YOR040W / GLO4

Mitochondrial glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR040W / GLO4

Click on Significant Values for Screen Details ID:SGTC_11|Compound:0438-0307|FD-Score:-12.10|P-value:1.62E-41 ID:SGTC_41|Compound:0478-0632|FD-Score:3.28|P-value:1.45E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.25|P-value:1.55E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:3.80|P-value:1.38E-5 ID:SGTC_188|Compound:3229-0966|FD-Score:3.29|P-value:1.44E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:3.61|P-value:3.41E-5 ID:SGTC_355|Compound:1311-2252|FD-Score:2.94|P-value:5.80E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:3.51|P-value:5.39E-5 ID:SGTC_713|Compound:1488-1073|FD-Score:3.56|P-value:4.21E-5 ID:SGTC_739|Compound:1486-1183|FD-Score:3.75|P-value:1.74E-5 ID:SGTC_878|Compound:0828-0289|FD-Score:3.51|P-value:5.28E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:-3.02|P-value:4.08E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:-4.88|P-value:3.10E-8 ID:SGTC_1105|Compound:epirubicin|FD-Score:-3.14|P-value:2.46E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:4.41|P-value:5.66E-7 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.76|P-value:1.67E-5 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.38|P-value:9.66E-5 ID:SGTC_1259|Compound:0671-0132|FD-Score:-2.96|P-value:5.05E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:3.65|P-value:2.82E-5 ID:SGTC_1691|Compound:st019933|FD-Score:3.51|P-value:5.29E-5 ID:SGTC_1737|Compound:st035557|FD-Score:-2.95|P-value:5.30E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.26|P-value:1.63E-4 ID:SGTC_2010|Compound:4012422|FD-Score:3.10|P-value:3.10E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.64|P-value:2.99E-5 ID:SGTC_2116|Compound:5511452|FD-Score:3.17|P-value:2.32E-4 ID:SGTC_2240|Compound:6690706|FD-Score:-3.32|P-value:1.15E-4 ID:SGTC_2290|Compound:7904846|FD-Score:-2.96|P-value:5.05E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:4.96|P-value:2.11E-8 ID:SGTC_2585|Compound:alliin|FD-Score:4.48|P-value:3.71E-7 ID:SGTC_2629|Compound:bisabolol|FD-Score:-2.97|P-value:4.96E-4 ID:SGTC_2814|Compound:7977482|FD-Score:3.72|P-value:2.02E-5 ID:SGTC_2969|Compound:9091408|FD-Score:4.04|P-value:4.13E-6 ID:SGTC_2970|Compound:9090938|FD-Score:2.88|P-value:7.46E-4 ID:SGTC_3132|Compound:9126706|FD-Score:3.68|P-value:2.45E-5 ID:SGTC_11|Compound:0438-0307|FD-Score:-12.10|P-value:1.62E-41 ID:SGTC_41|Compound:0478-0632|FD-Score:3.28|P-value:1.45E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.25|P-value:1.55E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:3.80|P-value:1.38E-5 ID:SGTC_188|Compound:3229-0966|FD-Score:3.29|P-value:1.44E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:3.61|P-value:3.41E-5 ID:SGTC_355|Compound:1311-2252|FD-Score:2.94|P-value:5.80E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:3.51|P-value:5.39E-5 ID:SGTC_713|Compound:1488-1073|FD-Score:3.56|P-value:4.21E-5 ID:SGTC_739|Compound:1486-1183|FD-Score:3.75|P-value:1.74E-5 ID:SGTC_878|Compound:0828-0289|FD-Score:3.51|P-value:5.28E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:-3.02|P-value:4.08E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:-4.88|P-value:3.10E-8 ID:SGTC_1105|Compound:epirubicin|FD-Score:-3.14|P-value:2.46E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:4.41|P-value:5.66E-7 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.76|P-value:1.67E-5 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.38|P-value:9.66E-5 ID:SGTC_1259|Compound:0671-0132|FD-Score:-2.96|P-value:5.05E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:3.65|P-value:2.82E-5 ID:SGTC_1691|Compound:st019933|FD-Score:3.51|P-value:5.29E-5 ID:SGTC_1737|Compound:st035557|FD-Score:-2.95|P-value:5.30E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.26|P-value:1.63E-4 ID:SGTC_2010|Compound:4012422|FD-Score:3.10|P-value:3.10E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.64|P-value:2.99E-5 ID:SGTC_2116|Compound:5511452|FD-Score:3.17|P-value:2.32E-4 ID:SGTC_2240|Compound:6690706|FD-Score:-3.32|P-value:1.15E-4 ID:SGTC_2290|Compound:7904846|FD-Score:-2.96|P-value:5.05E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:4.96|P-value:2.11E-8 ID:SGTC_2585|Compound:alliin|FD-Score:4.48|P-value:3.71E-7 ID:SGTC_2629|Compound:bisabolol|FD-Score:-2.97|P-value:4.96E-4 ID:SGTC_2814|Compound:7977482|FD-Score:3.72|P-value:2.02E-5 ID:SGTC_2969|Compound:9091408|FD-Score:4.04|P-value:4.13E-6 ID:SGTC_2970|Compound:9090938|FD-Score:2.88|P-value:7.46E-4 ID:SGTC_3132|Compound:9126706|FD-Score:3.68|P-value:2.45E-5

Top fitness defect scores for YOR040W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2583 asiatic acid 4.96 100.0 µM 2.11E-8 21 3.48E-7
2 SGTC_2585 alliin 4.48 100.0 µM 3.71E-7 14 3.69E-6
3 SGTC_1177 0983-0204 4.41 23.6 µM 5.66E-7 10 5.22E-6
4 SGTC_2969 9091408 4.04 28.7 µM 4.13E-6 24 2.69E-5
5 SGTC_171 k064-0041 3.80 9.7 µM 1.38E-5 heme requiring 30 7.32E-5
6 SGTC_1184 1269-1718 3.76 139.0 µM 1.67E-5 35 8.57E-5
7 SGTC_739 1486-1183 3.75 203.0 µM 1.74E-5 20 8.83E-5
8 SGTC_2814 7977482 3.72 43.0 µM 2.02E-5 60 1.00E-4
9 SGTC_3132 9126706 3.68 49.5 µM 2.45E-5 33 1.17E-4
10 SGTC_1568 digitonin 3.65 820.0 nM 2.82E-5 sphingolipid biosynthesis & PDR1 43 1.32E-4
11 SGTC_2014 4013930 3.64 200.0 µM 2.99E-5 52 1.38E-4
12 SGTC_193 1273-0060 3.61 1.6 µM 3.41E-5 ergosterol biosynthesis 15 1.54E-4
13 SGTC_713 1488-1073 3.56 324.0 µM 4.21E-5 ERG2 20 1.84E-4
14 SGTC_878 0828-0289 3.51 13.7 µM 5.28E-5 64 2.22E-4
15 SGTC_1691 st019933 3.51 84.6 µM 5.29E-5 23 2.22E-4
16 SGTC_356 1634-0012 3.51 32.5 µM 5.39E-5 36 2.26E-4
17 SGTC_1254 0550-0035 3.38 264.0 µM 9.66E-5 39 3.66E-4
18 SGTC_188 3229-0966 3.29 278.5 µM 1.44E-4 58 5.10E-4
19 SGTC_41 0478-0632 3.28 82.6 µM 1.45E-4 56 5.11E-4
20 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 3.26 14.9 µM 1.63E-4 33 5.64E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.122 1.26E-12 YNR055C HOL1 hom Putative transporter in the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; mutations in membrane-spanning domains permit cation and histidinol uptake
0.118 7.97E-12 YKL005C BYE1 hom Negative regulator of transcription elongation, contains a TFIIS-like domain and a PHD finger, multicopy suppressor of temperature-sensitive ess1 mutations, probably binds RNA polymerase II large subunit
0.106 6.64E-10 YLR097C HRT3 hom Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies
0.105 1.01E-9 YJR106W ECM27 hom Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p
0.102 3.18E-9 YDR192C NUP42 hom FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; interacts with Gle1p
0.102 3.59E-9 YHR073W OSH3 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.100 6.09E-9 YOR292C_p YOR292C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene
0.097 1.82E-8 YEL052W AFG1 hom Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain
0.095 3.76E-8 YFR015C GSY1 hom Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase; GSY1 has a paralog, GSY2, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.088 3.67E-7 YOR090C PTC5 hom Mitochondrial type 2C protein phosphatase (PP2C) involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; localizes to the intermembrane space and is imported via the presequence pathway and processed by the inner membrane protease (Imp1p-Imp2p); acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p
0.087 4.46E-7 YMR213W CEF1 het Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p
0.086 5.64E-7 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.086 6.69E-7 YHR022C-A_p YHR022C-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.084 9.74E-7 YHR182W YHR182W hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.080 3.66E-6 YGR005C TFG2 het TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30