Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YOL071W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.204 | 8.00E-33 | YBR169C | SSE2 | hom | Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication |
0.175 | 1.29E-24 | YGR123C | PPT1 | hom | Protein serine/threonine phosphatase, regulates Hsp90 chaperone by affecting its ATPase and cochaperone binding activities; has similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth |
0.167 | 2.19E-22 | YPR024W | YME1 | hom | Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover |
0.163 | 1.64E-21 | YMR322C_p | SNO4_p | hom | Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation |
0.162 | 3.27E-21 | YOR302W | YOR302W | hom | CPA1 uORF, Arginine attenuator peptide, regulates translation of the CPA1 mRNA |
0.153 | 4.76E-19 | YPR151C | SUE1 | hom | Mitochondrial protein required for degradation of unstable forms of cytochrome c |
0.152 | 7.97E-19 | YBR165W | UBS1 | hom | Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity |
0.150 | 2.38E-18 | YHR131C_p | YHR131C_p | hom | Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study |
0.149 | 3.86E-18 | YLR237W | THI7 | hom | Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia |
0.147 | 1.12E-17 | YOL080C | REX4 | hom | Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly |
0.141 | 1.91E-16 | YFL004W | VTC2 | hom | Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion |
0.138 | 8.69E-16 | YNR042W_d | YNR042W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2 |
0.137 | 1.96E-15 | YGR176W_d | YGR176W_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
0.136 | 2.81E-15 | YMR110C | HFD1 | hom | Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder |
0.131 | 2.13E-14 | YJL072C | PSF2 | het | Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery |