Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YOL058W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.303 | 3.76E-72 | YJL088W | ARG3 | hom | Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine |
0.296 | 1.76E-68 | YOL140W | ARG8 | hom | Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine |
0.198 | 4.51E-31 | YHR018C | ARG4 | hom | Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway |
0.182 | 2.68E-26 | YER069W | ARG5,6 | hom | Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine |
0.158 | 3.54E-20 | YOR130C | ORT1 | hom | Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome |
0.145 | 2.70E-17 | YDR340W_d | YDR340W_d | hom | Putative protein of unknown function |
0.145 | 3.67E-17 | YER068C-A_d | YER068C-A_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
0.142 | 1.49E-16 | YJL071W | ARG2 | hom | Acetylglutamate synthase (glutamate N-acetyltransferase), mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg5,6p |
0.141 | 2.00E-16 | YOR303W | CPA1 | hom | Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader |
0.134 | 5.40E-15 | YJR109C | CPA2 | hom | Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor |
0.108 | 3.79E-10 | YOR323C | PRO2 | hom | Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis |
0.104 | 1.70E-9 | YFR023W | PES4 | hom | Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation; PES4 has a paralog, MIP6, that arose from the whole genome duplication |
0.101 | 4.50E-9 | YEL009C | GCN4 | hom | Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels |
0.097 | 1.74E-8 | YML062C | MFT1 | hom | Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance |
0.097 | 1.81E-8 | YCL057C-A | MOS1 | hom | Mitochondrial protein essential for proper inner membrane organization; conserved component of the mitochondrial inner membrane organizing system (MICOS, MINOS, or MitOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture; ortholog of human MINOS1 |