YOR003W / YSP3

Putative precursor to the subtilisin-like protease III

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR003W / YSP3

Click on Significant Values for Screen Details ID:SGTC_134|Compound:0269-0018|FD-Score:3.19|P-value:2.85E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:-2.89|P-value:8.84E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.71|P-value:3.06E-5 ID:SGTC_324|Compound:1315-0088|FD-Score:3.33|P-value:1.59E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:3.18|P-value:2.93E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:4.10|P-value:4.69E-6 ID:SGTC_647|Compound:0140-0236|FD-Score:2.99|P-value:6.29E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:5.09|P-value:1.86E-8 ID:SGTC_651|Compound:3253-0966|FD-Score:-4.91|P-value:5.27E-8 ID:SGTC_658|Compound:3253-0951|FD-Score:-4.52|P-value:4.95E-7 ID:SGTC_661|Compound:1304-0007|FD-Score:-3.95|P-value:9.46E-6 ID:SGTC_668|Compound:1682-0499|FD-Score:-5.39|P-value:2.61E-9 ID:SGTC_743|Compound:1275-0778|FD-Score:3.10|P-value:4.15E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:2.96|P-value:6.91E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.06|P-value:4.73E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:3.15|P-value:3.34E-4 ID:SGTC_901|Compound:1112-0062|FD-Score:-2.93|P-value:7.50E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.00|P-value:5.95E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:2.91|P-value:8.30E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.37|P-value:1.36E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.50|P-value:7.73E-5 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.63|P-value:4.32E-5 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.37|P-value:1.38E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:-3.02|P-value:5.44E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.06|P-value:4.82E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.07|P-value:4.57E-4 ID:SGTC_1744|Compound:st037937|FD-Score:2.89|P-value:8.96E-4 ID:SGTC_1826|Compound:st055655|FD-Score:3.86|P-value:1.56E-5 ID:SGTC_1828|Compound:st055811|FD-Score:3.57|P-value:5.88E-5 ID:SGTC_1834|Compound:st055981|FD-Score:-3.70|P-value:3.04E-5 ID:SGTC_1838|Compound:st055369|FD-Score:-3.05|P-value:4.76E-4 ID:SGTC_1865|Compound:st057639|FD-Score:-3.08|P-value:4.19E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.46|P-value:8.99E-5 ID:SGTC_2044|Compound:5102272|FD-Score:-2.90|P-value:8.52E-4 ID:SGTC_2065|Compound:5221596|FD-Score:4.92|P-value:5.34E-8 ID:SGTC_2102|Compound:5377816|FD-Score:4.50|P-value:5.71E-7 ID:SGTC_2140|Compound:5586273|FD-Score:-2.90|P-value:8.27E-4 ID:SGTC_2161|Compound:5662504|FD-Score:-3.30|P-value:1.73E-4 ID:SGTC_2256|Compound:7954252|FD-Score:2.90|P-value:8.56E-4 ID:SGTC_2257|Compound:7960413|FD-Score:-4.47|P-value:6.51E-7 ID:SGTC_2286|Compound:7945697|FD-Score:-3.49|P-value:7.94E-5 ID:SGTC_2374|Compound:9071832|FD-Score:3.08|P-value:4.43E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:-3.71|P-value:2.87E-5 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.56|P-value:6.12E-5 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:-3.00|P-value:5.67E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.57|P-value:5.42E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.62|P-value:4.39E-5 ID:SGTC_2842|Compound:9000675|FD-Score:2.97|P-value:6.76E-4 ID:SGTC_2853|Compound:9015042|FD-Score:-5.18|P-value:1.01E-8 ID:SGTC_2998|Compound:9066762|FD-Score:3.69|P-value:3.41E-5 ID:SGTC_3068|Compound:9116768|FD-Score:-5.00|P-value:3.09E-8 ID:SGTC_3254|Compound:9136651|FD-Score:3.14|P-value:3.43E-4 ID:SGTC_3337|Compound:9144342|FD-Score:-2.89|P-value:8.84E-4 ID:SGTC_3348|Compound:9149464|FD-Score:3.39|P-value:1.27E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:3.19|P-value:2.85E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:-2.89|P-value:8.84E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.71|P-value:3.06E-5 ID:SGTC_324|Compound:1315-0088|FD-Score:3.33|P-value:1.59E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:3.18|P-value:2.93E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:4.10|P-value:4.69E-6 ID:SGTC_647|Compound:0140-0236|FD-Score:2.99|P-value:6.29E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:5.09|P-value:1.86E-8 ID:SGTC_651|Compound:3253-0966|FD-Score:-4.91|P-value:5.27E-8 ID:SGTC_658|Compound:3253-0951|FD-Score:-4.52|P-value:4.95E-7 ID:SGTC_661|Compound:1304-0007|FD-Score:-3.95|P-value:9.46E-6 ID:SGTC_668|Compound:1682-0499|FD-Score:-5.39|P-value:2.61E-9 ID:SGTC_743|Compound:1275-0778|FD-Score:3.10|P-value:4.15E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:2.96|P-value:6.91E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.06|P-value:4.73E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:3.15|P-value:3.34E-4 ID:SGTC_901|Compound:1112-0062|FD-Score:-2.93|P-value:7.50E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.00|P-value:5.95E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:2.91|P-value:8.30E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.37|P-value:1.36E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.50|P-value:7.73E-5 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.63|P-value:4.32E-5 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.37|P-value:1.38E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:-3.02|P-value:5.44E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.06|P-value:4.82E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.07|P-value:4.57E-4 ID:SGTC_1744|Compound:st037937|FD-Score:2.89|P-value:8.96E-4 ID:SGTC_1826|Compound:st055655|FD-Score:3.86|P-value:1.56E-5 ID:SGTC_1828|Compound:st055811|FD-Score:3.57|P-value:5.88E-5 ID:SGTC_1834|Compound:st055981|FD-Score:-3.70|P-value:3.04E-5 ID:SGTC_1838|Compound:st055369|FD-Score:-3.05|P-value:4.76E-4 ID:SGTC_1865|Compound:st057639|FD-Score:-3.08|P-value:4.19E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.46|P-value:8.99E-5 ID:SGTC_2044|Compound:5102272|FD-Score:-2.90|P-value:8.52E-4 ID:SGTC_2065|Compound:5221596|FD-Score:4.92|P-value:5.34E-8 ID:SGTC_2102|Compound:5377816|FD-Score:4.50|P-value:5.71E-7 ID:SGTC_2140|Compound:5586273|FD-Score:-2.90|P-value:8.27E-4 ID:SGTC_2161|Compound:5662504|FD-Score:-3.30|P-value:1.73E-4 ID:SGTC_2256|Compound:7954252|FD-Score:2.90|P-value:8.56E-4 ID:SGTC_2257|Compound:7960413|FD-Score:-4.47|P-value:6.51E-7 ID:SGTC_2286|Compound:7945697|FD-Score:-3.49|P-value:7.94E-5 ID:SGTC_2374|Compound:9071832|FD-Score:3.08|P-value:4.43E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:-3.71|P-value:2.87E-5 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.56|P-value:6.12E-5 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:-3.00|P-value:5.67E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.57|P-value:5.42E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.62|P-value:4.39E-5 ID:SGTC_2842|Compound:9000675|FD-Score:2.97|P-value:6.76E-4 ID:SGTC_2853|Compound:9015042|FD-Score:-5.18|P-value:1.01E-8 ID:SGTC_2998|Compound:9066762|FD-Score:3.69|P-value:3.41E-5 ID:SGTC_3068|Compound:9116768|FD-Score:-5.00|P-value:3.09E-8 ID:SGTC_3254|Compound:9136651|FD-Score:3.14|P-value:3.43E-4 ID:SGTC_3337|Compound:9144342|FD-Score:-2.89|P-value:8.84E-4 ID:SGTC_3348|Compound:9149464|FD-Score:3.39|P-value:1.27E-4

Top fitness defect scores for YOR003W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_649 1123-0311 5.09 367.0 µM 1.86E-8 endomembrane recycling 37 1.75E-7
2 SGTC_2065 5221596 4.92 34.3 µM 5.34E-8 6 4.35E-7
3 SGTC_2102 5377816 4.50 72.8 µM 5.71E-7 14 3.34E-6
4 SGTC_644 1498-1197 4.10 63.3 µM 4.69E-6 16 2.05E-5
5 SGTC_1826 st055655 3.86 41.6 µM 1.56E-5 ERG2 43 5.77E-5
6 SGTC_310 1273-0058 3.71 1.1 µM 3.06E-5 mitochondrial stress 263 1.03E-4
7 SGTC_2998 9066762 3.69 71.4 µM 3.41E-5 RPP1 & pyrimidine depletion 28 1.13E-4
8 SGTC_1357 1503-1303 3.63 39.5 µM 4.32E-5 45 1.39E-4
9 SGTC_1828 st055811 3.57 49.0 µM 5.88E-5 12 1.82E-4
10 SGTC_2420 aureobasidin a 3.56 50.0 nM 6.12E-5 58 1.88E-4
11 SGTC_1286 0929-0070 3.50 131.0 µM 7.73E-5 31 2.30E-4
12 SGTC_3348 9149464 3.39 3.5 µM 1.27E-4 32 3.53E-4
13 SGTC_1249 0481-0015 3.37 10.2 µM 1.36E-4 43 3.75E-4
14 SGTC_1358 1509-0022 3.37 2.5 µM 1.38E-4 28 3.79E-4
15 SGTC_324 1315-0088 3.33 19.6 µM 1.59E-4 RSC & ERG11 18 4.29E-4
16 SGTC_134 0269-0018 3.19 6.9 µM 2.85E-4 179 7.09E-4
17 SGTC_329 k048-0121 3.18 21.3 µM 2.93E-4 RSC & ERG11 36 7.26E-4
18 SGTC_856 0433-0016 3.15 11.3 µM 3.34E-4 39 8.15E-4
19 SGTC_3254 9136651 3.14 49.5 µM 3.43E-4 DNA damage response 54 8.34E-4
20 SGTC_743 1275-0778 3.10 158.0 µM 4.15E-4 excess fatty acid 82 9.83E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.125 3.47E-13 YKR054C DYN1 hom Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p
0.100 6.32E-9 YDR479C PEX29 hom Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress
0.098 1.18E-8 YLR344W RPL26A hom Ribosomal 60S subunit protein L26A; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26A has a paralog, RPL26B, that arose from the whole genome duplication
0.093 6.19E-8 YMR256C COX7 hom Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.088 2.87E-7 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.087 4.11E-7 YKL122C SRP21 het Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
0.087 5.16E-7 YOR305W RRG7 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YOR305W is not an essential gene
0.085 8.00E-7 YDL107W MSS2 hom Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p
0.085 8.18E-7 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.085 9.20E-7 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.084 1.12E-6 YGR149W_p YGR149W_p hom Putative protein of unknown function; predicted to be an integal membrane protein
0.083 1.57E-6 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.082 1.88E-6 YFR011C AIM13 hom Mitochondrial protein peripheral to the inner membrane; component of the mitochondrial inner membrane organizing system (MINOS, MitOS, or MICOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.081 2.31E-6 YKR065C PAM17 hom Constituent of the TIM23 complex; proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 (Translocase of the Inner mitochondrial Membrane) complex; protein abundance increases in response to DNA replication stress
0.080 3.12E-6 YKL117W SBA1 hom Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress