YOR013W_d / IRC11

Dubious opening reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YOR012C; null mutant displays increased levels of spontaneous Rad52 foci

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR013W / IRC11

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:4.78|P-value:7.13E-8 ID:SGTC_69|Compound:0096-0274|FD-Score:-4.58|P-value:3.06E-7 ID:SGTC_113|Compound:0099-0221|FD-Score:3.95|P-value:6.73E-6 ID:SGTC_204|Compound:1543-0184|FD-Score:-3.08|P-value:4.14E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.10|P-value:3.09E-4 ID:SGTC_389|Compound:tpck|FD-Score:3.11|P-value:3.06E-4 ID:SGTC_480|Compound:am 92016|FD-Score:3.33|P-value:1.23E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:3.28|P-value:1.47E-4 ID:SGTC_715|Compound:0868-0130|FD-Score:3.23|P-value:1.82E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:3.27|P-value:1.57E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:3.22|P-value:1.96E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.04|P-value:4.73E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.23|P-value:1.87E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:-4.86|P-value:5.82E-8 ID:SGTC_1531|Compound:st059297|FD-Score:3.38|P-value:9.77E-5 ID:SGTC_1654|Compound:st012436|FD-Score:2.87|P-value:7.71E-4 ID:SGTC_1662|Compound:st014054|FD-Score:2.99|P-value:4.86E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.51|P-value:5.44E-5 ID:SGTC_1856|Compound:st057054|FD-Score:2.93|P-value:6.17E-4 ID:SGTC_1940|Compound:st075990|FD-Score:6.72|P-value:7.76E-14 ID:SGTC_1945|Compound:st075991|FD-Score:5.42|P-value:1.26E-9 ID:SGTC_1950|Compound:st077106|FD-Score:3.49|P-value:5.92E-5 ID:SGTC_2034|Compound:5197015|FD-Score:3.33|P-value:1.20E-4 ID:SGTC_2069|Compound:5228469|FD-Score:3.06|P-value:3.65E-4 ID:SGTC_2074|Compound:5212007|FD-Score:3.23|P-value:1.81E-4 ID:SGTC_2075|Compound:5212009|FD-Score:3.01|P-value:4.47E-4 ID:SGTC_2088|Compound:5278280|FD-Score:2.89|P-value:7.06E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-3.60|P-value:4.53E-5 ID:SGTC_2337|Compound:9009472|FD-Score:5.59|P-value:4.06E-10 ID:SGTC_2397|Compound:5161689|FD-Score:4.34|P-value:8.63E-7 ID:SGTC_2456|Compound:5770359|FD-Score:2.87|P-value:7.75E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-3.57|P-value:5.21E-5 ID:SGTC_2485|Compound:5633444|FD-Score:-3.68|P-value:3.10E-5 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:2.96|P-value:5.41E-4 ID:SGTC_2505|Compound:galangin|FD-Score:3.37|P-value:1.02E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:2.97|P-value:5.33E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:4.12|P-value:2.79E-6 ID:SGTC_2628|Compound:lathosterol|FD-Score:4.07|P-value:3.68E-6 ID:SGTC_2689|Compound:tacrolimus|FD-Score:-3.09|P-value:3.91E-4 ID:SGTC_2791|Compound:5663188|FD-Score:-3.06|P-value:4.36E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-3.06|P-value:4.45E-4 ID:SGTC_2921|Compound:7974240|FD-Score:4.20|P-value:1.85E-6 ID:SGTC_2959|Compound:9079155|FD-Score:3.32|P-value:1.27E-4 ID:SGTC_3031|Compound:9088762|FD-Score:-2.86|P-value:9.56E-4 ID:SGTC_3094|Compound:9117742|FD-Score:3.23|P-value:1.87E-4 ID:SGTC_3159|Compound:9100096|FD-Score:2.94|P-value:5.89E-4 ID:SGTC_3186|Compound:9110464|FD-Score:3.10|P-value:3.13E-4 ID:SGTC_3253|Compound:9135987|FD-Score:3.42|P-value:8.11E-5 ID:SGTC_3284|Compound:9108171|FD-Score:3.31|P-value:1.32E-4 ID:SGTC_3291|Compound:9121177|FD-Score:3.14|P-value:2.66E-4 ID:SGTC_3296|Compound:9122258|FD-Score:-3.46|P-value:8.31E-5 ID:SGTC_3301|Compound:9125354|FD-Score:3.79|P-value:1.49E-5 ID:SGTC_3320|Compound:9137005|FD-Score:3.75|P-value:1.77E-5 ID:SGTC_3350|Compound:9150499|FD-Score:-3.20|P-value:2.53E-4 ID:SGTC_3353|Compound:9151644|FD-Score:3.36|P-value:1.05E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:4.78|P-value:7.13E-8 ID:SGTC_69|Compound:0096-0274|FD-Score:-4.58|P-value:3.06E-7 ID:SGTC_113|Compound:0099-0221|FD-Score:3.95|P-value:6.73E-6 ID:SGTC_204|Compound:1543-0184|FD-Score:-3.08|P-value:4.14E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.10|P-value:3.09E-4 ID:SGTC_389|Compound:tpck|FD-Score:3.11|P-value:3.06E-4 ID:SGTC_480|Compound:am 92016|FD-Score:3.33|P-value:1.23E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:3.28|P-value:1.47E-4 ID:SGTC_715|Compound:0868-0130|FD-Score:3.23|P-value:1.82E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:3.27|P-value:1.57E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:3.22|P-value:1.96E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.04|P-value:4.73E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.23|P-value:1.87E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:-4.86|P-value:5.82E-8 ID:SGTC_1531|Compound:st059297|FD-Score:3.38|P-value:9.77E-5 ID:SGTC_1654|Compound:st012436|FD-Score:2.87|P-value:7.71E-4 ID:SGTC_1662|Compound:st014054|FD-Score:2.99|P-value:4.86E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.51|P-value:5.44E-5 ID:SGTC_1856|Compound:st057054|FD-Score:2.93|P-value:6.17E-4 ID:SGTC_1940|Compound:st075990|FD-Score:6.72|P-value:7.76E-14 ID:SGTC_1945|Compound:st075991|FD-Score:5.42|P-value:1.26E-9 ID:SGTC_1950|Compound:st077106|FD-Score:3.49|P-value:5.92E-5 ID:SGTC_2034|Compound:5197015|FD-Score:3.33|P-value:1.20E-4 ID:SGTC_2069|Compound:5228469|FD-Score:3.06|P-value:3.65E-4 ID:SGTC_2074|Compound:5212007|FD-Score:3.23|P-value:1.81E-4 ID:SGTC_2075|Compound:5212009|FD-Score:3.01|P-value:4.47E-4 ID:SGTC_2088|Compound:5278280|FD-Score:2.89|P-value:7.06E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-3.60|P-value:4.53E-5 ID:SGTC_2337|Compound:9009472|FD-Score:5.59|P-value:4.06E-10 ID:SGTC_2397|Compound:5161689|FD-Score:4.34|P-value:8.63E-7 ID:SGTC_2456|Compound:5770359|FD-Score:2.87|P-value:7.75E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-3.57|P-value:5.21E-5 ID:SGTC_2485|Compound:5633444|FD-Score:-3.68|P-value:3.10E-5 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:2.96|P-value:5.41E-4 ID:SGTC_2505|Compound:galangin|FD-Score:3.37|P-value:1.02E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:2.97|P-value:5.33E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:4.12|P-value:2.79E-6 ID:SGTC_2628|Compound:lathosterol|FD-Score:4.07|P-value:3.68E-6 ID:SGTC_2689|Compound:tacrolimus|FD-Score:-3.09|P-value:3.91E-4 ID:SGTC_2791|Compound:5663188|FD-Score:-3.06|P-value:4.36E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-3.06|P-value:4.45E-4 ID:SGTC_2921|Compound:7974240|FD-Score:4.20|P-value:1.85E-6 ID:SGTC_2959|Compound:9079155|FD-Score:3.32|P-value:1.27E-4 ID:SGTC_3031|Compound:9088762|FD-Score:-2.86|P-value:9.56E-4 ID:SGTC_3094|Compound:9117742|FD-Score:3.23|P-value:1.87E-4 ID:SGTC_3159|Compound:9100096|FD-Score:2.94|P-value:5.89E-4 ID:SGTC_3186|Compound:9110464|FD-Score:3.10|P-value:3.13E-4 ID:SGTC_3253|Compound:9135987|FD-Score:3.42|P-value:8.11E-5 ID:SGTC_3284|Compound:9108171|FD-Score:3.31|P-value:1.32E-4 ID:SGTC_3291|Compound:9121177|FD-Score:3.14|P-value:2.66E-4 ID:SGTC_3296|Compound:9122258|FD-Score:-3.46|P-value:8.31E-5 ID:SGTC_3301|Compound:9125354|FD-Score:3.79|P-value:1.49E-5 ID:SGTC_3320|Compound:9137005|FD-Score:3.75|P-value:1.77E-5 ID:SGTC_3350|Compound:9150499|FD-Score:-3.20|P-value:2.53E-4 ID:SGTC_3353|Compound:9151644|FD-Score:3.36|P-value:1.05E-4

Top fitness defect scores for YOR013W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1940 st075990 6.72 51.1 µM 7.76E-14 60S ribosome export 2 9.17E-12
2 SGTC_2337 9009472 5.59 200.0 µM 4.06E-10 8 1.16E-8
3 SGTC_1945 st075991 5.42 56.6 µM 1.26E-9 60S ribosome export 2 2.99E-8
4 SGTC_64 000l-0018 4.78 272.1 µM 7.13E-8 ubiquinone biosynthesis & proteasome 115 8.68E-7
5 SGTC_2397 5161689 4.34 200.0 µM 8.63E-7 23 6.97E-6
6 SGTC_2921 7974240 4.20 10.7 µM 1.85E-6 41 1.32E-5
7 SGTC_2619 obliquin 4.12 87.9 µM 2.79E-6 cell wall 136 1.86E-5
8 SGTC_2628 lathosterol 4.07 100.0 µM 3.68E-6 30 2.34E-5
9 SGTC_113 0099-0221 3.95 2.5 µM 6.73E-6 24 3.88E-5
10 SGTC_3301 9125354 3.79 19.8 µM 1.49E-5 18 7.55E-5
11 SGTC_3320 9137005 3.75 35.1 µM 1.77E-5 endomembrane recycling 20 8.71E-5
12 SGTC_1678 st019265 3.51 80.2 µM 5.44E-5 60S ribosome export 34 2.23E-4
13 SGTC_1950 st077106 3.49 7.2 µM 5.92E-5 RNA processing & uracil transport 49 2.39E-4
14 SGTC_3253 9135987 3.42 49.5 µM 8.11E-5 60S ribosome export 22 3.11E-4
15 SGTC_1531 st059297 3.38 52.4 µM 9.77E-5 38 3.64E-4
16 SGTC_2505 galangin 3.37 7.9 µM 1.02E-4 RPP1 & pyrimidine depletion 22 3.77E-4
17 SGTC_3353 9151644 3.36 39.3 µM 1.05E-4 32 3.87E-4
18 SGTC_2034 5197015 3.33 53.1 µM 1.20E-4 SWF1 & branched chain AA biosynthesis 41 4.32E-4
19 SGTC_480 am 92016 3.33 50.0 µM 1.23E-4 30 4.42E-4
20 SGTC_2959 9079155 3.32 11.0 µM 1.27E-4 50 4.55E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.113 6.48E-11 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.112 9.67E-11 YKL086W SRX1 hom Sulfiredoxin; contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxin Tsa1p, which is formed upon exposure to oxidants; conserved in higher eukaryotes; protein abundance increases in response to DNA replication stress
0.107 6.16E-10 YNL024C_p YNL024C_p hom Putative methyltransferase; has seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; despite similarity to methyltransferases, null mutant does not display alterations in lysine methylation pattern
0.104 1.86E-9 YBL041W PRE7 het Beta 6 subunit of the 20S proteasome
0.101 4.88E-9 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.100 7.14E-9 YCR098C GIT1 hom Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability
0.099 9.08E-9 YLR101C_d YLR101C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF ERG27/YLR100W
0.099 9.73E-9 YER094C PUP3 het Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10
0.099 9.90E-9 YGR050C_p YGR050C_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data
0.095 3.17E-8 YKR090W PXL1 hom Protein that localizes to sites of polarized growth; required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; contains LIM domains and has similarity to metazoan paxillin; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.088 3.37E-7 YCL034W LSB5 hom Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; may mediate disassembly of the Pan1 complex from the endocytic coat
0.087 3.94E-7 YPL144W POC4 hom Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
0.087 4.22E-7 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.086 5.82E-7 YJL028W YJL028W hom Protein of unknown function; may interact with ribosomes, based on co-purification experiments
0.084 1.03E-6 YNL255C GIS2 hom Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; localizes to RNA processing bodies (P bodies) and to stress granules; may have a role in translation regulation under stress conditions; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2