YNR002C / ATO2

Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Y. lipolytica Gpr1p; ATO2 has a paralog, ADY2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR002C / ATO2

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:3.24|P-value:1.95E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:3.35|P-value:1.22E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:-3.12|P-value:4.10E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:3.38|P-value:1.08E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:3.24|P-value:1.97E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:-3.12|P-value:4.10E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.20|P-value:2.31E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:-3.54|P-value:7.25E-5 ID:SGTC_397|Compound:arbidol|FD-Score:2.93|P-value:6.60E-4 ID:SGTC_413|Compound:propylparaben|FD-Score:-3.84|P-value:1.82E-5 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.16|P-value:2.64E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:-4.58|P-value:4.10E-7 ID:SGTC_536|Compound:3852-0578|FD-Score:3.66|P-value:3.19E-5 ID:SGTC_538|Compound:2922-0838|FD-Score:3.31|P-value:1.47E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:3.65|P-value:3.33E-5 ID:SGTC_692|Compound:k241-0027|FD-Score:4.65|P-value:1.91E-7 ID:SGTC_710|Compound:3448-4187|FD-Score:-3.66|P-value:4.19E-5 ID:SGTC_975|Compound:1335-0046|FD-Score:-2.89|P-value:9.98E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.00|P-value:5.01E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:-3.05|P-value:5.46E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:5.06|P-value:1.71E-8 ID:SGTC_1129|Compound:3453-1384|FD-Score:4.11|P-value:3.57E-6 ID:SGTC_1172|Compound:0370-0043|FD-Score:2.87|P-value:8.12E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.00|P-value:4.96E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:2.97|P-value:5.67E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.07|P-value:3.81E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.07|P-value:3.90E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.27|P-value:1.75E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:3.62|P-value:3.73E-5 ID:SGTC_1949|Compound:st076024|FD-Score:3.42|P-value:9.14E-5 ID:SGTC_2274|Compound:7947094|FD-Score:-3.12|P-value:4.12E-4 ID:SGTC_2321|Compound:7390090|FD-Score:-3.44|P-value:1.09E-4 ID:SGTC_2340|Compound:7987427|FD-Score:2.85|P-value:8.92E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-3.16|P-value:3.49E-4 ID:SGTC_2447|Compound:5741742|FD-Score:3.14|P-value:2.96E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.09|P-value:3.60E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.74|P-value:2.15E-5 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.06|P-value:5.23E-4 ID:SGTC_2831|Compound:7999036|FD-Score:2.95|P-value:6.08E-4 ID:SGTC_2838|Compound:9002687|FD-Score:3.14|P-value:2.97E-4 ID:SGTC_2846|Compound:9008642|FD-Score:4.94|P-value:3.52E-8 ID:SGTC_2970|Compound:9090938|FD-Score:3.87|P-value:1.16E-5 ID:SGTC_2981|Compound:9013952|FD-Score:-4.17|P-value:3.69E-6 ID:SGTC_3146|Compound:9095609|FD-Score:5.72|P-value:2.20E-10 ID:SGTC_3170|Compound:9103054|FD-Score:-3.23|P-value:2.69E-4 ID:SGTC_3213|Compound:9129884|FD-Score:-3.82|P-value:2.03E-5 ID:SGTC_3234|Compound:9132280|FD-Score:2.89|P-value:7.67E-4 ID:SGTC_3299|Compound:9121982|FD-Score:3.20|P-value:2.32E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:3.24|P-value:1.95E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:3.35|P-value:1.22E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:-3.12|P-value:4.10E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:3.38|P-value:1.08E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:3.24|P-value:1.97E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:-3.12|P-value:4.10E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.20|P-value:2.31E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:-3.54|P-value:7.25E-5 ID:SGTC_397|Compound:arbidol|FD-Score:2.93|P-value:6.60E-4 ID:SGTC_413|Compound:propylparaben|FD-Score:-3.84|P-value:1.82E-5 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.16|P-value:2.64E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:-4.58|P-value:4.10E-7 ID:SGTC_536|Compound:3852-0578|FD-Score:3.66|P-value:3.19E-5 ID:SGTC_538|Compound:2922-0838|FD-Score:3.31|P-value:1.47E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:3.65|P-value:3.33E-5 ID:SGTC_692|Compound:k241-0027|FD-Score:4.65|P-value:1.91E-7 ID:SGTC_710|Compound:3448-4187|FD-Score:-3.66|P-value:4.19E-5 ID:SGTC_975|Compound:1335-0046|FD-Score:-2.89|P-value:9.98E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.00|P-value:5.01E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:-3.05|P-value:5.46E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:5.06|P-value:1.71E-8 ID:SGTC_1129|Compound:3453-1384|FD-Score:4.11|P-value:3.57E-6 ID:SGTC_1172|Compound:0370-0043|FD-Score:2.87|P-value:8.12E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.00|P-value:4.96E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:2.97|P-value:5.67E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.07|P-value:3.81E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.07|P-value:3.90E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.27|P-value:1.75E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:3.62|P-value:3.73E-5 ID:SGTC_1949|Compound:st076024|FD-Score:3.42|P-value:9.14E-5 ID:SGTC_2274|Compound:7947094|FD-Score:-3.12|P-value:4.12E-4 ID:SGTC_2321|Compound:7390090|FD-Score:-3.44|P-value:1.09E-4 ID:SGTC_2340|Compound:7987427|FD-Score:2.85|P-value:8.92E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-3.16|P-value:3.49E-4 ID:SGTC_2447|Compound:5741742|FD-Score:3.14|P-value:2.96E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.09|P-value:3.60E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.74|P-value:2.15E-5 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.06|P-value:5.23E-4 ID:SGTC_2831|Compound:7999036|FD-Score:2.95|P-value:6.08E-4 ID:SGTC_2838|Compound:9002687|FD-Score:3.14|P-value:2.97E-4 ID:SGTC_2846|Compound:9008642|FD-Score:4.94|P-value:3.52E-8 ID:SGTC_2970|Compound:9090938|FD-Score:3.87|P-value:1.16E-5 ID:SGTC_2981|Compound:9013952|FD-Score:-4.17|P-value:3.69E-6 ID:SGTC_3146|Compound:9095609|FD-Score:5.72|P-value:2.20E-10 ID:SGTC_3170|Compound:9103054|FD-Score:-3.23|P-value:2.69E-4 ID:SGTC_3213|Compound:9129884|FD-Score:-3.82|P-value:2.03E-5 ID:SGTC_3234|Compound:9132280|FD-Score:2.89|P-value:7.67E-4 ID:SGTC_3299|Compound:9121982|FD-Score:3.20|P-value:2.32E-4

Top fitness defect scores for YNR002C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3146 9095609 5.72 49.5 µM 2.20E-10 2 5.22E-9
2 SGTC_1061 3448-9325 5.06 110.0 µM 1.71E-8 8 2.12E-7
3 SGTC_2846 9008642 4.94 19.5 µM 3.52E-8 10 3.90E-7
4 SGTC_692 k241-0027 4.65 77.8 µM 1.91E-7 4 1.65E-6
5 SGTC_1129 3453-1384 4.11 223.0 µM 3.57E-6 36 1.99E-5
6 SGTC_2970 9090938 3.87 41.9 µM 1.16E-5 RNA processing & uracil transport 40 5.44E-5
7 SGTC_2593 nobiletin 3.74 86.2 µM 2.15E-5 34 9.18E-5
8 SGTC_536 3852-0578 3.66 10.6 µM 3.19E-5 38 1.28E-4
9 SGTC_550 4123-0385 3.65 25.7 µM 3.33E-5 TSC3-RPN4 36 1.33E-4
10 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 3.62 66.5 µM 3.73E-5 23 1.47E-4
11 SGTC_1949 st076024 3.42 69.1 µM 9.14E-5 46 3.14E-4
12 SGTC_353 1988-1175 3.38 58.3 µM 1.08E-4 unfolded protein response 39 3.63E-4
13 SGTC_344 k064-0035 3.35 6.4 µM 1.22E-4 60S ribosome export 43 4.03E-4
14 SGTC_538 2922-0838 3.31 53.3 µM 1.47E-4 Golgi 58 4.71E-4
15 SGTC_1453 4237-0541 3.27 195.0 µM 1.75E-4 heme biosynthesis & mitochondrial translocase 51 5.47E-4
16 SGTC_65 0798-0905 3.24 35.0 µM 1.95E-4 calcium & mitochondrial duress 139 6.00E-4
17 SGTC_366 0181-0206 3.24 4.3 µM 1.97E-4 Golgi 74 6.05E-4
18 SGTC_385 1494-0393 3.20 12.4 µM 2.31E-4 62 6.93E-4
19 SGTC_3299 9121982 3.20 43.1 µM 2.32E-4 63 6.96E-4
20 SGTC_418 lividomycin a 3.16 100.0 µM 2.64E-4 39 7.76E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.120 2.88E-12 YLR389C STE23 hom Metalloprotease involved, with homolog Axl1p, in N-terminal processing of pro-a-factor to the mature form; expressed in both haploids and diploids; member of the insulin-degrading enzyme family
0.119 4.36E-12 YBR148W YSW1 hom Protein required for normal prospore membrane formation; interacts with Gip1p, which is the meiosis-specific regulatory subunit of the Glc7p protein phosphatase; expressed specifically in spores and localizes to the prospore membrane
0.097 1.74E-8 YOL045W PSK2 hom PAS-domain containing serine/threonine protein kinase; regulates sugar flux and translation in response to an unknown metabolite by phosphorylating Ugp1p and Gsy2p (sugar flux) and Caf20p, Tif11p and Sro9p (translation); PSK2 has a paralog, PSK1, that arose from the whole genome duplication
0.093 7.15E-8 YOR376W_d YOR376W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.
0.092 8.74E-8 YPL160W CDC60 het Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA
0.091 1.46E-7 YOL010W RCL1 het Endonuclease that cleaves pre-rRNA at site A2 for 18S rRNA biogenesis; subunit of U3-containing 90S preribosome processome complex involved in small ribosomal subunit assembly; stimulates Bms1p GTPase and U3 binding activity; similar to RNA cyclase-like proteins but no cyclase activity detected
0.090 1.97E-7 YJL152W_d YJL152W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.086 6.63E-7 YMR206W_p YMR206W_p hom Putative protein of unknown function; not an essential gene; YMR206W has a paralog, YNR014W, that arose from the whole genome duplication
0.084 1.12E-6 YML047C PRM6 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; regulated by Ste12p during mating; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family
0.083 1.56E-6 YKR103W NFT1 hom Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds.
0.081 2.50E-6 YOR355W GDS1 hom Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.081 2.51E-6 YOL124C TRM11 hom Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain
0.081 2.70E-6 YBR089C-A NHP6B hom High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; homologous to mammalian HMGB1 and HMGB2; NHP6B has a paralog, NHP6A, that arose from the whole genome duplication
0.081 2.75E-6 YPR071W_p YPR071W_p hom Putative membrane protein; YPR071W is not an essential gene; YPR071W has paralog YIL029C
0.080 3.29E-6 YPL019C VTC3 hom Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion