HIPHOP chemogenomics database

YNR040W_p

Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain

fixedexpanded
Profile for YNR040W / YNR040W

Click on Significant Values for Screen Details

Top fitness defect scores for YNR040W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_3311	9131146	12.40	2.9 µM	6.40E-34	cell wall	10	1.22E-35
2	SGTC_3321	9137793	9.38	26.8 µM	3.26E-20	cell wall	7	3.33E-21
3	SGTC_188	3229-0966	8.69	278.5 µM	1.34E-17		2	1.88E-18
4	SGTC_528	3492-0019	8.00	172.0 µM	3.33E-15	calcium & mitochondrial duress	71	6.27E-16
5	SGTC_863	0466-0191	7.83	129.0 µM	1.17E-14	cell wall	18	2.36E-15
6	SGTC_467	ro 31-8220	7.30	72.8 µM	5.78E-13	calcium & mitochondrial duress	19	1.43E-13
7	SGTC_1800	st050079	6.94	29.1 µM	6.85E-12	NEO1-PIK1	25	1.93E-12
8	SGTC_2584	androsterone	6.57	48.7 µM	8.06E-11	cell wall	45	2.59E-11
9	SGTC_121	0557-0495	6.43	61.3 µM	1.93E-10	calcium & mitochondrial duress	14	6.50E-11
10	SGTC_1712	st032288	6.25	53.4 µM	5.92E-10	calcium & mitochondrial duress	73	2.11E-10
11	SGTC_363	0455-0021	5.92	3.1 µM	4.16E-9	azole & statin	33	1.64E-9
12	SGTC_514	4466-0038	5.71	2.6 nM	1.38E-8	cell wall	84	5.82E-9
13	SGTC_304	1310-0298	5.66	97.0 µM	1.81E-8	cell wall	23	7.70E-9
14	SGTC_922	1866-0035	5.47	480.0 µM	5.08E-8	excess fatty acid	25	2.29E-8
15	SGTC_2704	st078022	5.39	71.1 µM	7.86E-8		6	3.62E-8
16	SGTC_3185	9108267	5.31	49.5 µM	1.15E-7	60S ribosome export	3	5.39E-8
17	SGTC_6	0844-0013	5.19	19.8 µM	2.15E-7		31	1.04E-7
18	SGTC_1090	efavirenz	5.19	20.7 µM	2.21E-7		6	1.07E-7
19	SGTC_2091	4-phenylthiadiazole	4.96	200.0 µM	6.81E-7		5	3.51E-7
20	SGTC_2619	obliquin	4.87	87.9 µM	1.08E-6	cell wall	101	5.72E-7

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.375	2.34E-112	YDL021W	GPM2	hom	Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
0.330	4.30E-86	YDL066W	IDP1	hom	Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.325	3.40E-83	YBL006C	LDB7	hom	Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.301	3.10E-71	YJL099W	CHS6	hom	Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.296	6.58E-69	YLL032C	YLL032C	hom	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.289	2.23E-65	YJR142W_p	YJR142W_p	hom	Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.280	2.90E-61	YMR036C	MIH1	hom	Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
0.276	7.99E-60	YDL203C	ACK1	hom	Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.265	6.44E-55	YCL005W	LDB16	hom	Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.263	4.10E-54	YPL115C	BEM3	hom	Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
0.260	4.01E-53	YBL022C	PIM1	hom	ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria
0.260	6.10E-53	YLL040C	VPS13	hom	Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively
0.260	8.09E-53	YLR330W	CHS5	hom	Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane
0.256	2.70E-51	YDR475C	JIP4	hom	Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.246	2.84E-47	YJL073W	JEM1	hom	DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2