YOR051C / ETT1

Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR051C / ETT1

Click on Significant Values for Screen Details ID:SGTC_56|Compound:0957-0365|FD-Score:3.25|P-value:6.55E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:6.72|P-value:2.47E-11 ID:SGTC_138|Compound:0850-0259|FD-Score:11.10|P-value:1.47E-27 ID:SGTC_141|Compound:0443-0274|FD-Score:3.67|P-value:1.43E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:4.50|P-value:4.83E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:3.17|P-value:8.43E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:3.96|P-value:4.68E-5 ID:SGTC_217|Compound:ketoconazole|FD-Score:-4.08|P-value:5.26E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:5.27|P-value:1.14E-7 ID:SGTC_279|Compound:1273-0055|FD-Score:4.10|P-value:2.65E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:3.80|P-value:8.92E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:3.81|P-value:8.41E-5 ID:SGTC_438|Compound:sphingosine|FD-Score:3.19|P-value:7.91E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.24|P-value:1.47E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:7.72|P-value:2.32E-14 ID:SGTC_570|Compound:0987-0065|FD-Score:-3.79|P-value:1.63E-4 ID:SGTC_583|Compound:1488-1091|FD-Score:3.63|P-value:1.72E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:5.79|P-value:6.83E-9 ID:SGTC_852|Compound:0418-0143|FD-Score:3.34|P-value:4.70E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.77|P-value:1.01E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.90|P-value:6.10E-5 ID:SGTC_1177|Compound:0983-0204|FD-Score:-3.29|P-value:9.33E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.58|P-value:2.00E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:3.26|P-value:6.25E-4 ID:SGTC_1740|Compound:st038286|FD-Score:5.37|P-value:7.09E-8 ID:SGTC_1743|Compound:st037606|FD-Score:-3.48|P-value:4.90E-4 ID:SGTC_2064|Compound:5220758|FD-Score:-3.49|P-value:4.73E-4 ID:SGTC_2157|Compound:5649910|FD-Score:3.24|P-value:6.82E-4 ID:SGTC_2396|Compound:5342950|FD-Score:3.60|P-value:1.88E-4 ID:SGTC_2397|Compound:5161689|FD-Score:5.79|P-value:6.96E-9 ID:SGTC_2402|Compound:5553605|FD-Score:-3.31|P-value:8.58E-4 ID:SGTC_2404|Compound:5161160|FD-Score:-3.40|P-value:6.39E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.38|P-value:4.17E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:3.19|P-value:7.87E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.25|P-value:1.29E-7 ID:SGTC_2584|Compound:androsterone|FD-Score:3.33|P-value:4.98E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:5.42|P-value:5.27E-8 ID:SGTC_2600|Compound:tangeritin|FD-Score:5.39|P-value:6.23E-8 ID:SGTC_2619|Compound:obliquin|FD-Score:4.48|P-value:5.17E-6 ID:SGTC_2796|Compound:7949634|FD-Score:-3.29|P-value:9.41E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-5.13|P-value:4.95E-7 ID:SGTC_3126|Compound:9127922|FD-Score:3.16|P-value:8.88E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-4.12|P-value:4.47E-5 ID:SGTC_3311|Compound:9131146|FD-Score:3.21|P-value:7.41E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:3.25|P-value:6.55E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:6.72|P-value:2.47E-11 ID:SGTC_138|Compound:0850-0259|FD-Score:11.10|P-value:1.47E-27 ID:SGTC_141|Compound:0443-0274|FD-Score:3.67|P-value:1.43E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:4.50|P-value:4.83E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:3.17|P-value:8.43E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:3.96|P-value:4.68E-5 ID:SGTC_217|Compound:ketoconazole|FD-Score:-4.08|P-value:5.26E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:5.27|P-value:1.14E-7 ID:SGTC_279|Compound:1273-0055|FD-Score:4.10|P-value:2.65E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:3.80|P-value:8.92E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:3.81|P-value:8.41E-5 ID:SGTC_438|Compound:sphingosine|FD-Score:3.19|P-value:7.91E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.24|P-value:1.47E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:7.72|P-value:2.32E-14 ID:SGTC_570|Compound:0987-0065|FD-Score:-3.79|P-value:1.63E-4 ID:SGTC_583|Compound:1488-1091|FD-Score:3.63|P-value:1.72E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:5.79|P-value:6.83E-9 ID:SGTC_852|Compound:0418-0143|FD-Score:3.34|P-value:4.70E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.77|P-value:1.01E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.90|P-value:6.10E-5 ID:SGTC_1177|Compound:0983-0204|FD-Score:-3.29|P-value:9.33E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.58|P-value:2.00E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:3.26|P-value:6.25E-4 ID:SGTC_1740|Compound:st038286|FD-Score:5.37|P-value:7.09E-8 ID:SGTC_1743|Compound:st037606|FD-Score:-3.48|P-value:4.90E-4 ID:SGTC_2064|Compound:5220758|FD-Score:-3.49|P-value:4.73E-4 ID:SGTC_2157|Compound:5649910|FD-Score:3.24|P-value:6.82E-4 ID:SGTC_2396|Compound:5342950|FD-Score:3.60|P-value:1.88E-4 ID:SGTC_2397|Compound:5161689|FD-Score:5.79|P-value:6.96E-9 ID:SGTC_2402|Compound:5553605|FD-Score:-3.31|P-value:8.58E-4 ID:SGTC_2404|Compound:5161160|FD-Score:-3.40|P-value:6.39E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.38|P-value:4.17E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:3.19|P-value:7.87E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.25|P-value:1.29E-7 ID:SGTC_2584|Compound:androsterone|FD-Score:3.33|P-value:4.98E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:5.42|P-value:5.27E-8 ID:SGTC_2600|Compound:tangeritin|FD-Score:5.39|P-value:6.23E-8 ID:SGTC_2619|Compound:obliquin|FD-Score:4.48|P-value:5.17E-6 ID:SGTC_2796|Compound:7949634|FD-Score:-3.29|P-value:9.41E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-5.13|P-value:4.95E-7 ID:SGTC_3126|Compound:9127922|FD-Score:3.16|P-value:8.88E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-4.12|P-value:4.47E-5 ID:SGTC_3311|Compound:9131146|FD-Score:3.21|P-value:7.41E-4

Top fitness defect scores for YOR051C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_138 0850-0259 11.10 40.9 µM 1.47E-27 cell wall 35 6.08E-29
2 SGTC_514 4466-0038 7.72 2.6 nM 2.32E-14 cell wall 46 5.79E-15
3 SGTC_58 0957-0393 6.72 9.0 µM 2.47E-11 cell wall 173 9.16E-12
4 SGTC_839 0122-0028 5.79 230.0 µM 6.83E-9 RSC complex & mRNA processing 9 3.44E-9
5 SGTC_2397 5161689 5.79 200.0 µM 6.96E-9 6 3.51E-9
6 SGTC_2594 a-mangostin 5.42 100.0 µM 5.27E-8 13 2.96E-8
7 SGTC_2600 tangeritin 5.39 88.0 µM 6.23E-8 10 3.53E-8
8 SGTC_1740 st038286 5.37 13.2 µM 7.09E-8 8 4.04E-8
9 SGTC_236 1509-0011 5.27 5.3 µM 1.14E-7 310 6.65E-8
10 SGTC_2582 agaric acid 5.25 100.0 µM 1.29E-7 redox potentiating 208 7.59E-8
11 SGTC_149 3970-0822 4.50 46.1 µM 4.83E-6 tubulin folding & SWR complex 64 3.41E-6
12 SGTC_2619 obliquin 4.48 87.9 µM 5.17E-6 cell wall 119 3.67E-6
13 SGTC_453 enantio-paf c16 4.24 10.0 µM 1.47E-5 123 1.10E-5
14 SGTC_279 1273-0055 4.10 2.9 µM 2.65E-5 azole & statin 38 2.04E-5
15 SGTC_195 4234-0266 3.96 16.6 µM 4.68E-5 32 3.70E-5
16 SGTC_1133 3473-0247 3.90 50.0 µM 6.10E-5 RSC complex & mRNA processing 52 4.88E-5
17 SGTC_435 c-PAF 3.81 6.7 µM 8.41E-5 49 6.82E-5
18 SGTC_304 1310-0298 3.80 97.0 µM 8.92E-5 cell wall 66 7.26E-5
19 SGTC_994 3910-0338 3.77 138.0 µM 1.01E-4 calcium & mitochondrial duress 52 8.28E-5
20 SGTC_141 0443-0274 3.67 32.3 µM 1.43E-4 mitochondrial response to ROS 55 1.19E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.421 2.79E-144 YBR020W GAL1 hom Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication
0.398 5.39E-128 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.394 1.00E-124 YMR121C RPL15B hom Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress
0.380 1.51E-115 YPR061C JID1 hom Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae
0.360 2.69E-103 YGL033W HOP2 hom Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
0.355 1.62E-100 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.350 4.72E-97 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.339 4.36E-91 YML117W NAB6 hom Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP
0.332 5.39E-87 YOR091W TMA46 hom Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p
0.321 3.18E-81 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.317 2.86E-79 YDR335W MSN5 hom Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
0.297 3.77E-69 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.296 6.72E-69 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.295 2.01E-68 YPL269W KAR9 hom Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase
0.290 3.74E-66 YJR111C_p YJR111C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria