YOL131W_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL131W / YOL131W

Click on Significant Values for Screen Details ID:SGTC_26|Compound:0302-0163|FD-Score:-3.35|P-value:3.55E-4 ID:SGTC_189|Compound:3970-0742|FD-Score:4.82|P-value:5.79E-7 ID:SGTC_196|Compound:k015-0023|FD-Score:-3.24|P-value:5.24E-4 ID:SGTC_215|Compound:1287-0124|FD-Score:3.45|P-value:2.57E-4 ID:SGTC_322|Compound:k048-0136|FD-Score:3.30|P-value:4.37E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:4.03|P-value:2.41E-5 ID:SGTC_534|Compound:k292-0788|FD-Score:3.37|P-value:3.42E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:-4.27|P-value:8.25E-6 ID:SGTC_558|Compound:k064-0027|FD-Score:-4.02|P-value:2.42E-5 ID:SGTC_868|Compound:0527-0199|FD-Score:3.49|P-value:2.14E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:-3.44|P-value:2.58E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:-3.37|P-value:3.32E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:4.62|P-value:1.61E-6 ID:SGTC_952|Compound:1185-0122|FD-Score:3.36|P-value:3.49E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:3.36|P-value:3.58E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:4.14|P-value:1.48E-5 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.09|P-value:9.25E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.49|P-value:2.17E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.18|P-value:6.74E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.46|P-value:2.41E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:4.46|P-value:3.44E-6 ID:SGTC_1482|Compound:3346-2049|FD-Score:3.53|P-value:1.89E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:4.07|P-value:2.08E-5 ID:SGTC_1626|Compound:st003712|FD-Score:3.12|P-value:8.35E-4 ID:SGTC_1632|Compound:st005650|FD-Score:4.73|P-value:9.16E-7 ID:SGTC_1638|Compound:st008370|FD-Score:3.19|P-value:6.59E-4 ID:SGTC_1756|Compound:st041558|FD-Score:3.94|P-value:3.63E-5 ID:SGTC_1863|Compound:st057641|FD-Score:3.08|P-value:9.64E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.73|P-value:8.66E-5 ID:SGTC_2017|Compound:5132927|FD-Score:-3.57|P-value:1.55E-4 ID:SGTC_2024|Compound:5144227|FD-Score:-4.07|P-value:1.98E-5 ID:SGTC_2051|Compound:5263410|FD-Score:3.11|P-value:8.50E-4 ID:SGTC_2059|Compound:5238311|FD-Score:3.11|P-value:8.56E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:4.13|P-value:1.56E-5 ID:SGTC_2694|Compound:st077685|FD-Score:3.40|P-value:3.04E-4 ID:SGTC_2695|Compound:st077686|FD-Score:4.30|P-value:7.24E-6 ID:SGTC_3244|Compound:9134489|FD-Score:3.79|P-value:6.58E-5 ID:SGTC_26|Compound:0302-0163|FD-Score:-3.35|P-value:3.55E-4 ID:SGTC_189|Compound:3970-0742|FD-Score:4.82|P-value:5.79E-7 ID:SGTC_196|Compound:k015-0023|FD-Score:-3.24|P-value:5.24E-4 ID:SGTC_215|Compound:1287-0124|FD-Score:3.45|P-value:2.57E-4 ID:SGTC_322|Compound:k048-0136|FD-Score:3.30|P-value:4.37E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:4.03|P-value:2.41E-5 ID:SGTC_534|Compound:k292-0788|FD-Score:3.37|P-value:3.42E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:-4.27|P-value:8.25E-6 ID:SGTC_558|Compound:k064-0027|FD-Score:-4.02|P-value:2.42E-5 ID:SGTC_868|Compound:0527-0199|FD-Score:3.49|P-value:2.14E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:-3.44|P-value:2.58E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:-3.37|P-value:3.32E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:4.62|P-value:1.61E-6 ID:SGTC_952|Compound:1185-0122|FD-Score:3.36|P-value:3.49E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:3.36|P-value:3.58E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:4.14|P-value:1.48E-5 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.09|P-value:9.25E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.49|P-value:2.17E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.18|P-value:6.74E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.46|P-value:2.41E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:4.46|P-value:3.44E-6 ID:SGTC_1482|Compound:3346-2049|FD-Score:3.53|P-value:1.89E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:4.07|P-value:2.08E-5 ID:SGTC_1626|Compound:st003712|FD-Score:3.12|P-value:8.35E-4 ID:SGTC_1632|Compound:st005650|FD-Score:4.73|P-value:9.16E-7 ID:SGTC_1638|Compound:st008370|FD-Score:3.19|P-value:6.59E-4 ID:SGTC_1756|Compound:st041558|FD-Score:3.94|P-value:3.63E-5 ID:SGTC_1863|Compound:st057641|FD-Score:3.08|P-value:9.64E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.73|P-value:8.66E-5 ID:SGTC_2017|Compound:5132927|FD-Score:-3.57|P-value:1.55E-4 ID:SGTC_2024|Compound:5144227|FD-Score:-4.07|P-value:1.98E-5 ID:SGTC_2051|Compound:5263410|FD-Score:3.11|P-value:8.50E-4 ID:SGTC_2059|Compound:5238311|FD-Score:3.11|P-value:8.56E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:4.13|P-value:1.56E-5 ID:SGTC_2694|Compound:st077685|FD-Score:3.40|P-value:3.04E-4 ID:SGTC_2695|Compound:st077686|FD-Score:4.30|P-value:7.24E-6 ID:SGTC_3244|Compound:9134489|FD-Score:3.79|P-value:6.58E-5

Top fitness defect scores for YOL131W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_189 3970-0742 4.82 2.1 µM 5.79E-7 3 7.05E-7
2 SGTC_1632 st005650 4.73 90.0 µM 9.16E-7 11 1.11E-6
3 SGTC_949 1165-0505 4.62 146.0 µM 1.61E-6 9 1.93E-6
4 SGTC_1424 4048-1941 4.46 275.0 µM 3.44E-6 14 4.07E-6
5 SGTC_2695 st077686 4.30 52.0 µM 7.24E-6 28 8.47E-6
6 SGTC_1153 4055-0057 4.14 267.0 µM 1.48E-5 22 1.71E-5
7 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 4.13 100.0 µM 1.56E-5 60S ribosome export 19 1.80E-5
8 SGTC_1512 0259-0544 4.07 12.2 µM 2.08E-5 12 2.39E-5
9 SGTC_530 4358-1714 4.03 28.0 µM 2.41E-5 44 2.76E-5
10 SGTC_1756 st041558 3.94 35.5 µM 3.63E-5 13 4.14E-5
11 SGTC_3244 9134489 3.79 49.5 µM 6.58E-5 22 7.43E-5
12 SGTC_1879 gemcitabine 3.73 100.0 µM 8.66E-5 21 9.73E-5
13 SGTC_1482 3346-2049 3.53 8.5 µM 1.89E-4 39 2.10E-4
14 SGTC_868 0527-0199 3.49 213.0 µM 2.14E-4 fatty acid desaturase (OLE1) 41 2.37E-4
15 SGTC_1212 0520-0165 3.49 585.0 µM 2.17E-4 52 2.40E-4
16 SGTC_1376 2910-0861 3.46 41.3 µM 2.41E-4 35 2.67E-4
17 SGTC_215 1287-0124 3.45 461.5 µM 2.57E-4 5 2.84E-4
18 SGTC_2694 st077685 3.40 81.9 µM 3.04E-4 endomembrane recycling 46 3.35E-4
19 SGTC_534 k292-0788 3.37 63.4 µM 3.42E-4 mitochondrial processes 49 3.76E-4
20 SGTC_952 1185-0122 3.36 232.0 µM 3.49E-4 41 3.84E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.093 6.11E-8 YDL029W ARP2 het Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity
0.085 9.07E-7 YER004W FMP52 hom Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation
0.084 1.20E-6 YNL328C MDJ2 hom Constituent of the mitochondrial import motor associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain
0.083 1.50E-6 YDL093W PMT5 hom Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt3p, can instead interact with Pmt2p in some conditions; target for new antifungals
0.083 1.64E-6 YOR225W_d YOR225W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.080 3.84E-6 YOR218C_d YOR218C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene RFC1/YOR217W
0.079 4.91E-6 YNL160W YGP1 hom Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p
0.077 8.35E-6 YPR045C THP3 hom Protein that forms a complex with Csn12p that is recruited to transcribed genes and may have a role in transcription elongation; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes
0.075 1.41E-5 YEL039C CYC7 hom Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; protein abundance increases in response to DNA replication stress; CYC7 has a paralog, CYC1, that arose from the whole genome duplication
0.075 1.43E-5 YJL058C BIT61 hom Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication
0.074 1.82E-5 YGR015C_p YGR015C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.074 2.02E-5 YDR383C NKP1 hom Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein fta4
0.071 3.92E-5 YDL027C_p YDL027C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL027C is not an essential gene
0.071 4.10E-5 YDR408C ADE8 hom Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway
0.069 6.47E-5 YDR428C BNA7 hom Formylkynurenine formamidase, involved in the de novo biosynthesis of NAD from tryptophan via kynurenine