E-6
7 SGTC_996 3970-0799 4.43 1.8 µM 3.32E-6 65 4.82E-6
8 SGTC_2238 6671620 4.34 73.2 µM 4.88E-6 20 6.97E-6
9 SGTC_1733 st037357 4.13 54.9 µM 1.33E-5 60S ribosome export 20 1.82E-5
10 SGTC_2938 9059746 4.13 27.3 µM 1.35E-5 fatty acid desaturase (OLE1) 37 1.85E-5
11 SGTC_1965 Pectolinarigenin 4.12 58.4 µM 1.37E-5 RPP1 & pyrimidine depletion 11 1.88E-5
12 SGTC_2514 salinomycin 4.10 42.7 µM 1.50E-5 42 2.05E-5
13 SGTC_517 1365-0151 3.98 113.0 µM 2.53E-5 30 3.38E-5
14 SGTC_451 chloral hydrate 3.87 100.0 µM 4.18E-5 57 5.49E-5
15 SGTC_445 e6 berbamine 3.69 66.0 µM 8.90E-5 NEO1-PIK1 126 1.13E-4
16 SGTC_2956 9076196 3.67 2.5 µM 9.72E-5 28 1.23E-4
17 SGTC_3175 9106517 3.61 49.5 µM 1.23E-4 iron homeostasis 21 1.54E-4
18 SGTC_2761 levamisole 3.53 97.9 µM 1.69E-4 27 2.10E-4
19 SGTC_639 0833-0042 3.52 114.0 µM 1.71E-4 61 2.12E-4
20 SGTC_2029 5175081 3.49 200.0 µM 1.93E-4 36 2.38E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.165 7.47E-22 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.150 2.27E-18 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.142 1.35E-16 YJR094C IME1 hom Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
0.120 3.48E-12 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.112 8.98E-11 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.104 1.43E-9 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.100 5.81E-9 YPR201W ARR3 hom Plasma membrane metalloid/H+ antiporter; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite
0.097 2.09E-8 YGL083W SCY1 hom Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase
0.095 3.69E-8 YDL186W_p YDL186W_p hom Putative protein of unknown function; YDL186W is not an essential gene
0.093 7.60E-8 YGR085C RPL11B hom Ribosomal 60S subunit protein L11B; expressed at half the level of Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11B has a paralog, RPL11A, that arose from the whole genome duplication
0.092 9.60E-8 YMR178W YMR178W hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; YMR178W is not an essential gene; protein abundance increases in response to DNA replication stress
0.092 1.04E-7 YPL151C PRP46 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs
0.090 1.83E-7 YGL096W TOS8 hom Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication
0.089 2.19E-7 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.088 3.21E-7 YJL138C TIF2 hom Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF2 has a paralog, TIF1, that arose from the whole genome duplication