YOL159C

Soluble protein of unknown function; deletion mutants are viable and have elevated levels of Ty1 retrotransposition and Ty1 cDNA

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL159C / YOL159C

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:2.84|P-value:7.71E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:2.79|P-value:9.31E-4 ID:SGTC_89|Compound:0302-0250|FD-Score:-2.91|P-value:5.88E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.38|P-value:8.46E-5 ID:SGTC_164|Compound:4100-3994|FD-Score:3.72|P-value:1.70E-5 ID:SGTC_394|Compound:menadione|FD-Score:2.95|P-value:4.98E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:-4.56|P-value:1.91E-7 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-3.68|P-value:2.11E-5 ID:SGTC_418|Compound:lividomycin a|FD-Score:2.94|P-value:5.34E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:-2.99|P-value:4.40E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:3.04|P-value:3.60E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:3.36|P-value:9.07E-5 ID:SGTC_687|Compound:k029-0044|FD-Score:2.83|P-value:8.02E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:3.07|P-value:3.11E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:3.06|P-value:3.25E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:3.16|P-value:2.17E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:2.86|P-value:7.08E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:-3.08|P-value:3.04E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:-3.19|P-value:1.91E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:-2.88|P-value:6.57E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:-3.04|P-value:3.53E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:-3.25|P-value:1.48E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.80|P-value:1.15E-5 ID:SGTC_1754|Compound:st042065|FD-Score:3.89|P-value:7.41E-6 ID:SGTC_1800|Compound:st050079|FD-Score:2.81|P-value:8.57E-4 ID:SGTC_1803|Compound:st050068|FD-Score:3.57|P-value:3.54E-5 ID:SGTC_1818|Compound:st052136|FD-Score:4.41|P-value:4.55E-7 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.43|P-value:6.57E-5 ID:SGTC_2074|Compound:5212007|FD-Score:2.91|P-value:6.03E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.40|P-value:7.70E-5 ID:SGTC_2172|Compound:5754775|FD-Score:-3.26|P-value:1.39E-4 ID:SGTC_2258|Compound:7960471|FD-Score:-3.29|P-value:1.22E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.75|P-value:1.48E-5 ID:SGTC_2328|Compound:6201408|FD-Score:2.91|P-value:5.91E-4 ID:SGTC_2363|Compound:9053361|FD-Score:2.98|P-value:4.52E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-4.28|P-value:9.38E-7 ID:SGTC_2441|Compound:5730946|FD-Score:3.15|P-value:2.22E-4 ID:SGTC_2487|Compound:5918373|FD-Score:2.90|P-value:6.12E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:3.43|P-value:6.73E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.43|P-value:6.70E-5 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:-4.14|P-value:2.01E-6 ID:SGTC_2777|Compound:climbazole|FD-Score:3.91|P-value:6.76E-6 ID:SGTC_2778|Compound:tioconazole|FD-Score:2.94|P-value:5.33E-4 ID:SGTC_2796|Compound:7949634|FD-Score:-3.18|P-value:2.00E-4 ID:SGTC_2833|Compound:9001315|FD-Score:-3.15|P-value:2.24E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.89|P-value:7.45E-6 ID:SGTC_2838|Compound:9002687|FD-Score:3.64|P-value:2.50E-5 ID:SGTC_2840|Compound:9008771|FD-Score:-4.02|P-value:3.83E-6 ID:SGTC_2896|Compound:9052656|FD-Score:6.60|P-value:9.78E-14 ID:SGTC_2905|Compound:7799065|FD-Score:3.05|P-value:3.37E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-3.10|P-value:2.77E-4 ID:SGTC_2944|Compound:9067346|FD-Score:-2.87|P-value:6.92E-4 ID:SGTC_3037|Compound:9091026|FD-Score:4.01|P-value:3.89E-6 ID:SGTC_3052|Compound:9092717|FD-Score:3.12|P-value:2.50E-4 ID:SGTC_3126|Compound:9127922|FD-Score:5.86|P-value:3.37E-11 ID:SGTC_3135|Compound:9127742|FD-Score:3.54|P-value:4.09E-5 ID:SGTC_3137|Compound:9097352|FD-Score:2.82|P-value:8.26E-4 ID:SGTC_3340|Compound:9146634|FD-Score:2.83|P-value:8.12E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:2.84|P-value:7.71E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:2.79|P-value:9.31E-4 ID:SGTC_89|Compound:0302-0250|FD-Score:-2.91|P-value:5.88E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.38|P-value:8.46E-5 ID:SGTC_164|Compound:4100-3994|FD-Score:3.72|P-value:1.70E-5 ID:SGTC_394|Compound:menadione|FD-Score:2.95|P-value:4.98E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:-4.56|P-value:1.91E-7 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-3.68|P-value:2.11E-5 ID:SGTC_418|Compound:lividomycin a|FD-Score:2.94|P-value:5.34E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:-2.99|P-value:4.40E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:3.04|P-value:3.60E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:3.36|P-value:9.07E-5 ID:SGTC_687|Compound:k029-0044|FD-Score:2.83|P-value:8.02E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:3.07|P-value:3.11E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:3.06|P-value:3.25E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:3.16|P-value:2.17E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:2.86|P-value:7.08E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:-3.08|P-value:3.04E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:-3.19|P-value:1.91E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:-2.88|P-value:6.57E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:-3.04|P-value:3.53E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:-3.25|P-value:1.48E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.80|P-value:1.15E-5 ID:SGTC_1754|Compound:st042065|FD-Score:3.89|P-value:7.41E-6 ID:SGTC_1800|Compound:st050079|FD-Score:2.81|P-value:8.57E-4 ID:SGTC_1803|Compound:st050068|FD-Score:3.57|P-value:3.54E-5 ID:SGTC_1818|Compound:st052136|FD-Score:4.41|P-value:4.55E-7 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.43|P-value:6.57E-5 ID:SGTC_2074|Compound:5212007|FD-Score:2.91|P-value:6.03E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.40|P-value:7.70E-5 ID:SGTC_2172|Compound:5754775|FD-Score:-3.26|P-value:1.39E-4 ID:SGTC_2258|Compound:7960471|FD-Score:-3.29|P-value:1.22E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.75|P-value:1.48E-5 ID:SGTC_2328|Compound:6201408|FD-Score:2.91|P-value:5.91E-4 ID:SGTC_2363|Compound:9053361|FD-Score:2.98|P-value:4.52E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-4.28|P-value:9.38E-7 ID:SGTC_2441|Compound:5730946|FD-Score:3.15|P-value:2.22E-4 ID:SGTC_2487|Compound:5918373|FD-Score:2.90|P-value:6.12E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:3.43|P-value:6.73E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.43|P-value:6.70E-5 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:-4.14|P-value:2.01E-6 ID:SGTC_2777|Compound:climbazole|FD-Score:3.91|P-value:6.76E-6 ID:SGTC_2778|Compound:tioconazole|FD-Score:2.94|P-value:5.33E-4 ID:SGTC_2796|Compound:7949634|FD-Score:-3.18|P-value:2.00E-4 ID:SGTC_2833|Compound:9001315|FD-Score:-3.15|P-value:2.24E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.89|P-value:7.45E-6 ID:SGTC_2838|Compound:9002687|FD-Score:3.64|P-value:2.50E-5 ID:SGTC_2840|Compound:9008771|FD-Score:-4.02|P-value:3.83E-6 ID:SGTC_2896|Compound:9052656|FD-Score:6.60|P-value:9.78E-14 ID:SGTC_2905|Compound:7799065|FD-Score:3.05|P-value:3.37E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-3.10|P-value:2.77E-4 ID:SGTC_2944|Compound:9067346|FD-Score:-2.87|P-value:6.92E-4 ID:SGTC_3037|Compound:9091026|FD-Score:4.01|P-value:3.89E-6 ID:SGTC_3052|Compound:9092717|FD-Score:3.12|P-value:2.50E-4 ID:SGTC_3126|Compound:9127922|FD-Score:5.86|P-value:3.37E-11 ID:SGTC_3135|Compound:9127742|FD-Score:3.54|P-value:4.09E-5 ID:SGTC_3137|Compound:9097352|FD-Score:2.82|P-value:8.26E-4 ID:SGTC_3340|Compound:9146634|FD-Score:2.83|P-value:8.12E-4

Top fitness defect scores for YOL159C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2896 9052656 6.60 71.4 µM 9.78E-14 endomembrane recycling 30 2.08E-11
2 SGTC_3126 9127922 5.86 49.5 µM 3.37E-11 fatty acid desaturase (OLE1) 17 2.35E-9
3 SGTC_1818 st052136 4.41 56.3 µM 4.55E-7 NEO1-PIK1 33 5.24E-6
4 SGTC_3037 9091026 4.01 49.5 µM 3.89E-6 NEO1-PIK1 121 3.00E-5
5 SGTC_2777 climbazole 3.91 1.5 µM 6.76E-6 iron homeostasis 54 4.70E-5
6 SGTC_1754 st042065 3.89 16.1 µM 7.41E-6 NEO1-PIK1 184 5.06E-5
7 SGTC_1745 st081495 3.80 74.0 µM 1.15E-5 RNA processing & uracil transport 79 7.23E-5
8 SGTC_2322 7413319 3.75 38.2 µM 1.48E-5 ERAD & cell cycle 168 8.90E-5
9 SGTC_164 4100-3994 3.72 89.6 µM 1.70E-5 40 9.94E-5
10 SGTC_2838 9002687 3.64 71.4 µM 2.50E-5 fatty acid desaturase (OLE1) 26 1.36E-4
11 SGTC_1803 st050068 3.57 52.4 µM 3.54E-5 NEO1-PIK1 211 1.81E-4
12 SGTC_3135 9127742 3.54 49.5 µM 4.09E-5 34 2.04E-4
13 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 3.43 14.9 µM 6.57E-5 25 3.00E-4
14 SGTC_2752 diclazuril 3.43 33.1 µM 6.70E-5 162 3.04E-4
15 SGTC_2722 naftopidil 3.43 47.2 µM 6.73E-5 15 3.06E-4
16 SGTC_2111 5486399 3.40 200.0 µM 7.70E-5 76 3.41E-4
17 SGTC_159 3970-0959 3.38 50.0 µM 8.46E-5 119 3.68E-4
18 SGTC_673 1082-0474 3.36 110.0 µM 9.07E-5 RSC complex & mRNA processing 93 3.90E-4
19 SGTC_988 1497-1057 3.16 103.0 µM 2.17E-4 31 7.95E-4
20 SGTC_2441 5730946 3.15 39.1 µM 2.22E-4 48 8.11E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.199 3.22E-31 YEL048C TCA17 hom Subunit of TRAPPII, a multimeric GEF involved in intra-Golgi and endosome-to-Golgi transport; promotes association of TRAPPII-specific subunits with the core complex; sedlin related; human Sedlin mutations cause SEDT, a skeletal disorder
0.190 1.05E-28 YBR245C ISW1 hom ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; ATPase; forms a complex with Ioc3p (Isw1a), and a complex with Ioc2p and Ioc4p (Isw1b); Isw1a and Isw1b have partially overlapping and distinct roles, Isw1a involved in repression of transcription initiation and Isw1b involved in regulation of transcription elongation; Isw1b recruited to open reading frames by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions
0.180 6.48E-26 YGR166W TRS65 hom Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response
0.176 1.04E-24 YLR020C YEH2 hom Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
0.165 6.73E-22 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.162 4.62E-21 YOR115C TRS33 hom One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.158 2.79E-20 YLR172C DPH5 hom Methyltransferase required for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm
0.157 7.54E-20 YLR360W VPS38 hom Part of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity; required for overflow degradation of misfolded proteins when ERAD is saturated
0.154 2.68E-19 YDL167C NRP1 hom Putative RNA binding protein of unknown function; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis
0.154 2.87E-19 YGL035C MIG1 hom Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion
0.150 2.08E-18 YDR084C TVP23 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.150 2.51E-18 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.148 5.25E-18 YOR357C SNX3 hom Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.145 2.63E-17 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.143 7.02E-17 YNL183C NPR1 hom Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex