YOL013W-B_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the long terminal repeat (LTR) of a Ty1 element

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL013W-B / YOL013W-B

Click on Significant Values for Screen Details ID:SGTC_69|Compound:0096-0274|FD-Score:2.79|P-value:7.34E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:-3.24|P-value:9.24E-5 ID:SGTC_174|Compound:3553-0389|FD-Score:3.15|P-value:1.60E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:2.91|P-value:4.49E-4 ID:SGTC_230|Compound:MPP+|FD-Score:3.45|P-value:4.14E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:5.24|P-value:1.06E-9 ID:SGTC_244|Compound:nsc-207895|FD-Score:-2.74|P-value:7.69E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.06|P-value:2.34E-4 ID:SGTC_303|Compound:1348-1668|FD-Score:2.98|P-value:3.32E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:2.89|P-value:4.91E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:2.77|P-value:7.85E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:2.93|P-value:4.08E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.15|P-value:1.60E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:2.77|P-value:7.80E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:2.99|P-value:3.22E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:3.26|P-value:9.78E-5 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.83|P-value:6.02E-6 ID:SGTC_1235|Compound:benzylparaben|FD-Score:2.94|P-value:3.93E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:2.82|P-value:6.53E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.14|P-value:1.67E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:-3.10|P-value:1.75E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.00|P-value:3.11E-4 ID:SGTC_1713|Compound:st033146|FD-Score:-7.61|P-value:1.07E-18 ID:SGTC_1715|Compound:st032160|FD-Score:-5.35|P-value:3.66E-10 ID:SGTC_1773|Compound:st048542|FD-Score:3.03|P-value:2.76E-4 ID:SGTC_1868|Compound:st057644|FD-Score:-2.73|P-value:8.21E-4 ID:SGTC_1940|Compound:st075990|FD-Score:2.91|P-value:4.48E-4 ID:SGTC_1948|Compound:st076329|FD-Score:3.15|P-value:1.62E-4 ID:SGTC_2022|Compound:5136654|FD-Score:3.21|P-value:1.22E-4 ID:SGTC_2024|Compound:5144227|FD-Score:3.73|P-value:1.03E-5 ID:SGTC_2264|Compound:7948757|FD-Score:-4.42|P-value:1.75E-7 ID:SGTC_2390|Compound:9097792|FD-Score:3.17|P-value:1.51E-4 ID:SGTC_2415|Compound:st077333|FD-Score:2.73|P-value:9.34E-4 ID:SGTC_2474|Compound:5321570|FD-Score:3.37|P-value:5.83E-5 ID:SGTC_2544|Compound:sphondin|FD-Score:3.03|P-value:2.76E-4 ID:SGTC_2602|Compound:kawain|FD-Score:2.79|P-value:7.18E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:5.56|P-value:1.04E-10 ID:SGTC_2692|Compound:st077426|FD-Score:3.08|P-value:2.23E-4 ID:SGTC_2705|Compound:st078069|FD-Score:-2.85|P-value:5.08E-4 ID:SGTC_2748|Compound:diazoxide|FD-Score:3.07|P-value:2.33E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:-2.88|P-value:4.36E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-2.95|P-value:3.35E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:2.84|P-value:5.98E-4 ID:SGTC_3013|Compound:9080133|FD-Score:2.72|P-value:9.59E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.04|P-value:2.57E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-4.39|P-value:2.14E-7 ID:SGTC_3251|Compound:9135047|FD-Score:3.10|P-value:2.01E-4 ID:SGTC_3253|Compound:9135987|FD-Score:3.00|P-value:3.15E-4 ID:SGTC_3314|Compound:9135860|FD-Score:2.84|P-value:6.06E-4 ID:SGTC_3332|Compound:9141069|FD-Score:-3.01|P-value:2.56E-4 ID:SGTC_3346|Compound:9158254|FD-Score:4.32|P-value:3.90E-7 ID:SGTC_3356|Compound:9151811|FD-Score:-2.97|P-value:3.06E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:2.79|P-value:7.34E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:-3.24|P-value:9.24E-5 ID:SGTC_174|Compound:3553-0389|FD-Score:3.15|P-value:1.60E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:2.91|P-value:4.49E-4 ID:SGTC_230|Compound:MPP+|FD-Score:3.45|P-value:4.14E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:5.24|P-value:1.06E-9 ID:SGTC_244|Compound:nsc-207895|FD-Score:-2.74|P-value:7.69E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.06|P-value:2.34E-4 ID:SGTC_303|Compound:1348-1668|FD-Score:2.98|P-value:3.32E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:2.89|P-value:4.91E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:2.77|P-value:7.85E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:2.93|P-value:4.08E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.15|P-value:1.60E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:2.77|P-value:7.80E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:2.99|P-value:3.22E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:3.26|P-value:9.78E-5 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.83|P-value:6.02E-6 ID:SGTC_1235|Compound:benzylparaben|FD-Score:2.94|P-value:3.93E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:2.82|P-value:6.53E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.14|P-value:1.67E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:-3.10|P-value:1.75E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.00|P-value:3.11E-4 ID:SGTC_1713|Compound:st033146|FD-Score:-7.61|P-value:1.07E-18 ID:SGTC_1715|Compound:st032160|FD-Score:-5.35|P-value:3.66E-10 ID:SGTC_1773|Compound:st048542|FD-Score:3.03|P-value:2.76E-4 ID:SGTC_1868|Compound:st057644|FD-Score:-2.73|P-value:8.21E-4 ID:SGTC_1940|Compound:st075990|FD-Score:2.91|P-value:4.48E-4 ID:SGTC_1948|Compound:st076329|FD-Score:3.15|P-value:1.62E-4 ID:SGTC_2022|Compound:5136654|FD-Score:3.21|P-value:1.22E-4 ID:SGTC_2024|Compound:5144227|FD-Score:3.73|P-value:1.03E-5 ID:SGTC_2264|Compound:7948757|FD-Score:-4.42|P-value:1.75E-7 ID:SGTC_2390|Compound:9097792|FD-Score:3.17|P-value:1.51E-4 ID:SGTC_2415|Compound:st077333|FD-Score:2.73|P-value:9.34E-4 ID:SGTC_2474|Compound:5321570|FD-Score:3.37|P-value:5.83E-5 ID:SGTC_2544|Compound:sphondin|FD-Score:3.03|P-value:2.76E-4 ID:SGTC_2602|Compound:kawain|FD-Score:2.79|P-value:7.18E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:5.56|P-value:1.04E-10 ID:SGTC_2692|Compound:st077426|FD-Score:3.08|P-value:2.23E-4 ID:SGTC_2705|Compound:st078069|FD-Score:-2.85|P-value:5.08E-4 ID:SGTC_2748|Compound:diazoxide|FD-Score:3.07|P-value:2.33E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:-2.88|P-value:4.36E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-2.95|P-value:3.35E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:2.84|P-value:5.98E-4 ID:SGTC_3013|Compound:9080133|FD-Score:2.72|P-value:9.59E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.04|P-value:2.57E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-4.39|P-value:2.14E-7 ID:SGTC_3251|Compound:9135047|FD-Score:3.10|P-value:2.01E-4 ID:SGTC_3253|Compound:9135987|FD-Score:3.00|P-value:3.15E-4 ID:SGTC_3314|Compound:9135860|FD-Score:2.84|P-value:6.06E-4 ID:SGTC_3332|Compound:9141069|FD-Score:-3.01|P-value:2.56E-4 ID:SGTC_3346|Compound:9158254|FD-Score:4.32|P-value:3.90E-7 ID:SGTC_3356|Compound:9151811|FD-Score:-2.97|P-value:3.06E-4

Top fitness defect scores for YOL013W-B deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2640 pentamidine 5.56 10.4 µM 1.04E-10 mitochondrial processes 9 1.38E-8
2 SGTC_236 1509-0011 5.24 5.3 µM 1.06E-9 314 8.22E-8
3 SGTC_3346 9158254 4.32 43.6 µM 3.90E-7 7 7.73E-6
4 SGTC_1030 k029-0042 3.83 36.7 µM 6.02E-6 TSC3-RPN4 29 6.38E-5
5 SGTC_2024 5144227 3.73 134.0 µM 1.03E-5 42 9.66E-5
6 SGTC_230 MPP+ 3.45 141.7 µM 4.14E-5 31 2.84E-4
7 SGTC_2474 5321570 3.37 43.3 µM 5.83E-5 30 3.70E-4
8 SGTC_706 4262-0057 3.26 46.9 µM 9.78E-5 fatty acid desaturase (OLE1) 67 5.52E-4
9 SGTC_2022 5136654 3.21 200.0 µM 1.22E-4 48 6.54E-4
10 SGTC_2390 9097792 3.17 176.6 µM 1.51E-4 41 7.75E-4
11 SGTC_174 3553-0389 3.15 74.3 µM 1.60E-4 47 8.08E-4
12 SGTC_651 3253-0966 3.15 34.4 µM 1.60E-4 calcium & mitochondrial duress 71 8.11E-4
13 SGTC_1948 st076329 3.15 66.6 µM 1.62E-4 61 8.16E-4
14 SGTC_1378 2093-0007 3.14 380.0 nM 1.67E-4 54 8.35E-4
15 SGTC_3251 9135047 3.10 49.5 µM 2.01E-4 60S ribosome export 22 9.66E-4
16 SGTC_2692 st077426 3.08 47.7 µM 2.23E-4 62 0.00105
17 SGTC_2748 diazoxide 3.07 86.7 µM 2.33E-4 29 0.00108
18 SGTC_275 trichlorophene 3.06 5.7 µM 2.34E-4 mitochondrial stress 294 0.00109
19 SGTC_3208 9114115 3.04 49.5 µM 2.57E-4 87 0.00117
20 SGTC_1773 st048542 3.03 73.6 µM 2.76E-4 90 0.00123

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.216 1.18E-36 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.212 2.22E-35 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.209 1.34E-34 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.203 1.61E-32 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.203 1.98E-32 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.199 2.92E-31 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.196 2.74E-30 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.189 2.27E-28 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.185 2.87E-27 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.180 7.78E-26 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.179 1.65E-25 YKL087C CYT2 hom Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
0.179 1.90E-25 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.176 1.02E-24 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.175 1.42E-24 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.171 1.69E-23 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases