Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
Zygosity: Homozygous strain
fixedexpanded
![]() ![]() Click on Significant Values for Screen Details |
Top fitness defect scores for YOL079W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.134 | 5.46E-15 | YOR374W | ALD4 | hom | Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed |
0.133 | 9.87E-15 | YLR361C | DCR2 | hom | Phosphoesterase involved in downregulation of the unfolded protein response, at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START |
0.123 | 8.25E-13 | YLR351C | NIT3 | hom | Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member |
0.120 | 3.17E-12 | YGR124W | ASN2 | hom | Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN2 has a paralog, ASN1, that arose from the whole genome duplication |
0.118 | 5.69E-12 | YML010W | SPT5 | het | Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair |
0.114 | 3.24E-11 | YDR163W | CWC15 | hom | Non-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p; has similarity to S. pombe Cwf15p |
0.113 | 4.44E-11 | YNR005C_d | YNR005C_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
0.113 | 5.87E-11 | YJL186W | MNN5 | hom | Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment |
0.112 | 8.49E-11 | YHL001W | RPL14B | hom | Ribosomal 60S subunit protein L14B; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14B has a paralog, RPL14A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress |
0.109 | 2.59E-10 | YPL199C_p | YPL199C_p | hom | Putative protein of unknown function, predicted to be palmitoylated |
0.108 | 3.53E-10 | YGR206W | MVB12 | hom | ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin |
0.105 | 8.98E-10 | YGR154C | GTO1 | hom | Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization |
0.104 | 1.62E-9 | YNL219C | ALG9 | hom | Mannosyltransferase, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation |
0.102 | 3.40E-9 | YOR164C | GET4 | hom | Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Mdy2p; highly conserved across species and homologous to human gene C7orf20 |
0.102 | 3.65E-9 | YHR190W | ERG9 | het | Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway |