YOL107W_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and colocalizes in a punctate pattern with the early golgi/COPI vesicles; YOL107W is not an essential protein

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL107W / YOL107W

Click on Significant Values for Screen Details ID:SGTC_12|Compound:0849-0099|FD-Score:3.37|P-value:2.14E-4 ID:SGTC_19|Compound:0279-0214|FD-Score:3.28|P-value:3.04E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:3.46|P-value:1.49E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:3.03|P-value:7.58E-4 ID:SGTC_230|Compound:MPP+|FD-Score:3.52|P-value:1.16E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:3.91|P-value:2.18E-5 ID:SGTC_490|Compound:phenamil|FD-Score:2.99|P-value:8.83E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:2.96|P-value:9.92E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:3.26|P-value:3.28E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:3.18|P-value:4.36E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:4.94|P-value:1.23E-7 ID:SGTC_768|Compound:0384-0033|FD-Score:3.28|P-value:3.00E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:5.00|P-value:8.49E-8 ID:SGTC_965|Compound:1291-5240|FD-Score:-3.19|P-value:4.29E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:-5.10|P-value:5.12E-8 ID:SGTC_1027|Compound:k015-0025|FD-Score:4.63|P-value:6.45E-7 ID:SGTC_1031|Compound:k035-0009|FD-Score:6.99|P-value:1.32E-13 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:3.11|P-value:5.66E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.01|P-value:8.22E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.03|P-value:7.55E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.00|P-value:8.64E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.62|P-value:7.70E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.17|P-value:4.50E-4 ID:SGTC_1609|Compound:st001574|FD-Score:3.14|P-value:5.03E-4 ID:SGTC_1675|Compound:st018485|FD-Score:-5.12|P-value:4.40E-8 ID:SGTC_1676|Compound:st018489|FD-Score:5.63|P-value:2.01E-9 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.65|P-value:6.72E-5 ID:SGTC_1701|Compound:st028638|FD-Score:-3.21|P-value:4.05E-4 ID:SGTC_1703|Compound:st026983|FD-Score:-3.52|P-value:1.20E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.44|P-value:1.63E-4 ID:SGTC_1865|Compound:st057639|FD-Score:3.00|P-value:8.44E-4 ID:SGTC_1950|Compound:st077106|FD-Score:4.59|P-value:8.01E-7 ID:SGTC_2011|Compound:4012611|FD-Score:3.42|P-value:1.73E-4 ID:SGTC_2267|Compound:7931562|FD-Score:3.27|P-value:3.10E-4 ID:SGTC_2269|Compound:7935389|FD-Score:4.14|P-value:7.30E-6 ID:SGTC_2271|Compound:7849410|FD-Score:-3.45|P-value:1.58E-4 ID:SGTC_2331|Compound:7980721|FD-Score:3.72|P-value:5.10E-5 ID:SGTC_2336|Compound:9001819|FD-Score:4.05|P-value:1.13E-5 ID:SGTC_2337|Compound:9009472|FD-Score:-3.43|P-value:1.73E-4 ID:SGTC_2379|Compound:9035213|FD-Score:3.41|P-value:1.80E-4 ID:SGTC_2397|Compound:5161689|FD-Score:-5.29|P-value:1.71E-8 ID:SGTC_2568|Compound:diosmetin|FD-Score:-3.17|P-value:4.62E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:2.97|P-value:9.57E-4 ID:SGTC_2785|Compound:7756463|FD-Score:3.58|P-value:9.00E-5 ID:SGTC_2844|Compound:9010103|FD-Score:-3.16|P-value:4.87E-4 ID:SGTC_2902|Compound:5787006|FD-Score:3.06|P-value:6.82E-4 ID:SGTC_2906|Compound:7926292|FD-Score:3.27|P-value:3.14E-4 ID:SGTC_2912|Compound:7964298|FD-Score:-3.07|P-value:6.70E-4 ID:SGTC_2913|Compound:7966556|FD-Score:3.17|P-value:4.54E-4 ID:SGTC_2936|Compound:9038235|FD-Score:3.01|P-value:8.11E-4 ID:SGTC_3105|Compound:9121040|FD-Score:2.97|P-value:9.35E-4 ID:SGTC_3242|Compound:9133940|FD-Score:3.29|P-value:2.94E-4 ID:SGTC_3263|Compound:9137018|FD-Score:3.09|P-value:6.21E-4 ID:SGTC_3306|Compound:9127676|FD-Score:2.97|P-value:9.59E-4 ID:SGTC_12|Compound:0849-0099|FD-Score:3.37|P-value:2.14E-4 ID:SGTC_19|Compound:0279-0214|FD-Score:3.28|P-value:3.04E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:3.46|P-value:1.49E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:3.03|P-value:7.58E-4 ID:SGTC_230|Compound:MPP+|FD-Score:3.52|P-value:1.16E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:3.91|P-value:2.18E-5 ID:SGTC_490|Compound:phenamil|FD-Score:2.99|P-value:8.83E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:2.96|P-value:9.92E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:3.26|P-value:3.28E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:3.18|P-value:4.36E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:4.94|P-value:1.23E-7 ID:SGTC_768|Compound:0384-0033|FD-Score:3.28|P-value:3.00E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:5.00|P-value:8.49E-8 ID:SGTC_965|Compound:1291-5240|FD-Score:-3.19|P-value:4.29E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:-5.10|P-value:5.12E-8 ID:SGTC_1027|Compound:k015-0025|FD-Score:4.63|P-value:6.45E-7 ID:SGTC_1031|Compound:k035-0009|FD-Score:6.99|P-value:1.32E-13 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:3.11|P-value:5.66E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.01|P-value:8.22E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.03|P-value:7.55E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.00|P-value:8.64E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.62|P-value:7.70E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.17|P-value:4.50E-4 ID:SGTC_1609|Compound:st001574|FD-Score:3.14|P-value:5.03E-4 ID:SGTC_1675|Compound:st018485|FD-Score:-5.12|P-value:4.40E-8 ID:SGTC_1676|Compound:st018489|FD-Score:5.63|P-value:2.01E-9 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.65|P-value:6.72E-5 ID:SGTC_1701|Compound:st028638|FD-Score:-3.21|P-value:4.05E-4 ID:SGTC_1703|Compound:st026983|FD-Score:-3.52|P-value:1.20E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.44|P-value:1.63E-4 ID:SGTC_1865|Compound:st057639|FD-Score:3.00|P-value:8.44E-4 ID:SGTC_1950|Compound:st077106|FD-Score:4.59|P-value:8.01E-7 ID:SGTC_2011|Compound:4012611|FD-Score:3.42|P-value:1.73E-4 ID:SGTC_2267|Compound:7931562|FD-Score:3.27|P-value:3.10E-4 ID:SGTC_2269|Compound:7935389|FD-Score:4.14|P-value:7.30E-6 ID:SGTC_2271|Compound:7849410|FD-Score:-3.45|P-value:1.58E-4 ID:SGTC_2331|Compound:7980721|FD-Score:3.72|P-value:5.10E-5 ID:SGTC_2336|Compound:9001819|FD-Score:4.05|P-value:1.13E-5 ID:SGTC_2337|Compound:9009472|FD-Score:-3.43|P-value:1.73E-4 ID:SGTC_2379|Compound:9035213|FD-Score:3.41|P-value:1.80E-4 ID:SGTC_2397|Compound:5161689|FD-Score:-5.29|P-value:1.71E-8 ID:SGTC_2568|Compound:diosmetin|FD-Score:-3.17|P-value:4.62E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:2.97|P-value:9.57E-4 ID:SGTC_2785|Compound:7756463|FD-Score:3.58|P-value:9.00E-5 ID:SGTC_2844|Compound:9010103|FD-Score:-3.16|P-value:4.87E-4 ID:SGTC_2902|Compound:5787006|FD-Score:3.06|P-value:6.82E-4 ID:SGTC_2906|Compound:7926292|FD-Score:3.27|P-value:3.14E-4 ID:SGTC_2912|Compound:7964298|FD-Score:-3.07|P-value:6.70E-4 ID:SGTC_2913|Compound:7966556|FD-Score:3.17|P-value:4.54E-4 ID:SGTC_2936|Compound:9038235|FD-Score:3.01|P-value:8.11E-4 ID:SGTC_3105|Compound:9121040|FD-Score:2.97|P-value:9.35E-4 ID:SGTC_3242|Compound:9133940|FD-Score:3.29|P-value:2.94E-4 ID:SGTC_3263|Compound:9137018|FD-Score:3.09|P-value:6.21E-4 ID:SGTC_3306|Compound:9127676|FD-Score:2.97|P-value:9.59E-4

Top fitness defect scores for YOL107W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1031 k035-0009 6.99 16.0 µM 1.32E-13 2 1.34E-12
2 SGTC_1676 st018489 5.63 23.4 µM 2.01E-9 60S ribosome export 7 9.15E-9
3 SGTC_956 1185-0240 5.00 191.0 µM 8.49E-8 12 2.85E-7
4 SGTC_751 0833-0568 4.94 350.0 µM 1.23E-7 8 4.00E-7
5 SGTC_1027 k015-0025 4.63 8.7 µM 6.45E-7 15 1.83E-6
6 SGTC_1950 st077106 4.59 7.2 µM 8.01E-7 RNA processing & uracil transport 14 2.24E-6
7 SGTC_2269 7935389 4.14 174.4 µM 7.30E-6 tubulin folding & SWR complex 22 1.70E-5
8 SGTC_2336 9001819 4.05 198.7 µM 1.13E-5 heme biosynthesis & mitochondrial translocase 50 2.55E-5
9 SGTC_348 k064-0012 3.91 10.7 µM 2.18E-5 60S ribosome export 14 4.66E-5
10 SGTC_2331 7980721 3.72 200.0 µM 5.10E-5 32 1.02E-4
11 SGTC_1679 4130-1276 3.65 6.7 µM 6.72E-5 Golgi 80 1.31E-4
12 SGTC_1276 0871-0068 3.62 94.2 µM 7.70E-5 22 1.48E-4
13 SGTC_2785 7756463 3.58 72.7 µM 9.00E-5 40 1.71E-4
14 SGTC_230 MPP+ 3.52 141.7 µM 1.16E-4 27 2.17E-4
15 SGTC_86 0417-1630 3.46 471.9 µM 1.49E-4 ubiquinone biosynthesis & proteasome 183 2.72E-4
16 SGTC_1862 st057513 3.44 3.8 µM 1.63E-4 31 2.96E-4
17 SGTC_2011 4012611 3.42 177.0 µM 1.73E-4 mitochondrial processes 50 3.13E-4
18 SGTC_2379 9035213 3.41 200.0 µM 1.80E-4 41 3.24E-4
19 SGTC_12 0849-0099 3.37 9.3 µM 2.14E-4 33 3.79E-4
20 SGTC_3242 9133940 3.29 49.5 µM 2.94E-4 26 5.09E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.118 8.32E-12 YMR078C CTF18 hom Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint
0.091 1.23E-7 YDL133W SRF1 hom Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients
0.091 1.38E-7 YGR279C SCW4 hom Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating
0.085 7.28E-7 YBR204C LDH1 hom Serine hydrolase; exhibits active esterase plus weak triacylglycerol lipase activities; proposed role in lipid homeostasis, regulating phospholipid and non-polar lipid levels and required for mobilization of LD-stored lipids; localizes to the lipid droplet (LD) surface; contains a classical serine containing catalytic triad (GxSxG motif)
0.084 9.94E-7 YMR278W PGM3 hom Phosphoglucomutase, catalyzes interconversion of glucose-1-phosphate and glucose-6-phospate; transcription induced in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential
0.084 1.13E-6 YHR146W CRP1 hom Protein that binds to cruciform DNA structures
0.082 2.17E-6 YGR142W BTN2 hom v-SNARE binding protein; facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase; BTN2 has a paralog, CUR1, that arose from the whole genome duplication
0.080 3.86E-6 YMR079W SEC14 het Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs
0.079 4.10E-6 YJR024C MDE1 hom 5'-methylthioribulose-1-phosphate dehydratase; acts in the methionine salvage pathway; potential Smt3p sumoylation substrate; expression downregulated by caspofungin and deletion mutant is caspofungin resistant
0.076 9.41E-6 YOL008W COQ10 hom Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q6 to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes
0.076 1.17E-5 YNL159C ASI2 hom Integral inner nuclear membrane protein that acts with Asi1p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals
0.076 1.18E-5 YBL071C_d YBL071C_d hom Dubious open reading frame, predicted protein contains a peroxisomal targeting signal
0.075 1.29E-5 YFL021W GAT1 hom Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p
0.074 1.76E-5 YLR202C_d YLR202C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron
0.074 1.79E-5 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)