YOR073W / SGO1

Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR073W / SGO1

Click on Significant Values for Screen Details ID:SGTC_93|Compound:0109-0045|FD-Score:3.64|P-value:4.22E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:3.79|P-value:2.61E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-5.48|P-value:3.13E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:-13.00|P-value:1.04E-32 ID:SGTC_335|Compound:4077-0256|FD-Score:-4.45|P-value:2.64E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:3.89|P-value:1.85E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:5.91|P-value:3.20E-8 ID:SGTC_381|Compound:3461-2219|FD-Score:3.66|P-value:3.96E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-3.66|P-value:4.48E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.80|P-value:2.78E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:5.12|P-value:1.44E-6 ID:SGTC_519|Compound:k048-0011|FD-Score:5.39|P-value:4.07E-7 ID:SGTC_568|Compound:1193-0097|FD-Score:3.49|P-value:6.86E-4 ID:SGTC_575|Compound:k072-0246|FD-Score:4.03|P-value:1.12E-4 ID:SGTC_583|Compound:1488-1091|FD-Score:3.47|P-value:7.37E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:4.00|P-value:1.26E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:3.54|P-value:6.00E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.90|P-value:1.79E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:4.15|P-value:7.30E-5 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.56|P-value:5.49E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.98|P-value:1.33E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.89|P-value:1.82E-4 ID:SGTC_1604|Compound:st002052|FD-Score:4.57|P-value:1.42E-5 ID:SGTC_1606|Compound:st000094|FD-Score:4.02|P-value:1.16E-4 ID:SGTC_1618|Compound:st003135|FD-Score:4.22|P-value:5.57E-5 ID:SGTC_1642|Compound:st009582|FD-Score:-3.85|P-value:2.40E-4 ID:SGTC_1750|Compound:st081859|FD-Score:4.02|P-value:1.18E-4 ID:SGTC_1762|Compound:st045503|FD-Score:4.82|P-value:5.07E-6 ID:SGTC_2040|Compound:5100729|FD-Score:4.10|P-value:8.69E-5 ID:SGTC_2100|Compound:5377183|FD-Score:3.39|P-value:9.56E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:3.93|P-value:1.61E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-5.67|P-value:1.30E-7 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.81|P-value:2.74E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-3.70|P-value:3.88E-4 ID:SGTC_3131|Compound:9127911|FD-Score:-3.54|P-value:6.61E-4 ID:SGTC_3221|Compound:9128209|FD-Score:3.44|P-value:8.05E-4 ID:SGTC_3237|Compound:9133362|FD-Score:-3.70|P-value:3.92E-4 ID:SGTC_3247|Compound:9135149|FD-Score:3.69|P-value:3.66E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:3.64|P-value:4.22E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:3.79|P-value:2.61E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-5.48|P-value:3.13E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:-13.00|P-value:1.04E-32 ID:SGTC_335|Compound:4077-0256|FD-Score:-4.45|P-value:2.64E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:3.89|P-value:1.85E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:5.91|P-value:3.20E-8 ID:SGTC_381|Compound:3461-2219|FD-Score:3.66|P-value:3.96E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-3.66|P-value:4.48E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.80|P-value:2.78E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:5.12|P-value:1.44E-6 ID:SGTC_519|Compound:k048-0011|FD-Score:5.39|P-value:4.07E-7 ID:SGTC_568|Compound:1193-0097|FD-Score:3.49|P-value:6.86E-4 ID:SGTC_575|Compound:k072-0246|FD-Score:4.03|P-value:1.12E-4 ID:SGTC_583|Compound:1488-1091|FD-Score:3.47|P-value:7.37E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:4.00|P-value:1.26E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:3.54|P-value:6.00E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.90|P-value:1.79E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:4.15|P-value:7.30E-5 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.56|P-value:5.49E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.98|P-value:1.33E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.89|P-value:1.82E-4 ID:SGTC_1604|Compound:st002052|FD-Score:4.57|P-value:1.42E-5 ID:SGTC_1606|Compound:st000094|FD-Score:4.02|P-value:1.16E-4 ID:SGTC_1618|Compound:st003135|FD-Score:4.22|P-value:5.57E-5 ID:SGTC_1642|Compound:st009582|FD-Score:-3.85|P-value:2.40E-4 ID:SGTC_1750|Compound:st081859|FD-Score:4.02|P-value:1.18E-4 ID:SGTC_1762|Compound:st045503|FD-Score:4.82|P-value:5.07E-6 ID:SGTC_2040|Compound:5100729|FD-Score:4.10|P-value:8.69E-5 ID:SGTC_2100|Compound:5377183|FD-Score:3.39|P-value:9.56E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:3.93|P-value:1.61E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-5.67|P-value:1.30E-7 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.81|P-value:2.74E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-3.70|P-value:3.88E-4 ID:SGTC_3131|Compound:9127911|FD-Score:-3.54|P-value:6.61E-4 ID:SGTC_3221|Compound:9128209|FD-Score:3.44|P-value:8.05E-4 ID:SGTC_3237|Compound:9133362|FD-Score:-3.70|P-value:3.92E-4 ID:SGTC_3247|Compound:9135149|FD-Score:3.69|P-value:3.66E-4

Top fitness defect scores for YOR073W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_379 3970-0972 5.91 5.9 µM 3.20E-8 tubulin folding & SWR complex 4 1.67E-9
2 SGTC_519 k048-0011 5.39 62.8 µM 4.07E-7 4 3.47E-8
3 SGTC_517 1365-0151 5.12 113.0 µM 1.44E-6 16 1.57E-7
4 SGTC_1762 st045503 4.82 25.5 µM 5.07E-6 11 7.01E-7
5 SGTC_1604 st002052 4.57 72.4 µM 1.42E-5 TSC3-RPN4 18 2.39E-6
6 SGTC_1618 st003135 4.22 44.5 µM 5.57E-5 10 1.21E-5
7 SGTC_1350 1495-0454 4.15 146.0 µM 7.30E-5 20 1.67E-5
8 SGTC_2040 5100729 4.10 123.0 µM 8.69E-5 40 2.06E-5
9 SGTC_575 k072-0246 4.03 11.9 µM 1.12E-4 21 2.78E-5
10 SGTC_1606 st000094 4.02 49.2 µM 1.16E-4 60S ribosome export 16 2.91E-5
11 SGTC_1750 st081859 4.02 2.4 µM 1.18E-4 endomembrane recycling 180 2.95E-5
12 SGTC_740 k014-0057 4.00 261.0 µM 1.26E-4 25 3.20E-5
13 SGTC_1388 3346-4487 3.98 254.0 µM 1.33E-4 24 3.40E-5
14 SGTC_2532 xanthone 3.93 78.9 µM 1.61E-4 29 4.29E-5
15 SGTC_1007 4101-0031 3.90 70.0 µM 1.79E-4 19 4.84E-5
16 SGTC_1513 0337-0559 3.89 19.0 µM 1.82E-4 19 4.94E-5
17 SGTC_373 0844-0104 3.89 25.9 µM 1.85E-4 ERAD & cell cycle 49 5.05E-5
18 SGTC_123 0083-0120 3.79 66.7 µM 2.61E-4 53 7.60E-5
19 SGTC_3247 9135149 3.69 49.5 µM 3.66E-4 DNA damage response 27 1.13E-4
20 SGTC_381 3461-2219 3.66 42.7 µM 3.96E-4 copper-dependent oxidative stress 23 1.24E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.228 8.35E-41 YLR315W NKP2 hom Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2
0.207 7.35E-34 YFL001W DEG1 hom tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability
0.202 3.94E-32 YAL047C SPC72 hom Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization
0.176 8.25E-25 YAL059W ECM1 hom Pre-ribosomal factor involved in 60S ribosomal protein subunit export; associates with the pre-60S particle; shuttles between the nucleus and cytoplasm
0.154 2.30E-19 YNL067W RPL9B hom Ribosomal 60S subunit protein L9B; nearly identical to paralog Rpl9Ap; homologous to mammalian ribosomal protein L9 and bacterial L6
0.154 2.59E-19 YGR159C NSR1 hom Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
0.153 6.78E-19 YGR085C RPL11B hom Ribosomal 60S subunit protein L11B; expressed at half the level of Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11B has a paralog, RPL11A, that arose from the whole genome duplication
0.150 3.42E-18 YDR378C LSM6 hom Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
0.144 5.33E-17 YBR111W-A SUS1 hom Component of both the SAGA histone acetylase and TREX-2 complexes; interacts with RNA polymerase II; involved in mRNA export coupled transcription activation and elongation; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP
0.141 2.28E-16 YBR189W RPS9B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication
0.140 3.51E-16 YGR160W_d YGR160W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.137 1.52E-15 YDR417C_d YDR417C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W
0.135 4.13E-15 YML012C-A_d YML012C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SEL1
0.131 2.75E-14 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.128 1.11E-13 YNL256W FOL1 het Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities