YOL057W

Dipeptidyl-peptidase III; cleaves dipeptides from the amino terminus of target proteins; highly active on synthetic substrate Arg-Arg-2-naphthylamide; mammalian ortholog may be a biomarker for some cancers

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL057W / YOL057W

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:-4.36|P-value:1.67E-6 ID:SGTC_43|Compound:0570-0105|FD-Score:-2.95|P-value:8.47E-4 ID:SGTC_249|Compound:wiskostatin|FD-Score:2.95|P-value:8.34E-4 ID:SGTC_251|Compound:melphalan|FD-Score:3.82|P-value:2.32E-5 ID:SGTC_369|Compound:0957-0393|FD-Score:-3.24|P-value:2.79E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:3.06|P-value:5.68E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:-2.91|P-value:9.76E-4 ID:SGTC_559|Compound:1550-0661|FD-Score:3.16|P-value:3.84E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:-3.88|P-value:1.78E-5 ID:SGTC_821|Compound:1114-0266|FD-Score:-3.84|P-value:2.17E-5 ID:SGTC_822|Compound:1487-0950|FD-Score:3.28|P-value:2.36E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.98|P-value:1.11E-5 ID:SGTC_1041|Compound:0206-0046|FD-Score:3.61|P-value:6.07E-5 ID:SGTC_1053|Compound:3366-3204|FD-Score:3.65|P-value:5.02E-5 ID:SGTC_1074|Compound:carmofur|FD-Score:2.96|P-value:7.99E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:-3.06|P-value:5.62E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:-3.22|P-value:2.98E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:-2.97|P-value:7.76E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.13|P-value:4.32E-4 ID:SGTC_1400|Compound:3771-8998|FD-Score:3.53|P-value:8.70E-5 ID:SGTC_1646|Compound:st011709|FD-Score:3.72|P-value:3.76E-5 ID:SGTC_1660|Compound:st012960|FD-Score:3.82|P-value:2.37E-5 ID:SGTC_1683|Compound:st010134|FD-Score:4.47|P-value:9.56E-7 ID:SGTC_1751|Compound:st044839|FD-Score:4.10|P-value:6.22E-6 ID:SGTC_1760|Compound:st045453|FD-Score:3.82|P-value:2.34E-5 ID:SGTC_1764|Compound:st044502|FD-Score:4.07|P-value:7.38E-6 ID:SGTC_1827|Compound:berberine|FD-Score:-3.19|P-value:3.41E-4 ID:SGTC_2026|Compound:5148700|FD-Score:3.44|P-value:1.24E-4 ID:SGTC_2031|Compound:5180455|FD-Score:-5.07|P-value:3.22E-8 ID:SGTC_2033|Compound:5192550|FD-Score:-4.87|P-value:1.09E-7 ID:SGTC_2343|Compound:7990716|FD-Score:-3.06|P-value:5.59E-4 ID:SGTC_2359|Compound:9039622|FD-Score:-3.11|P-value:4.62E-4 ID:SGTC_2360|Compound:9040895|FD-Score:3.19|P-value:3.36E-4 ID:SGTC_2364|Compound:9055074|FD-Score:-3.22|P-value:2.97E-4 ID:SGTC_2367|Compound:9070478|FD-Score:-4.98|P-value:5.54E-8 ID:SGTC_2576|Compound:guaiol|FD-Score:3.31|P-value:2.11E-4 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:-3.04|P-value:6.01E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-3.79|P-value:2.67E-5 ID:SGTC_2863|Compound:9028737|FD-Score:3.07|P-value:5.37E-4 ID:SGTC_3005|Compound:9076496|FD-Score:-3.55|P-value:7.78E-5 ID:SGTC_3207|Compound:9114163|FD-Score:3.73|P-value:3.56E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:-4.36|P-value:1.67E-6 ID:SGTC_43|Compound:0570-0105|FD-Score:-2.95|P-value:8.47E-4 ID:SGTC_249|Compound:wiskostatin|FD-Score:2.95|P-value:8.34E-4 ID:SGTC_251|Compound:melphalan|FD-Score:3.82|P-value:2.32E-5 ID:SGTC_369|Compound:0957-0393|FD-Score:-3.24|P-value:2.79E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:3.06|P-value:5.68E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:-2.91|P-value:9.76E-4 ID:SGTC_559|Compound:1550-0661|FD-Score:3.16|P-value:3.84E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:-3.88|P-value:1.78E-5 ID:SGTC_821|Compound:1114-0266|FD-Score:-3.84|P-value:2.17E-5 ID:SGTC_822|Compound:1487-0950|FD-Score:3.28|P-value:2.36E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.98|P-value:1.11E-5 ID:SGTC_1041|Compound:0206-0046|FD-Score:3.61|P-value:6.07E-5 ID:SGTC_1053|Compound:3366-3204|FD-Score:3.65|P-value:5.02E-5 ID:SGTC_1074|Compound:carmofur|FD-Score:2.96|P-value:7.99E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:-3.06|P-value:5.62E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:-3.22|P-value:2.98E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:-2.97|P-value:7.76E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.13|P-value:4.32E-4 ID:SGTC_1400|Compound:3771-8998|FD-Score:3.53|P-value:8.70E-5 ID:SGTC_1646|Compound:st011709|FD-Score:3.72|P-value:3.76E-5 ID:SGTC_1660|Compound:st012960|FD-Score:3.82|P-value:2.37E-5 ID:SGTC_1683|Compound:st010134|FD-Score:4.47|P-value:9.56E-7 ID:SGTC_1751|Compound:st044839|FD-Score:4.10|P-value:6.22E-6 ID:SGTC_1760|Compound:st045453|FD-Score:3.82|P-value:2.34E-5 ID:SGTC_1764|Compound:st044502|FD-Score:4.07|P-value:7.38E-6 ID:SGTC_1827|Compound:berberine|FD-Score:-3.19|P-value:3.41E-4 ID:SGTC_2026|Compound:5148700|FD-Score:3.44|P-value:1.24E-4 ID:SGTC_2031|Compound:5180455|FD-Score:-5.07|P-value:3.22E-8 ID:SGTC_2033|Compound:5192550|FD-Score:-4.87|P-value:1.09E-7 ID:SGTC_2343|Compound:7990716|FD-Score:-3.06|P-value:5.59E-4 ID:SGTC_2359|Compound:9039622|FD-Score:-3.11|P-value:4.62E-4 ID:SGTC_2360|Compound:9040895|FD-Score:3.19|P-value:3.36E-4 ID:SGTC_2364|Compound:9055074|FD-Score:-3.22|P-value:2.97E-4 ID:SGTC_2367|Compound:9070478|FD-Score:-4.98|P-value:5.54E-8 ID:SGTC_2576|Compound:guaiol|FD-Score:3.31|P-value:2.11E-4 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:-3.04|P-value:6.01E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-3.79|P-value:2.67E-5 ID:SGTC_2863|Compound:9028737|FD-Score:3.07|P-value:5.37E-4 ID:SGTC_3005|Compound:9076496|FD-Score:-3.55|P-value:7.78E-5 ID:SGTC_3207|Compound:9114163|FD-Score:3.73|P-value:3.56E-5

Top fitness defect scores for YOL057W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1683 st010134 4.47 710.0 nM 9.56E-7 15 3.88E-6
2 SGTC_1751 st044839 4.10 27.2 µM 6.22E-6 Golgi 10 2.04E-5
3 SGTC_1764 st044502 4.07 93.5 µM 7.38E-6 30 2.37E-5
4 SGTC_874 0599-0792 3.98 117.0 µM 1.11E-5 26 3.41E-5
5 SGTC_251 melphalan 3.82 456.5 µM 2.32E-5 DNA damage response 32 6.54E-5
6 SGTC_1760 st045453 3.82 10.4 µM 2.34E-5 NEO1-PIK1 149 6.60E-5
7 SGTC_1660 st012960 3.82 28.1 µM 2.37E-5 iron homeostasis 44 6.69E-5
8 SGTC_3207 9114163 3.73 49.5 µM 3.56E-5 39 9.59E-5
9 SGTC_1646 st011709 3.72 75.6 µM 3.76E-5 19 1.01E-4
10 SGTC_1053 3366-3204 3.65 134.0 µM 5.02E-5 cell wall 45 1.30E-4
11 SGTC_1041 0206-0046 3.61 107.0 µM 6.07E-5 42 1.54E-4
12 SGTC_1400 3771-8998 3.53 51.5 µM 8.70E-5 17 2.12E-4
13 SGTC_2026 5148700 3.44 152.0 µM 1.24E-4 32 2.90E-4
14 SGTC_2576 guaiol 3.31 23.1 µM 2.11E-4 55 4.66E-4
15 SGTC_822 1487-0950 3.28 154.0 µM 2.36E-4 36 5.15E-4
16 SGTC_2360 9040895 3.19 200.0 µM 3.36E-4 RPP1 & pyrimidine depletion 39 7.04E-4
17 SGTC_559 1550-0661 3.16 158.0 µM 3.84E-4 32 7.93E-4
18 SGTC_1179 1021-1431 3.13 9.3 µM 4.32E-4 85 8.79E-4
19 SGTC_2863 9028737 3.07 58.4 µM 5.37E-4 23 0.00107
20 SGTC_540 1187-0821 3.06 17.3 µM 5.68E-4 42 0.00112

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.134 7.73E-15 YML097C VPS9 hom A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin
0.125 3.76E-13 YHR108W GGA2 hom Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin
0.113 5.55E-11 YDR055W PST1 hom Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1
0.098 1.29E-8 YJL152W_d YJL152W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.089 2.31E-7 YLR289W GUF1 hom Mitochondrial matrix GTPase that associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor
0.089 2.53E-7 YJL083W TAX4 hom EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; TAX4 has a paralog, IRS4, that arose from the whole genome duplication
0.087 5.18E-7 YIL059C_d YIL059C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YIL060W
0.086 5.45E-7 YPL116W HOS3 hom Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats
0.083 1.59E-6 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.080 3.36E-6 YDR323C PEP7 hom Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance
0.079 4.54E-6 YAR042W SWH1 hom Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction
0.078 6.84E-6 YBL077W_d YBL077W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ILS1/YBL076C
0.077 8.28E-6 YDR029W_d YDR029W_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
0.076 9.21E-6 YOL054W PSH1 hom E3 ubiquitin ligase that mediates poyubiquitination and degradation of centromere-binding protein Cse4p and prevents Cse4p from mislocalizing to euchromatin; ubiquitylation of Cse4p may be antagonized by Scm3p
0.076 1.07E-5 YAL002W VPS8 hom Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif