Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YOR073W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.228 | 8.35E-41 | YLR315W | NKP2 | hom | Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2 |
0.207 | 7.35E-34 | YFL001W | DEG1 | hom | tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability |
0.202 | 3.94E-32 | YAL047C | SPC72 | hom | Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization |
0.176 | 8.25E-25 | YAL059W | ECM1 | hom | Pre-ribosomal factor involved in 60S ribosomal protein subunit export; associates with the pre-60S particle; shuttles between the nucleus and cytoplasm |
0.154 | 2.30E-19 | YNL067W | RPL9B | hom | Ribosomal 60S subunit protein L9B; nearly identical to paralog Rpl9Ap; homologous to mammalian ribosomal protein L9 and bacterial L6 |
0.154 | 2.59E-19 | YGR159C | NSR1 | hom | Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis |
0.153 | 6.78E-19 | YGR085C | RPL11B | hom | Ribosomal 60S subunit protein L11B; expressed at half the level of Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11B has a paralog, RPL11A, that arose from the whole genome duplication |
0.150 | 3.42E-18 | YDR378C | LSM6 | hom | Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA |
0.144 | 5.33E-17 | YBR111W-A | SUS1 | hom | Component of both the SAGA histone acetylase and TREX-2 complexes; interacts with RNA polymerase II; involved in mRNA export coupled transcription activation and elongation; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP |
0.141 | 2.28E-16 | YBR189W | RPS9B | hom | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication |
0.140 | 3.51E-16 | YGR160W_d | YGR160W_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
0.137 | 1.52E-15 | YDR417C_d | YDR417C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W |
0.135 | 4.13E-15 | YML012C-A_d | YML012C-A_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SEL1 |
0.131 | 2.75E-14 | YMR126C_p | DLT1_p | hom | Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA) |
0.128 | 1.11E-13 | YNL256W | FOL1 | het | Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities |