YNR075W / COS10

Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR075W / COS10

Click on Significant Values for Screen Details ID:SGTC_14|Compound:0354-0009|FD-Score:3.18|P-value:4.33E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:3.66|P-value:6.52E-5 ID:SGTC_67|Compound:0335-0847|FD-Score:-3.44|P-value:2.65E-4 ID:SGTC_250|Compound:brefeldin a|FD-Score:3.80|P-value:3.65E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:3.18|P-value:4.26E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:4.00|P-value:1.48E-5 ID:SGTC_873|Compound:0591-4978|FD-Score:3.21|P-value:3.89E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:-3.16|P-value:7.32E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:-3.27|P-value:4.85E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.47|P-value:1.41E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:4.78|P-value:3.23E-7 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.39|P-value:1.96E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.01|P-value:8.05E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:-3.13|P-value:8.25E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:4.40|P-value:2.25E-6 ID:SGTC_1356|Compound:1502-0781|FD-Score:3.19|P-value:4.17E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:3.42|P-value:1.74E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.03|P-value:7.50E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:5.89|P-value:4.95E-10 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.06|P-value:6.82E-4 ID:SGTC_1617|Compound:st002906|FD-Score:3.66|P-value:6.71E-5 ID:SGTC_1774|Compound:st048371|FD-Score:3.81|P-value:3.52E-5 ID:SGTC_2030|Compound:5175110|FD-Score:-4.05|P-value:2.11E-5 ID:SGTC_2152|Compound:5568786|FD-Score:3.20|P-value:3.96E-4 ID:SGTC_2179|Compound:6298986|FD-Score:3.12|P-value:5.37E-4 ID:SGTC_2308|Compound:7584454|FD-Score:-3.08|P-value:9.65E-4 ID:SGTC_2352|Compound:9027995|FD-Score:3.39|P-value:1.94E-4 ID:SGTC_2378|Compound:9074213|FD-Score:3.25|P-value:3.38E-4 ID:SGTC_2427|Compound:5545055|FD-Score:4.25|P-value:4.70E-6 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.26|P-value:3.23E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:3.68|P-value:6.09E-5 ID:SGTC_2803|Compound:7707263|FD-Score:-3.19|P-value:6.62E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.41|P-value:1.78E-4 ID:SGTC_2998|Compound:9066762|FD-Score:3.02|P-value:7.61E-4 ID:SGTC_3352|Compound:9151559|FD-Score:3.20|P-value:4.03E-4 ID:SGTC_14|Compound:0354-0009|FD-Score:3.18|P-value:4.33E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:3.66|P-value:6.52E-5 ID:SGTC_67|Compound:0335-0847|FD-Score:-3.44|P-value:2.65E-4 ID:SGTC_250|Compound:brefeldin a|FD-Score:3.80|P-value:3.65E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:3.18|P-value:4.26E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:4.00|P-value:1.48E-5 ID:SGTC_873|Compound:0591-4978|FD-Score:3.21|P-value:3.89E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:-3.16|P-value:7.32E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:-3.27|P-value:4.85E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.47|P-value:1.41E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:4.78|P-value:3.23E-7 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.39|P-value:1.96E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.01|P-value:8.05E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:-3.13|P-value:8.25E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:4.40|P-value:2.25E-6 ID:SGTC_1356|Compound:1502-0781|FD-Score:3.19|P-value:4.17E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:3.42|P-value:1.74E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.03|P-value:7.50E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:5.89|P-value:4.95E-10 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.06|P-value:6.82E-4 ID:SGTC_1617|Compound:st002906|FD-Score:3.66|P-value:6.71E-5 ID:SGTC_1774|Compound:st048371|FD-Score:3.81|P-value:3.52E-5 ID:SGTC_2030|Compound:5175110|FD-Score:-4.05|P-value:2.11E-5 ID:SGTC_2152|Compound:5568786|FD-Score:3.20|P-value:3.96E-4 ID:SGTC_2179|Compound:6298986|FD-Score:3.12|P-value:5.37E-4 ID:SGTC_2308|Compound:7584454|FD-Score:-3.08|P-value:9.65E-4 ID:SGTC_2352|Compound:9027995|FD-Score:3.39|P-value:1.94E-4 ID:SGTC_2378|Compound:9074213|FD-Score:3.25|P-value:3.38E-4 ID:SGTC_2427|Compound:5545055|FD-Score:4.25|P-value:4.70E-6 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.26|P-value:3.23E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:3.68|P-value:6.09E-5 ID:SGTC_2803|Compound:7707263|FD-Score:-3.19|P-value:6.62E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.41|P-value:1.78E-4 ID:SGTC_2998|Compound:9066762|FD-Score:3.02|P-value:7.61E-4 ID:SGTC_3352|Compound:9151559|FD-Score:3.20|P-value:4.03E-4

Top fitness defect scores for YNR075W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1489 4065-0444 5.89 182.0 µM 4.95E-10 4 1.96E-9
2 SGTC_1038 k292-0204 4.78 154.0 µM 3.23E-7 5 8.62E-7
3 SGTC_1264 0783-0040 4.40 158.0 µM 2.25E-6 13 5.32E-6
4 SGTC_2427 5545055 4.25 42.8 µM 4.70E-6 9 1.06E-5
5 SGTC_450 aminopyrene 4.00 156.0 nM 1.48E-5 32 3.11E-5
6 SGTC_1774 st048371 3.81 48.5 µM 3.52E-5 RNA processing & uracil transport 21 7.01E-5
7 SGTC_250 brefeldin a 3.80 552.2 µM 3.65E-5 PDR1 18 7.26E-5
8 SGTC_2580 diallyl disulphide 3.68 81.4 µM 6.09E-5 26 1.17E-4
9 SGTC_20 0481-0013 3.66 4.9 µM 6.52E-5 33 1.25E-4
10 SGTC_1617 st002906 3.66 78.0 µM 6.71E-5 32 1.28E-4
11 SGTC_1034 k072-0165 3.47 12.7 µM 1.41E-4 Golgi 36 2.57E-4
12 SGTC_1414 3917-0015 3.42 5.4 µM 1.74E-4 20 3.13E-4
13 SGTC_2887 9044784 3.41 58.4 µM 1.78E-4 fatty acid desaturase (OLE1) 60 3.20E-4
14 SGTC_2352 9027995 3.39 87.8 µM 1.94E-4 tubulin folding & SWR complex 43 3.47E-4
15 SGTC_1153 4055-0057 3.39 267.0 µM 1.96E-4 48 3.50E-4
16 SGTC_2535 4',4'-dimethoxydalbergione 3.26 51.2 µM 3.23E-4 DNA damage response 36 5.60E-4
17 SGTC_2378 9074213 3.25 121.4 µM 3.38E-4 RSC complex & mRNA processing 48 5.83E-4
18 SGTC_873 0591-4978 3.21 488.0 µM 3.89E-4 39 6.65E-4
19 SGTC_2152 5568786 3.20 200.0 µM 3.96E-4 37 6.76E-4
20 SGTC_3352 9151559 3.20 45.6 µM 4.03E-4 32 6.88E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.155 1.51E-19 YDR032C PST2 hom Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication
0.113 6.53E-11 YGR286C BIO2 hom Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant
0.084 1.24E-6 YOL059W GPD2 hom NAD-dependent glycerol 3-phosphate dehydrogenase, homolog of Gpd1p, expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria; constitutively active but is inactivated via phosphorylation by energy-stress responsive kinase SNF1
0.083 1.59E-6 YPL258C THI21 hom Hydroxymethylpyrimidine (HMP) and HMP-phosphate kinase; involved in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p
0.083 1.62E-6 YLR389C STE23 hom Metalloprotease involved, with homolog Axl1p, in N-terminal processing of pro-a-factor to the mature form; expressed in both haploids and diploids; member of the insulin-degrading enzyme family
0.074 2.02E-5 YNR026C SEC12 het Guanine nucleotide exchange factor (GEF), activates Sar1p by catalyzing the exchange of GDP for GTP; required for the initiation of COPII vesicle formation in ER to Golgi transport; glycosylated integral membrane protein of the ER
0.073 2.11E-5 YPR013C_p CMR3_p hom Putative zinc finger protein; YPR013C is not an essential gene
0.073 2.35E-5 YBR281C DUG2 hom Component of glutamine amidotransferase (GATase II); forms a complex with Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)
0.071 3.73E-5 YMR042W ARG80 hom Transcription factor involved in regulation of arginine-responsive genes; acts with Arg81p and Arg82p
0.071 4.07E-5 YGR295C COS6 hom Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.070 4.69E-5 YPR176C BET2 het Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
0.069 7.06E-5 YGR013W SNU71 het Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart
0.068 7.66E-5 YOR338W_p YOR338W_p hom Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen; YOR338W has a paralog, FUN19, that arose from the whole genome duplication
0.068 7.94E-5 YOL152W FRE7 hom Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels
0.066 1.31E-4 YNL009W IDP3 hom Peroxisomal NADP-dependent isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids; IDP3 has a paralog, IDP2, that arose from the whole genome duplication