Lipid particle protein of unknown function; contains a putative lipase serine active site; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
Profile for YOR059C / YOR059C

Click on Significant Values for Screen Details

Top fitness defect scores for YOR059C deletion by condition

RankScreen IDConditionFD ScoreConc
1 SGTC_1626 st003712 9.83 1.8 µM 1.63E-27 2 4.16E-23
2 SGTC_1625 st003711 6.25 30.1 µM 3.31E-12 calcium & mitochondrial duress 7 2.08E-10
3 SGTC_42 0133-0086 5.66 60.6 µM 2.51E-10 4 7.57E-9
4 SGTC_2278 7948257 4.92 134.3 µM 3.30E-8 9 4.39E-7
5 SGTC_1740 st038286 4.85 13.2 µM 4.90E-8 13 6.11E-7
6 SGTC_31 0508-1974 4.62 57.2 µM 1.97E-7 12 1.94E-6
7 SGTC_176 1486-1328 3.96 72.8 µM 6.71E-6 52 3.69E-5
8 SGTC_2625 euphol 3.81 100.0 µM 1.45E-5 30 7.03E-5
9 SGTC_4 0960-0234 3.80 25.7 µM 1.52E-5 Golgi 16 7.31E-5
10 SGTC_2282 7944268 3.77 200.0 µM 1.70E-5 RPP1 & pyrimidine depletion 38 8.04E-5
11 SGTC_728 3030-5151 3.63 22.5 µM 3.32E-5 22 1.41E-4
12 SGTC_1250 0485-0349 3.59 40.2 µM 4.12E-5 46 1.68E-4
13 SGTC_2023 5144124 3.57 124.0 µM 4.49E-5 28 1.81E-4
14 SGTC_2275 7947463 3.56 200.0 µM 4.59E-5 iron homeostasis 48 1.84E-4
15 SGTC_1467 k284-1082 3.56 293.0 µM 4.59E-5 28 1.84E-4
16 SGTC_203 k066-0004 3.55 30.9 µM 4.83E-5 RSC & ERG11 32 1.92E-4
17 SGTC_1719 st032227 3.51 49.2 µM 5.91E-5 36 2.27E-4
18 SGTC_2919 7978188 3.43 46.4 µM 8.43E-5 40 3.06E-4
19 SGTC_1917 st066507 3.43 28.5 µM 8.47E-5 Golgi 66 3.07E-4
20 SGTC_759 3486-0358 3.42 89.3 µM 8.64E-5 34 3.13E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.153 3.99E-19 YKL067W YNK1 hom Nucleoside diphosphate kinase; catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate; protein abundance increases in response to DNA replication stress
0.144 4.90E-17 YHR021W-A_p ECM12_p hom Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity
0.139 6.75E-16 YGL154C LYS5 hom Phosphopantetheinyl transferase involved in lysine biosynthesis; converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine
0.125 4.19E-13 YGL090W LIF1 hom Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein
0.117 1.09E-11 YJR053W BFA1 hom Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis
0.108 3.04E-10 YPR105C COG4 het Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.101 3.98E-9 YJR017C ESS1 het Peptidylprolyl-cis/trans-isomerase (PPIase); specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNAP II large subunit (Rpo21p) C-terminal domain (CTD); associates with phospho-Ser5 form of RNAP II in vivo; regulates phosphorylation of Ser7 within CTD; present along entire coding length of genes; represses initiation of CUTs; required for efficient termination of mRNA transcription and trimethylation of histone H3
0.098 1.44E-8 YHR110W ERP5 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.097 1.74E-8 YJL027C_p YJL027C_p hom Putative protein of unknown function
0.097 2.03E-8 YJL136W-A_p YJL136W-A_p hom Putative protein of unknown function; identified by SAGE
0.096 2.54E-8 YGL210W YPT32 hom Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance increases in response to DNA replication stress; YPT32 has a paralog, YPT31, that arose from the whole genome duplication
0.091 1.19E-7 YHR175W-A_p YHR175W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.089 2.36E-7 YNR051C BRE5 hom Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A
0.087 4.86E-7 YHR032W ERC1 hom Member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily; overproduction confers ethionine resistance and accumulation of S-adenosylmethionine
0.086 5.91E-7 YML078W CPR3 hom Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria