YNR067C / DSE4

Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR067C / DSE4

Click on Significant Values for Screen Details ID:SGTC_110|Compound:0850-0284|FD-Score:-3.43|P-value:7.25E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:5.71|P-value:5.93E-9 ID:SGTC_289|Compound:k017-0060|FD-Score:3.73|P-value:8.06E-5 ID:SGTC_309|Compound:k408-0051|FD-Score:3.09|P-value:7.97E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:-3.47|P-value:6.35E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.21|P-value:5.42E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:3.80|P-value:5.98E-5 ID:SGTC_859|Compound:0439-0102|FD-Score:3.17|P-value:6.10E-4 ID:SGTC_895|Compound:0964-0006|FD-Score:-3.56|P-value:4.61E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:3.23|P-value:5.06E-4 ID:SGTC_898|Compound:1000-0849|FD-Score:3.14|P-value:6.73E-4 ID:SGTC_901|Compound:1112-0062|FD-Score:-3.54|P-value:5.10E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:4.12|P-value:1.64E-5 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.41|P-value:2.65E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:4.27|P-value:8.32E-6 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.41|P-value:7.77E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.20|P-value:5.55E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:3.11|P-value:7.41E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:-3.73|P-value:2.56E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.29|P-value:4.04E-4 ID:SGTC_1649|Compound:st011737|FD-Score:4.49|P-value:3.12E-6 ID:SGTC_1782|Compound:st039423|FD-Score:4.14|P-value:1.45E-5 ID:SGTC_1847|Compound:st056231|FD-Score:3.41|P-value:2.59E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:3.40|P-value:2.74E-4 ID:SGTC_2073|Compound:5212005|FD-Score:-3.52|P-value:5.33E-4 ID:SGTC_2084|Compound:5306078|FD-Score:3.48|P-value:2.07E-4 ID:SGTC_2108|Compound:5365811|FD-Score:3.13|P-value:7.03E-4 ID:SGTC_2146|Compound:5545642|FD-Score:3.63|P-value:1.16E-4 ID:SGTC_2168|Compound:5727979|FD-Score:3.03|P-value:9.72E-4 ID:SGTC_2242|Compound:6630449|FD-Score:-4.02|P-value:8.59E-5 ID:SGTC_2252|Compound:omeprazole|FD-Score:3.36|P-value:3.13E-4 ID:SGTC_2374|Compound:9071832|FD-Score:-4.34|P-value:2.40E-5 ID:SGTC_2412|Compound:st077135|FD-Score:3.30|P-value:3.92E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:4.18|P-value:1.25E-5 ID:SGTC_2576|Compound:guaiol|FD-Score:3.62|P-value:1.21E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-11.70|P-value:1.76E-29 ID:SGTC_2935|Compound:9038016|FD-Score:4.43|P-value:4.14E-6 ID:SGTC_2946|Compound:9065502|FD-Score:4.65|P-value:1.46E-6 ID:SGTC_3026|Compound:9090633|FD-Score:3.12|P-value:7.14E-4 ID:SGTC_3027|Compound:9089541|FD-Score:3.25|P-value:4.61E-4 ID:SGTC_3054|Compound:9094397|FD-Score:4.62|P-value:1.73E-6 ID:SGTC_3056|Compound:9094900|FD-Score:6.53|P-value:4.07E-11 ID:SGTC_3114|Compound:9122766|FD-Score:3.33|P-value:3.47E-4 ID:SGTC_110|Compound:0850-0284|FD-Score:-3.43|P-value:7.25E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:5.71|P-value:5.93E-9 ID:SGTC_289|Compound:k017-0060|FD-Score:3.73|P-value:8.06E-5 ID:SGTC_309|Compound:k408-0051|FD-Score:3.09|P-value:7.97E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:-3.47|P-value:6.35E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.21|P-value:5.42E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:3.80|P-value:5.98E-5 ID:SGTC_859|Compound:0439-0102|FD-Score:3.17|P-value:6.10E-4 ID:SGTC_895|Compound:0964-0006|FD-Score:-3.56|P-value:4.61E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:3.23|P-value:5.06E-4 ID:SGTC_898|Compound:1000-0849|FD-Score:3.14|P-value:6.73E-4 ID:SGTC_901|Compound:1112-0062|FD-Score:-3.54|P-value:5.10E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:4.12|P-value:1.64E-5 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.41|P-value:2.65E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:4.27|P-value:8.32E-6 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.41|P-value:7.77E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.20|P-value:5.55E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:3.11|P-value:7.41E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:-3.73|P-value:2.56E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.29|P-value:4.04E-4 ID:SGTC_1649|Compound:st011737|FD-Score:4.49|P-value:3.12E-6 ID:SGTC_1782|Compound:st039423|FD-Score:4.14|P-value:1.45E-5 ID:SGTC_1847|Compound:st056231|FD-Score:3.41|P-value:2.59E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:3.40|P-value:2.74E-4 ID:SGTC_2073|Compound:5212005|FD-Score:-3.52|P-value:5.33E-4 ID:SGTC_2084|Compound:5306078|FD-Score:3.48|P-value:2.07E-4 ID:SGTC_2108|Compound:5365811|FD-Score:3.13|P-value:7.03E-4 ID:SGTC_2146|Compound:5545642|FD-Score:3.63|P-value:1.16E-4 ID:SGTC_2168|Compound:5727979|FD-Score:3.03|P-value:9.72E-4 ID:SGTC_2242|Compound:6630449|FD-Score:-4.02|P-value:8.59E-5 ID:SGTC_2252|Compound:omeprazole|FD-Score:3.36|P-value:3.13E-4 ID:SGTC_2374|Compound:9071832|FD-Score:-4.34|P-value:2.40E-5 ID:SGTC_2412|Compound:st077135|FD-Score:3.30|P-value:3.92E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:4.18|P-value:1.25E-5 ID:SGTC_2576|Compound:guaiol|FD-Score:3.62|P-value:1.21E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-11.70|P-value:1.76E-29 ID:SGTC_2935|Compound:9038016|FD-Score:4.43|P-value:4.14E-6 ID:SGTC_2946|Compound:9065502|FD-Score:4.65|P-value:1.46E-6 ID:SGTC_3026|Compound:9090633|FD-Score:3.12|P-value:7.14E-4 ID:SGTC_3027|Compound:9089541|FD-Score:3.25|P-value:4.61E-4 ID:SGTC_3054|Compound:9094397|FD-Score:4.62|P-value:1.73E-6 ID:SGTC_3056|Compound:9094900|FD-Score:6.53|P-value:4.07E-11 ID:SGTC_3114|Compound:9122766|FD-Score:3.33|P-value:3.47E-4

Top fitness defect scores for YNR067C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3056 9094900 6.53 49.5 µM 4.07E-11 2 3.34E-11
2 SGTC_150 3970-0969 5.71 77.2 µM 5.93E-9 24 5.69E-9
3 SGTC_2946 9065502 4.65 71.4 µM 1.46E-6 5 1.62E-6
4 SGTC_3054 9094397 4.62 49.5 µM 1.73E-6 fatty acid desaturase (OLE1) 15 1.93E-6
5 SGTC_1649 st011737 4.49 51.3 µM 3.12E-6 23 3.54E-6
6 SGTC_2935 9038016 4.43 30.0 µM 4.14E-6 10 4.73E-6
7 SGTC_1039 k821-0043 4.27 94.0 µM 8.32E-6 Golgi 18 9.64E-6
8 SGTC_2531 methyl deoxycholate 4.18 70.1 µM 1.25E-5 19 1.46E-5
9 SGTC_1782 st039423 4.14 80.6 µM 1.45E-5 17 1.70E-5
10 SGTC_948 3448-0295 4.12 75.3 µM 1.64E-5 23 1.93E-5
11 SGTC_836 0330-0104 3.80 1.4 µM 5.98E-5 20 7.20E-5
12 SGTC_289 k017-0060 3.73 526.0 µM 8.06E-5 5 9.76E-5
13 SGTC_2146 5545642 3.63 200.0 µM 1.16E-4 24 1.42E-4
14 SGTC_2576 guaiol 3.62 23.1 µM 1.21E-4 36 1.48E-4
15 SGTC_2084 5306078 3.48 60.6 µM 2.07E-4 31 2.54E-4
16 SGTC_1847 st056231 3.41 15.0 µM 2.59E-4 51 3.19E-4
17 SGTC_1024 4507-0395 3.41 26.0 µM 2.65E-4 TSC3-RPN4 41 3.27E-4
18 SGTC_1876 myriocin 3.40 605.0 nM 2.74E-4 52 3.38E-4
19 SGTC_2252 omeprazole 3.36 400.0 µM 3.13E-4 17 3.87E-4
20 SGTC_3114 9122766 3.33 49.5 µM 3.47E-4 35 4.29E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.296 6.20E-69 YER066W_p RRT13_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
0.258 2.53E-52 YLR395C COX8 hom Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.248 2.54E-48 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.218 1.55E-37 YGR015C_p YGR015C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.207 9.56E-34 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.193 1.40E-29 YJL043W_p YJL043W_p hom Putative protein of unknown function; YJL043W is a non-essential gene
0.179 1.76E-25 YNL220W ADE12 hom Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence
0.176 1.21E-24 YIL115C NUP159 het FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport; regulates ADP release from the ATP-dependent RNA helicase Dbp5p; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup116p)
0.174 3.15E-24 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.168 1.00E-22 YGL144C ROG1 hom Protein with putative serine active lipase domain; ROG1 has a paralog, YDL109C, that arose from the whole genome duplication
0.166 3.38E-22 YER068W MOT2 hom Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications
0.152 8.00E-19 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.148 6.82E-18 YPL100W ATG21 hom Phosphoinositide binding protein required for vesicle formation in the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein
0.141 2.47E-16 YAL004W_d YAL004W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene SSA1/YAL005C
0.136 2.75E-15 YCL036W GFD2 hom Protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; GFD2 has a paralog, YDR514C, that arose from the whole genome duplication