YOR050C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR050C / YOR050C

Click on Significant Values for Screen Details ID:SGTC_140|Compound:0062-0056|FD-Score:-5.13|P-value:8.36E-9 ID:SGTC_173|Compound:1273-0061|FD-Score:3.31|P-value:1.26E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:2.87|P-value:7.73E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:-2.98|P-value:5.24E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:-3.12|P-value:3.07E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:8.05|P-value:3.39E-19 ID:SGTC_495|Compound:decylubiquinone|FD-Score:4.46|P-value:4.16E-7 ID:SGTC_536|Compound:3852-0578|FD-Score:-3.18|P-value:2.44E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:3.17|P-value:2.29E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.25|P-value:1.63E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.05|P-value:3.82E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:3.29|P-value:1.39E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:-3.01|P-value:4.72E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:-3.14|P-value:2.81E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:-3.44|P-value:8.03E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-7.30|P-value:4.79E-16 ID:SGTC_1463|Compound:k081-0032|FD-Score:-6.64|P-value:1.35E-13 ID:SGTC_1583|Compound:clindamycin|FD-Score:-3.22|P-value:2.04E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:-2.83|P-value:9.35E-4 ID:SGTC_1712|Compound:st032288|FD-Score:6.64|P-value:1.24E-13 ID:SGTC_2026|Compound:5148700|FD-Score:-3.57|P-value:4.36E-5 ID:SGTC_2126|Compound:5251174|FD-Score:4.79|P-value:6.22E-8 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.24|P-value:1.75E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:12.90|P-value:2.53E-46 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.00|P-value:4.55E-4 ID:SGTC_2698|Compound:st077697|FD-Score:-3.32|P-value:1.35E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-3.14|P-value:2.87E-4 ID:SGTC_2829|Compound:7992743|FD-Score:2.80|P-value:9.68E-4 ID:SGTC_2919|Compound:7978188|FD-Score:2.90|P-value:6.80E-4 ID:SGTC_2931|Compound:9014674|FD-Score:-3.08|P-value:3.61E-4 ID:SGTC_2983|Compound:9022671|FD-Score:3.20|P-value:2.06E-4 ID:SGTC_3070|Compound:9117005|FD-Score:-4.90|P-value:3.52E-8 ID:SGTC_3077|Compound:9117319|FD-Score:-3.86|P-value:1.13E-5 ID:SGTC_3350|Compound:9150499|FD-Score:-3.10|P-value:3.37E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-5.13|P-value:8.36E-9 ID:SGTC_173|Compound:1273-0061|FD-Score:3.31|P-value:1.26E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:2.87|P-value:7.73E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:-2.98|P-value:5.24E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:-3.12|P-value:3.07E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:8.05|P-value:3.39E-19 ID:SGTC_495|Compound:decylubiquinone|FD-Score:4.46|P-value:4.16E-7 ID:SGTC_536|Compound:3852-0578|FD-Score:-3.18|P-value:2.44E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:3.17|P-value:2.29E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.25|P-value:1.63E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.05|P-value:3.82E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:3.29|P-value:1.39E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:-3.01|P-value:4.72E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:-3.14|P-value:2.81E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:-3.44|P-value:8.03E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-7.30|P-value:4.79E-16 ID:SGTC_1463|Compound:k081-0032|FD-Score:-6.64|P-value:1.35E-13 ID:SGTC_1583|Compound:clindamycin|FD-Score:-3.22|P-value:2.04E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:-2.83|P-value:9.35E-4 ID:SGTC_1712|Compound:st032288|FD-Score:6.64|P-value:1.24E-13 ID:SGTC_2026|Compound:5148700|FD-Score:-3.57|P-value:4.36E-5 ID:SGTC_2126|Compound:5251174|FD-Score:4.79|P-value:6.22E-8 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.24|P-value:1.75E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:12.90|P-value:2.53E-46 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.00|P-value:4.55E-4 ID:SGTC_2698|Compound:st077697|FD-Score:-3.32|P-value:1.35E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-3.14|P-value:2.87E-4 ID:SGTC_2829|Compound:7992743|FD-Score:2.80|P-value:9.68E-4 ID:SGTC_2919|Compound:7978188|FD-Score:2.90|P-value:6.80E-4 ID:SGTC_2931|Compound:9014674|FD-Score:-3.08|P-value:3.61E-4 ID:SGTC_2983|Compound:9022671|FD-Score:3.20|P-value:2.06E-4 ID:SGTC_3070|Compound:9117005|FD-Score:-4.90|P-value:3.52E-8 ID:SGTC_3077|Compound:9117319|FD-Score:-3.86|P-value:1.13E-5 ID:SGTC_3350|Compound:9150499|FD-Score:-3.10|P-value:3.37E-4

Top fitness defect scores for YOR050C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2582 agaric acid 12.90 100.0 µM 2.53E-46 redox potentiating 29 1.74E-38
2 SGTC_453 enantio-paf c16 8.05 10.0 µM 3.39E-19 13 4.10E-16
3 SGTC_1712 st032288 6.64 53.4 µM 1.24E-13 calcium & mitochondrial duress 61 1.60E-11
4 SGTC_2126 5251174 4.79 33.9 µM 6.22E-8 12 8.32E-7
5 SGTC_495 decylubiquinone 4.46 155.0 µM 4.16E-7 copper-dependent oxidative stress 15 4.02E-6
6 SGTC_173 1273-0061 3.31 2.7 µM 1.26E-4 mitochondrial stress 215 4.61E-4
7 SGTC_1298 1079-1278 3.29 263.0 µM 1.39E-4 DNA damage response 45 5.01E-4
8 SGTC_1106 tegaserod maleate 3.25 11.7 µM 1.63E-4 50 5.71E-4
9 SGTC_2407 paclitaxel 3.24 400.0 µM 1.75E-4 67 6.06E-4
10 SGTC_2983 9022671 3.20 13.0 µM 2.06E-4 60S ribosome export 31 6.94E-4
11 SGTC_810 3825-7150 3.17 143.0 µM 2.29E-4 60S ribosome export 28 7.57E-4
12 SGTC_1247 0448-0043 3.05 5.8 µM 3.82E-4 ERG2 106 0.00116
13 SGTC_2688 kanamycin b 3.00 96.7 µM 4.55E-4 calcium & mitochondrial duress 536 0.00134
14 SGTC_2919 7978188 2.90 46.4 µM 6.80E-4 78 0.00187
15 SGTC_299 1273-0059 2.87 1.4 µM 7.73E-4 70 0.00208
16 SGTC_2829 7992743 2.80 58.4 µM 9.68E-4 112 0.00252
17 SGTC_2350 9023895 2.77 38.9 µM 0.00112 ergosterol biosynthesis 99 0.00283
18 SGTC_2970 9090938 2.77 41.9 µM 0.00112 RNA processing & uracil transport 135 0.00284
19 SGTC_808 0711-0032 2.76 135.0 µM 0.00116 71 0.00292
20 SGTC_1103 duloxetine 2.75 36.1 µM 0.00118 106 0.00298

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.414 6.42E-139 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.358 3.86E-102 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.338 2.60E-90 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.334 2.64E-88 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.325 2.08E-83 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.316 9.14E-79 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.309 3.49E-75 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.299 2.11E-70 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.298 8.15E-70 YML102W CAC2 hom Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription
0.295 2.10E-68 YOR301W RAX1 hom Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily
0.295 3.03E-68 YGL178W MPT5 hom mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
0.290 3.41E-66 YKL130C SHE2 hom RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud
0.286 2.42E-64 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.279 1.83E-60 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.272 3.63E-58 YIL056W VHR1 hom Transcriptional activator; required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations; VHR1 has a paralog, VHR2, that arose from the whole genome duplication