YNR056C / BIO5

Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR056C / BIO5

Click on Significant Values for Screen Details ID:SGTC_4|Compound:0960-0234|FD-Score:3.95|P-value:3.96E-5 ID:SGTC_6|Compound:0844-0013|FD-Score:3.42|P-value:3.08E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:3.90|P-value:4.79E-5 ID:SGTC_35|Compound:0133-0054|FD-Score:4.41|P-value:5.30E-6 ID:SGTC_97|Compound:0535-0701|FD-Score:3.10|P-value:9.43E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:-3.29|P-value:6.09E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:3.17|P-value:7.64E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.46|P-value:2.71E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:3.26|P-value:5.61E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:3.32|P-value:4.45E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:4.44|P-value:4.64E-6 ID:SGTC_639|Compound:0833-0042|FD-Score:3.75|P-value:8.85E-5 ID:SGTC_764|Compound:1951-2361|FD-Score:3.41|P-value:3.22E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:4.88|P-value:5.64E-7 ID:SGTC_976|Compound:1348-1067|FD-Score:3.16|P-value:7.91E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:-3.52|P-value:2.67E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.61|P-value:1.52E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.17|P-value:7.45E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.43|P-value:3.04E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.27|P-value:5.36E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.91|P-value:4.65E-5 ID:SGTC_1240|Compound:0356-0016|FD-Score:-3.29|P-value:6.13E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:4.61|P-value:2.07E-6 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.42|P-value:3.07E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.20|P-value:6.69E-4 ID:SGTC_1840|Compound:st055363|FD-Score:-3.20|P-value:8.27E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.38|P-value:3.56E-4 ID:SGTC_1953|Compound:st076800|FD-Score:4.06|P-value:2.47E-5 ID:SGTC_1983|Compound:st071813|FD-Score:4.14|P-value:1.79E-5 ID:SGTC_2279|Compound:7948423|FD-Score:4.20|P-value:1.37E-5 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.77|P-value:8.21E-5 ID:SGTC_2754|Compound:granisetron|FD-Score:4.01|P-value:3.07E-5 ID:SGTC_2814|Compound:7977482|FD-Score:3.10|P-value:9.46E-4 ID:SGTC_2819|Compound:7996655|FD-Score:3.40|P-value:3.37E-4 ID:SGTC_2825|Compound:7998094|FD-Score:3.90|P-value:4.92E-5 ID:SGTC_2871|Compound:9038510|FD-Score:3.20|P-value:6.91E-4 ID:SGTC_2881|Compound:9058953|FD-Score:3.13|P-value:8.62E-4 ID:SGTC_3137|Compound:9097352|FD-Score:4.36|P-value:6.72E-6 ID:SGTC_3245|Compound:9134821|FD-Score:3.70|P-value:1.09E-4 ID:SGTC_4|Compound:0960-0234|FD-Score:3.95|P-value:3.96E-5 ID:SGTC_6|Compound:0844-0013|FD-Score:3.42|P-value:3.08E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:3.90|P-value:4.79E-5 ID:SGTC_35|Compound:0133-0054|FD-Score:4.41|P-value:5.30E-6 ID:SGTC_97|Compound:0535-0701|FD-Score:3.10|P-value:9.43E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:-3.29|P-value:6.09E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:3.17|P-value:7.64E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.46|P-value:2.71E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:3.26|P-value:5.61E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:3.32|P-value:4.45E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:4.44|P-value:4.64E-6 ID:SGTC_639|Compound:0833-0042|FD-Score:3.75|P-value:8.85E-5 ID:SGTC_764|Compound:1951-2361|FD-Score:3.41|P-value:3.22E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:4.88|P-value:5.64E-7 ID:SGTC_976|Compound:1348-1067|FD-Score:3.16|P-value:7.91E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:-3.52|P-value:2.67E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.61|P-value:1.52E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.17|P-value:7.45E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.43|P-value:3.04E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.27|P-value:5.36E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.91|P-value:4.65E-5 ID:SGTC_1240|Compound:0356-0016|FD-Score:-3.29|P-value:6.13E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:4.61|P-value:2.07E-6 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.42|P-value:3.07E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.20|P-value:6.69E-4 ID:SGTC_1840|Compound:st055363|FD-Score:-3.20|P-value:8.27E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.38|P-value:3.56E-4 ID:SGTC_1953|Compound:st076800|FD-Score:4.06|P-value:2.47E-5 ID:SGTC_1983|Compound:st071813|FD-Score:4.14|P-value:1.79E-5 ID:SGTC_2279|Compound:7948423|FD-Score:4.20|P-value:1.37E-5 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.77|P-value:8.21E-5 ID:SGTC_2754|Compound:granisetron|FD-Score:4.01|P-value:3.07E-5 ID:SGTC_2814|Compound:7977482|FD-Score:3.10|P-value:9.46E-4 ID:SGTC_2819|Compound:7996655|FD-Score:3.40|P-value:3.37E-4 ID:SGTC_2825|Compound:7998094|FD-Score:3.90|P-value:4.92E-5 ID:SGTC_2871|Compound:9038510|FD-Score:3.20|P-value:6.91E-4 ID:SGTC_2881|Compound:9058953|FD-Score:3.13|P-value:8.62E-4 ID:SGTC_3137|Compound:9097352|FD-Score:4.36|P-value:6.72E-6 ID:SGTC_3245|Compound:9134821|FD-Score:3.70|P-value:1.09E-4

Top fitness defect scores for YNR056C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_963 1269-2853 4.88 151.0 µM 5.64E-7 15 5.35E-7
2 SGTC_1251 0490-5699 4.61 265.0 µM 2.07E-6 17 1.98E-6
3 SGTC_573 3702-0553 4.44 84.7 µM 4.64E-6 6 4.49E-6
4 SGTC_35 0133-0054 4.41 64.1 µM 5.30E-6 22 5.14E-6
5 SGTC_3137 9097352 4.36 49.5 µM 6.72E-6 30 6.52E-6
6 SGTC_2279 7948423 4.20 32.9 µM 1.37E-5 9 1.34E-5
7 SGTC_1983 st071813 4.14 46.9 µM 1.79E-5 RPP1 & pyrimidine depletion 12 1.75E-5
8 SGTC_1953 st076800 4.06 12.1 µM 2.47E-5 45 2.43E-5
9 SGTC_2754 granisetron 4.01 64.0 µM 3.07E-5 28 3.02E-5
10 SGTC_4 0960-0234 3.95 25.7 µM 3.96E-5 Golgi 14 3.91E-5
11 SGTC_1157 4092-0394 3.91 27.6 µM 4.65E-5 32 4.59E-5
12 SGTC_24 0417-1663 3.90 219.0 µM 4.79E-5 17 4.73E-5
13 SGTC_2825 7998094 3.90 58.4 µM 4.92E-5 fatty acid desaturase (OLE1) 33 4.86E-5
14 SGTC_2595 hexamethylquercetagetin 3.77 100.0 µM 8.21E-5 31 8.15E-5
15 SGTC_639 0833-0042 3.75 114.0 µM 8.85E-5 52 8.79E-5
16 SGTC_3245 9134821 3.70 49.5 µM 1.09E-4 27 1.08E-4
17 SGTC_1119 parthenolide 3.61 318.5 nM 1.52E-4 TSC3-RPN4 50 1.52E-4
18 SGTC_392 N-ethylmaleimide 3.46 8.3 µM 2.71E-4 RNA pol III & RNase P/MRP 27 2.72E-4
19 SGTC_1129 3453-1384 3.43 223.0 µM 3.04E-4 61 3.05E-4
20 SGTC_1252 0493-0875 3.42 34.8 µM 3.07E-4 47 3.09E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.140 4.44E-16 YGR012W YGR012W hom Putative cysteine synthase, localized to the mitochondrial outer membrane
0.116 1.85E-11 YOR060C SLD7 het Protein with a role in chromosomal DNA replication; interacts with Sld3p and reduces its affinity for Cdc45p; deletion mutant has aberrant mitochondria
0.107 4.99E-10 YHR097C_p YHR097C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
0.095 3.53E-8 YDR503C LPP1 hom Lipid phosphate phosphatase, catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate; involved in control of the cellular levels of phosphatidylinositol and PA
0.092 1.01E-7 YDR210W_p YDR210W_p hom Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.091 1.10E-7 YOR149C SMP3 het Alpha 1,2-mannosyltransferase involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure
0.091 1.14E-7 YDR502C SAM2 hom S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM2 has a paralog, SAM1, that arose from the whole genome duplication
0.090 1.83E-7 YHR106W TRR2 hom Mitochondrial thioredoxin reductase; involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif (CAVC) present in prokaryotic orthologs; binds NADPH and FAD; TRR2 has a paralog, TRR1, that arose from the whole genome duplication
0.087 4.57E-7 YMR244C-A COA6 hom Protein involved in cytochrome c oxidase assembly; also required for efficient formation of respiratory supercomplexes comprised of Complexes III and IV; localizes to the mitochondrial intermembrane space; has a human homolog; transcription is induced in response to the DNA-damaging agent MMS; protein abundance increases in response to DNA replication stress
0.085 8.01E-7 YLR097C HRT3 hom Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies
0.082 2.10E-6 YJR147W HMS2 hom Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant; HMS2 has a paralog, SKN7, that arose from the whole genome duplication
0.079 5.10E-6 YGL080W FMP37 hom Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; null mutant displays slow growth that is complemented by expression of human or mouse ortholog; mutation in human ortholog is associated with lactic acidosis and hyperpyruvatemia
0.079 5.13E-6 YPL093W NOG1 het Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins
0.078 5.49E-6 YGR236C SPG1 hom Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.078 6.12E-6 YMR288W HSH155 het U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155