YOL162W_p

Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL162W / YOL162W

Click on Significant Values for Screen Details ID:SGTC_46|Compound:0329-0187a|FD-Score:2.88|P-value:7.44E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.04|P-value:3.44E-6 ID:SGTC_66|Compound:0109-0187|FD-Score:-2.80|P-value:9.03E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:2.87|P-value:7.49E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:2.84|P-value:8.65E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:3.40|P-value:8.52E-5 ID:SGTC_413|Compound:propylparaben|FD-Score:-2.83|P-value:8.05E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:3.18|P-value:2.23E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:-3.34|P-value:1.01E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:4.11|P-value:2.80E-6 ID:SGTC_917|Compound:harmaline|FD-Score:2.94|P-value:5.81E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:-2.88|P-value:6.72E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.55|P-value:4.45E-5 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.34|P-value:1.11E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:-3.31|P-value:1.16E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.18|P-value:2.25E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:-3.39|P-value:8.21E-5 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:2.84|P-value:8.50E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.41|P-value:8.05E-5 ID:SGTC_1630|Compound:st005209|FD-Score:3.54|P-value:4.63E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.39|P-value:8.15E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:-2.95|P-value:5.18E-4 ID:SGTC_1903|Compound:st060211|FD-Score:3.28|P-value:1.47E-4 ID:SGTC_1906|Compound:st060206|FD-Score:3.69|P-value:2.31E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.02|P-value:3.84E-4 ID:SGTC_1957|Compound:st077035|FD-Score:-3.29|P-value:1.25E-4 ID:SGTC_1960|Compound:st011366|FD-Score:-2.80|P-value:9.02E-4 ID:SGTC_2024|Compound:5144227|FD-Score:-2.79|P-value:9.60E-4 ID:SGTC_2080|Compound:5212524|FD-Score:3.65|P-value:2.70E-5 ID:SGTC_2138|Compound:5575593|FD-Score:3.42|P-value:7.87E-5 ID:SGTC_2198|Compound:6589944|FD-Score:-3.00|P-value:4.11E-4 ID:SGTC_2301|Compound:7769476|FD-Score:2.94|P-value:5.89E-4 ID:SGTC_2303|Compound:7774051|FD-Score:3.76|P-value:1.57E-5 ID:SGTC_2332|Compound:7982454|FD-Score:-3.30|P-value:1.20E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-6.07|P-value:7.92E-12 ID:SGTC_2482|Compound:5981709|FD-Score:3.17|P-value:2.34E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-4.41|P-value:4.80E-7 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.67|P-value:2.53E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.41|P-value:8.31E-5 ID:SGTC_2814|Compound:7977482|FD-Score:4.97|P-value:1.89E-8 ID:SGTC_2823|Compound:7987624|FD-Score:3.52|P-value:4.97E-5 ID:SGTC_2837|Compound:9008476|FD-Score:-4.89|P-value:2.73E-8 ID:SGTC_2839|Compound:9003951|FD-Score:3.36|P-value:1.01E-4 ID:SGTC_2973|Compound:9094665|FD-Score:3.35|P-value:1.08E-4 ID:SGTC_2997|Compound:9067075|FD-Score:6.19|P-value:3.71E-12 ID:SGTC_3017|Compound:9080681|FD-Score:3.16|P-value:2.35E-4 ID:SGTC_3245|Compound:9134821|FD-Score:3.87|P-value:9.36E-6 ID:SGTC_3299|Compound:9121982|FD-Score:3.02|P-value:4.19E-4 ID:SGTC_3312|Compound:9133330|FD-Score:3.13|P-value:2.72E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:2.88|P-value:7.44E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.04|P-value:3.44E-6 ID:SGTC_66|Compound:0109-0187|FD-Score:-2.80|P-value:9.03E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:2.87|P-value:7.49E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:2.84|P-value:8.65E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:3.40|P-value:8.52E-5 ID:SGTC_413|Compound:propylparaben|FD-Score:-2.83|P-value:8.05E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:3.18|P-value:2.23E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:-3.34|P-value:1.01E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:4.11|P-value:2.80E-6 ID:SGTC_917|Compound:harmaline|FD-Score:2.94|P-value:5.81E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:-2.88|P-value:6.72E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.55|P-value:4.45E-5 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.34|P-value:1.11E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:-3.31|P-value:1.16E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.18|P-value:2.25E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:-3.39|P-value:8.21E-5 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:2.84|P-value:8.50E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.41|P-value:8.05E-5 ID:SGTC_1630|Compound:st005209|FD-Score:3.54|P-value:4.63E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.39|P-value:8.15E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:-2.95|P-value:5.18E-4 ID:SGTC_1903|Compound:st060211|FD-Score:3.28|P-value:1.47E-4 ID:SGTC_1906|Compound:st060206|FD-Score:3.69|P-value:2.31E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.02|P-value:3.84E-4 ID:SGTC_1957|Compound:st077035|FD-Score:-3.29|P-value:1.25E-4 ID:SGTC_1960|Compound:st011366|FD-Score:-2.80|P-value:9.02E-4 ID:SGTC_2024|Compound:5144227|FD-Score:-2.79|P-value:9.60E-4 ID:SGTC_2080|Compound:5212524|FD-Score:3.65|P-value:2.70E-5 ID:SGTC_2138|Compound:5575593|FD-Score:3.42|P-value:7.87E-5 ID:SGTC_2198|Compound:6589944|FD-Score:-3.00|P-value:4.11E-4 ID:SGTC_2301|Compound:7769476|FD-Score:2.94|P-value:5.89E-4 ID:SGTC_2303|Compound:7774051|FD-Score:3.76|P-value:1.57E-5 ID:SGTC_2332|Compound:7982454|FD-Score:-3.30|P-value:1.20E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-6.07|P-value:7.92E-12 ID:SGTC_2482|Compound:5981709|FD-Score:3.17|P-value:2.34E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-4.41|P-value:4.80E-7 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.67|P-value:2.53E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.41|P-value:8.31E-5 ID:SGTC_2814|Compound:7977482|FD-Score:4.97|P-value:1.89E-8 ID:SGTC_2823|Compound:7987624|FD-Score:3.52|P-value:4.97E-5 ID:SGTC_2837|Compound:9008476|FD-Score:-4.89|P-value:2.73E-8 ID:SGTC_2839|Compound:9003951|FD-Score:3.36|P-value:1.01E-4 ID:SGTC_2973|Compound:9094665|FD-Score:3.35|P-value:1.08E-4 ID:SGTC_2997|Compound:9067075|FD-Score:6.19|P-value:3.71E-12 ID:SGTC_3017|Compound:9080681|FD-Score:3.16|P-value:2.35E-4 ID:SGTC_3245|Compound:9134821|FD-Score:3.87|P-value:9.36E-6 ID:SGTC_3299|Compound:9121982|FD-Score:3.02|P-value:4.19E-4 ID:SGTC_3312|Compound:9133330|FD-Score:3.13|P-value:2.72E-4

Top fitness defect scores for YOL162W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2997 9067075 6.19 71.4 µM 3.71E-12 unfolded protein response 18 3.05E-10
2 SGTC_2814 7977482 4.97 43.0 µM 1.89E-8 22 3.32E-7
3 SGTC_778 3456-2434 4.11 196.0 µM 2.80E-6 mitochondrial response to ROS 70 2.01E-5
4 SGTC_3245 9134821 3.87 49.5 µM 9.36E-6 20 5.43E-5
5 SGTC_2303 7774051 3.76 200.0 µM 1.57E-5 23 8.34E-5
6 SGTC_1906 st060206 3.69 94.7 µM 2.31E-5 23 1.14E-4
7 SGTC_2621 lithochol-11-enic acid 3.67 100.0 µM 2.53E-5 34 1.23E-4
8 SGTC_2080 5212524 3.65 12.4 µM 2.70E-5 copper-dependent oxidative stress 20 1.30E-4
9 SGTC_1222 0366-0074 3.55 1.2 µM 4.45E-5 TSC3-RPN4 27 1.96E-4
10 SGTC_1630 st005209 3.54 31.3 µM 4.63E-5 38 2.03E-4
11 SGTC_2823 7987624 3.52 58.4 µM 4.97E-5 48 2.15E-4
12 SGTC_2138 5575593 3.42 77.7 µM 7.87E-5 21 3.14E-4
13 SGTC_1586 deoxycorticosterone acetate 3.41 53.7 µM 8.05E-5 27 3.20E-4
14 SGTC_2768 sulfasalazine 3.41 50.2 µM 8.31E-5 33 3.29E-4
15 SGTC_404 fumagillin 3.40 50.0 µM 8.52E-5 41 3.35E-4
16 SGTC_2839 9003951 3.36 26.0 µM 1.01E-4 26 3.87E-4
17 SGTC_2973 9094665 3.35 18.0 µM 1.08E-4 NEO1 51 4.09E-4
18 SGTC_1224 0823-0416 3.34 294.0 µM 1.11E-4 26 4.18E-4
19 SGTC_1903 st060211 3.28 78.3 µM 1.47E-4 53 5.26E-4
20 SGTC_562 3772-2733 3.18 112.0 µM 2.23E-4 ERG2 124 7.42E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.145 3.03E-17 YLR097C HRT3 hom Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies
0.129 5.42E-14 YLR326W_p YLR326W_p hom Putative protein of unknown function, predicted to be palmitoylated
0.121 1.86E-12 YJL050W MTR4 het ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation both as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing
0.121 2.32E-12 YEL068C_p YEL068C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.112 8.80E-11 YBL073W_d YBL073W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene AAR2/YBL074C
0.108 3.81E-10 YPL107W_p YPL107W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YPL107W is not an essential gene
0.106 7.34E-10 YOL132W GAS4 hom 1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall
0.104 1.69E-9 YDL131W LYS21 hom Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS21 has a paralog, LYS20, that arose from the whole genome duplication
0.102 3.02E-9 YER060W-A FCY22 hom Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
0.101 3.87E-9 YBR165W UBS1 hom Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity
0.100 6.00E-9 YIR016W_p YIR016W_p hom Putative protein of unknown function; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; overexpression causes a cell cycle delay or arrest; non-essential gene; YIR016W has a paralog, YOL036W, that arose from the whole genome duplication
0.099 8.19E-9 YGR216C GPI1 het Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs
0.097 1.79E-8 YDR104C SPO71 hom Meiosis-specific protein of unknown function, required for spore wall formation during sporulation, in particular for the proper size of the prospore membrane (PSM); interacts with SPO1; dispensable for both nuclear divisions during meiosis; contains two PH domains
0.095 3.30E-8 YML011C RAD33 hom Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
0.095 3.92E-8 YAL045C_d YAL045C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A