YOL030W / GAS5

1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL030W / GAS5

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:3.90|P-value:3.40E-5 ID:SGTC_61|Compound:0978-8327|FD-Score:3.16|P-value:6.24E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:3.28|P-value:4.08E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.13|P-value:6.91E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:3.96|P-value:2.62E-5 ID:SGTC_433|Compound:pimozide|FD-Score:-3.30|P-value:3.48E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-5.21|P-value:4.61E-8 ID:SGTC_438|Compound:sphingosine|FD-Score:-4.49|P-value:2.10E-6 ID:SGTC_502|Compound:l-744,832|FD-Score:3.12|P-value:7.23E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:3.20|P-value:5.37E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:3.22|P-value:5.13E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:3.07|P-value:8.78E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:3.24|P-value:4.63E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.24|P-value:4.63E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:5.60|P-value:5.16E-9 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.37|P-value:2.86E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:-3.27|P-value:3.94E-4 ID:SGTC_1630|Compound:st005209|FD-Score:-3.65|P-value:8.91E-5 ID:SGTC_1748|Compound:st037455|FD-Score:3.04|P-value:9.68E-4 ID:SGTC_1749|Compound:st037932|FD-Score:3.35|P-value:3.10E-4 ID:SGTC_1830|Compound:st055982|FD-Score:3.08|P-value:8.33E-4 ID:SGTC_1952|Compound:st077036|FD-Score:3.04|P-value:9.60E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.37|P-value:2.68E-4 ID:SGTC_2065|Compound:5221596|FD-Score:3.30|P-value:3.84E-4 ID:SGTC_2238|Compound:6671620|FD-Score:5.40|P-value:1.74E-8 ID:SGTC_2292|Compound:7671323|FD-Score:3.56|P-value:1.42E-4 ID:SGTC_2467|Compound:5474540|FD-Score:3.63|P-value:1.07E-4 ID:SGTC_2474|Compound:5321570|FD-Score:3.89|P-value:3.56E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.24|P-value:4.77E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.23|P-value:4.89E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.50|P-value:1.75E-4 ID:SGTC_3202|Compound:9113761|FD-Score:3.68|P-value:8.51E-5 ID:SGTC_7|Compound:0192-1582|FD-Score:3.90|P-value:3.40E-5 ID:SGTC_61|Compound:0978-8327|FD-Score:3.16|P-value:6.24E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:3.28|P-value:4.08E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.13|P-value:6.91E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:3.96|P-value:2.62E-5 ID:SGTC_433|Compound:pimozide|FD-Score:-3.30|P-value:3.48E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-5.21|P-value:4.61E-8 ID:SGTC_438|Compound:sphingosine|FD-Score:-4.49|P-value:2.10E-6 ID:SGTC_502|Compound:l-744,832|FD-Score:3.12|P-value:7.23E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:3.20|P-value:5.37E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:3.22|P-value:5.13E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:3.07|P-value:8.78E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:3.24|P-value:4.63E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.24|P-value:4.63E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:5.60|P-value:5.16E-9 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.37|P-value:2.86E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:-3.27|P-value:3.94E-4 ID:SGTC_1630|Compound:st005209|FD-Score:-3.65|P-value:8.91E-5 ID:SGTC_1748|Compound:st037455|FD-Score:3.04|P-value:9.68E-4 ID:SGTC_1749|Compound:st037932|FD-Score:3.35|P-value:3.10E-4 ID:SGTC_1830|Compound:st055982|FD-Score:3.08|P-value:8.33E-4 ID:SGTC_1952|Compound:st077036|FD-Score:3.04|P-value:9.60E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.37|P-value:2.68E-4 ID:SGTC_2065|Compound:5221596|FD-Score:3.30|P-value:3.84E-4 ID:SGTC_2238|Compound:6671620|FD-Score:5.40|P-value:1.74E-8 ID:SGTC_2292|Compound:7671323|FD-Score:3.56|P-value:1.42E-4 ID:SGTC_2467|Compound:5474540|FD-Score:3.63|P-value:1.07E-4 ID:SGTC_2474|Compound:5321570|FD-Score:3.89|P-value:3.56E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.24|P-value:4.77E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.23|P-value:4.89E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.50|P-value:1.75E-4 ID:SGTC_3202|Compound:9113761|FD-Score:3.68|P-value:8.51E-5

Top fitness defect scores for YOL030W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1200 1643-0193 5.60 18.4 µM 5.16E-9 4 1.06E-8
2 SGTC_2238 6671620 5.40 73.2 µM 1.74E-8 8 3.40E-8
3 SGTC_409 arachidonic acid 3.96 100.0 µM 2.62E-5 18 3.74E-5
4 SGTC_7 0192-1582 3.90 4.2 µM 3.40E-5 58 4.81E-5
5 SGTC_2474 5321570 3.89 43.3 µM 3.56E-5 13 5.03E-5
6 SGTC_3202 9113761 3.68 49.5 µM 8.51E-5 56 1.16E-4
7 SGTC_2467 5474540 3.63 200.0 µM 1.07E-4 25 1.44E-4
8 SGTC_2292 7671323 3.56 168.1 µM 1.42E-4 RNA processing & uracil transport 47 1.89E-4
9 SGTC_2767 sibutramine 3.50 71.5 µM 1.75E-4 33 2.31E-4
10 SGTC_1579 chlormadinone acetate 3.37 49.4 µM 2.86E-4 24 3.70E-4
11 SGTC_1749 st037932 3.35 54.2 µM 3.10E-4 44 4.01E-4
12 SGTC_2065 5221596 3.30 34.3 µM 3.84E-4 33 4.91E-4
13 SGTC_164 4100-3994 3.28 89.6 µM 4.08E-4 65 5.21E-4
14 SGTC_903 1134-0042 3.24 114.0 µM 4.63E-4 52 5.88E-4
15 SGTC_1044 1222-0021 3.24 1.8 µM 4.63E-4 heme biosynthesis & mitochondrial translocase 64 5.88E-4
16 SGTC_2573 2',4'-dihydroxychalcone 3.24 15.0 µM 4.77E-4 94 6.06E-4
17 SGTC_2634 4'-methoxyflavone 3.23 100.0 µM 4.89E-4 60 6.20E-4
18 SGTC_826 1683-5028 3.22 118.0 µM 5.13E-4 39 6.49E-4
19 SGTC_648 0375-0473 3.20 33.3 µM 5.37E-4 44 6.78E-4
20 SGTC_61 0978-8327 3.16 98.6 µM 6.24E-4 ergosterol biosynthesis 64 7.84E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.101 4.99E-9 YOR291W YPK9 hom Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
0.100 7.51E-9 YKL015W PUT3 hom Transcriptional activator of proline utilization genes, constitutively binds PUT1 and PUT2 promoter sequences as a dimer and undergoes a conformational change to form the active state; differentially phosphorylated in the presence of different nitrogen sources; has a Zn(2)-Cys(6) binuclear cluster domain
0.096 2.80E-8 YOR190W SPR1 hom Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance
0.094 4.39E-8 YDR453C TSA2 hom Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants; protein abundance increases in response to DNA replication stress
0.093 5.95E-8 YDR041W RSM10 het Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
0.093 6.01E-8 YIL132C CSM2 hom Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; structural analysis reveals a similar DNA-binding region in both Psy3p and Csm2p and that both regions work together to form a single DNA binding site; required for accurate chromosome segregation during meiosis
0.092 8.55E-8 YBR263W SHM1 hom Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine
0.091 1.13E-7 YKL191W DPH2 hom Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p
0.088 3.79E-7 YHL008C_p YHL008C_p hom Putative protein of unknown function, may be involved in the uptake of chloride ions; does not appear to be involved in monocarboxylic acid transport; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
0.082 2.20E-6 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.081 2.65E-6 YPR033C HTS1 het Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mutations in human ortholog HARS2 are associated with Perrault syndrome
0.081 2.82E-6 YOR172W YRM1 hom Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes
0.080 3.43E-6 YER114C BOI2 hom Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; BOI2 has a paralog, BOI1, that arose from the whole genome duplication
0.079 4.06E-6 YGR129W SYF2 hom Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; isy1 syf2 cells have defective spindles activiating cell cycle arrest
0.079 4.09E-6 YBR221C PDB1 hom E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondria