YOL077W-A / ATP19

Subunit k of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL077W-A / ATP19

Click on Significant Values for Screen Details ID:SGTC_175|Compound:3793-3120|FD-Score:-3.12|P-value:3.24E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.23|P-value:2.09E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.40|P-value:7.54E-7 ID:SGTC_378|Compound:3970-0959|FD-Score:2.96|P-value:6.01E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:-3.94|P-value:8.44E-6 ID:SGTC_409|Compound:arachidonic acid|FD-Score:-3.90|P-value:1.02E-5 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:-4.21|P-value:2.17E-6 ID:SGTC_432|Compound:NS 1619|FD-Score:-3.53|P-value:5.77E-5 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.58|P-value:4.64E-5 ID:SGTC_708|Compound:3448-5400|FD-Score:-3.17|P-value:2.72E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:2.92|P-value:7.12E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:-2.86|P-value:8.86E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:-2.89|P-value:8.12E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:-3.63|P-value:3.68E-5 ID:SGTC_1064|Compound:honokiol|FD-Score:3.21|P-value:2.29E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:3.93|P-value:8.57E-6 ID:SGTC_1422|Compound:4031-0024|FD-Score:2.99|P-value:5.43E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-2.88|P-value:8.26E-4 ID:SGTC_1610|Compound:st001799|FD-Score:-3.23|P-value:2.10E-4 ID:SGTC_1686|Compound:st019653|FD-Score:4.26|P-value:1.62E-6 ID:SGTC_1794|Compound:st048918|FD-Score:3.44|P-value:8.49E-5 ID:SGTC_1986|Compound:st071812|FD-Score:-2.88|P-value:8.23E-4 ID:SGTC_2086|Compound:5274770|FD-Score:3.96|P-value:7.63E-6 ID:SGTC_2104|Compound:5389443|FD-Score:3.04|P-value:4.39E-4 ID:SGTC_2107|Compound:5363541|FD-Score:3.18|P-value:2.59E-4 ID:SGTC_2109|Compound:5483026|FD-Score:-4.04|P-value:5.09E-6 ID:SGTC_2114|Compound:5491910|FD-Score:3.27|P-value:1.80E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.34|P-value:1.29E-4 ID:SGTC_2380|Compound:9035439|FD-Score:2.97|P-value:5.81E-4 ID:SGTC_2385|Compound:9074692|FD-Score:4.10|P-value:3.72E-6 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.63|P-value:2.16E-7 ID:SGTC_2408|Compound:sulbentine|FD-Score:4.13|P-value:3.15E-6 ID:SGTC_2421|Compound:5690543|FD-Score:3.96|P-value:7.51E-6 ID:SGTC_2423|Compound:st077119|FD-Score:-2.86|P-value:8.82E-4 ID:SGTC_2427|Compound:5545055|FD-Score:4.24|P-value:1.84E-6 ID:SGTC_2430|Compound:5571206|FD-Score:4.66|P-value:1.78E-7 ID:SGTC_2453|Compound:5731132|FD-Score:3.06|P-value:4.12E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:-3.13|P-value:3.12E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.25|P-value:1.90E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.57|P-value:4.73E-5 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.39|P-value:1.05E-4 ID:SGTC_2623|Compound:humulene|FD-Score:5.83|P-value:9.66E-11 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-3.70|P-value:2.59E-5 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-5.47|P-value:1.16E-9 ID:SGTC_2628|Compound:lathosterol|FD-Score:-4.54|P-value:3.51E-7 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:3.06|P-value:4.18E-4 ID:SGTC_2714|Compound:st079313|FD-Score:-3.21|P-value:2.27E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.86|P-value:1.25E-5 ID:SGTC_2788|Compound:5282734|FD-Score:-4.78|P-value:8.73E-8 ID:SGTC_3097|Compound:9117246|FD-Score:-3.19|P-value:2.47E-4 ID:SGTC_3214|Compound:9129694|FD-Score:3.69|P-value:2.73E-5 ID:SGTC_3215|Compound:9129942|FD-Score:3.63|P-value:3.66E-5 ID:SGTC_3220|Compound:9131269|FD-Score:-4.22|P-value:1.98E-6 ID:SGTC_3297|Compound:9117502|FD-Score:3.09|P-value:3.66E-4 ID:SGTC_3301|Compound:9125354|FD-Score:-3.76|P-value:2.01E-5 ID:SGTC_175|Compound:3793-3120|FD-Score:-3.12|P-value:3.24E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.23|P-value:2.09E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.40|P-value:7.54E-7 ID:SGTC_378|Compound:3970-0959|FD-Score:2.96|P-value:6.01E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:-3.94|P-value:8.44E-6 ID:SGTC_409|Compound:arachidonic acid|FD-Score:-3.90|P-value:1.02E-5 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:-4.21|P-value:2.17E-6 ID:SGTC_432|Compound:NS 1619|FD-Score:-3.53|P-value:5.77E-5 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.58|P-value:4.64E-5 ID:SGTC_708|Compound:3448-5400|FD-Score:-3.17|P-value:2.72E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:2.92|P-value:7.12E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:-2.86|P-value:8.86E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:-2.89|P-value:8.12E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:-3.63|P-value:3.68E-5 ID:SGTC_1064|Compound:honokiol|FD-Score:3.21|P-value:2.29E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:3.93|P-value:8.57E-6 ID:SGTC_1422|Compound:4031-0024|FD-Score:2.99|P-value:5.43E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-2.88|P-value:8.26E-4 ID:SGTC_1610|Compound:st001799|FD-Score:-3.23|P-value:2.10E-4 ID:SGTC_1686|Compound:st019653|FD-Score:4.26|P-value:1.62E-6 ID:SGTC_1794|Compound:st048918|FD-Score:3.44|P-value:8.49E-5 ID:SGTC_1986|Compound:st071812|FD-Score:-2.88|P-value:8.23E-4 ID:SGTC_2086|Compound:5274770|FD-Score:3.96|P-value:7.63E-6 ID:SGTC_2104|Compound:5389443|FD-Score:3.04|P-value:4.39E-4 ID:SGTC_2107|Compound:5363541|FD-Score:3.18|P-value:2.59E-4 ID:SGTC_2109|Compound:5483026|FD-Score:-4.04|P-value:5.09E-6 ID:SGTC_2114|Compound:5491910|FD-Score:3.27|P-value:1.80E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.34|P-value:1.29E-4 ID:SGTC_2380|Compound:9035439|FD-Score:2.97|P-value:5.81E-4 ID:SGTC_2385|Compound:9074692|FD-Score:4.10|P-value:3.72E-6 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.63|P-value:2.16E-7 ID:SGTC_2408|Compound:sulbentine|FD-Score:4.13|P-value:3.15E-6 ID:SGTC_2421|Compound:5690543|FD-Score:3.96|P-value:7.51E-6 ID:SGTC_2423|Compound:st077119|FD-Score:-2.86|P-value:8.82E-4 ID:SGTC_2427|Compound:5545055|FD-Score:4.24|P-value:1.84E-6 ID:SGTC_2430|Compound:5571206|FD-Score:4.66|P-value:1.78E-7 ID:SGTC_2453|Compound:5731132|FD-Score:3.06|P-value:4.12E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:-3.13|P-value:3.12E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.25|P-value:1.90E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.57|P-value:4.73E-5 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.39|P-value:1.05E-4 ID:SGTC_2623|Compound:humulene|FD-Score:5.83|P-value:9.66E-11 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-3.70|P-value:2.59E-5 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-5.47|P-value:1.16E-9 ID:SGTC_2628|Compound:lathosterol|FD-Score:-4.54|P-value:3.51E-7 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:3.06|P-value:4.18E-4 ID:SGTC_2714|Compound:st079313|FD-Score:-3.21|P-value:2.27E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.86|P-value:1.25E-5 ID:SGTC_2788|Compound:5282734|FD-Score:-4.78|P-value:8.73E-8 ID:SGTC_3097|Compound:9117246|FD-Score:-3.19|P-value:2.47E-4 ID:SGTC_3214|Compound:9129694|FD-Score:3.69|P-value:2.73E-5 ID:SGTC_3215|Compound:9129942|FD-Score:3.63|P-value:3.66E-5 ID:SGTC_3220|Compound:9131269|FD-Score:-4.22|P-value:1.98E-6 ID:SGTC_3297|Compound:9117502|FD-Score:3.09|P-value:3.66E-4 ID:SGTC_3301|Compound:9125354|FD-Score:-3.76|P-value:2.01E-5

Top fitness defect scores for YOL077W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2623 humulene 5.83 100.0 µM 9.66E-11 4 2.82E-9
2 SGTC_2430 5571206 4.66 200.0 µM 1.78E-7 37 1.58E-6
3 SGTC_236 1509-0011 4.40 5.3 µM 7.54E-7 362 5.36E-6
4 SGTC_1686 st019653 4.26 115.5 µM 1.62E-6 mitochondrial processes 6 1.02E-5
5 SGTC_2427 5545055 4.24 42.8 µM 1.84E-6 10 1.14E-5
6 SGTC_2408 sulbentine 4.13 18.4 µM 3.15E-6 43 1.79E-5
7 SGTC_2385 9074692 4.10 200.0 µM 3.72E-6 39 2.06E-5
8 SGTC_2421 5690543 3.96 90.7 µM 7.51E-6 19 3.73E-5
9 SGTC_2086 5274770 3.96 176.6 µM 7.63E-6 23 3.78E-5
10 SGTC_1211 1056-0033 3.93 32.3 µM 8.57E-6 10 4.17E-5
11 SGTC_2780 5215298 3.86 71.4 µM 1.25E-5 42 5.72E-5
12 SGTC_3214 9129694 3.69 49.5 µM 2.73E-5 35 1.11E-4
13 SGTC_3215 9129942 3.63 49.5 µM 3.66E-5 13 1.42E-4
14 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 3.58 150.0 µM 4.64E-5 Golgi 52 1.74E-4
15 SGTC_2573 2',4'-dihydroxychalcone 3.57 15.0 µM 4.73E-5 75 1.77E-4
16 SGTC_1794 st048918 3.44 76.9 µM 8.49E-5 17 2.90E-4
17 SGTC_2608 thymoquinone 3.39 42.7 µM 1.05E-4 32 3.48E-4
18 SGTC_2114 5491910 3.27 81.2 µM 1.80E-4 34 5.47E-4
19 SGTC_2514 salinomycin 3.25 42.7 µM 1.90E-4 87 5.74E-4
20 SGTC_1064 honokiol 3.21 6.8 µM 2.29E-4 48 6.71E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.162 3.98E-21 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.151 1.58E-18 YLR361C-A_p YLR361C-A_p hom Putative protein of unknown function
0.140 3.53E-16 YDL069C CBS1 hom Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader
0.133 1.34E-14 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.132 2.10E-14 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.131 2.97E-14 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.130 3.55E-14 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.127 1.57E-13 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.120 3.13E-12 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.119 5.09E-12 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.116 1.71E-11 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.113 5.21E-11 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.113 5.91E-11 YBL021C HAP3 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding
0.113 6.07E-11 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.112 8.16E-11 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER