YOR079C / ATX2

Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR079C / ATX2

Click on Significant Values for Screen Details ID:SGTC_179|Compound:1273-0063|FD-Score:-3.02|P-value:1.58E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:2.62|P-value:9.23E-4 ID:SGTC_500|Compound:h-89|FD-Score:2.89|P-value:2.87E-4 ID:SGTC_559|Compound:1550-0661|FD-Score:-2.83|P-value:3.61E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:3.94|P-value:1.35E-6 ID:SGTC_653|Compound:0203-0016|FD-Score:2.87|P-value:3.15E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:2.82|P-value:3.95E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:2.60|P-value:9.99E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:2.71|P-value:6.22E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:-2.83|P-value:3.63E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.18|P-value:7.60E-5 ID:SGTC_1367|Compound:1812-0510|FD-Score:2.76|P-value:5.00E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:2.73|P-value:5.71E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.13|P-value:9.56E-5 ID:SGTC_1741|Compound:st038134|FD-Score:2.85|P-value:3.42E-4 ID:SGTC_1940|Compound:st075990|FD-Score:2.88|P-value:3.02E-4 ID:SGTC_1954|Compound:st077032|FD-Score:-3.11|P-value:1.01E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:3.23|P-value:6.02E-5 ID:SGTC_2316|Compound:5844804|FD-Score:3.04|P-value:1.44E-4 ID:SGTC_2325|Compound:6158266|FD-Score:-4.28|P-value:1.64E-7 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-3.19|P-value:7.15E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:2.93|P-value:2.47E-4 ID:SGTC_2876|Compound:9059903|FD-Score:3.43|P-value:2.25E-5 ID:SGTC_2877|Compound:9040724|FD-Score:2.97|P-value:2.02E-4 ID:SGTC_2920|Compound:7982904|FD-Score:-2.99|P-value:1.77E-4 ID:SGTC_2930|Compound:9013230|FD-Score:2.96|P-value:2.10E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-2.62|P-value:8.99E-4 ID:SGTC_2940|Compound:9060638|FD-Score:3.20|P-value:6.78E-5 ID:SGTC_2962|Compound:9082311|FD-Score:2.81|P-value:4.06E-4 ID:SGTC_3011|Compound:9081274|FD-Score:2.71|P-value:6.21E-4 ID:SGTC_3104|Compound:9120930|FD-Score:2.70|P-value:6.43E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-3.69|P-value:5.28E-6 ID:SGTC_3203|Compound:9113543|FD-Score:2.82|P-value:3.92E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-3.62|P-value:7.75E-6 ID:SGTC_3294|Compound:9122953|FD-Score:-2.78|P-value:4.54E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:-3.02|P-value:1.58E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:2.62|P-value:9.23E-4 ID:SGTC_500|Compound:h-89|FD-Score:2.89|P-value:2.87E-4 ID:SGTC_559|Compound:1550-0661|FD-Score:-2.83|P-value:3.61E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:3.94|P-value:1.35E-6 ID:SGTC_653|Compound:0203-0016|FD-Score:2.87|P-value:3.15E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:2.82|P-value:3.95E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:2.60|P-value:9.99E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:2.71|P-value:6.22E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:-2.83|P-value:3.63E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.18|P-value:7.60E-5 ID:SGTC_1367|Compound:1812-0510|FD-Score:2.76|P-value:5.00E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:2.73|P-value:5.71E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.13|P-value:9.56E-5 ID:SGTC_1741|Compound:st038134|FD-Score:2.85|P-value:3.42E-4 ID:SGTC_1940|Compound:st075990|FD-Score:2.88|P-value:3.02E-4 ID:SGTC_1954|Compound:st077032|FD-Score:-3.11|P-value:1.01E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:3.23|P-value:6.02E-5 ID:SGTC_2316|Compound:5844804|FD-Score:3.04|P-value:1.44E-4 ID:SGTC_2325|Compound:6158266|FD-Score:-4.28|P-value:1.64E-7 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-3.19|P-value:7.15E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:2.93|P-value:2.47E-4 ID:SGTC_2876|Compound:9059903|FD-Score:3.43|P-value:2.25E-5 ID:SGTC_2877|Compound:9040724|FD-Score:2.97|P-value:2.02E-4 ID:SGTC_2920|Compound:7982904|FD-Score:-2.99|P-value:1.77E-4 ID:SGTC_2930|Compound:9013230|FD-Score:2.96|P-value:2.10E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-2.62|P-value:8.99E-4 ID:SGTC_2940|Compound:9060638|FD-Score:3.20|P-value:6.78E-5 ID:SGTC_2962|Compound:9082311|FD-Score:2.81|P-value:4.06E-4 ID:SGTC_3011|Compound:9081274|FD-Score:2.71|P-value:6.21E-4 ID:SGTC_3104|Compound:9120930|FD-Score:2.70|P-value:6.43E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-3.69|P-value:5.28E-6 ID:SGTC_3203|Compound:9113543|FD-Score:2.82|P-value:3.92E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-3.62|P-value:7.75E-6 ID:SGTC_3294|Compound:9122953|FD-Score:-2.78|P-value:4.54E-4

Top fitness defect scores for YOR079C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_650 1328-0195 3.94 38.0 µM 1.35E-6 19 4.08E-5
2 SGTC_2876 9059903 3.43 26.0 µM 2.25E-5 26 3.06E-4
3 SGTC_2091 4-phenylthiadiazole 3.23 200.0 µM 6.02E-5 35 6.21E-4
4 SGTC_2940 9060638 3.20 45.9 µM 6.78E-5 amide catabolism 59 6.76E-4
5 SGTC_1235 benzylparaben 3.18 21.5 µM 7.60E-5 31 7.34E-4
6 SGTC_2316 5844804 3.04 197.4 µM 1.44E-4 88 0.00116
7 SGTC_2877 9040724 2.97 71.4 µM 2.02E-4 56 0.00149
8 SGTC_2930 9013230 2.96 14.9 µM 2.10E-4 heme biosynthesis & mitochondrial translocase 98 0.00153
9 SGTC_2752 diclazuril 2.93 33.1 µM 2.47E-4 206 0.00171
10 SGTC_500 h-89 2.89 112.0 µM 2.87E-4 cell wall signaling 79 0.00191
11 SGTC_1940 st075990 2.88 51.1 µM 3.02E-4 60S ribosome export 74 0.00198
12 SGTC_653 0203-0016 2.87 55.2 µM 3.15E-4 67 0.00205
13 SGTC_1741 st038134 2.85 10.2 µM 3.42E-4 87 0.00217
14 SGTC_3203 9113543 2.82 49.5 µM 3.92E-4 95 0.00240
15 SGTC_656 4090-1979 2.82 187.0 µM 3.95E-4 86 0.00241
16 SGTC_2962 9082311 2.81 13.2 µM 4.06E-4 81 0.00246
17 SGTC_1367 1812-0510 2.76 76.9 µM 5.00E-4 90 0.00286
18 SGTC_1368 1852-0141 2.73 284.0 µM 5.71E-4 ERG2 105 0.00315
19 SGTC_3011 9081274 2.71 71.4 µM 6.21E-4 83 0.00334
20 SGTC_942 3253-1115 2.71 227.0 µM 6.22E-4 101 0.00334

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.151 1.24E-18 YMR030W RSF1 hom Protein required for respiratory growth; localized to both the nucleus and mitochondrion; may interact with transcription factors to mediate the transition to respiratory growth and activate transcription of nuclear and mitochondrial genes
0.146 2.06E-17 YEL067C_p YEL067C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.142 1.71E-16 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.142 1.72E-16 YGL067W NPY1 hom NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; nudix hydrolase family member
0.138 8.82E-16 YCL035C GRX1 hom Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.137 1.82E-15 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.133 1.04E-14 YDR096W GIS1 hom Histone demethylase and transcription factor; regulates genes during nutrient limitation; negatively regulates DPP1, PHR1; activity modulated by limited proteasome-mediated proteolysis; has JmjC and JmjN domain in N-terminal region that interact, promoting stability and proper transcriptional activity; contains two transactivating domains downstream of Jmj domains and a C-terminal DNA binding domain; GIS1 has a paralog, RPH1, that arose from the whole genome duplication
0.130 5.14E-14 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.129 5.48E-14 YDL230W PTP1 hom Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation
0.129 7.15E-14 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.128 1.16E-13 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.127 1.80E-13 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.122 1.49E-12 YPR126C_d YPR126C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.120 3.13E-12 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.119 5.06E-12 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability