YOR028C / CIN5

Basic leucine zipper (bZIP) transcription factor of the yAP-1 family; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions; CIN5 has a paralog, YAP6, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR028C / CIN5

Click on Significant Values for Screen Details ID:SGTC_25|Compound:0118-0223|FD-Score:3.31|P-value:1.81E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:3.16|P-value:3.32E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:2.89|P-value:8.98E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:3.94|P-value:1.15E-5 ID:SGTC_892|Compound:0929-0076|FD-Score:3.05|P-value:5.06E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:-3.86|P-value:2.46E-5 ID:SGTC_965|Compound:1291-5240|FD-Score:-3.64|P-value:6.72E-5 ID:SGTC_975|Compound:1335-0046|FD-Score:3.68|P-value:3.77E-5 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-3.03|P-value:7.43E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:2.96|P-value:7.19E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:2.88|P-value:9.47E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:6.13|P-value:2.63E-11 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:3.00|P-value:6.12E-4 ID:SGTC_1443|Compound:4112-3303|FD-Score:-3.36|P-value:2.13E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:3.71|P-value:3.28E-5 ID:SGTC_1555|Compound:citronellol|FD-Score:-2.96|P-value:9.81E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:2.92|P-value:8.32E-4 ID:SGTC_2105|Compound:5350118|FD-Score:-3.19|P-value:4.17E-4 ID:SGTC_2113|Compound:5491891|FD-Score:-3.67|P-value:5.76E-5 ID:SGTC_2253|Compound:7938677|FD-Score:-3.19|P-value:4.05E-4 ID:SGTC_2298|Compound:7976326|FD-Score:3.29|P-value:1.98E-4 ID:SGTC_2301|Compound:7769476|FD-Score:-2.97|P-value:9.18E-4 ID:SGTC_2319|Compound:6033012|FD-Score:3.22|P-value:2.68E-4 ID:SGTC_2377|Compound:9073351|FD-Score:2.87|P-value:9.83E-4 ID:SGTC_2413|Compound:inermin|FD-Score:-3.29|P-value:2.75E-4 ID:SGTC_2484|Compound:5809818|FD-Score:-3.06|P-value:6.64E-4 ID:SGTC_2834|Compound:9001755|FD-Score:3.28|P-value:2.05E-4 ID:SGTC_2988|Compound:9073640|FD-Score:2.87|P-value:9.97E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:3.31|P-value:1.81E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:3.16|P-value:3.32E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:2.89|P-value:8.98E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:3.94|P-value:1.15E-5 ID:SGTC_892|Compound:0929-0076|FD-Score:3.05|P-value:5.06E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:-3.86|P-value:2.46E-5 ID:SGTC_965|Compound:1291-5240|FD-Score:-3.64|P-value:6.72E-5 ID:SGTC_975|Compound:1335-0046|FD-Score:3.68|P-value:3.77E-5 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-3.03|P-value:7.43E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:2.96|P-value:7.19E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:2.88|P-value:9.47E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:6.13|P-value:2.63E-11 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:3.00|P-value:6.12E-4 ID:SGTC_1443|Compound:4112-3303|FD-Score:-3.36|P-value:2.13E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:3.71|P-value:3.28E-5 ID:SGTC_1555|Compound:citronellol|FD-Score:-2.96|P-value:9.81E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:2.92|P-value:8.32E-4 ID:SGTC_2105|Compound:5350118|FD-Score:-3.19|P-value:4.17E-4 ID:SGTC_2113|Compound:5491891|FD-Score:-3.67|P-value:5.76E-5 ID:SGTC_2253|Compound:7938677|FD-Score:-3.19|P-value:4.05E-4 ID:SGTC_2298|Compound:7976326|FD-Score:3.29|P-value:1.98E-4 ID:SGTC_2301|Compound:7769476|FD-Score:-2.97|P-value:9.18E-4 ID:SGTC_2319|Compound:6033012|FD-Score:3.22|P-value:2.68E-4 ID:SGTC_2377|Compound:9073351|FD-Score:2.87|P-value:9.83E-4 ID:SGTC_2413|Compound:inermin|FD-Score:-3.29|P-value:2.75E-4 ID:SGTC_2484|Compound:5809818|FD-Score:-3.06|P-value:6.64E-4 ID:SGTC_2834|Compound:9001755|FD-Score:3.28|P-value:2.05E-4 ID:SGTC_2988|Compound:9073640|FD-Score:2.87|P-value:9.97E-4

Top fitness defect scores for YOR028C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1405 3909-7894 6.13 12.0 µM 2.63E-11 60S ribosome export 1 4.31E-10
2 SGTC_532 1548-0774 3.94 215.0 µM 1.15E-5 20 4.05E-5
3 SGTC_1532 4',5'-dihydroxyflavone 3.71 78.7 µM 3.28E-5 Golgi 25 1.02E-4
4 SGTC_975 1335-0046 3.68 28.5 µM 3.77E-5 RPP1 & pyrimidine depletion 48 1.16E-4
5 SGTC_25 0118-0223 3.31 35.7 µM 1.81E-4 38 4.61E-4
6 SGTC_2298 7976326 3.29 193.8 µM 1.98E-4 22 5.00E-4
7 SGTC_2834 9001755 3.28 58.4 µM 2.05E-4 61 5.14E-4
8 SGTC_2319 6033012 3.22 152.6 µM 2.68E-4 tubulin folding & SWR complex 54 6.51E-4
9 SGTC_196 k015-0023 3.16 18.1 µM 3.32E-4 PDR1 49 7.88E-4
10 SGTC_892 0929-0076 3.05 29.0 µM 5.06E-4 TRP & mitochondrial translation 92 0.00114
11 SGTC_1420 4'-methoxyflavone 3.00 42.0 µM 6.12E-4 40 0.00135
12 SGTC_1191 1487-1166 2.96 10.6 µM 7.19E-4 azole & statin 76 0.00156
13 SGTC_1576 erythromycin ethylsuccinate 2.92 23.2 µM 8.32E-4 76 0.00177
14 SGTC_380 3970-0968 2.89 6.0 µM 8.98E-4 59 0.00190
15 SGTC_1215 3852-0577 2.88 11.2 µM 9.47E-4 64 0.00199
16 SGTC_2377 9073351 2.87 62.6 µM 9.83E-4 ergosterol biosynthesis 74 0.00205
17 SGTC_2988 9073640 2.87 71.4 µM 9.97E-4 60 0.00208
18 SGTC_382 3229-0966 2.82 23.2 µM 0.00117 68 0.00240
19 SGTC_1053 3366-3204 2.79 134.0 µM 0.00131 cell wall 98 0.00265
20 SGTC_1179 1021-1431 2.76 9.3 µM 0.00145 120 0.00290

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.100 5.54E-9 YIL120W QDR1 hom Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for resistance to quinidine, ketoconazole, fluconazole, and barban; QDR1 has a paralog, AQR1, that arose from the whole genome duplication
0.099 8.56E-9 YKL040C NFU1 hom Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria
0.098 1.20E-8 YPR160W GPH1 hom Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
0.096 2.38E-8 YOL151W GRE2 hom 3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress
0.085 7.18E-7 YNL089C_d YNL089C_d hom Dubious open reading frame unlikely to encode a functional protein; almost completely overlaps YNL090W/RHO2 which encodes a small GTPase of the Rho/Rac subfamily of Ras-like proteins
0.084 1.19E-6 YKL133C_p YKL133C_p hom Putative protein of unknown function; has similarity to Mgr3p, but unlike MGR3, is not required for growth of cells lacking the mitochondrial genome (null mutation does not confer a petite-negative phenotype)
0.082 2.13E-6 YGR203W YCH1 hom Phosphatase with sequence similarity to Cdc25p, Arr2p and Mih1p; member of the single-domain rhodanese homology superfamily; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.079 4.38E-6 YNL143C_p YNL143C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.079 4.51E-6 YOL145C CTR9 hom Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cyclin genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; contains TPR repeats
0.079 4.81E-6 YGR053C_p YGR053C_p hom Putative protein of unknown function
0.075 1.21E-5 YLR376C PSY3 hom Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; structural analysis reveals a similar DNA-binding region in both Psy3p and Csm2p and that both regions work together to form a single DNA binding site; deletion of PSY3 results in a mutator phenotype; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C
0.075 1.49E-5 YOR011W AUS1 hom Plasma membrane sterol transporter of the ATP-binding cassette family; required, along with Pdr11p, for uptake of exogenous sterols and their incorporation into the plasma membrane; activity is stimulated by phosphatidylserine; sterol uptake is required for anaerobic growth because sterol biosynthesis requires oxygen
0.073 2.48E-5 YNL292W PUS4 hom Pseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype)
0.073 2.55E-5 YML041C VPS71 hom Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
0.072 2.65E-5 YOR021C SFM1 hom SPOUT methyltransferase; catalyzes omega-monomethylation of Rps3p on Arg-146; not an essential gene; predicted to be involved in rRNA processing and ribosome biogenesis and in biopolymer catabolism