YOL079W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL079W / YOL079W

Click on Significant Values for Screen Details ID:SGTC_25|Compound:0118-0223|FD-Score:3.42|P-value:6.09E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:8.88|P-value:1.27E-17 ID:SGTC_58|Compound:0957-0393|FD-Score:-8.01|P-value:6.60E-15 ID:SGTC_234|Compound:nsc-17383|FD-Score:3.51|P-value:4.47E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:4.13|P-value:4.50E-5 ID:SGTC_747|Compound:3448-8087|FD-Score:3.84|P-value:1.38E-4 ID:SGTC_895|Compound:0964-0006|FD-Score:3.48|P-value:4.90E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:-3.35|P-value:5.99E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:3.71|P-value:2.20E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-5.00|P-value:7.03E-7 ID:SGTC_1556|Compound:plumbagin|FD-Score:3.46|P-value:5.25E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:4.43|P-value:1.29E-5 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:-3.63|P-value:2.23E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:4.21|P-value:3.28E-5 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.49|P-value:4.68E-4 ID:SGTC_1683|Compound:st010134|FD-Score:4.27|P-value:2.51E-5 ID:SGTC_1713|Compound:st033146|FD-Score:-3.48|P-value:3.83E-4 ID:SGTC_1956|Compound:st077085|FD-Score:4.88|P-value:1.76E-6 ID:SGTC_1958|Compound:st076513|FD-Score:-3.77|P-value:1.34E-4 ID:SGTC_2005|Compound:4024620|FD-Score:4.68|P-value:4.43E-6 ID:SGTC_2273|Compound:7815444|FD-Score:3.29|P-value:9.23E-4 ID:SGTC_2381|Compound:9035592|FD-Score:-3.55|P-value:2.98E-4 ID:SGTC_2416|Compound:tofa|FD-Score:4.19|P-value:3.47E-5 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.69|P-value:2.39E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:5.23|P-value:3.26E-7 ID:SGTC_2815|Compound:7968870|FD-Score:5.20|P-value:3.93E-7 ID:SGTC_2880|Compound:9042983|FD-Score:3.64|P-value:2.86E-4 ID:SGTC_3336|Compound:9143619|FD-Score:-3.20|P-value:9.62E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:3.42|P-value:6.09E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:8.88|P-value:1.27E-17 ID:SGTC_58|Compound:0957-0393|FD-Score:-8.01|P-value:6.60E-15 ID:SGTC_234|Compound:nsc-17383|FD-Score:3.51|P-value:4.47E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:4.13|P-value:4.50E-5 ID:SGTC_747|Compound:3448-8087|FD-Score:3.84|P-value:1.38E-4 ID:SGTC_895|Compound:0964-0006|FD-Score:3.48|P-value:4.90E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:-3.35|P-value:5.99E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:3.71|P-value:2.20E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-5.00|P-value:7.03E-7 ID:SGTC_1556|Compound:plumbagin|FD-Score:3.46|P-value:5.25E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:4.43|P-value:1.29E-5 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:-3.63|P-value:2.23E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:4.21|P-value:3.28E-5 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.49|P-value:4.68E-4 ID:SGTC_1683|Compound:st010134|FD-Score:4.27|P-value:2.51E-5 ID:SGTC_1713|Compound:st033146|FD-Score:-3.48|P-value:3.83E-4 ID:SGTC_1956|Compound:st077085|FD-Score:4.88|P-value:1.76E-6 ID:SGTC_1958|Compound:st076513|FD-Score:-3.77|P-value:1.34E-4 ID:SGTC_2005|Compound:4024620|FD-Score:4.68|P-value:4.43E-6 ID:SGTC_2273|Compound:7815444|FD-Score:3.29|P-value:9.23E-4 ID:SGTC_2381|Compound:9035592|FD-Score:-3.55|P-value:2.98E-4 ID:SGTC_2416|Compound:tofa|FD-Score:4.19|P-value:3.47E-5 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.69|P-value:2.39E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:5.23|P-value:3.26E-7 ID:SGTC_2815|Compound:7968870|FD-Score:5.20|P-value:3.93E-7 ID:SGTC_2880|Compound:9042983|FD-Score:3.64|P-value:2.86E-4 ID:SGTC_3336|Compound:9143619|FD-Score:-3.20|P-value:9.62E-4

Top fitness defect scores for YOL079W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_50 0929-0078 8.88 56.4 µM 1.27E-17 13 3.32E-19
2 SGTC_2539 epi(13)torulosol 5.23 80.0 µM 3.26E-7 9 8.28E-8
3 SGTC_2815 7968870 5.20 71.4 µM 3.93E-7 7 1.02E-7
4 SGTC_1956 st077085 4.88 54.0 µM 1.76E-6 8 5.23E-7
5 SGTC_2005 4024620 4.68 188.0 µM 4.43E-6 10 1.44E-6
6 SGTC_1579 chlormadinone acetate 4.43 49.4 µM 1.29E-5 5 4.64E-6
7 SGTC_1683 st010134 4.27 710.0 nM 2.51E-5 18 9.65E-6
8 SGTC_1589 2',5'-dimethoxyflavone 4.21 47.2 µM 3.28E-5 11 1.29E-5
9 SGTC_2416 tofa 4.19 880.0 nM 3.47E-5 sphingolipid biosynthesis & PDR1 43 1.38E-5
10 SGTC_243 5hr heat shock (37°C) + splitomicin 4.13 1.0 µM 4.50E-5 heat shock/prefoldin 48 1.83E-5
11 SGTC_747 3448-8087 3.84 38.7 µM 1.38E-4 30 6.24E-5
12 SGTC_974 1326-0144 3.71 138.0 µM 2.20E-4 ERG2 49 1.04E-4
13 SGTC_2454 5-benzylidenerhodanine 3.69 10.4 µM 2.39E-4 TRP & mitochondrial translation 48 1.14E-4
14 SGTC_2880 9042983 3.64 58.4 µM 2.86E-4 fatty acid desaturase (OLE1) 36 1.39E-4
15 SGTC_234 nsc-17383 3.51 10.7 µM 4.47E-4 ERG2 33 2.26E-4
16 SGTC_1592 4',5'-dihydroxyflavone 3.49 8.8 µM 4.68E-4 60S ribosome export 25 2.38E-4
17 SGTC_895 0964-0006 3.48 13.7 µM 4.90E-4 28 2.50E-4
18 SGTC_1556 plumbagin 3.46 1.5 µM 5.25E-4 superoxide 29 2.70E-4
19 SGTC_25 0118-0223 3.42 35.7 µM 6.09E-4 36 3.17E-4
20 SGTC_2273 7815444 3.29 169.1 µM 9.23E-4 51 5.00E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.134 5.46E-15 YOR374W ALD4 hom Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed
0.133 9.87E-15 YLR361C DCR2 hom Phosphoesterase involved in downregulation of the unfolded protein response, at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START
0.123 8.25E-13 YLR351C NIT3 hom Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member
0.120 3.17E-12 YGR124W ASN2 hom Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN2 has a paralog, ASN1, that arose from the whole genome duplication
0.118 5.69E-12 YML010W SPT5 het Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair
0.114 3.24E-11 YDR163W CWC15 hom Non-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p; has similarity to S. pombe Cwf15p
0.113 4.44E-11 YNR005C_d YNR005C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.113 5.87E-11 YJL186W MNN5 hom Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment
0.112 8.49E-11 YHL001W RPL14B hom Ribosomal 60S subunit protein L14B; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14B has a paralog, RPL14A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.109 2.59E-10 YPL199C_p YPL199C_p hom Putative protein of unknown function, predicted to be palmitoylated
0.108 3.53E-10 YGR206W MVB12 hom ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin
0.105 8.98E-10 YGR154C GTO1 hom Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization
0.104 1.62E-9 YNL219C ALG9 hom Mannosyltransferase, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation
0.102 3.40E-9 YOR164C GET4 hom Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Mdy2p; highly conserved across species and homologous to human gene C7orf20
0.102 3.65E-9 YHR190W ERG9 het Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway