HIPHOP chemogenomics database

YOR087W / YVC1

Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock

Zygosity: Homozygous strain

fixedexpanded
Profile for YOR087W / YVC1

Click on Significant Values for Screen Details

Top fitness defect scores for YOR087W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2750	bromebric acid	5.17	70.2 µM	1.14E-8		10	1.18E-7
2	SGTC_425	3825-7017	3.82	13.1 µM	1.89E-5		25	6.76E-5
3	SGTC_334	1502-1024	3.81	68.5 µM	1.94E-5		14	6.91E-5
4	SGTC_402	epigallocatechin gallate	3.74	10.0 µM	2.66E-5		34	9.06E-5
5	SGTC_65	0798-0905	3.67	35.0 µM	3.70E-5	calcium & mitochondrial duress	104	1.20E-4
6	SGTC_2311	7694451	3.47	200.0 µM	9.19E-5		35	2.63E-4
7	SGTC_2435	5706476	3.28	10.6 µM	2.03E-4		47	5.21E-4
8	SGTC_336	4111-0029	3.13	111.0 µM	3.73E-4		22	8.80E-4
9	SGTC_1174	0739-0097	2.94	51.1 µM	7.77E-4	redox potentiating	84	0.00166
10	SGTC_1912	st060209	2.89	90.8 µM	9.41E-4		90	0.00195
11	SGTC_737	1950-0117	2.83	57.9 µM	0.00116		72	0.00234
12	SGTC_1748	st037455	2.82	53.6 µM	0.00121		101	0.00244
13	SGTC_263	alizarin	2.81	107.9 µM	0.00126	iron homeostasis	152	0.00251
14	SGTC_605	1315-0399	2.77	119.0 µM	0.00144	Golgi	88	0.00282
15	SGTC_337	1315-0038	2.75	354.0 µM	0.00155	amide catabolism	81	0.00300
16	SGTC_739	1486-1183	2.74	203.0 µM	0.00156		68	0.00303
17	SGTC_2295	7971645	2.69	200.0 µM	0.00187		101	0.00354
18	SGTC_2583	asiatic acid	2.64	100.0 µM	0.00225		103	0.00415
19	SGTC_1449	4112-4002	2.63	201.0 µM	0.00232	RPP1 & pyrimidine depletion	79	0.00427
20	SGTC_1086	cerivastatin	2.62	2.2 µM	0.00244	azole & statin	63	0.00445

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.241	2.04E-45	YNL312W	RFA2	het	Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress
0.238	2.15E-44	YHR003C	YHR003C	hom	Protein of unknown function, localized to the mitochondrial outer membrane
0.188	3.42E-28	YEL049W	PAU2	hom	Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.156	9.21E-20	YNL260C	LTO1	het	Essential protein that forms a complex with Rli1p and Yae1p; ortholog of human ORAOV1, which is overexpressed in solid tumors; inviability of null mutant under standard conditions is complemented by overexpression of ORAOV1; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species
0.146	1.45E-17	YMR118C_p	SHH3_p	hom	Putative mitochondrial inner membrane protein of unknown function; although similar to Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase
0.132	1.91E-14	YLL012W	YEH1	hom	Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.128	8.65E-14	YDR534C	FIT1	hom	Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.126	2.01E-13	YBR118W	TEF2	hom	Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication
0.123	8.09E-13	YHR106W	TRR2	hom	Mitochondrial thioredoxin reductase; involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif (CAVC) present in prokaryotic orthologs; binds NADPH and FAD; TRR2 has a paralog, TRR1, that arose from the whole genome duplication
0.121	2.02E-12	YPR010C	RPA135	het	RNA polymerase I second largest subunit A135
0.113	4.46E-11	YEL066W	HPA3	hom	D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro
0.112	7.45E-11	YGR082W	TOM20	het	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins
0.109	2.48E-10	YJR109C	CPA2	hom	Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor
0.107	5.46E-10	YKL187C	FAT3	hom	Protein required for fatty acid uptake; Fat3p abundance increases in cortical patches in response to oleate exposure; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies
0.107	5.37E-10	YDR531W	CAB1	het	Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A (CoA); transcriptionally regulated by Upc2p via a sterol response element