YNR072W / HXT17

Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR072W / HXT17

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.68|P-value:6.78E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.88|P-value:3.01E-5 ID:SGTC_89|Compound:0302-0250|FD-Score:-3.22|P-value:4.38E-4 ID:SGTC_105|Compound:0111-0055|FD-Score:3.63|P-value:8.51E-5 ID:SGTC_251|Compound:melphalan|FD-Score:3.24|P-value:3.95E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.09|P-value:6.95E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:3.97|P-value:1.97E-5 ID:SGTC_486|Compound:niguldipine|FD-Score:3.28|P-value:3.38E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:3.60|P-value:9.46E-5 ID:SGTC_557|Compound:1315-0110|FD-Score:-3.14|P-value:5.74E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:3.24|P-value:3.96E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:3.19|P-value:4.74E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:4.48|P-value:1.77E-6 ID:SGTC_684|Compound:1140-0066|FD-Score:3.39|P-value:2.27E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:4.22|P-value:6.26E-6 ID:SGTC_819|Compound:1013-0258|FD-Score:5.23|P-value:3.14E-8 ID:SGTC_829|Compound:1635-0120|FD-Score:3.26|P-value:3.73E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:3.01|P-value:9.04E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:3.34|P-value:2.69E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:3.38|P-value:2.31E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:4.40|P-value:2.61E-6 ID:SGTC_1025|Compound:k007-0731|FD-Score:-3.33|P-value:2.86E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.24|P-value:3.92E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:3.05|P-value:7.90E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:3.10|P-value:6.64E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.60|P-value:9.63E-5 ID:SGTC_1363|Compound:1636-0063|FD-Score:4.08|P-value:1.18E-5 ID:SGTC_1460|Compound:k062-0059|FD-Score:-3.27|P-value:3.63E-4 ID:SGTC_1526|Compound:st051518|FD-Score:-3.08|P-value:7.24E-4 ID:SGTC_1547|Compound:harmine|FD-Score:3.19|P-value:4.73E-4 ID:SGTC_1741|Compound:st038134|FD-Score:6.67|P-value:2.58E-12 ID:SGTC_1748|Compound:st037455|FD-Score:-3.29|P-value:3.38E-4 ID:SGTC_1769|Compound:st044406|FD-Score:3.10|P-value:6.52E-4 ID:SGTC_1891|Compound:st059073|FD-Score:4.53|P-value:1.34E-6 ID:SGTC_1906|Compound:st060206|FD-Score:4.32|P-value:3.90E-6 ID:SGTC_1984|Compound:st072354|FD-Score:3.29|P-value:3.32E-4 ID:SGTC_2061|Compound:5245884|FD-Score:3.72|P-value:5.95E-5 ID:SGTC_2370|Compound:9071495|FD-Score:3.08|P-value:7.07E-4 ID:SGTC_2523|Compound:spermine|FD-Score:-3.25|P-value:3.96E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.18|P-value:4.93E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:4.19|P-value:7.16E-6 ID:SGTC_2877|Compound:9040724|FD-Score:3.53|P-value:1.28E-4 ID:SGTC_2971|Compound:9092186|FD-Score:3.63|P-value:8.44E-5 ID:SGTC_3149|Compound:9097855|FD-Score:3.35|P-value:2.60E-4 ID:SGTC_3264|Compound:9137442|FD-Score:3.78|P-value:4.45E-5 ID:SGTC_10|Compound:0279-0212|FD-Score:3.68|P-value:6.78E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.88|P-value:3.01E-5 ID:SGTC_89|Compound:0302-0250|FD-Score:-3.22|P-value:4.38E-4 ID:SGTC_105|Compound:0111-0055|FD-Score:3.63|P-value:8.51E-5 ID:SGTC_251|Compound:melphalan|FD-Score:3.24|P-value:3.95E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.09|P-value:6.95E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:3.97|P-value:1.97E-5 ID:SGTC_486|Compound:niguldipine|FD-Score:3.28|P-value:3.38E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:3.60|P-value:9.46E-5 ID:SGTC_557|Compound:1315-0110|FD-Score:-3.14|P-value:5.74E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:3.24|P-value:3.96E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:3.19|P-value:4.74E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:4.48|P-value:1.77E-6 ID:SGTC_684|Compound:1140-0066|FD-Score:3.39|P-value:2.27E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:4.22|P-value:6.26E-6 ID:SGTC_819|Compound:1013-0258|FD-Score:5.23|P-value:3.14E-8 ID:SGTC_829|Compound:1635-0120|FD-Score:3.26|P-value:3.73E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:3.01|P-value:9.04E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:3.34|P-value:2.69E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:3.38|P-value:2.31E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:4.40|P-value:2.61E-6 ID:SGTC_1025|Compound:k007-0731|FD-Score:-3.33|P-value:2.86E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.24|P-value:3.92E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:3.05|P-value:7.90E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:3.10|P-value:6.64E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.60|P-value:9.63E-5 ID:SGTC_1363|Compound:1636-0063|FD-Score:4.08|P-value:1.18E-5 ID:SGTC_1460|Compound:k062-0059|FD-Score:-3.27|P-value:3.63E-4 ID:SGTC_1526|Compound:st051518|FD-Score:-3.08|P-value:7.24E-4 ID:SGTC_1547|Compound:harmine|FD-Score:3.19|P-value:4.73E-4 ID:SGTC_1741|Compound:st038134|FD-Score:6.67|P-value:2.58E-12 ID:SGTC_1748|Compound:st037455|FD-Score:-3.29|P-value:3.38E-4 ID:SGTC_1769|Compound:st044406|FD-Score:3.10|P-value:6.52E-4 ID:SGTC_1891|Compound:st059073|FD-Score:4.53|P-value:1.34E-6 ID:SGTC_1906|Compound:st060206|FD-Score:4.32|P-value:3.90E-6 ID:SGTC_1984|Compound:st072354|FD-Score:3.29|P-value:3.32E-4 ID:SGTC_2061|Compound:5245884|FD-Score:3.72|P-value:5.95E-5 ID:SGTC_2370|Compound:9071495|FD-Score:3.08|P-value:7.07E-4 ID:SGTC_2523|Compound:spermine|FD-Score:-3.25|P-value:3.96E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.18|P-value:4.93E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:4.19|P-value:7.16E-6 ID:SGTC_2877|Compound:9040724|FD-Score:3.53|P-value:1.28E-4 ID:SGTC_2971|Compound:9092186|FD-Score:3.63|P-value:8.44E-5 ID:SGTC_3149|Compound:9097855|FD-Score:3.35|P-value:2.60E-4 ID:SGTC_3264|Compound:9137442|FD-Score:3.78|P-value:4.45E-5

Top fitness defect scores for YNR072W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1741 st038134 6.67 10.2 µM 2.58E-12 4 1.32E-11
2 SGTC_819 1013-0258 5.23 27.7 µM 3.14E-8 20 8.66E-8
3 SGTC_1891 st059073 4.53 26.2 µM 1.34E-6 TSC3-RPN4 10 2.91E-6
4 SGTC_672 1441-0018 4.48 53.7 µM 1.77E-6 11 3.76E-6
5 SGTC_996 3970-0799 4.40 1.8 µM 2.61E-6 66 5.42E-6
6 SGTC_1906 st060206 4.32 94.7 µM 3.90E-6 13 7.90E-6
7 SGTC_685 1278-0033 4.22 54.9 µM 6.26E-6 60S ribosome export 14 1.23E-5
8 SGTC_2754 granisetron 4.19 64.0 µM 7.16E-6 26 1.39E-5
9 SGTC_1363 1636-0063 4.08 10.4 µM 1.18E-5 Golgi 26 2.23E-5
10 SGTC_301 4119-0100 3.97 24.5 µM 1.97E-5 NEO1 82 3.59E-5
11 SGTC_3264 9137442 3.78 49.5 µM 4.45E-5 17 7.71E-5
12 SGTC_2061 5245884 3.72 81.0 µM 5.95E-5 tubulin folding & SWR complex 28 1.01E-4
13 SGTC_10 0279-0212 3.68 42.6 µM 6.78E-5 TRP & mitochondrial translation 144 1.14E-4
14 SGTC_2971 9092186 3.63 9.9 µM 8.44E-5 ergosterol biosynthesis 40 1.40E-4
15 SGTC_105 0111-0055 3.63 734.8 µM 8.51E-5 12 1.42E-4
16 SGTC_519 k048-0011 3.60 62.8 µM 9.46E-5 31 1.56E-4
17 SGTC_1349 flufenamic acid 3.60 69.0 µM 9.63E-5 24 1.59E-4
18 SGTC_2877 9040724 3.53 71.4 µM 1.28E-4 20 2.08E-4
19 SGTC_684 1140-0066 3.39 328.0 µM 2.27E-4 Golgi 57 3.56E-4
20 SGTC_899 1083-0020 3.38 478.0 µM 2.31E-4 40 3.61E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.166 3.67E-22 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.164 1.42E-21 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.151 1.23E-18 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.131 2.78E-14 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.122 1.21E-12 YDL177C_p YDL177C_p hom Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene
0.119 5.08E-12 YDL086W_p YDL086W_p hom Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene
0.118 6.17E-12 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.114 3.27E-11 YJL149W DAS1 hom Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C
0.107 4.99E-10 YOR202W HIS3 hom Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p
0.106 6.96E-10 YGR035C_p YGR035C_p hom Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
0.103 2.62E-9 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.096 2.35E-8 YIR028W DAL4 hom Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
0.095 4.23E-8 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.092 8.55E-8 YHR140W_p YHR140W_p hom Putative integral membrane protein of unknown function
0.091 1.45E-7 YIR031C DAL7 hom Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation