YOR095C / RKI1

Ribose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR095C / RKI1

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:3.05|P-value:4.19E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.19|P-value:2.25E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:-2.93|P-value:6.34E-4 ID:SGTC_321|Compound:4534-3890|FD-Score:2.88|P-value:8.16E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:3.71|P-value:2.42E-5 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.06|P-value:4.14E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:4.39|P-value:7.49E-7 ID:SGTC_537|Compound:1334-0398|FD-Score:2.89|P-value:7.92E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:5.44|P-value:1.24E-9 ID:SGTC_774|Compound:k060-0086|FD-Score:3.59|P-value:4.17E-5 ID:SGTC_783|Compound:0848-0141|FD-Score:3.58|P-value:4.41E-5 ID:SGTC_1210|Compound:3013-0140|FD-Score:3.38|P-value:1.09E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.30|P-value:1.53E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:-2.85|P-value:8.70E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.24|P-value:1.99E-4 ID:SGTC_1458|Compound:k015-0034|FD-Score:3.22|P-value:2.12E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:3.06|P-value:4.06E-4 ID:SGTC_1770|Compound:st043884|FD-Score:-2.83|P-value:9.09E-4 ID:SGTC_1808|Compound:st050063|FD-Score:2.95|P-value:6.19E-4 ID:SGTC_1939|Compound:st074455|FD-Score:3.46|P-value:7.52E-5 ID:SGTC_1941|Compound:st076221|FD-Score:4.46|P-value:5.22E-7 ID:SGTC_1944|Compound:st076371|FD-Score:-2.82|P-value:9.73E-4 ID:SGTC_1948|Compound:st076329|FD-Score:4.54|P-value:3.38E-7 ID:SGTC_1954|Compound:st077032|FD-Score:-5.67|P-value:2.30E-10 ID:SGTC_1983|Compound:st071813|FD-Score:-2.84|P-value:8.98E-4 ID:SGTC_2121|Compound:5257820|FD-Score:3.19|P-value:2.42E-4 ID:SGTC_2161|Compound:5662504|FD-Score:3.75|P-value:2.02E-5 ID:SGTC_2171|Compound:5739187|FD-Score:-3.71|P-value:2.31E-5 ID:SGTC_2173|Compound:5763948|FD-Score:-3.83|P-value:1.26E-5 ID:SGTC_2241|Compound:6772625|FD-Score:-3.32|P-value:1.32E-4 ID:SGTC_2267|Compound:7931562|FD-Score:3.94|P-value:7.96E-6 ID:SGTC_2326|Compound:6164455|FD-Score:3.10|P-value:3.48E-4 ID:SGTC_2356|Compound:9061756|FD-Score:2.97|P-value:5.77E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.10|P-value:3.41E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-2.83|P-value:9.39E-4 ID:SGTC_2782|Compound:7736369|FD-Score:4.59|P-value:2.53E-7 ID:SGTC_2787|Compound:5284540|FD-Score:5.16|P-value:7.75E-9 ID:SGTC_2790|Compound:5423970|FD-Score:3.48|P-value:6.88E-5 ID:SGTC_2878|Compound:9043973|FD-Score:3.31|P-value:1.45E-4 ID:SGTC_3284|Compound:9108171|FD-Score:3.18|P-value:2.48E-4 ID:SGTC_3326|Compound:9140064|FD-Score:3.37|P-value:1.14E-4 ID:SGTC_3329|Compound:9141233|FD-Score:3.42|P-value:8.98E-5 ID:SGTC_3333|Compound:9141820|FD-Score:5.04|P-value:1.67E-8 ID:SGTC_3343|Compound:9148379|FD-Score:2.83|P-value:9.79E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:3.05|P-value:4.19E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.19|P-value:2.25E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:-2.93|P-value:6.34E-4 ID:SGTC_321|Compound:4534-3890|FD-Score:2.88|P-value:8.16E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:3.71|P-value:2.42E-5 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.06|P-value:4.14E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:4.39|P-value:7.49E-7 ID:SGTC_537|Compound:1334-0398|FD-Score:2.89|P-value:7.92E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:5.44|P-value:1.24E-9 ID:SGTC_774|Compound:k060-0086|FD-Score:3.59|P-value:4.17E-5 ID:SGTC_783|Compound:0848-0141|FD-Score:3.58|P-value:4.41E-5 ID:SGTC_1210|Compound:3013-0140|FD-Score:3.38|P-value:1.09E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.30|P-value:1.53E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:-2.85|P-value:8.70E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.24|P-value:1.99E-4 ID:SGTC_1458|Compound:k015-0034|FD-Score:3.22|P-value:2.12E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:3.06|P-value:4.06E-4 ID:SGTC_1770|Compound:st043884|FD-Score:-2.83|P-value:9.09E-4 ID:SGTC_1808|Compound:st050063|FD-Score:2.95|P-value:6.19E-4 ID:SGTC_1939|Compound:st074455|FD-Score:3.46|P-value:7.52E-5 ID:SGTC_1941|Compound:st076221|FD-Score:4.46|P-value:5.22E-7 ID:SGTC_1944|Compound:st076371|FD-Score:-2.82|P-value:9.73E-4 ID:SGTC_1948|Compound:st076329|FD-Score:4.54|P-value:3.38E-7 ID:SGTC_1954|Compound:st077032|FD-Score:-5.67|P-value:2.30E-10 ID:SGTC_1983|Compound:st071813|FD-Score:-2.84|P-value:8.98E-4 ID:SGTC_2121|Compound:5257820|FD-Score:3.19|P-value:2.42E-4 ID:SGTC_2161|Compound:5662504|FD-Score:3.75|P-value:2.02E-5 ID:SGTC_2171|Compound:5739187|FD-Score:-3.71|P-value:2.31E-5 ID:SGTC_2173|Compound:5763948|FD-Score:-3.83|P-value:1.26E-5 ID:SGTC_2241|Compound:6772625|FD-Score:-3.32|P-value:1.32E-4 ID:SGTC_2267|Compound:7931562|FD-Score:3.94|P-value:7.96E-6 ID:SGTC_2326|Compound:6164455|FD-Score:3.10|P-value:3.48E-4 ID:SGTC_2356|Compound:9061756|FD-Score:2.97|P-value:5.77E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.10|P-value:3.41E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-2.83|P-value:9.39E-4 ID:SGTC_2782|Compound:7736369|FD-Score:4.59|P-value:2.53E-7 ID:SGTC_2787|Compound:5284540|FD-Score:5.16|P-value:7.75E-9 ID:SGTC_2790|Compound:5423970|FD-Score:3.48|P-value:6.88E-5 ID:SGTC_2878|Compound:9043973|FD-Score:3.31|P-value:1.45E-4 ID:SGTC_3284|Compound:9108171|FD-Score:3.18|P-value:2.48E-4 ID:SGTC_3326|Compound:9140064|FD-Score:3.37|P-value:1.14E-4 ID:SGTC_3329|Compound:9141233|FD-Score:3.42|P-value:8.98E-5 ID:SGTC_3333|Compound:9141820|FD-Score:5.04|P-value:1.67E-8 ID:SGTC_3343|Compound:9148379|FD-Score:2.83|P-value:9.79E-4

Top fitness defect scores for YOR095C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_538 2922-0838 5.44 53.3 µM 1.24E-9 Golgi 1 2.61E-8 1.06
2 SGTC_2787 5284540 5.16 71.4 µM 7.75E-9 3 1.21E-7 0.10
3 SGTC_3333 9141820 5.04 12.1 µM 1.67E-8 1 2.31E-7 0.58
4 SGTC_2782 7736369 4.59 71.4 µM 2.53E-7 4 2.24E-6 0.06
5 SGTC_1948 st076329 4.54 66.6 µM 3.38E-7 1 2.86E-6 0.35
6 SGTC_1941 st076221 4.46 61.8 µM 5.22E-7 sphingolipid biosynthesis & PDR1 7 4.11E-6 0.06
7 SGTC_524 r073-0010 4.39 27.8 µM 7.49E-7 11 5.57E-6 0.06
8 SGTC_2267 7931562 3.94 200.0 µM 7.96E-6 5 4.04E-5 0.18
9 SGTC_2161 5662504 3.75 8.5 µM 2.02E-5 tubulin folding & SWR complex 8 8.83E-5 0.23
10 SGTC_357 1325-0123 3.71 420.0 µM 2.42E-5 4 1.03E-4 0.37
11 SGTC_774 k060-0086 3.59 136.0 µM 4.17E-5 8 1.63E-4 0.27
12 SGTC_783 0848-0141 3.58 92.7 µM 4.41E-5 RSC & ERG11 19 1.70E-4 0.01
13 SGTC_2790 5423970 3.48 71.4 µM 6.88E-5 endomembrane recycling 22 2.48E-4 0.24
14 SGTC_1939 st074455 3.46 53.6 µM 7.52E-5 9 2.67E-4 0.06
15 SGTC_3329 9141233 3.42 27.6 µM 8.98E-5 6 3.10E-4 0.32
16 SGTC_1210 3013-0140 3.38 750.0 nM 1.09E-4 5 3.64E-4 0.12
17 SGTC_3326 9140064 3.37 16.4 µM 1.14E-4 10 3.80E-4 0.05
18 SGTC_2878 9043973 3.31 26.0 µM 1.45E-4 2 4.64E-4 0.11
19 SGTC_1221 2958-7315 3.30 257.0 µM 1.53E-4 7 4.87E-4 0.17
20 SGTC_1450 4112-4260 3.24 37.6 µM 1.99E-4 calcium & mitochondrial duress 11 6.05E-4 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.133 8.54E-15 YBL075C SSA3 hom ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSA3 has a paralog, SSA4, that arose from the whole genome duplication
0.132 2.03E-14 YOL077C BRX1 het Nucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif
0.124 6.64E-13 YHL032C GUT1 hom Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p
0.112 7.59E-11 YJR022W LSM8 het Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA
0.110 1.80E-10 YDL161W ENT1 hom Epsin-like protein involved in endocytosis and actin patch assembly; functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.108 3.80E-10 YNL304W YPT11 hom Rab family GTPase that interacts with the C-terminal tail domain of Myo2p; mediates distribution of mitochondria and endoplasmic reticuli to daughter cells
0.102 2.62E-9 YBR063C_p YBR063C_p hom Putative protein of unknown function; YBR063C is not an essential gene
0.096 2.40E-8 YAL004W_d YAL004W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene SSA1/YAL005C
0.091 1.17E-7 YDR453C TSA2 hom Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants; protein abundance increases in response to DNA replication stress
0.082 2.20E-6 YOR375C GDH1 hom NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources; GDH1 has a paralog, GDH3, that arose from the whole genome duplication
0.081 2.36E-6 YMR084W_p YMR084W_p hom Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1
0.081 2.64E-6 YPR071W_p YPR071W_p hom Putative membrane protein; YPR071W is not an essential gene; YPR071W has paralog YIL029C
0.079 4.73E-6 YFR048W RMD8 hom Cytosolic protein required for sporulation
0.077 7.06E-6 YBR130C SHE3 hom Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance
0.076 9.49E-6 YGL254W FZF1 hom Transcription factor involved in sulfite metabolism; sole identified regulatory target is SSU1; overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers; protein abundance increases in response to DNA replication stress