YNR049C / MSO1

Probable component of the secretory vesicle docking complex; acts at a late step in secretion; shows genetic and physical interactions with Sec1p; required for prospore membrane formation during sporulation; relocalizes from bud neck to nucleus upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR049C / MSO1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-3.34|P-value:3.98E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:-3.39|P-value:3.37E-4 ID:SGTC_192|Compound:3455-0609|FD-Score:-3.89|P-value:4.74E-5 ID:SGTC_295|Compound:k015-0027|FD-Score:3.18|P-value:6.96E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:-4.03|P-value:2.67E-5 ID:SGTC_577|Compound:r071-0003|FD-Score:-3.85|P-value:5.66E-5 ID:SGTC_578|Compound:3460-0051|FD-Score:3.14|P-value:8.03E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:3.08|P-value:9.89E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:3.48|P-value:2.31E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:5.54|P-value:1.28E-8 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.09|P-value:9.60E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:-3.70|P-value:1.00E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:5.56|P-value:1.15E-8 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.11|P-value:8.78E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:3.13|P-value:8.27E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:-4.80|P-value:7.31E-7 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.84|P-value:5.71E-5 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.53|P-value:2.02E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.15|P-value:7.65E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:3.52|P-value:2.03E-4 ID:SGTC_1473|Compound:k844-0725|FD-Score:-3.14|P-value:8.04E-4 ID:SGTC_1474|Compound:0330-0125|FD-Score:-3.09|P-value:9.65E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:3.26|P-value:5.19E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:3.22|P-value:6.05E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-4.93|P-value:3.72E-7 ID:SGTC_1508|Compound:1080-0625|FD-Score:3.34|P-value:3.87E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:3.34|P-value:3.93E-4 ID:SGTC_1628|Compound:st004252|FD-Score:-3.10|P-value:9.34E-4 ID:SGTC_1673|Compound:st016611|FD-Score:4.06|P-value:2.24E-5 ID:SGTC_1808|Compound:st050063|FD-Score:3.14|P-value:7.92E-4 ID:SGTC_1852|Compound:st056254|FD-Score:-3.15|P-value:7.96E-4 ID:SGTC_1859|Compound:st055998|FD-Score:3.92|P-value:4.03E-5 ID:SGTC_1933|Compound:st074711|FD-Score:-3.36|P-value:3.74E-4 ID:SGTC_1937|Compound:st074714|FD-Score:-3.28|P-value:5.02E-4 ID:SGTC_2093|Compound:5331342|FD-Score:3.29|P-value:4.77E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.12|P-value:8.52E-4 ID:SGTC_2381|Compound:9035592|FD-Score:3.45|P-value:2.63E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.25|P-value:5.40E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.27|P-value:5.02E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.11|P-value:8.93E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:-3.28|P-value:5.07E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.80|P-value:6.62E-5 ID:SGTC_2739|Compound:tacrine|FD-Score:4.07|P-value:2.19E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:7.43|P-value:4.28E-14 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.31|P-value:4.39E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.27|P-value:5.10E-4 ID:SGTC_2807|Compound:7945238|FD-Score:-3.52|P-value:2.03E-4 ID:SGTC_2831|Compound:7999036|FD-Score:-3.17|P-value:7.41E-4 ID:SGTC_2935|Compound:9038016|FD-Score:3.29|P-value:4.64E-4 ID:SGTC_2963|Compound:9082507|FD-Score:3.15|P-value:7.62E-4 ID:SGTC_3055|Compound:9094636|FD-Score:3.61|P-value:1.40E-4 ID:SGTC_3100|Compound:9120536|FD-Score:3.33|P-value:4.14E-4 ID:SGTC_3151|Compound:9099821|FD-Score:3.36|P-value:3.64E-4 ID:SGTC_3255|Compound:9139072|FD-Score:3.70|P-value:9.80E-5 ID:SGTC_3300|Compound:9124615|FD-Score:3.14|P-value:8.10E-4 ID:SGTC_3310|Compound:9130229|FD-Score:3.87|P-value:5.10E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.34|P-value:3.98E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:-3.39|P-value:3.37E-4 ID:SGTC_192|Compound:3455-0609|FD-Score:-3.89|P-value:4.74E-5 ID:SGTC_295|Compound:k015-0027|FD-Score:3.18|P-value:6.96E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:-4.03|P-value:2.67E-5 ID:SGTC_577|Compound:r071-0003|FD-Score:-3.85|P-value:5.66E-5 ID:SGTC_578|Compound:3460-0051|FD-Score:3.14|P-value:8.03E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:3.08|P-value:9.89E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:3.48|P-value:2.31E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:5.54|P-value:1.28E-8 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.09|P-value:9.60E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:-3.70|P-value:1.00E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:5.56|P-value:1.15E-8 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.11|P-value:8.78E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:3.13|P-value:8.27E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:-4.80|P-value:7.31E-7 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.84|P-value:5.71E-5 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.53|P-value:2.02E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.15|P-value:7.65E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:3.52|P-value:2.03E-4 ID:SGTC_1473|Compound:k844-0725|FD-Score:-3.14|P-value:8.04E-4 ID:SGTC_1474|Compound:0330-0125|FD-Score:-3.09|P-value:9.65E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:3.26|P-value:5.19E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:3.22|P-value:6.05E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-4.93|P-value:3.72E-7 ID:SGTC_1508|Compound:1080-0625|FD-Score:3.34|P-value:3.87E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:3.34|P-value:3.93E-4 ID:SGTC_1628|Compound:st004252|FD-Score:-3.10|P-value:9.34E-4 ID:SGTC_1673|Compound:st016611|FD-Score:4.06|P-value:2.24E-5 ID:SGTC_1808|Compound:st050063|FD-Score:3.14|P-value:7.92E-4 ID:SGTC_1852|Compound:st056254|FD-Score:-3.15|P-value:7.96E-4 ID:SGTC_1859|Compound:st055998|FD-Score:3.92|P-value:4.03E-5 ID:SGTC_1933|Compound:st074711|FD-Score:-3.36|P-value:3.74E-4 ID:SGTC_1937|Compound:st074714|FD-Score:-3.28|P-value:5.02E-4 ID:SGTC_2093|Compound:5331342|FD-Score:3.29|P-value:4.77E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.12|P-value:8.52E-4 ID:SGTC_2381|Compound:9035592|FD-Score:3.45|P-value:2.63E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.25|P-value:5.40E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.27|P-value:5.02E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.11|P-value:8.93E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:-3.28|P-value:5.07E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.80|P-value:6.62E-5 ID:SGTC_2739|Compound:tacrine|FD-Score:4.07|P-value:2.19E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:7.43|P-value:4.28E-14 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.31|P-value:4.39E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.27|P-value:5.10E-4 ID:SGTC_2807|Compound:7945238|FD-Score:-3.52|P-value:2.03E-4 ID:SGTC_2831|Compound:7999036|FD-Score:-3.17|P-value:7.41E-4 ID:SGTC_2935|Compound:9038016|FD-Score:3.29|P-value:4.64E-4 ID:SGTC_2963|Compound:9082507|FD-Score:3.15|P-value:7.62E-4 ID:SGTC_3055|Compound:9094636|FD-Score:3.61|P-value:1.40E-4 ID:SGTC_3100|Compound:9120536|FD-Score:3.33|P-value:4.14E-4 ID:SGTC_3151|Compound:9099821|FD-Score:3.36|P-value:3.64E-4 ID:SGTC_3255|Compound:9139072|FD-Score:3.70|P-value:9.80E-5 ID:SGTC_3300|Compound:9124615|FD-Score:3.14|P-value:8.10E-4 ID:SGTC_3310|Compound:9130229|FD-Score:3.87|P-value:5.10E-5

Top fitness defect scores for YNR049C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2756 carbadox 7.43 75.1 µM 4.28E-14 9 5.62E-14
2 SGTC_1027 k015-0025 5.56 8.7 µM 1.15E-8 5 1.35E-8
3 SGTC_994 3910-0338 5.54 138.0 µM 1.28E-8 calcium & mitochondrial duress 17 1.49E-8
4 SGTC_2739 tacrine 4.07 100.9 µM 2.19E-5 heme requiring 12 2.40E-5
5 SGTC_1673 st016611 4.06 27.3 µM 2.24E-5 41 2.45E-5
6 SGTC_1859 st055998 3.92 20.0 µM 4.03E-5 24 4.39E-5
7 SGTC_3310 9130229 3.87 44.1 µM 5.10E-5 Golgi 29 5.54E-5
8 SGTC_1133 3473-0247 3.84 50.0 µM 5.71E-5 RSC complex & mRNA processing 55 6.19E-5
9 SGTC_2682 pyrogallin 3.80 40.0 µM 6.62E-5 copper-dependent oxidative stress 31 7.18E-5
10 SGTC_3255 9139072 3.70 49.5 µM 9.80E-5 22 1.06E-4
11 SGTC_3055 9094636 3.61 49.5 µM 1.40E-4 17 1.51E-4
12 SGTC_1302 1159-0335 3.52 255.0 µM 2.03E-4 25 2.18E-4
13 SGTC_947 3447-0010 3.48 211.0 µM 2.31E-4 28 2.48E-4
14 SGTC_2381 9035592 3.45 200.0 µM 2.63E-4 36 2.82E-4
15 SGTC_3151 9099821 3.36 49.5 µM 3.64E-4 38 3.88E-4
16 SGTC_1508 1080-0625 3.34 72.9 µM 3.87E-4 37 4.13E-4
17 SGTC_1529 apigenin 3.34 74.0 µM 3.93E-4 56 4.19E-4
18 SGTC_3100 9120536 3.33 49.5 µM 4.14E-4 26 4.42E-4
19 SGTC_2758 dehydroepiandrosterone 3.31 69.3 µM 4.39E-4 70 4.68E-4
20 SGTC_2935 9038016 3.29 30.0 µM 4.64E-4 45 4.94E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.110 1.92E-10 YGL210W YPT32 hom Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance increases in response to DNA replication stress; YPT32 has a paralog, YPT31, that arose from the whole genome duplication
0.108 3.00E-10 YOL137W BSC6 hom Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
0.107 5.72E-10 YNR068C_p YNR068C_p hom Putative protein of unknown function; exhibits homology to C-terminal end of Bul1p; expressed as a readthrough product of BSC5, the readthrough locus being termed BUL3; the BUL3 readthrough product is involved in ubiquitin-mediated sorting of plasma membrane proteins and interacts with WW domains of Rsp5p in vitro, but in a functionally different way than the non-readthrough form
0.088 3.01E-7 YLL019C KNS1 hom Protein kinase involved in negative regulation of PolIII transcription; effector kinase of the TOR signaling pathway and phosphorylates Rpc53p to regulate ribosome and tRNA biosynthesis; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues; capable of autophosphorylation
0.088 3.05E-7 YPR096C YPR096C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments
0.085 7.48E-7 YLR459W GAB1 het GPI transamidase subunit, involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPI
0.085 7.90E-7 YMR206W_p YMR206W_p hom Putative protein of unknown function; not an essential gene; YMR206W has a paralog, YNR014W, that arose from the whole genome duplication
0.080 3.94E-6 YMR061W RNA14 het Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping
0.078 6.50E-6 YFR033C QCR6 hom Subunit 6 of the ubiquinol cytochrome-c reductase complex; the complex, also known as the cytochrome bc(1) complex or Complex III, is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1; may be loosely associated with the complex since it is easily released into the intermembrane space
0.078 6.76E-6 YJL057C IKS1 hom Protein kinase of unknown cellular role; putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p
0.074 1.64E-5 YOL059W GPD2 hom NAD-dependent glycerol 3-phosphate dehydrogenase, homolog of Gpd1p, expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria; constitutively active but is inactivated via phosphorylation by energy-stress responsive kinase SNF1
0.074 1.99E-5 YLR427W MAG2 hom Cytoplasmic protein of unknown function; induced in response to mycotoxin patulin; ubiquitinated protein similar to the human ring finger motif protein RNF10; predicted to be involved in repair of alkylated DNA due to interaction with MAG1
0.072 2.75E-5 YIR011C STS1 het Protein required for localizing proteasomes to the nucleus; interacts with the karyopherin Srp1p; involved in ubiquitin-mediated protein degradation
0.072 3.07E-5 YER066C-A_d YER066C-A_d hom Dubious open reading frame unlikely to encode a protein, partially overlaps uncharacterized ORF YER067W
0.072 3.39E-5 YJR070C LIA1 hom Deoxyhypusine hydroxylase; HEAT-repeat containing metalloenzyme that catalyzes hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning; protein abundance increases in response to DNA replication stress