HIPHOP chemogenomics database

YOL079W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain

fixedexpanded
Profile for YOL079W / YOL079W

Click on Significant Values for Screen Details

Top fitness defect scores for YOL079W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_50	0929-0078	8.88	56.4 µM	1.27E-17		13	3.32E-19
2	SGTC_2539	epi(13)torulosol	5.23	80.0 µM	3.26E-7		9	8.28E-8
3	SGTC_2815	7968870	5.20	71.4 µM	3.93E-7		7	1.02E-7
4	SGTC_1956	st077085	4.88	54.0 µM	1.76E-6		8	5.23E-7
5	SGTC_2005	4024620	4.68	188.0 µM	4.43E-6		10	1.44E-6
6	SGTC_1579	chlormadinone acetate	4.43	49.4 µM	1.29E-5		5	4.64E-6
7	SGTC_1683	st010134	4.27	710.0 nM	2.51E-5		18	9.65E-6
8	SGTC_1589	2',5'-dimethoxyflavone	4.21	47.2 µM	3.28E-5		11	1.29E-5
9	SGTC_2416	tofa	4.19	880.0 nM	3.47E-5	sphingolipid biosynthesis & PDR1	43	1.38E-5
10	SGTC_243	5hr heat shock (37°C) + splitomicin	4.13	1.0 µM	4.50E-5	heat shock/prefoldin	48	1.83E-5
11	SGTC_747	3448-8087	3.84	38.7 µM	1.38E-4		30	6.24E-5
12	SGTC_974	1326-0144	3.71	138.0 µM	2.20E-4	ERG2	49	1.04E-4
13	SGTC_2454	5-benzylidenerhodanine	3.69	10.4 µM	2.39E-4	TRP & mitochondrial translation	48	1.14E-4
14	SGTC_2880	9042983	3.64	58.4 µM	2.86E-4	fatty acid desaturase (OLE1)	36	1.39E-4
15	SGTC_234	nsc-17383	3.51	10.7 µM	4.47E-4	ERG2	33	2.26E-4
16	SGTC_1592	4',5'-dihydroxyflavone	3.49	8.8 µM	4.68E-4	60S ribosome export	25	2.38E-4
17	SGTC_895	0964-0006	3.48	13.7 µM	4.90E-4		28	2.50E-4
18	SGTC_1556	plumbagin	3.46	1.5 µM	5.25E-4	superoxide	29	2.70E-4
19	SGTC_25	0118-0223	3.42	35.7 µM	6.09E-4		36	3.17E-4
20	SGTC_2273	7815444	3.29	169.1 µM	9.23E-4		51	5.00E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.134	5.46E-15	YOR374W	ALD4	hom	Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed
0.133	9.87E-15	YLR361C	DCR2	hom	Phosphoesterase involved in downregulation of the unfolded protein response, at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START
0.123	8.25E-13	YLR351C	NIT3	hom	Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member
0.120	3.17E-12	YGR124W	ASN2	hom	Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN2 has a paralog, ASN1, that arose from the whole genome duplication
0.118	5.69E-12	YML010W	SPT5	het	Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair
0.114	3.24E-11	YDR163W	CWC15	hom	Non-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p; has similarity to S. pombe Cwf15p
0.113	4.44E-11	YNR005C_d	YNR005C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.113	5.87E-11	YJL186W	MNN5	hom	Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment
0.112	8.49E-11	YHL001W	RPL14B	hom	Ribosomal 60S subunit protein L14B; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14B has a paralog, RPL14A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.109	2.59E-10	YPL199C_p	YPL199C_p	hom	Putative protein of unknown function, predicted to be palmitoylated
0.108	3.53E-10	YGR206W	MVB12	hom	ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin
0.105	8.98E-10	YGR154C	GTO1	hom	Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization
0.104	1.62E-9	YNL219C	ALG9	hom	Mannosyltransferase, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation
0.102	3.40E-9	YOR164C	GET4	hom	Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Mdy2p; highly conserved across species and homologous to human gene C7orf20
0.102	3.65E-9	YHR190W	ERG9	het	Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway