YOR066W / MSA1

Activator of G1-specific transcription factors, MBF and SBF; involved in regulation of the timing of G1-specific gene transcription and cell cycle initiation; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR066W / MSA1

Click on Significant Values for Screen Details ID:SGTC_87|Compound:0100-0052|FD-Score:3.24|P-value:3.99E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:3.21|P-value:4.55E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.66|P-value:7.55E-5 ID:SGTC_175|Compound:3793-3120|FD-Score:3.25|P-value:3.84E-4 ID:SGTC_225|Compound:nsc-122657|FD-Score:-3.43|P-value:1.82E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:3.48|P-value:1.58E-4 ID:SGTC_276|Compound:colchicine|FD-Score:4.01|P-value:1.67E-5 ID:SGTC_277|Compound:nystatin|FD-Score:4.52|P-value:1.46E-6 ID:SGTC_325|Compound:2810-4341|FD-Score:3.50|P-value:1.49E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:-3.20|P-value:4.33E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:-3.04|P-value:7.65E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:3.00|P-value:9.59E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:4.74|P-value:4.57E-7 ID:SGTC_686|Compound:1319-0111|FD-Score:4.30|P-value:4.32E-6 ID:SGTC_726|Compound:3448-4391|FD-Score:3.65|P-value:8.17E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:4.78|P-value:3.75E-7 ID:SGTC_803|Compound:4488-1585|FD-Score:3.63|P-value:8.74E-5 ID:SGTC_806|Compound:3966-4455|FD-Score:-3.08|P-value:6.61E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:3.15|P-value:5.55E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:3.03|P-value:8.79E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:-3.85|P-value:3.08E-5 ID:SGTC_1078|Compound:idebenone|FD-Score:3.19|P-value:4.82E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:8.02|P-value:4.76E-17 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.15|P-value:5.63E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.14|P-value:5.92E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:3.96|P-value:2.12E-5 ID:SGTC_1520|Compound:flindersine|FD-Score:-3.09|P-value:6.48E-4 ID:SGTC_1605|Compound:st000082|FD-Score:3.62|P-value:9.19E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:3.03|P-value:8.73E-4 ID:SGTC_1771|Compound:st048882|FD-Score:-3.04|P-value:7.71E-4 ID:SGTC_1795|Compound:st049545|FD-Score:3.22|P-value:4.35E-4 ID:SGTC_1847|Compound:st056231|FD-Score:3.25|P-value:3.86E-4 ID:SGTC_1933|Compound:st074711|FD-Score:3.66|P-value:7.60E-5 ID:SGTC_2035|Compound:5154463|FD-Score:3.22|P-value:4.36E-4 ID:SGTC_2070|Compound:5230947|FD-Score:3.08|P-value:7.31E-4 ID:SGTC_2278|Compound:7948257|FD-Score:3.20|P-value:4.78E-4 ID:SGTC_2291|Compound:7917025|FD-Score:-3.19|P-value:4.53E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.16|P-value:5.50E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:4.33|P-value:3.67E-6 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.71|P-value:6.21E-5 ID:SGTC_2576|Compound:guaiol|FD-Score:3.43|P-value:1.99E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.28|P-value:3.22E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.90|P-value:2.71E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.74|P-value:5.46E-5 ID:SGTC_2720|Compound:fluspirilene|FD-Score:3.24|P-value:4.01E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:-3.16|P-value:5.03E-4 ID:SGTC_2784|Compound:7567673|FD-Score:3.98|P-value:1.90E-5 ID:SGTC_2849|Compound:9019321|FD-Score:-3.73|P-value:5.30E-5 ID:SGTC_2874|Compound:9043904|FD-Score:3.31|P-value:3.09E-4 ID:SGTC_2900|Compound:5328528|FD-Score:3.74|P-value:5.57E-5 ID:SGTC_3044|Compound:9093193|FD-Score:-3.68|P-value:6.34E-5 ID:SGTC_3153|Compound:9100258|FD-Score:3.51|P-value:1.44E-4 ID:SGTC_3155|Compound:9099265|FD-Score:3.66|P-value:7.72E-5 ID:SGTC_3241|Compound:9133421|FD-Score:-3.31|P-value:2.84E-4 ID:SGTC_3301|Compound:9125354|FD-Score:-4.03|P-value:1.39E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:3.24|P-value:3.99E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:3.21|P-value:4.55E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.66|P-value:7.55E-5 ID:SGTC_175|Compound:3793-3120|FD-Score:3.25|P-value:3.84E-4 ID:SGTC_225|Compound:nsc-122657|FD-Score:-3.43|P-value:1.82E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:3.48|P-value:1.58E-4 ID:SGTC_276|Compound:colchicine|FD-Score:4.01|P-value:1.67E-5 ID:SGTC_277|Compound:nystatin|FD-Score:4.52|P-value:1.46E-6 ID:SGTC_325|Compound:2810-4341|FD-Score:3.50|P-value:1.49E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:-3.20|P-value:4.33E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:-3.04|P-value:7.65E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:3.00|P-value:9.59E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:4.74|P-value:4.57E-7 ID:SGTC_686|Compound:1319-0111|FD-Score:4.30|P-value:4.32E-6 ID:SGTC_726|Compound:3448-4391|FD-Score:3.65|P-value:8.17E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:4.78|P-value:3.75E-7 ID:SGTC_803|Compound:4488-1585|FD-Score:3.63|P-value:8.74E-5 ID:SGTC_806|Compound:3966-4455|FD-Score:-3.08|P-value:6.61E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:3.15|P-value:5.55E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:3.03|P-value:8.79E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:-3.85|P-value:3.08E-5 ID:SGTC_1078|Compound:idebenone|FD-Score:3.19|P-value:4.82E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:8.02|P-value:4.76E-17 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.15|P-value:5.63E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.14|P-value:5.92E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:3.96|P-value:2.12E-5 ID:SGTC_1520|Compound:flindersine|FD-Score:-3.09|P-value:6.48E-4 ID:SGTC_1605|Compound:st000082|FD-Score:3.62|P-value:9.19E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:3.03|P-value:8.73E-4 ID:SGTC_1771|Compound:st048882|FD-Score:-3.04|P-value:7.71E-4 ID:SGTC_1795|Compound:st049545|FD-Score:3.22|P-value:4.35E-4 ID:SGTC_1847|Compound:st056231|FD-Score:3.25|P-value:3.86E-4 ID:SGTC_1933|Compound:st074711|FD-Score:3.66|P-value:7.60E-5 ID:SGTC_2035|Compound:5154463|FD-Score:3.22|P-value:4.36E-4 ID:SGTC_2070|Compound:5230947|FD-Score:3.08|P-value:7.31E-4 ID:SGTC_2278|Compound:7948257|FD-Score:3.20|P-value:4.78E-4 ID:SGTC_2291|Compound:7917025|FD-Score:-3.19|P-value:4.53E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.16|P-value:5.50E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:4.33|P-value:3.67E-6 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.71|P-value:6.21E-5 ID:SGTC_2576|Compound:guaiol|FD-Score:3.43|P-value:1.99E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.28|P-value:3.22E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.90|P-value:2.71E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.74|P-value:5.46E-5 ID:SGTC_2720|Compound:fluspirilene|FD-Score:3.24|P-value:4.01E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:-3.16|P-value:5.03E-4 ID:SGTC_2784|Compound:7567673|FD-Score:3.98|P-value:1.90E-5 ID:SGTC_2849|Compound:9019321|FD-Score:-3.73|P-value:5.30E-5 ID:SGTC_2874|Compound:9043904|FD-Score:3.31|P-value:3.09E-4 ID:SGTC_2900|Compound:5328528|FD-Score:3.74|P-value:5.57E-5 ID:SGTC_3044|Compound:9093193|FD-Score:-3.68|P-value:6.34E-5 ID:SGTC_3153|Compound:9100258|FD-Score:3.51|P-value:1.44E-4 ID:SGTC_3155|Compound:9099265|FD-Score:3.66|P-value:7.72E-5 ID:SGTC_3241|Compound:9133421|FD-Score:-3.31|P-value:2.84E-4 ID:SGTC_3301|Compound:9125354|FD-Score:-4.03|P-value:1.39E-5

Top fitness defect scores for YOR066W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1294 1000-1494 8.02 117.0 µM 4.76E-17 14 5.16E-16
2 SGTC_789 1309-1135 4.78 70.6 µM 3.75E-7 ERG2 13 8.70E-7
3 SGTC_657 3534-0529 4.74 86.7 µM 4.57E-7 4 1.05E-6
4 SGTC_277 nystatin 4.52 15.5 µM 1.46E-6 4 3.10E-6
5 SGTC_2541 muurolladie-3-one 4.33 83.1 µM 3.67E-6 excess fatty acid 19 7.34E-6
6 SGTC_686 1319-0111 4.30 510.0 µM 4.32E-6 60S ribosome export 22 8.53E-6
7 SGTC_276 colchicine 4.01 750.0 µM 1.67E-5 17 3.01E-5
8 SGTC_2784 7567673 3.98 72.7 µM 1.90E-5 iron homeostasis 28 3.41E-5
9 SGTC_1517 deoxycholic acid methyl ester 3.96 49.2 µM 2.12E-5 9 3.78E-5
10 SGTC_2598 perillyl alcohol 3.90 100.0 µM 2.71E-5 33 4.76E-5
11 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 3.74 100.0 µM 5.46E-5 29 9.15E-5
12 SGTC_2900 5328528 3.74 85.3 µM 5.57E-5 Golgi 35 9.32E-5
13 SGTC_2546 rhodinyl acetate 3.71 100.0 µM 6.21E-5 16 1.03E-4
14 SGTC_163 1327-0036 3.66 7.5 µM 7.55E-5 125 1.24E-4
15 SGTC_1933 st074711 3.66 15.9 µM 7.60E-5 51 1.25E-4
16 SGTC_3155 9099265 3.66 49.5 µM 7.72E-5 32 1.26E-4
17 SGTC_726 3448-4391 3.65 34.2 µM 8.17E-5 18 1.33E-4
18 SGTC_803 4488-1585 3.63 147.0 µM 8.74E-5 19 1.42E-4
19 SGTC_1605 st000082 3.62 49.1 µM 9.19E-5 60S ribosome export 25 1.49E-4
20 SGTC_3153 9100258 3.51 49.5 µM 1.44E-4 39 2.27E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.282 1.60E-62 YDL207W GLE1 het Cytoplasmic nucleoporin required for polyadenylated RNA export; not essential for protein import; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase activity at the nuclear pore complex during mRNA export
0.159 2.00E-20 YJR129C_p YJR129C_p hom Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.153 3.91E-19 YCL014W BUD3 hom Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
0.131 2.61E-14 YFR007W YFH7 hom Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
0.124 6.52E-13 YNL128W TEP1 hom PTEN homolog with no demonstrated inositol lipid phosphatase activity; plays a role in normal sporulation; homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 and fission yeast ptn1
0.121 1.89E-12 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.115 2.78E-11 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.112 6.96E-11 YNL134C YNL134C hom Protein of unknown function; similar to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress
0.103 2.01E-9 YHR044C DOG1 hom 2-deoxyglucose-6-phosphate phosphatase; paralogous to DOG2; member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed, in vivo substrate has not yet been identified
0.099 8.82E-9 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.095 3.25E-8 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.093 6.25E-8 YHR179W OYE2 hom Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress
0.091 1.18E-7 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.091 1.20E-7 YER089C PTC2 hom Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; inactivates the DNA damage checkpoint; PTC2 has a paralog, PTC3, that arose from the whole genome duplication
0.087 4.62E-7 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair