YNR032W / PPG1

Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR032W / PPG1

Click on Significant Values for Screen Details ID:SGTC_439|Compound:amiodarone|FD-Score:-3.90|P-value:1.68E-5 ID:SGTC_442|Compound:cape|FD-Score:-3.57|P-value:7.28E-5 ID:SGTC_452|Compound:diindolylmethane|FD-Score:-3.18|P-value:3.54E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.62|P-value:1.30E-9 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.46|P-value:1.20E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:3.07|P-value:6.88E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:3.45|P-value:1.60E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:4.78|P-value:2.90E-7 ID:SGTC_954|Compound:1189-0853|FD-Score:3.38|P-value:2.14E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:-3.61|P-value:6.16E-5 ID:SGTC_1193|Compound:1488-0126|FD-Score:3.37|P-value:2.15E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:-3.35|P-value:1.86E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.28|P-value:3.14E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:-2.91|P-value:9.80E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.21|P-value:3.14E-4 ID:SGTC_1442|Compound:4112-3290|FD-Score:3.02|P-value:8.27E-4 ID:SGTC_1674|Compound:st016616|FD-Score:3.08|P-value:6.65E-4 ID:SGTC_1691|Compound:st019933|FD-Score:-3.14|P-value:4.18E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.49|P-value:1.36E-4 ID:SGTC_1935|Compound:st074532|FD-Score:-3.26|P-value:2.67E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-2.96|P-value:8.07E-4 ID:SGTC_2025|Compound:5147754|FD-Score:-3.00|P-value:6.89E-4 ID:SGTC_2027|Compound:5150920|FD-Score:-3.67|P-value:4.90E-5 ID:SGTC_2107|Compound:5363541|FD-Score:-3.31|P-value:2.17E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-3.24|P-value:2.82E-4 ID:SGTC_2167|Compound:5876490|FD-Score:-3.43|P-value:1.31E-4 ID:SGTC_2335|Compound:9018011|FD-Score:-2.98|P-value:7.54E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.50|P-value:1.30E-4 ID:SGTC_2695|Compound:st077686|FD-Score:4.12|P-value:8.48E-6 ID:SGTC_2763|Compound:lisinopril|FD-Score:-2.96|P-value:8.15E-4 ID:SGTC_2839|Compound:9003951|FD-Score:3.01|P-value:8.44E-4 ID:SGTC_2844|Compound:9010103|FD-Score:4.38|P-value:2.27E-6 ID:SGTC_2857|Compound:9024691|FD-Score:3.01|P-value:8.57E-4 ID:SGTC_2894|Compound:9048625|FD-Score:3.21|P-value:4.01E-4 ID:SGTC_2986|Compound:9022445|FD-Score:-3.21|P-value:3.22E-4 ID:SGTC_2994|Compound:9053520|FD-Score:-3.03|P-value:6.18E-4 ID:SGTC_3086|Compound:9117350|FD-Score:-3.10|P-value:4.78E-4 ID:SGTC_3090|Compound:9117696|FD-Score:-3.46|P-value:1.15E-4 ID:SGTC_3096|Compound:9117468|FD-Score:-3.57|P-value:7.44E-5 ID:SGTC_3230|Compound:9131665|FD-Score:-3.76|P-value:3.29E-5 ID:SGTC_3245|Compound:9134821|FD-Score:3.17|P-value:4.76E-4 ID:SGTC_3250|Compound:9135583|FD-Score:4.40|P-value:2.12E-6 ID:SGTC_3313|Compound:9133968|FD-Score:-2.97|P-value:7.94E-4 ID:SGTC_3314|Compound:9135860|FD-Score:-3.49|P-value:1.04E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:-3.90|P-value:1.68E-5 ID:SGTC_442|Compound:cape|FD-Score:-3.57|P-value:7.28E-5 ID:SGTC_452|Compound:diindolylmethane|FD-Score:-3.18|P-value:3.54E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.62|P-value:1.30E-9 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.46|P-value:1.20E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:3.07|P-value:6.88E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:3.45|P-value:1.60E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:4.78|P-value:2.90E-7 ID:SGTC_954|Compound:1189-0853|FD-Score:3.38|P-value:2.14E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:-3.61|P-value:6.16E-5 ID:SGTC_1193|Compound:1488-0126|FD-Score:3.37|P-value:2.15E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:-3.35|P-value:1.86E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.28|P-value:3.14E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:-2.91|P-value:9.80E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.21|P-value:3.14E-4 ID:SGTC_1442|Compound:4112-3290|FD-Score:3.02|P-value:8.27E-4 ID:SGTC_1674|Compound:st016616|FD-Score:3.08|P-value:6.65E-4 ID:SGTC_1691|Compound:st019933|FD-Score:-3.14|P-value:4.18E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.49|P-value:1.36E-4 ID:SGTC_1935|Compound:st074532|FD-Score:-3.26|P-value:2.67E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-2.96|P-value:8.07E-4 ID:SGTC_2025|Compound:5147754|FD-Score:-3.00|P-value:6.89E-4 ID:SGTC_2027|Compound:5150920|FD-Score:-3.67|P-value:4.90E-5 ID:SGTC_2107|Compound:5363541|FD-Score:-3.31|P-value:2.17E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-3.24|P-value:2.82E-4 ID:SGTC_2167|Compound:5876490|FD-Score:-3.43|P-value:1.31E-4 ID:SGTC_2335|Compound:9018011|FD-Score:-2.98|P-value:7.54E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.50|P-value:1.30E-4 ID:SGTC_2695|Compound:st077686|FD-Score:4.12|P-value:8.48E-6 ID:SGTC_2763|Compound:lisinopril|FD-Score:-2.96|P-value:8.15E-4 ID:SGTC_2839|Compound:9003951|FD-Score:3.01|P-value:8.44E-4 ID:SGTC_2844|Compound:9010103|FD-Score:4.38|P-value:2.27E-6 ID:SGTC_2857|Compound:9024691|FD-Score:3.01|P-value:8.57E-4 ID:SGTC_2894|Compound:9048625|FD-Score:3.21|P-value:4.01E-4 ID:SGTC_2986|Compound:9022445|FD-Score:-3.21|P-value:3.22E-4 ID:SGTC_2994|Compound:9053520|FD-Score:-3.03|P-value:6.18E-4 ID:SGTC_3086|Compound:9117350|FD-Score:-3.10|P-value:4.78E-4 ID:SGTC_3090|Compound:9117696|FD-Score:-3.46|P-value:1.15E-4 ID:SGTC_3096|Compound:9117468|FD-Score:-3.57|P-value:7.44E-5 ID:SGTC_3230|Compound:9131665|FD-Score:-3.76|P-value:3.29E-5 ID:SGTC_3245|Compound:9134821|FD-Score:3.17|P-value:4.76E-4 ID:SGTC_3250|Compound:9135583|FD-Score:4.40|P-value:2.12E-6 ID:SGTC_3313|Compound:9133968|FD-Score:-2.97|P-value:7.94E-4 ID:SGTC_3314|Compound:9135860|FD-Score:-3.49|P-value:1.04E-4

Top fitness defect scores for YNR032W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_909 3448-9333 4.78 149.0 µM 2.90E-7 8 8.94E-7
2 SGTC_3250 9135583 4.40 49.5 µM 2.12E-6 7 5.46E-6
3 SGTC_2844 9010103 4.38 26.0 µM 2.27E-6 22 5.83E-6
4 SGTC_2695 st077686 4.12 52.0 µM 8.48E-6 31 1.93E-5
5 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.50 3.7 µM 1.30E-4 127 2.33E-4
6 SGTC_1728 st035614 3.49 33.8 µM 1.36E-4 78 2.44E-4
7 SGTC_627 1391-0720 3.45 175.0 µM 1.60E-4 27 2.82E-4
8 SGTC_954 1189-0853 3.38 2.9 µM 2.14E-4 endomembrane recycling 59 3.68E-4
9 SGTC_1193 1488-0126 3.37 41.5 µM 2.15E-4 45 3.71E-4
10 SGTC_1369 1866-0067 3.28 208.0 µM 3.14E-4 RPP1 & pyrimidine depletion 66 5.23E-4
11 SGTC_2894 9048625 3.21 32.5 µM 4.01E-4 34 6.54E-4
12 SGTC_3245 9134821 3.17 49.5 µM 4.76E-4 47 7.66E-4
13 SGTC_1674 st016616 3.08 23.6 µM 6.65E-4 65 0.00104
14 SGTC_573 3702-0553 3.07 84.7 µM 6.88E-4 41 0.00107
15 SGTC_1442 4112-3290 3.02 3.0 µM 8.27E-4 50 0.00127
16 SGTC_2839 9003951 3.01 26.0 µM 8.44E-4 47 0.00129
17 SGTC_2857 9024691 3.01 58.4 µM 8.57E-4 74 0.00131
18 SGTC_2607 solasodine 2.96 47.4 µM 0.00101 106 0.00153
19 SGTC_733 4069-0007 2.93 56.1 µM 0.00112 ERAD & cell cycle 155 0.00167
20 SGTC_3356 9151811 2.93 4.5 µM 0.00113 cell wall 64 0.00169

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.133 1.15E-14 YLR185W RPL37A hom Ribosomal 60S subunit protein L37A; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37A has a paralog, RPL37B, that arose from the whole genome duplication
0.118 8.25E-12 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.117 1.01E-11 YLR382C NAM2 hom Mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance
0.112 9.24E-11 YDR484W VPS52 hom Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin
0.111 1.04E-10 YMR031C EIS1 hom Component of the eisosome required for proper eisosome assembly; similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress
0.111 1.12E-10 YMR080C NAM7 hom ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance; forms cytoplasmic foci upon DNA replication stress
0.108 3.14E-10 YOR214C_p YOR214C_p hom Putative protein of unknown function; YOR214C is not an essential gene
0.101 4.18E-9 YHL002W HSE1 hom Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes
0.101 4.64E-9 YER082C UTP7 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.101 4.75E-9 YER009W NTF2 het Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
0.101 5.18E-9 YML016C PPZ1 hom Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
0.101 5.57E-9 YDR095C_d YDR095C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.100 7.66E-9 YMR026C PEX12 hom C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder
0.099 9.41E-9 YOL137W BSC6 hom Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
0.099 1.09E-8 YOR008C-A_p YOR008C-A_p hom Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres