YOL014W_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL014W / YOL014W

Click on Significant Values for Screen Details ID:SGTC_77|Compound:0828-0286|FD-Score:3.71|P-value:2.39E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:-5.04|P-value:5.55E-7 ID:SGTC_538|Compound:2922-0838|FD-Score:3.34|P-value:8.33E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:3.38|P-value:7.53E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:3.78|P-value:1.86E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:4.35|P-value:2.01E-5 ID:SGTC_1028|Compound:k015-0029|FD-Score:3.63|P-value:3.15E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:-4.29|P-value:1.63E-5 ID:SGTC_1477|Compound:0139-0234|FD-Score:3.66|P-value:2.81E-4 ID:SGTC_1654|Compound:st012436|FD-Score:-3.31|P-value:6.51E-4 ID:SGTC_1670|Compound:st016595|FD-Score:6.42|P-value:5.85E-10 ID:SGTC_1713|Compound:st033146|FD-Score:-3.33|P-value:6.03E-4 ID:SGTC_1717|Compound:st033143|FD-Score:-3.93|P-value:6.93E-5 ID:SGTC_2071|Compound:5230951|FD-Score:4.34|P-value:2.08E-5 ID:SGTC_2072|Compound:5231554|FD-Score:3.63|P-value:3.20E-4 ID:SGTC_2077|Compound:5212015|FD-Score:-3.21|P-value:9.04E-4 ID:SGTC_2438|Compound:5259590|FD-Score:7.08|P-value:9.74E-12 ID:SGTC_2444|Compound:5485484|FD-Score:-3.46|P-value:3.87E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:4.27|P-value:2.86E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.91|P-value:1.15E-4 ID:SGTC_2935|Compound:9038016|FD-Score:-4.77|P-value:2.00E-6 ID:SGTC_77|Compound:0828-0286|FD-Score:3.71|P-value:2.39E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:-5.04|P-value:5.55E-7 ID:SGTC_538|Compound:2922-0838|FD-Score:3.34|P-value:8.33E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:3.38|P-value:7.53E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:3.78|P-value:1.86E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:4.35|P-value:2.01E-5 ID:SGTC_1028|Compound:k015-0029|FD-Score:3.63|P-value:3.15E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:-4.29|P-value:1.63E-5 ID:SGTC_1477|Compound:0139-0234|FD-Score:3.66|P-value:2.81E-4 ID:SGTC_1654|Compound:st012436|FD-Score:-3.31|P-value:6.51E-4 ID:SGTC_1670|Compound:st016595|FD-Score:6.42|P-value:5.85E-10 ID:SGTC_1713|Compound:st033146|FD-Score:-3.33|P-value:6.03E-4 ID:SGTC_1717|Compound:st033143|FD-Score:-3.93|P-value:6.93E-5 ID:SGTC_2071|Compound:5230951|FD-Score:4.34|P-value:2.08E-5 ID:SGTC_2072|Compound:5231554|FD-Score:3.63|P-value:3.20E-4 ID:SGTC_2077|Compound:5212015|FD-Score:-3.21|P-value:9.04E-4 ID:SGTC_2438|Compound:5259590|FD-Score:7.08|P-value:9.74E-12 ID:SGTC_2444|Compound:5485484|FD-Score:-3.46|P-value:3.87E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:4.27|P-value:2.86E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.91|P-value:1.15E-4 ID:SGTC_2935|Compound:9038016|FD-Score:-4.77|P-value:2.00E-6

Top fitness defect scores for YOL014W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2438 5259590 7.08 200.0 µM 9.74E-12 2 7.39E-13
2 SGTC_1670 st016595 6.42 4.0 µM 5.85E-10 2 6.73E-11
3 SGTC_920 mycophenolic acid 4.35 780.4 nM 2.01E-5 21 6.77E-6
4 SGTC_2071 5230951 4.34 39.9 µM 2.08E-5 TSC3-RPN4 15 7.01E-6
5 SGTC_2630 antimycin a 4.27 100.0 µM 2.86E-5 mitochondrial processes 30 9.95E-6
6 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 3.91 100.0 µM 1.15E-4 26 4.64E-5
7 SGTC_792 4534-1957 3.78 155.0 µM 1.86E-4 38 7.88E-5
8 SGTC_77 0828-0286 3.71 12.5 µM 2.39E-4 TSC3-RPN4 46 1.04E-4
9 SGTC_1477 0139-0234 3.66 16.0 µM 2.81E-4 12 1.24E-4
10 SGTC_1028 k015-0029 3.63 4.8 µM 3.15E-4 31 1.41E-4
11 SGTC_2072 5231554 3.63 129.0 µM 3.20E-4 14 1.43E-4
12 SGTC_785 1270-0111 3.38 65.3 µM 7.53E-4 49 3.68E-4
13 SGTC_538 2922-0838 3.34 53.3 µM 8.33E-4 Golgi 54 4.12E-4
14 SGTC_3057 9095946 3.20 49.5 µM 0.00133 Golgi 33 6.92E-4
15 SGTC_69 0096-0274 3.19 206.7 µM 0.00136 mitochondrial processes 86 7.08E-4
16 SGTC_425 3825-7017 3.16 13.1 µM 0.00149 62 7.80E-4
17 SGTC_876 0720-0963 3.16 56.8 µM 0.00151 43 7.95E-4
18 SGTC_816 0325-0417 3.09 81.3 µM 0.00189 40 0.00102
19 SGTC_539 4859-0462 3.07 2.5 µM 0.00199 RNA pol III & RNase P/MRP 57 0.00108
20 SGTC_1992 st073643 3.06 23.3 µM 0.00203 mitochondrial processes 38 0.00110

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.149 3.64E-18 YMR148W OSW5 hom Protein of unknown function that may play a role in spore wall assembly; predicted to contain an N-terminal transmembrane domain; osw5 null mutant spores exhibit increased spore wall permeability and sensitivity to beta-glucanase digestion
0.128 1.16E-13 YLR121C YPS3 hom Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
0.122 1.45E-12 YJL216C IMA5 hom Alpha-glucosidase; specificity for isomaltose, maltose, and palatinose, but not alpha-methylglucoside; member of the IMA isomaltase family; not required for isomaltose utilization, but Ima5p overexpression allows the ima1 null mutant to grow on isomaltose
0.101 4.51E-9 YDL083C RPS16B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16B has a paralog, RPS16A, that arose from the whole genome duplication
0.099 1.12E-8 YMR132C_p JLP2_p hom Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)
0.097 1.87E-8 YLR002C NOC3 het Component of a nuclear complex with Noc2p and pre-replicative complexes; the Noc2p-Noc3p complex binds to 66S ribosomal precursors to mediate their maturation and intranuclear transport; binds to chromatin at active replication origins, and is required for pre-RC formation and maintenance during DNA replication licensing
0.095 3.14E-8 YPL270W MDL2 hom Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, required for respiratory growth at high temperature; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis
0.095 3.17E-8 YKR071C DRE2 het Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18pin an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress
0.094 5.56E-8 YCR005C CIT2 hom Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors; CIT2 has a paralog, CIT1, that arose from the whole genome duplication
0.094 5.72E-8 YJL201W ECM25 hom Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p
0.093 6.76E-8 YBR250W SPO23 hom Protein of unknown function; associates with meiosis-specific protein Spo1p
0.092 9.47E-8 YOR139C_d YOR139C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SFL1/YOR140W
0.092 1.11E-7 YLR198C_d YLR198C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W
0.091 1.21E-7 YLR186W EMG1 het Methyltransferase for rRNA; catalyzes methylation of the pseudouridine residue 1191 of 18S rRNA; member of the SPOUT methyltransferase family; required for maturation of 18S rRNA and for 40S ribosomal subunit production independently of methyltransferase activity; forms homodimers; human ortholog is mutated in Bowen-Conradi syndrome, and the equivalent mutation in yeast affects Emg1p dimerization and localization but not its methyltransferase activity
0.087 4.10E-7 YOL136C PFK27 hom 6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A