YOL070C / NBA1

Protein of unknown function, localizes to the bud neck and cytoplasm; interacts with Nap1p; may interact with ribosomes, based on co-purification experiments; potential Cdc28p substrate

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL070C / NBA1

Click on Significant Values for Screen Details ID:SGTC_20|Compound:0481-0013|FD-Score:4.13|P-value:2.44E-5 ID:SGTC_37|Compound:0566-0070|FD-Score:-3.22|P-value:6.76E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:3.80|P-value:9.08E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:4.92|P-value:6.25E-7 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.24|P-value:6.28E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:-3.42|P-value:3.34E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:-3.17|P-value:8.15E-4 ID:SGTC_235|Compound:0330-0087|FD-Score:-3.77|P-value:9.02E-5 ID:SGTC_247|Compound:mechlorethamine|FD-Score:4.20|P-value:1.74E-5 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.15|P-value:9.68E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:3.56|P-value:2.35E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:4.04|P-value:3.46E-5 ID:SGTC_1030|Compound:k029-0042|FD-Score:-4.16|P-value:1.76E-5 ID:SGTC_1380|Compound:2291-0730|FD-Score:-3.20|P-value:7.41E-4 ID:SGTC_1648|Compound:st011736|FD-Score:-3.12|P-value:9.48E-4 ID:SGTC_1717|Compound:st033143|FD-Score:-3.35|P-value:4.36E-4 ID:SGTC_1724|Compound:st037281|FD-Score:5.14|P-value:2.04E-7 ID:SGTC_1755|Compound:st041960|FD-Score:5.21|P-value:1.43E-7 ID:SGTC_1806|Compound:st050005|FD-Score:-3.55|P-value:2.12E-4 ID:SGTC_1975|Compound:st070967|FD-Score:-3.32|P-value:4.82E-4 ID:SGTC_2043|Compound:5101342|FD-Score:-3.44|P-value:3.11E-4 ID:SGTC_2104|Compound:5389443|FD-Score:3.97|P-value:4.72E-5 ID:SGTC_2125|Compound:5246583|FD-Score:3.38|P-value:4.47E-4 ID:SGTC_2190|Compound:6049624|FD-Score:-3.35|P-value:4.36E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:-3.14|P-value:8.91E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:-3.23|P-value:6.47E-4 ID:SGTC_2273|Compound:7815444|FD-Score:3.83|P-value:8.27E-5 ID:SGTC_2342|Compound:7990637|FD-Score:3.73|P-value:1.23E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.14|P-value:9.99E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:4.37|P-value:8.28E-6 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.43|P-value:3.67E-4 ID:SGTC_2821|Compound:7996764|FD-Score:-4.05|P-value:2.90E-5 ID:SGTC_2885|Compound:9057732|FD-Score:3.51|P-value:2.77E-4 ID:SGTC_2892|Compound:9047358|FD-Score:3.75|P-value:1.12E-4 ID:SGTC_2896|Compound:9052656|FD-Score:5.51|P-value:2.76E-8 ID:SGTC_2897|Compound:9048598|FD-Score:3.48|P-value:3.11E-4 ID:SGTC_2927|Compound:9011802|FD-Score:3.28|P-value:6.34E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-3.17|P-value:7.96E-4 ID:SGTC_2949|Compound:9072542|FD-Score:4.29|P-value:1.21E-5 ID:SGTC_3174|Compound:9107204|FD-Score:-3.25|P-value:6.18E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:4.13|P-value:2.44E-5 ID:SGTC_37|Compound:0566-0070|FD-Score:-3.22|P-value:6.76E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:3.80|P-value:9.08E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:4.92|P-value:6.25E-7 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.24|P-value:6.28E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:-3.42|P-value:3.34E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:-3.17|P-value:8.15E-4 ID:SGTC_235|Compound:0330-0087|FD-Score:-3.77|P-value:9.02E-5 ID:SGTC_247|Compound:mechlorethamine|FD-Score:4.20|P-value:1.74E-5 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.15|P-value:9.68E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:3.56|P-value:2.35E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:4.04|P-value:3.46E-5 ID:SGTC_1030|Compound:k029-0042|FD-Score:-4.16|P-value:1.76E-5 ID:SGTC_1380|Compound:2291-0730|FD-Score:-3.20|P-value:7.41E-4 ID:SGTC_1648|Compound:st011736|FD-Score:-3.12|P-value:9.48E-4 ID:SGTC_1717|Compound:st033143|FD-Score:-3.35|P-value:4.36E-4 ID:SGTC_1724|Compound:st037281|FD-Score:5.14|P-value:2.04E-7 ID:SGTC_1755|Compound:st041960|FD-Score:5.21|P-value:1.43E-7 ID:SGTC_1806|Compound:st050005|FD-Score:-3.55|P-value:2.12E-4 ID:SGTC_1975|Compound:st070967|FD-Score:-3.32|P-value:4.82E-4 ID:SGTC_2043|Compound:5101342|FD-Score:-3.44|P-value:3.11E-4 ID:SGTC_2104|Compound:5389443|FD-Score:3.97|P-value:4.72E-5 ID:SGTC_2125|Compound:5246583|FD-Score:3.38|P-value:4.47E-4 ID:SGTC_2190|Compound:6049624|FD-Score:-3.35|P-value:4.36E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:-3.14|P-value:8.91E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:-3.23|P-value:6.47E-4 ID:SGTC_2273|Compound:7815444|FD-Score:3.83|P-value:8.27E-5 ID:SGTC_2342|Compound:7990637|FD-Score:3.73|P-value:1.23E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.14|P-value:9.99E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:4.37|P-value:8.28E-6 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.43|P-value:3.67E-4 ID:SGTC_2821|Compound:7996764|FD-Score:-4.05|P-value:2.90E-5 ID:SGTC_2885|Compound:9057732|FD-Score:3.51|P-value:2.77E-4 ID:SGTC_2892|Compound:9047358|FD-Score:3.75|P-value:1.12E-4 ID:SGTC_2896|Compound:9052656|FD-Score:5.51|P-value:2.76E-8 ID:SGTC_2897|Compound:9048598|FD-Score:3.48|P-value:3.11E-4 ID:SGTC_2927|Compound:9011802|FD-Score:3.28|P-value:6.34E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-3.17|P-value:7.96E-4 ID:SGTC_2949|Compound:9072542|FD-Score:4.29|P-value:1.21E-5 ID:SGTC_3174|Compound:9107204|FD-Score:-3.25|P-value:6.18E-4

Top fitness defect scores for YOL070C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2896 9052656 5.51 71.4 µM 2.76E-8 endomembrane recycling 46 1.77E-8
2 SGTC_1755 st041960 5.21 45.2 µM 1.43E-7 10 9.55E-8
3 SGTC_1724 st037281 5.14 8.3 µM 2.04E-7 16 1.37E-7
4 SGTC_64 000l-0018 4.92 272.1 µM 6.25E-7 ubiquinone biosynthesis & proteasome 111 4.32E-7
5 SGTC_2611 pyromycin 4.37 23.9 µM 8.28E-6 16 6.11E-6
6 SGTC_2949 9072542 4.29 2.2 µM 1.21E-5 TSC3-RPN4 28 9.01E-6
7 SGTC_247 mechlorethamine 4.20 29.7 µM 1.74E-5 DNA damage response 12 1.31E-5
8 SGTC_20 0481-0013 4.13 4.9 µM 2.44E-5 19 1.85E-5
9 SGTC_858 0438-0351 4.04 2.8 µM 3.46E-5 copper-dependent oxidative stress 20 2.65E-5
10 SGTC_2104 5389443 3.97 200.0 µM 4.72E-5 14 3.65E-5
11 SGTC_2273 7815444 3.83 169.1 µM 8.27E-5 26 6.48E-5
12 SGTC_60 0986-0278 3.80 202.0 µM 9.08E-5 19 7.13E-5
13 SGTC_2892 9047358 3.75 58.4 µM 1.12E-4 12 8.83E-5
14 SGTC_2342 7990637 3.73 118.9 µM 1.23E-4 RNA processing & uracil transport 43 9.70E-5
15 SGTC_773 4358-1457 3.56 44.6 µM 2.35E-4 56 1.89E-4
16 SGTC_2885 9057732 3.51 52.0 µM 2.77E-4 25 2.24E-4
17 SGTC_2897 9048598 3.48 13.0 µM 3.11E-4 29 2.52E-4
18 SGTC_2627 acetyl isogambogic acid 3.43 100.0 µM 3.67E-4 TSC3-RPN4 64 2.98E-4
19 SGTC_2125 5246583 3.38 200.0 µM 4.47E-4 tubulin folding & SWR complex 69 3.66E-4
20 SGTC_2927 9011802 3.28 47.9 µM 6.34E-4 49 5.24E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.138 8.92E-16 YDR032C PST2 hom Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication
0.127 1.59E-13 YKL066W_d YKL066W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene YNK1
0.122 1.15E-12 YBL041W PRE7 het Beta 6 subunit of the 20S proteasome
0.094 4.66E-8 YNR069C BSC5 hom Protein of unknown function; shows homology with N-terminal end of Bul1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough expression includes YNR068C and the locus for this readthrough is termed BUL3; Bul3p is involved in ubiquitin-mediated sorting of plasma membrane proteins; readthrough and shortened forms of Bul3p interact with Rsp5p differently in vitro
0.094 5.29E-8 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.093 6.50E-8 YLR199C PBA1 hom Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly
0.091 1.14E-7 YPL144W POC4 hom Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
0.091 1.19E-7 YER094C PUP3 het Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10
0.091 1.50E-7 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.088 2.91E-7 YBR175W SWD3 hom Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5
0.086 5.79E-7 YLR329W REC102 hom Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination
0.084 1.04E-6 YEL067C_p YEL067C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.083 1.64E-6 YCL075W YCL075W hom Pseudogene: encodes fragment of Ty Pol protein
0.082 2.09E-6 YMR314W PRE5 het Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress
0.082 2.24E-6 YLR021W IRC25 hom Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions