YOR019W

Protein of unknown function that may interact with ribosomes, based on co-purification experiments

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR019W / YOR019W

Click on Significant Values for Screen Details ID:SGTC_53|Compound:0973-0023|FD-Score:5.23|P-value:1.38E-8 ID:SGTC_369|Compound:0957-0393|FD-Score:3.06|P-value:6.01E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:3.64|P-value:5.70E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:-3.30|P-value:2.04E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:4.51|P-value:8.56E-7 ID:SGTC_685|Compound:1278-0033|FD-Score:3.06|P-value:5.94E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:3.85|P-value:2.19E-5 ID:SGTC_827|Compound:3253-0474|FD-Score:3.45|P-value:1.27E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:-4.93|P-value:6.84E-8 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.80|P-value:2.80E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:5.82|P-value:3.10E-10 ID:SGTC_1208|Compound:2323-2347|FD-Score:2.95|P-value:8.99E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:2.95|P-value:8.81E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.80|P-value:2.75E-5 ID:SGTC_1288|Compound:0973-0013|FD-Score:-3.36|P-value:1.58E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:2.97|P-value:8.13E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:-3.48|P-value:9.78E-5 ID:SGTC_1523|Compound:st012844|FD-Score:3.38|P-value:1.67E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:4.41|P-value:1.42E-6 ID:SGTC_1613|Compound:st002381|FD-Score:-2.89|P-value:9.62E-4 ID:SGTC_2056|Compound:5235370|FD-Score:3.78|P-value:3.10E-5 ID:SGTC_2338|Compound:7999974|FD-Score:-3.41|P-value:1.33E-4 ID:SGTC_2388|Compound:9080168|FD-Score:-2.98|P-value:7.14E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.75|P-value:2.96E-5 ID:SGTC_2438|Compound:5259590|FD-Score:-2.91|P-value:9.20E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.59|P-value:7.03E-5 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:3.28|P-value:2.56E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:-3.45|P-value:1.11E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.25|P-value:2.91E-4 ID:SGTC_2618|Compound:avocadyne|FD-Score:-3.61|P-value:5.47E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:3.62|P-value:6.17E-5 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:-3.21|P-value:2.96E-4 ID:SGTC_2623|Compound:humulene|FD-Score:-4.17|P-value:4.03E-6 ID:SGTC_2624|Compound:nerol|FD-Score:-4.87|P-value:9.46E-8 ID:SGTC_2691|Compound:st077356|FD-Score:3.35|P-value:1.95E-4 ID:SGTC_2888|Compound:9058547|FD-Score:3.77|P-value:3.13E-5 ID:SGTC_2953|Compound:9074162|FD-Score:4.84|P-value:1.43E-7 ID:SGTC_2957|Compound:9076800|FD-Score:-4.54|P-value:5.97E-7 ID:SGTC_3165|Compound:9101544|FD-Score:-4.10|P-value:5.69E-6 ID:SGTC_3173|Compound:9105693|FD-Score:3.72|P-value:3.95E-5 ID:SGTC_3178|Compound:9107506|FD-Score:-3.94|P-value:1.26E-5 ID:SGTC_3181|Compound:9108277|FD-Score:-2.89|P-value:9.86E-4 ID:SGTC_3182|Compound:9108849|FD-Score:-3.29|P-value:2.10E-4 ID:SGTC_3291|Compound:9121177|FD-Score:3.53|P-value:9.29E-5 ID:SGTC_53|Compound:0973-0023|FD-Score:5.23|P-value:1.38E-8 ID:SGTC_369|Compound:0957-0393|FD-Score:3.06|P-value:6.01E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:3.64|P-value:5.70E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:-3.30|P-value:2.04E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:4.51|P-value:8.56E-7 ID:SGTC_685|Compound:1278-0033|FD-Score:3.06|P-value:5.94E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:3.85|P-value:2.19E-5 ID:SGTC_827|Compound:3253-0474|FD-Score:3.45|P-value:1.27E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:-4.93|P-value:6.84E-8 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.80|P-value:2.80E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:5.82|P-value:3.10E-10 ID:SGTC_1208|Compound:2323-2347|FD-Score:2.95|P-value:8.99E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:2.95|P-value:8.81E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.80|P-value:2.75E-5 ID:SGTC_1288|Compound:0973-0013|FD-Score:-3.36|P-value:1.58E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:2.97|P-value:8.13E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:-3.48|P-value:9.78E-5 ID:SGTC_1523|Compound:st012844|FD-Score:3.38|P-value:1.67E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:4.41|P-value:1.42E-6 ID:SGTC_1613|Compound:st002381|FD-Score:-2.89|P-value:9.62E-4 ID:SGTC_2056|Compound:5235370|FD-Score:3.78|P-value:3.10E-5 ID:SGTC_2338|Compound:7999974|FD-Score:-3.41|P-value:1.33E-4 ID:SGTC_2388|Compound:9080168|FD-Score:-2.98|P-value:7.14E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.75|P-value:2.96E-5 ID:SGTC_2438|Compound:5259590|FD-Score:-2.91|P-value:9.20E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.59|P-value:7.03E-5 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:3.28|P-value:2.56E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:-3.45|P-value:1.11E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.25|P-value:2.91E-4 ID:SGTC_2618|Compound:avocadyne|FD-Score:-3.61|P-value:5.47E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:3.62|P-value:6.17E-5 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:-3.21|P-value:2.96E-4 ID:SGTC_2623|Compound:humulene|FD-Score:-4.17|P-value:4.03E-6 ID:SGTC_2624|Compound:nerol|FD-Score:-4.87|P-value:9.46E-8 ID:SGTC_2691|Compound:st077356|FD-Score:3.35|P-value:1.95E-4 ID:SGTC_2888|Compound:9058547|FD-Score:3.77|P-value:3.13E-5 ID:SGTC_2953|Compound:9074162|FD-Score:4.84|P-value:1.43E-7 ID:SGTC_2957|Compound:9076800|FD-Score:-4.54|P-value:5.97E-7 ID:SGTC_3165|Compound:9101544|FD-Score:-4.10|P-value:5.69E-6 ID:SGTC_3173|Compound:9105693|FD-Score:3.72|P-value:3.95E-5 ID:SGTC_3178|Compound:9107506|FD-Score:-3.94|P-value:1.26E-5 ID:SGTC_3181|Compound:9108277|FD-Score:-2.89|P-value:9.86E-4 ID:SGTC_3182|Compound:9108849|FD-Score:-3.29|P-value:2.10E-4 ID:SGTC_3291|Compound:9121177|FD-Score:3.53|P-value:9.29E-5

Top fitness defect scores for YOR019W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1130 3454-2858 5.82 15.9 µM 3.10E-10 NEO1 46 2.89E-9
2 SGTC_53 0973-0023 5.23 40.0 µM 1.38E-8 RNA processing & uracil transport 5 8.35E-8
3 SGTC_2953 9074162 4.84 66.5 µM 1.43E-7 10 6.65E-7
4 SGTC_530 4358-1714 4.51 28.0 µM 8.56E-7 31 3.27E-6
5 SGTC_1527 coumarin 4.41 137.0 µM 1.42E-6 14 5.11E-6
6 SGTC_737 1950-0117 3.85 57.9 µM 2.19E-5 27 5.84E-5
7 SGTC_1278 0874-0585 3.80 172.0 µM 2.75E-5 16 7.15E-5
8 SGTC_1129 3453-1384 3.80 223.0 µM 2.80E-5 42 7.27E-5
9 SGTC_2056 5235370 3.78 200.0 µM 3.10E-5 48 7.95E-5
10 SGTC_2888 9058547 3.77 13.0 µM 3.13E-5 7 8.02E-5
11 SGTC_3173 9105693 3.72 49.5 µM 3.95E-5 28 9.86E-5
12 SGTC_387 norethindrone acetate 3.64 66.7 µM 5.70E-5 24 1.37E-4
13 SGTC_2619 obliquin 3.62 87.9 µM 6.17E-5 cell wall 162 1.47E-4
14 SGTC_2519 cryptotanshinone 3.59 88.0 µM 7.03E-5 heme biosynthesis & mitochondrial translocase 22 1.65E-4
15 SGTC_3291 9121177 3.53 71.4 µM 9.29E-5 21 2.11E-4
16 SGTC_827 3253-0474 3.45 693.0 µM 1.27E-4 37 2.79E-4
17 SGTC_1523 st012844 3.38 44.7 µM 1.67E-4 60S ribosome export 45 3.56E-4
18 SGTC_2691 st077356 3.35 60.2 µM 1.95E-4 57 4.09E-4
19 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 3.28 19.9 µM 2.56E-4 redox potentiating 23 5.23E-4
20 SGTC_2603 homopterocarpin 3.25 100.0 µM 2.91E-4 83 5.85E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.138 1.23E-15 YER156C_p YER156C_p hom Putative protein of unknown function; interacts with Hsp82p and copurifies with Ipl1p; expression is copper responsive and downregulated in strains deleted for MAC1, a copper-responsive transcription factor; similarity to mammalian MYG1
0.131 2.21E-14 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.129 6.82E-14 YEL066W HPA3 hom D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro
0.113 5.62E-11 YGR087C PDC6 hom Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
0.111 1.07E-10 YDR400W URH1 hom Uridine nucleosidase (uridine-cytidine N-ribohydrolase), cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathways
0.103 2.47E-9 YKL189W HYM1 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response
0.102 2.83E-9 YLR124W_d YLR124W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.099 8.34E-9 YLL023C POM33 hom Transmembrane nucleoporin; involved in nuclear pore complex (NPC) distribution, assembly or stabilization; highly conserved across species, orthologous to human TMEM33 and paralogous to Per33p; protein abundance increases in response to DNA replication stress
0.096 2.94E-8 YLR106C MDN1 het Huge dynein-related AAA-type ATPase (midasin), forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p); acts in removal of ribosomal biogenesis factors at successive steps of pre-60S assembly and export from nucleus
0.095 3.62E-8 YJL002C OST1 het Alpha subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
0.091 1.14E-7 YGR108W CLB1 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
0.083 1.69E-6 YPL002C SNF8 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression
0.082 1.73E-6 YLR043C TRX1 hom Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress
0.082 1.81E-6 YOR007C SGT2 hom Glutamine-rich cytoplasmic cochaperone; serves as a scaffold bringing together Get4, Get5p, and other TRC complex members that are required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; interacts with the prion domain of Sup35p; amyloid sensor; plays a role in targeting chaperones to prion aggregates; has similarity to human cochaperone SGT; forms cytoplasmic foci upon DNA replication stress
0.080 3.68E-6 YHL001W RPL14B hom Ribosomal 60S subunit protein L14B; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14B has a paralog, RPL14A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress