YOL052C / SPE2

S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL052C / SPE2

Click on Significant Values for Screen Details ID:SGTC_431|Compound:k089-0097|FD-Score:4.04|P-value:5.97E-5 ID:SGTC_760|Compound:0568-0725|FD-Score:3.26|P-value:9.72E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:-3.87|P-value:1.00E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:4.01|P-value:6.63E-5 ID:SGTC_1046|Compound:2001-0062|FD-Score:3.70|P-value:2.14E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:3.46|P-value:4.91E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:-3.46|P-value:4.40E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.08|P-value:5.02E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:-4.31|P-value:1.79E-5 ID:SGTC_1418|Compound:3966-3099|FD-Score:-3.27|P-value:8.25E-4 ID:SGTC_2005|Compound:4024620|FD-Score:3.65|P-value:2.57E-4 ID:SGTC_2009|Compound:4012297|FD-Score:3.25|P-value:9.89E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:3.44|P-value:5.23E-4 ID:SGTC_2040|Compound:5100729|FD-Score:3.46|P-value:4.89E-4 ID:SGTC_2051|Compound:5263410|FD-Score:3.76|P-value:1.69E-4 ID:SGTC_2052|Compound:5265182|FD-Score:-3.55|P-value:3.29E-4 ID:SGTC_2055|Compound:5235184|FD-Score:3.46|P-value:4.99E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:4.16|P-value:3.70E-5 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-3.83|P-value:1.17E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:4.32|P-value:1.94E-5 ID:SGTC_2762|Compound:leflunomide|FD-Score:4.25|P-value:2.55E-5 ID:SGTC_2785|Compound:7756463|FD-Score:3.33|P-value:7.54E-4 ID:SGTC_2840|Compound:9008771|FD-Score:-3.96|P-value:7.27E-5 ID:SGTC_2843|Compound:9000894|FD-Score:-3.62|P-value:2.54E-4 ID:SGTC_2931|Compound:9014674|FD-Score:3.74|P-value:1.87E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:4.04|P-value:5.97E-5 ID:SGTC_760|Compound:0568-0725|FD-Score:3.26|P-value:9.72E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:-3.87|P-value:1.00E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:4.01|P-value:6.63E-5 ID:SGTC_1046|Compound:2001-0062|FD-Score:3.70|P-value:2.14E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:3.46|P-value:4.91E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:-3.46|P-value:4.40E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.08|P-value:5.02E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:-4.31|P-value:1.79E-5 ID:SGTC_1418|Compound:3966-3099|FD-Score:-3.27|P-value:8.25E-4 ID:SGTC_2005|Compound:4024620|FD-Score:3.65|P-value:2.57E-4 ID:SGTC_2009|Compound:4012297|FD-Score:3.25|P-value:9.89E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:3.44|P-value:5.23E-4 ID:SGTC_2040|Compound:5100729|FD-Score:3.46|P-value:4.89E-4 ID:SGTC_2051|Compound:5263410|FD-Score:3.76|P-value:1.69E-4 ID:SGTC_2052|Compound:5265182|FD-Score:-3.55|P-value:3.29E-4 ID:SGTC_2055|Compound:5235184|FD-Score:3.46|P-value:4.99E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:4.16|P-value:3.70E-5 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-3.83|P-value:1.17E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:4.32|P-value:1.94E-5 ID:SGTC_2762|Compound:leflunomide|FD-Score:4.25|P-value:2.55E-5 ID:SGTC_2785|Compound:7756463|FD-Score:3.33|P-value:7.54E-4 ID:SGTC_2840|Compound:9008771|FD-Score:-3.96|P-value:7.27E-5 ID:SGTC_2843|Compound:9000894|FD-Score:-3.62|P-value:2.54E-4 ID:SGTC_2931|Compound:9014674|FD-Score:3.74|P-value:1.87E-4

Top fitness defect scores for YOL052C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2615 purpurogallin-4-carboxylic acid 4.32 100.0 µM 1.94E-5 redox potentiating 58 7.81E-6
2 SGTC_2762 leflunomide 4.25 42.1 µM 2.55E-5 19 1.05E-5
3 SGTC_2606 farnesol 4.16 9.8 µM 3.70E-5 16 1.59E-5
4 SGTC_1131 3454-3128 4.08 32.3 µM 5.02E-5 40 2.22E-5
5 SGTC_431 k089-0097 4.04 107.0 µM 5.97E-5 iron homeostasis 38 2.68E-5
6 SGTC_1045 1348-1485 4.01 165.0 µM 6.63E-5 28 3.00E-5
7 SGTC_2051 5263410 3.76 176.0 µM 1.69E-4 18 8.34E-5
8 SGTC_2931 9014674 3.74 55.7 µM 1.87E-4 28 9.29E-5
9 SGTC_1046 2001-0062 3.70 216.0 µM 2.14E-4 25 1.08E-4
10 SGTC_2005 4024620 3.65 188.0 µM 2.57E-4 30 1.32E-4
11 SGTC_2040 5100729 3.46 123.0 µM 4.89E-4 54 2.66E-4
12 SGTC_1056 3448-1962 3.46 115.0 µM 4.91E-4 amide catabolism 32 2.67E-4
13 SGTC_2055 5235184 3.46 200.0 µM 4.99E-4 ERG2 55 2.72E-4
14 SGTC_2039 Aminomethylbenzodioxan 3.44 200.0 µM 5.23E-4 13 2.86E-4
15 SGTC_2785 7756463 3.33 72.7 µM 7.54E-4 54 4.27E-4
16 SGTC_760 0568-0725 3.26 82.9 µM 9.72E-4 26 5.63E-4
17 SGTC_2009 4012297 3.25 12.1 µM 9.89E-4 cell wall signaling 98 5.74E-4
18 SGTC_2607 solasodine 3.22 47.4 µM 0.00111 93 6.50E-4
19 SGTC_2984 9022109 3.19 39.0 µM 0.00120 27 7.07E-4
20 SGTC_1469 k284-2957 3.14 126.0 µM 0.00142 31 8.54E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.153 5.59E-19 YPR177C_d YPR177C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 5' end of the essential PRP4 gene encoding a component of the U4/U6-U5 snRNP complex
0.119 3.75E-12 YLR354C TAL1 hom Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate
0.119 4.55E-12 YBL059W_p YBL059W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YBL059W has a paralog, YER093C-A, that arose from the whole genome duplication
0.106 6.44E-10 YJR046W TAH11 het DNA replication licensing factor, required for pre-replication complex assembly
0.105 9.14E-10 YIL166C_p YIL166C_p hom Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene
0.102 2.70E-9 YMR251W GTO3 hom Omega class glutathione transferase; putative cytosolic localization
0.101 5.36E-9 YGR096W TPC1 hom Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family
0.098 1.49E-8 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.097 2.03E-8 YER123W YCK3 hom Palmitoylated, vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of Vps41p; shares essential functions with Hrr25p; regulates vesicle fusion in AP-3 pathway
0.095 3.74E-8 YML091C RPM2 het Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus
0.093 6.98E-8 YPL222W_p FMP40_p hom Putative protein of unknown function; proposed to be involved in responding to environmental stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.092 1.00E-7 YMR304W UBP15 hom Ubiquitin-specific protease involved in protein deubiquitination; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; forms a complex with AAA peroxins Pex1p and Pex6p
0.091 1.27E-7 YLR191W PEX13 hom Integral peroxisomal membrane protein required for translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p
0.091 1.50E-7 YOR162C YRR1 hom Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication
0.089 2.65E-7 YPR082C DIB1 het 17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein