YNR048W

Protein that interacts with phospholipid translocase (flippase) Dnf3p; YNR048W has a paralog, CDC50, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR048W / YNR048W

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:4.32|P-value:9.43E-6 ID:SGTC_17|Compound:0960-0276|FD-Score:3.26|P-value:6.12E-4 ID:SGTC_26|Compound:0302-0163|FD-Score:3.22|P-value:7.06E-4 ID:SGTC_48|Compound:0382-0018|FD-Score:-4.08|P-value:2.70E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.02|P-value:3.46E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:3.43|P-value:3.40E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:4.44|P-value:5.35E-6 ID:SGTC_160|Compound:3453-0671|FD-Score:5.29|P-value:7.96E-8 ID:SGTC_177|Compound:1327-0068|FD-Score:3.32|P-value:4.94E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:3.55|P-value:2.19E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:-3.80|P-value:8.27E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:-5.46|P-value:3.28E-8 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:4.19|P-value:1.66E-5 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:5.00|P-value:3.67E-7 ID:SGTC_416|Compound:estradiol valerate|FD-Score:3.84|P-value:7.20E-5 ID:SGTC_442|Compound:cape|FD-Score:3.34|P-value:4.62E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:4.30|P-value:9.96E-6 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.59|P-value:1.85E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:-4.13|P-value:2.12E-5 ID:SGTC_771|Compound:0250-0039|FD-Score:-3.18|P-value:8.22E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:3.42|P-value:3.49E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:4.18|P-value:1.75E-5 ID:SGTC_1032|Compound:k061-1018|FD-Score:-3.67|P-value:1.40E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:4.14|P-value:2.04E-5 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.27|P-value:5.92E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:4.26|P-value:1.19E-5 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.40|P-value:3.79E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.19|P-value:7.95E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.13|P-value:9.50E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.32|P-value:5.06E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:3.37|P-value:4.19E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.42|P-value:3.56E-4 ID:SGTC_1682|Compound:st012968|FD-Score:3.18|P-value:8.11E-4 ID:SGTC_1725|Compound:st036284|FD-Score:3.76|P-value:9.82E-5 ID:SGTC_1726|Compound:st035556|FD-Score:-4.33|P-value:8.83E-6 ID:SGTC_1734|Compound:st037168|FD-Score:3.71|P-value:1.19E-4 ID:SGTC_1843|Compound:st055809|FD-Score:3.14|P-value:9.40E-4 ID:SGTC_1950|Compound:st077106|FD-Score:3.25|P-value:6.45E-4 ID:SGTC_1985|Compound:st071382|FD-Score:3.95|P-value:4.45E-5 ID:SGTC_1998|Compound:st075797|FD-Score:-3.56|P-value:2.14E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.62|P-value:1.68E-4 ID:SGTC_2081|Compound:5214970|FD-Score:-3.24|P-value:6.76E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:3.23|P-value:6.79E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-3.34|P-value:4.63E-4 ID:SGTC_2917|Compound:7979103|FD-Score:4.51|P-value:3.90E-6 ID:SGTC_2919|Compound:7978188|FD-Score:3.13|P-value:9.52E-4 ID:SGTC_2972|Compound:9093619|FD-Score:-4.33|P-value:8.91E-6 ID:SGTC_3129|Compound:9127257|FD-Score:3.26|P-value:6.09E-4 ID:SGTC_3164|Compound:9100705|FD-Score:4.41|P-value:6.16E-6 ID:SGTC_3322|Compound:9139058|FD-Score:3.99|P-value:3.90E-5 ID:SGTC_8|Compound:0354-0001|FD-Score:4.32|P-value:9.43E-6 ID:SGTC_17|Compound:0960-0276|FD-Score:3.26|P-value:6.12E-4 ID:SGTC_26|Compound:0302-0163|FD-Score:3.22|P-value:7.06E-4 ID:SGTC_48|Compound:0382-0018|FD-Score:-4.08|P-value:2.70E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.02|P-value:3.46E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:3.43|P-value:3.40E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:4.44|P-value:5.35E-6 ID:SGTC_160|Compound:3453-0671|FD-Score:5.29|P-value:7.96E-8 ID:SGTC_177|Compound:1327-0068|FD-Score:3.32|P-value:4.94E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:3.55|P-value:2.19E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:-3.80|P-value:8.27E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:-5.46|P-value:3.28E-8 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:4.19|P-value:1.66E-5 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:5.00|P-value:3.67E-7 ID:SGTC_416|Compound:estradiol valerate|FD-Score:3.84|P-value:7.20E-5 ID:SGTC_442|Compound:cape|FD-Score:3.34|P-value:4.62E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:4.30|P-value:9.96E-6 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.59|P-value:1.85E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:-4.13|P-value:2.12E-5 ID:SGTC_771|Compound:0250-0039|FD-Score:-3.18|P-value:8.22E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:3.42|P-value:3.49E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:4.18|P-value:1.75E-5 ID:SGTC_1032|Compound:k061-1018|FD-Score:-3.67|P-value:1.40E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:4.14|P-value:2.04E-5 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.27|P-value:5.92E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:4.26|P-value:1.19E-5 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.40|P-value:3.79E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.19|P-value:7.95E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.13|P-value:9.50E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.32|P-value:5.06E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:3.37|P-value:4.19E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.42|P-value:3.56E-4 ID:SGTC_1682|Compound:st012968|FD-Score:3.18|P-value:8.11E-4 ID:SGTC_1725|Compound:st036284|FD-Score:3.76|P-value:9.82E-5 ID:SGTC_1726|Compound:st035556|FD-Score:-4.33|P-value:8.83E-6 ID:SGTC_1734|Compound:st037168|FD-Score:3.71|P-value:1.19E-4 ID:SGTC_1843|Compound:st055809|FD-Score:3.14|P-value:9.40E-4 ID:SGTC_1950|Compound:st077106|FD-Score:3.25|P-value:6.45E-4 ID:SGTC_1985|Compound:st071382|FD-Score:3.95|P-value:4.45E-5 ID:SGTC_1998|Compound:st075797|FD-Score:-3.56|P-value:2.14E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.62|P-value:1.68E-4 ID:SGTC_2081|Compound:5214970|FD-Score:-3.24|P-value:6.76E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:3.23|P-value:6.79E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-3.34|P-value:4.63E-4 ID:SGTC_2917|Compound:7979103|FD-Score:4.51|P-value:3.90E-6 ID:SGTC_2919|Compound:7978188|FD-Score:3.13|P-value:9.52E-4 ID:SGTC_2972|Compound:9093619|FD-Score:-4.33|P-value:8.91E-6 ID:SGTC_3129|Compound:9127257|FD-Score:3.26|P-value:6.09E-4 ID:SGTC_3164|Compound:9100705|FD-Score:4.41|P-value:6.16E-6 ID:SGTC_3322|Compound:9139058|FD-Score:3.99|P-value:3.90E-5

Top fitness defect scores for YNR048W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_160 3453-0671 5.29 289.7 µM 7.96E-8 18 6.13E-8
2 SGTC_415 dibenzyl ketone 5.00 100.0 µM 3.67E-7 5 2.91E-7
3 SGTC_2917 7979103 4.51 53.8 µM 3.90E-6 17 3.22E-6
4 SGTC_136 0097-0015 4.44 404.5 µM 5.35E-6 60S ribosome export 11 4.45E-6
5 SGTC_3164 9100705 4.41 49.5 µM 6.16E-6 3 5.13E-6
6 SGTC_8 0354-0001 4.32 70.0 µM 9.43E-6 63 7.91E-6
7 SGTC_451 chloral hydrate 4.30 100.0 µM 9.96E-6 38 8.37E-6
8 SGTC_1179 1021-1431 4.26 9.3 µM 1.19E-5 33 1.01E-5
9 SGTC_410 α-linolenic acid 4.19 100.0 µM 1.66E-5 excess fatty acid 30 1.41E-5
10 SGTC_1029 k015-0030 4.18 64.7 µM 1.75E-5 23 1.49E-5
11 SGTC_1080 nisoldipine 4.14 24.4 µM 2.04E-5 TSC3-RPN4 23 1.74E-5
12 SGTC_3322 9139058 3.99 2.1 µM 3.90E-5 cell wall 26 3.36E-5
13 SGTC_1985 st071382 3.95 65.5 µM 4.45E-5 20 3.84E-5
14 SGTC_416 estradiol valerate 3.84 100.0 µM 7.20E-5 13 6.27E-5
15 SGTC_1725 st036284 3.76 20.6 µM 9.82E-5 31 8.59E-5
16 SGTC_1734 st037168 3.71 69.4 µM 1.19E-4 34 1.05E-4
17 SGTC_2035 5154463 3.62 94.6 µM 1.68E-4 24 1.48E-4
18 SGTC_457 grayanotoxin iii 3.59 135.0 µM 1.85E-4 92 1.63E-4
19 SGTC_188 3229-0966 3.55 278.5 µM 2.19E-4 37 1.94E-4
20 SGTC_129 0088-0017 3.43 176.6 µM 3.40E-4 87 3.04E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.107 5.63E-10 YGR055W MUP1 hom High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake
0.082 1.86E-6 YNL319W_d YNL319W_d hom Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HXT14
0.077 7.01E-6 YOR047C STD1 hom Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]
0.075 1.49E-5 YNL268W LYP1 hom Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids
0.075 1.55E-5 YDR067C_p OCA6_p hom Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT
0.074 1.57E-5 YJL038C LOH1 hom Protein of unknown function with proposed roles in maintenance of genome integrity and also in spore wall assembly; induced during sporulation; repressed during vegetative growth by Sum1p and Hst1p; sequence similar to IRC1
0.074 1.69E-5 YNL275W BOR1 hom Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1
0.074 1.78E-5 YJR145C RPS4A hom Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, that arose from the whole genome duplication
0.074 2.03E-5 YHR034C PIH1 hom Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II
0.073 2.34E-5 YBR031W RPL4A hom Ribosomal 60S subunit protein L4A; N-terminally acetylated; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4A has a paralog, RPL4B, that arose from the whole genome duplication
0.073 2.46E-5 YJL135W_d YJL135W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
0.072 3.09E-5 YOR311C DGK1 hom Diacylglycerol kinase, localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain
0.072 3.14E-5 YOL062C APM4 hom Mu2-like subunit of the clathrin associated protein complex (AP-2); involved in vesicle transport
0.071 3.89E-5 YDR313C PIB1 hom RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain
0.070 5.00E-5 YGR068C ART5 hom Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane