YOL073C

Subunit of the DSC ubiquitin ligase complex; ortholog of fission yeast dsc2

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL073C / YOL073C

Click on Significant Values for Screen Details

Top fitness defect scores for YOL073C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_2058 5236698 7.77 133.0 µM 1.08E-15 5 3.79E-15
2 SGTC_143 4032-1194 5.30 15.7 µM 3.17E-8 25 5.65E-8
3 SGTC_528 3492-0019 5.25 172.0 µM 4.27E-8 calcium & mitochondrial duress 148 7.53E-8
4 SGTC_1184 1269-1718 4.85 139.0 µM 3.85E-7 12 6.23E-7
5 SGTC_457 grayanotoxin iii 4.48 135.0 µM 2.47E-6 44 3.73E-6
6 SGTC_821 1114-0266 4.47 29.2 µM 2.61E-6 11 3.94E-6
7 SGTC_1675 st018485 4.42 24.5 µM 3.31E-6 60S ribosome export 16 4.95E-6
8 SGTC_3211 9128781 4.18 49.5 µM 1.02E-5 48 1.47E-5
9 SGTC_1144 3486-0183 4.17 12.5 µM 1.08E-5 22 1.54E-5
10 SGTC_1674 st016616 4.01 23.6 µM 2.17E-5 25 3.02E-5
11 SGTC_358 0075-0058 3.98 9.4 µM 2.46E-5 61 3.41E-5
12 SGTC_450 aminopyrene 3.98 156.0 nM 2.49E-5 33 3.45E-5
13 SGTC_445 e6 berbamine 3.94 66.0 µM 2.95E-5 NEO1-PIK1 108 4.06E-5
14 SGTC_322 k048-0136 3.85 19.3 µM 4.38E-5 RSC & ERG11 14 5.93E-5
15 SGTC_3130 9127414 3.80 49.5 µM 5.29E-5 24 7.11E-5
16 SGTC_2053 5265679 3.69 138.0 µM 8.57E-5 31 1.13E-4
17 SGTC_1920 st075728 3.60 45.7 µM 1.20E-4 35 1.57E-4
18 SGTC_2098 5376439 3.53 882.5 nM 1.62E-4 20 2.09E-4
19 SGTC_2592 piperlongumine 3.53 83.3 µM 1.64E-4 TSC3-RPN4 58 2.11E-4
20 SGTC_1550 gossypolone 3.51 36.6 µM 1.71E-4 21 2.21E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.161 7.13E-21 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.130 4.27E-14 YER068C-A_d YER068C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.119 4.47E-12 YJL135W_d YJL135W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
0.117 1.34E-11 YOR233W KIN4 hom Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication
0.113 5.11E-11 YGR181W TIM13 hom Mitochondrial intermembrane space protein, forms a complex with Tim8p that delivers a subset of hydrophobic proteins to the TIM22 complex for insertion into the inner membrane
0.111 1.01E-10 YDL095W PMT1 hom Protein O-mannosyltransferase of the ER membrane; transfers mannose from dolichyl phosphate-D-mannose to protein serine and threonine residues; 1 of 7 related proteins involved in O-glycosylation which is essential for cell wall rigidity; involved in ER quality control; amino terminus faces cytoplasm, carboxyl terminus faces ER lumen
0.108 4.00E-10 YDL023C_d YDL023C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance
0.107 4.35E-10 YDL096C_d OPI6_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential
0.107 5.87E-10 YNL264C PDR17 hom Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition
0.104 1.48E-9 YJR088C EMC2 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35
0.102 3.40E-9 YJR119C JHD2 hom JmjC domain family histone demethylase specific for H3-K4 (histone H3 Lys4); removes methyl groups specifically added by Set1p methyltransferase; protein levels regulated by Not4p (E3 ubiquitin ligase) polyubiquitin-mediated degradation
0.101 3.99E-9 YDR093W DNF2 hom Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
0.101 4.80E-9 YIL002C INP51 hom Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth
0.101 4.87E-9 YGR164W_d YGR164W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.099 1.00E-8 YDR018C_p YDR018C_p hom Probable membrane protein with three predicted transmembrane domains; similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; YDR018C has a paralog, CST26, that arose from the whole genome duplication