Ribose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YOR095C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.133 | 8.54E-15 | YBL075C | SSA3 | hom | ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSA3 has a paralog, SSA4, that arose from the whole genome duplication |
0.132 | 2.03E-14 | YOL077C | BRX1 | het | Nucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif |
0.124 | 6.64E-13 | YHL032C | GUT1 | hom | Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p |
0.112 | 7.59E-11 | YJR022W | LSM8 | het | Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA |
0.110 | 1.80E-10 | YDL161W | ENT1 | hom | Epsin-like protein involved in endocytosis and actin patch assembly; functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus; relocalizes from bud neck to cytoplasm upon DNA replication stress |
0.108 | 3.80E-10 | YNL304W | YPT11 | hom | Rab family GTPase that interacts with the C-terminal tail domain of Myo2p; mediates distribution of mitochondria and endoplasmic reticuli to daughter cells |
0.102 | 2.62E-9 | YBR063C_p | YBR063C_p | hom | Putative protein of unknown function; YBR063C is not an essential gene |
0.096 | 2.40E-8 | YAL004W_d | YAL004W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene SSA1/YAL005C |
0.091 | 1.17E-7 | YDR453C | TSA2 | hom | Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants; protein abundance increases in response to DNA replication stress |
0.082 | 2.20E-6 | YOR375C | GDH1 | hom | NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources; GDH1 has a paralog, GDH3, that arose from the whole genome duplication |
0.081 | 2.36E-6 | YMR084W_p | YMR084W_p | hom | Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1 |
0.081 | 2.64E-6 | YPR071W_p | YPR071W_p | hom | Putative membrane protein; YPR071W is not an essential gene; YPR071W has paralog YIL029C |
0.079 | 4.73E-6 | YFR048W | RMD8 | hom | Cytosolic protein required for sporulation |
0.077 | 7.06E-6 | YBR130C | SHE3 | hom | Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance |
0.076 | 9.49E-6 | YGL254W | FZF1 | hom | Transcription factor involved in sulfite metabolism; sole identified regulatory target is SSU1; overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers; protein abundance increases in response to DNA replication stress |