YOL037C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOL036W

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL037C / YOL037C

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:3.68|P-value:1.60E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:3.61|P-value:2.14E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:3.61|P-value:2.11E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:3.84|P-value:8.85E-5 ID:SGTC_255|Compound:tunicamycin|FD-Score:4.73|P-value:1.85E-6 ID:SGTC_362|Compound:0310-0100|FD-Score:-4.50|P-value:3.91E-6 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:3.34|P-value:5.57E-4 ID:SGTC_500|Compound:h-89|FD-Score:3.28|P-value:6.79E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.42|P-value:4.17E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:-3.50|P-value:2.50E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:-3.18|P-value:7.79E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:3.22|P-value:8.46E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.32|P-value:5.92E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.10|P-value:9.99E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:3.50|P-value:3.20E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:3.39|P-value:4.61E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.37|P-value:5.10E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.34|P-value:5.51E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.54|P-value:2.77E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:4.11|P-value:2.89E-5 ID:SGTC_1274|Compound:0865-0114|FD-Score:3.83|P-value:8.98E-5 ID:SGTC_1286|Compound:0929-0070|FD-Score:6.84|P-value:9.83E-12 ID:SGTC_1314|Compound:1222-0010|FD-Score:3.82|P-value:9.31E-5 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.64|P-value:1.89E-4 ID:SGTC_1847|Compound:st056231|FD-Score:-3.50|P-value:2.51E-4 ID:SGTC_1948|Compound:st076329|FD-Score:3.87|P-value:7.68E-5 ID:SGTC_1956|Compound:st077085|FD-Score:4.46|P-value:6.26E-6 ID:SGTC_2023|Compound:5144124|FD-Score:3.51|P-value:3.05E-4 ID:SGTC_2073|Compound:5212005|FD-Score:3.27|P-value:7.05E-4 ID:SGTC_2074|Compound:5212007|FD-Score:-3.25|P-value:5.98E-4 ID:SGTC_2261|Compound:9010538|FD-Score:-3.74|P-value:1.01E-4 ID:SGTC_2273|Compound:7815444|FD-Score:-3.85|P-value:6.35E-5 ID:SGTC_2327|Compound:6189656|FD-Score:3.24|P-value:7.73E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.84|P-value:8.90E-5 ID:SGTC_2570|Compound:licareol|FD-Score:-3.58|P-value:1.81E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.75|P-value:1.26E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.82|P-value:9.29E-5 ID:SGTC_2606|Compound:farnesol|FD-Score:3.83|P-value:9.11E-5 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.37|P-value:4.94E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:7.33|P-value:3.12E-13 ID:SGTC_2698|Compound:st077697|FD-Score:-3.53|P-value:2.26E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.19|P-value:7.46E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:4.05|P-value:3.76E-5 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.38|P-value:4.79E-4 ID:SGTC_2895|Compound:9054447|FD-Score:-3.67|P-value:1.32E-4 ID:SGTC_2943|Compound:9068529|FD-Score:-3.24|P-value:6.19E-4 ID:SGTC_2950|Compound:9072895|FD-Score:4.76|P-value:1.58E-6 ID:SGTC_2955|Compound:9076254|FD-Score:-3.65|P-value:1.41E-4 ID:SGTC_2999|Compound:9069765|FD-Score:-4.77|P-value:1.08E-6 ID:SGTC_3011|Compound:9081274|FD-Score:4.69|P-value:2.21E-6 ID:SGTC_3076|Compound:9116187|FD-Score:-3.53|P-value:2.19E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.78|P-value:1.11E-4 ID:SGTC_3322|Compound:9139058|FD-Score:-3.22|P-value:6.67E-4 ID:SGTC_3329|Compound:9141233|FD-Score:3.35|P-value:5.31E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:3.68|P-value:1.60E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:3.61|P-value:2.14E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:3.61|P-value:2.11E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:3.84|P-value:8.85E-5 ID:SGTC_255|Compound:tunicamycin|FD-Score:4.73|P-value:1.85E-6 ID:SGTC_362|Compound:0310-0100|FD-Score:-4.50|P-value:3.91E-6 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:3.34|P-value:5.57E-4 ID:SGTC_500|Compound:h-89|FD-Score:3.28|P-value:6.79E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.42|P-value:4.17E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:-3.50|P-value:2.50E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:-3.18|P-value:7.79E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:3.22|P-value:8.46E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.32|P-value:5.92E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.10|P-value:9.99E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:3.50|P-value:3.20E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:3.39|P-value:4.61E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.37|P-value:5.10E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.34|P-value:5.51E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.54|P-value:2.77E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:4.11|P-value:2.89E-5 ID:SGTC_1274|Compound:0865-0114|FD-Score:3.83|P-value:8.98E-5 ID:SGTC_1286|Compound:0929-0070|FD-Score:6.84|P-value:9.83E-12 ID:SGTC_1314|Compound:1222-0010|FD-Score:3.82|P-value:9.31E-5 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.64|P-value:1.89E-4 ID:SGTC_1847|Compound:st056231|FD-Score:-3.50|P-value:2.51E-4 ID:SGTC_1948|Compound:st076329|FD-Score:3.87|P-value:7.68E-5 ID:SGTC_1956|Compound:st077085|FD-Score:4.46|P-value:6.26E-6 ID:SGTC_2023|Compound:5144124|FD-Score:3.51|P-value:3.05E-4 ID:SGTC_2073|Compound:5212005|FD-Score:3.27|P-value:7.05E-4 ID:SGTC_2074|Compound:5212007|FD-Score:-3.25|P-value:5.98E-4 ID:SGTC_2261|Compound:9010538|FD-Score:-3.74|P-value:1.01E-4 ID:SGTC_2273|Compound:7815444|FD-Score:-3.85|P-value:6.35E-5 ID:SGTC_2327|Compound:6189656|FD-Score:3.24|P-value:7.73E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.84|P-value:8.90E-5 ID:SGTC_2570|Compound:licareol|FD-Score:-3.58|P-value:1.81E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.75|P-value:1.26E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.82|P-value:9.29E-5 ID:SGTC_2606|Compound:farnesol|FD-Score:3.83|P-value:9.11E-5 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.37|P-value:4.94E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:7.33|P-value:3.12E-13 ID:SGTC_2698|Compound:st077697|FD-Score:-3.53|P-value:2.26E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.19|P-value:7.46E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:4.05|P-value:3.76E-5 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.38|P-value:4.79E-4 ID:SGTC_2895|Compound:9054447|FD-Score:-3.67|P-value:1.32E-4 ID:SGTC_2943|Compound:9068529|FD-Score:-3.24|P-value:6.19E-4 ID:SGTC_2950|Compound:9072895|FD-Score:4.76|P-value:1.58E-6 ID:SGTC_2955|Compound:9076254|FD-Score:-3.65|P-value:1.41E-4 ID:SGTC_2999|Compound:9069765|FD-Score:-4.77|P-value:1.08E-6 ID:SGTC_3011|Compound:9081274|FD-Score:4.69|P-value:2.21E-6 ID:SGTC_3076|Compound:9116187|FD-Score:-3.53|P-value:2.19E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.78|P-value:1.11E-4 ID:SGTC_3322|Compound:9139058|FD-Score:-3.22|P-value:6.67E-4 ID:SGTC_3329|Compound:9141233|FD-Score:3.35|P-value:5.31E-4

Top fitness defect scores for YOL037C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2638 epoxomicin 7.33 18.0 µM 3.12E-13 1 1.14E-13
2 SGTC_1286 0929-0070 6.84 131.0 µM 9.83E-12 1 4.02E-12
3 SGTC_2950 9072895 4.76 21.5 µM 1.58E-6 20 9.67E-7
4 SGTC_255 tunicamycin 4.73 200.5 nM 1.85E-6 unfolded protein response 48 1.14E-6
5 SGTC_3011 9081274 4.69 71.4 µM 2.21E-6 4 1.37E-6
6 SGTC_1956 st077085 4.46 54.0 µM 6.26E-6 10 4.02E-6
7 SGTC_1248 0469-0687 4.11 58.6 µM 2.89E-5 25 1.96E-5
8 SGTC_2771 fluoxetine 4.05 41.0 µM 3.76E-5 18 2.57E-5
9 SGTC_1948 st076329 3.87 66.6 µM 7.68E-5 31 5.39E-5
10 SGTC_184 1494-0393 3.84 24.7 µM 8.85E-5 64 6.24E-5
11 SGTC_2402 5553605 3.84 200.0 µM 8.90E-5 32 6.27E-5
12 SGTC_1274 0865-0114 3.83 173.0 µM 8.98E-5 24 6.34E-5
13 SGTC_2606 farnesol 3.83 9.8 µM 9.11E-5 21 6.43E-5
14 SGTC_2581 avocatin a 3.82 64.0 µM 9.29E-5 sphingolipid biosynthesis & PDR1 56 6.56E-5
15 SGTC_1314 1222-0010 3.82 41.1 µM 9.31E-5 13 6.57E-5
16 SGTC_3211 9128781 3.78 49.5 µM 1.11E-4 69 7.89E-5
17 SGTC_2575 plumbagin 3.75 510.0 nM 1.26E-4 superoxide 51 9.01E-5
18 SGTC_8 0354-0001 3.68 70.0 µM 1.60E-4 87 1.15E-4
19 SGTC_1419 3993-2473 3.64 62.6 µM 1.89E-4 26 1.37E-4
20 SGTC_42 0133-0086 3.61 60.6 µM 2.11E-4 39 1.53E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.111 1.37E-10 YBR243C ALG7 het UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
0.107 4.47E-10 YMR020W FMS1 hom Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis
0.104 1.53E-9 YJL048C UBX6 hom UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline; UBX6 has a paralog, UBX7, that arose from the whole genome duplication
0.099 8.94E-9 YGR055W MUP1 hom High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake
0.094 5.06E-8 YLR180W SAM1 hom S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM1 has a paralog, SAM2, that arose from the whole genome duplication
0.093 8.08E-8 YBR182C-A_p YBR182C-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.087 3.88E-7 YOL032W OPI10 hom Protein with a possible role in phospholipid biosynthesis; null mutant displays an inositol-excreting phenotype that is suppressed by exogenous choline; protein abundance increases in response to DNA replication stress
0.087 4.80E-7 YNR070W_p PDR18_p hom Putative transporter of the ATP-binding cassette (ABC) family, implicated in pleiotropic drug resistance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.086 6.15E-7 YER069W ARG5,6 hom Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine
0.085 7.47E-7 YGR044C RME1 hom Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.084 1.02E-6 YKL159C RCN1 hom Protein involved in calcineurin regulation during calcium signaling; has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region
0.083 1.30E-6 YLL062C MHT1 hom S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio
0.083 1.40E-6 YKR078W YKR078W hom Cytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)
0.083 1.65E-6 YJR025C BNA1 hom 3-hydroxyanthranilic acid dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p
0.082 1.78E-6 YKL104C GFA1 het Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication