YOR107W / RGS2

Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR107W / RGS2

Click on Significant Values for Screen Details ID:SGTC_422|Compound:cantharidin|FD-Score:4.21|P-value:2.79E-5 ID:SGTC_517|Compound:1365-0151|FD-Score:-4.49|P-value:7.30E-6 ID:SGTC_748|Compound:0136-0228|FD-Score:3.46|P-value:4.69E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:4.33|P-value:1.68E-5 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.47|P-value:4.49E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:5.31|P-value:1.82E-7 ID:SGTC_1146|Compound:3579-1023|FD-Score:3.53|P-value:3.72E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.30|P-value:8.21E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.28|P-value:8.73E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:-3.37|P-value:5.55E-4 ID:SGTC_1431|Compound:4049-0260|FD-Score:3.79|P-value:1.45E-4 ID:SGTC_1458|Compound:k015-0034|FD-Score:3.32|P-value:7.50E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:4.81|P-value:2.11E-6 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.34|P-value:6.98E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.35|P-value:6.83E-4 ID:SGTC_1809|Compound:st050081|FD-Score:3.77|P-value:1.57E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:3.38|P-value:6.14E-4 ID:SGTC_2043|Compound:5101342|FD-Score:3.26|P-value:9.21E-4 ID:SGTC_2180|Compound:6301957|FD-Score:3.71|P-value:1.96E-4 ID:SGTC_2183|Compound:6420625|FD-Score:4.85|P-value:1.68E-6 ID:SGTC_2184|Compound:6075246|FD-Score:5.23|P-value:2.81E-7 ID:SGTC_2186|Compound:6124449|FD-Score:3.26|P-value:9.19E-4 ID:SGTC_2308|Compound:7584454|FD-Score:-3.25|P-value:8.51E-4 ID:SGTC_2319|Compound:6033012|FD-Score:4.57|P-value:6.23E-6 ID:SGTC_2332|Compound:7982454|FD-Score:3.37|P-value:6.48E-4 ID:SGTC_2425|Compound:5628681|FD-Score:3.41|P-value:5.50E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:3.36|P-value:6.51E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:-3.32|P-value:6.69E-4 ID:SGTC_2868|Compound:9035608|FD-Score:3.71|P-value:1.94E-4 ID:SGTC_2871|Compound:9038510|FD-Score:3.42|P-value:5.40E-4 ID:SGTC_2872|Compound:9044037|FD-Score:3.76|P-value:1.62E-4 ID:SGTC_2873|Compound:9040596|FD-Score:3.47|P-value:4.55E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:4.21|P-value:2.79E-5 ID:SGTC_517|Compound:1365-0151|FD-Score:-4.49|P-value:7.30E-6 ID:SGTC_748|Compound:0136-0228|FD-Score:3.46|P-value:4.69E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:4.33|P-value:1.68E-5 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.47|P-value:4.49E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:5.31|P-value:1.82E-7 ID:SGTC_1146|Compound:3579-1023|FD-Score:3.53|P-value:3.72E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.30|P-value:8.21E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.28|P-value:8.73E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:-3.37|P-value:5.55E-4 ID:SGTC_1431|Compound:4049-0260|FD-Score:3.79|P-value:1.45E-4 ID:SGTC_1458|Compound:k015-0034|FD-Score:3.32|P-value:7.50E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:4.81|P-value:2.11E-6 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.34|P-value:6.98E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.35|P-value:6.83E-4 ID:SGTC_1809|Compound:st050081|FD-Score:3.77|P-value:1.57E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:3.38|P-value:6.14E-4 ID:SGTC_2043|Compound:5101342|FD-Score:3.26|P-value:9.21E-4 ID:SGTC_2180|Compound:6301957|FD-Score:3.71|P-value:1.96E-4 ID:SGTC_2183|Compound:6420625|FD-Score:4.85|P-value:1.68E-6 ID:SGTC_2184|Compound:6075246|FD-Score:5.23|P-value:2.81E-7 ID:SGTC_2186|Compound:6124449|FD-Score:3.26|P-value:9.19E-4 ID:SGTC_2308|Compound:7584454|FD-Score:-3.25|P-value:8.51E-4 ID:SGTC_2319|Compound:6033012|FD-Score:4.57|P-value:6.23E-6 ID:SGTC_2332|Compound:7982454|FD-Score:3.37|P-value:6.48E-4 ID:SGTC_2425|Compound:5628681|FD-Score:3.41|P-value:5.50E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:3.36|P-value:6.51E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:-3.32|P-value:6.69E-4 ID:SGTC_2868|Compound:9035608|FD-Score:3.71|P-value:1.94E-4 ID:SGTC_2871|Compound:9038510|FD-Score:3.42|P-value:5.40E-4 ID:SGTC_2872|Compound:9044037|FD-Score:3.76|P-value:1.62E-4 ID:SGTC_2873|Compound:9040596|FD-Score:3.47|P-value:4.55E-4

Top fitness defect scores for YOR107W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1144 3486-0183 5.31 12.5 µM 1.82E-7 8 5.43E-8
2 SGTC_2184 6075246 5.23 200.0 µM 2.81E-7 8 8.68E-8
3 SGTC_2183 6420625 4.85 130.5 µM 1.68E-6 mitochondrial processes 32 6.04E-7
4 SGTC_1476 4112-3294 4.81 3.3 µM 2.11E-6 60S ribosome export 6 7.70E-7
5 SGTC_2319 6033012 4.57 152.6 µM 6.23E-6 tubulin folding & SWR complex 22 2.49E-6
6 SGTC_1038 k292-0204 4.33 154.0 µM 1.68E-5 10 7.31E-6
7 SGTC_422 cantharidin 4.21 155.0 µM 2.79E-5 cell wall signaling 49 1.27E-5
8 SGTC_1431 4049-0260 3.79 9.1 µM 1.45E-4 7 7.55E-5
9 SGTC_1809 st050081 3.77 57.6 µM 1.57E-4 17 8.21E-5
10 SGTC_2872 9044037 3.76 26.0 µM 1.62E-4 8 8.49E-5
11 SGTC_2868 9035608 3.71 32.5 µM 1.94E-4 20 1.03E-4
12 SGTC_2180 6301957 3.71 200.0 µM 1.96E-4 RSC complex & mRNA processing 12 1.04E-4
13 SGTC_1146 3579-1023 3.53 7.0 µM 3.72E-4 30 2.09E-4
14 SGTC_1121 fusaric acid 3.47 630.5 nM 4.49E-4 50 2.56E-4
15 SGTC_2873 9040596 3.47 71.4 µM 4.55E-4 68 2.60E-4
16 SGTC_748 0136-0228 3.46 77.9 µM 4.69E-4 redox potentiating 97 2.69E-4
17 SGTC_2871 9038510 3.42 13.0 µM 5.40E-4 38 3.13E-4
18 SGTC_2425 5628681 3.41 7.8 µM 5.50E-4 48 3.19E-4
19 SGTC_1880 MG-132 3.38 525.0 µM 6.14E-4 35 3.60E-4
20 SGTC_2332 7982454 3.37 138.9 µM 6.48E-4 82 3.81E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.134 6.86E-15 YPL004C LSP1 hom Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; member of the BAR domain family
0.097 1.98E-8 YDR334W SWR1 hom Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
0.095 3.23E-8 YDR374C_p YDR374C_p hom Putative protein of unknown function
0.095 3.15E-8 YOR215C AIM41 hom Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss
0.094 5.76E-8 YNL039W BDP1 het Essential subunit of RNA polymerase III transcription factor (TFIIIB), which is involved in transcription of genes encoding tRNAs, 5S rRNA, U6 snRNA, and other small RNAs
0.093 6.31E-8 YML041C VPS71 hom Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
0.092 8.70E-8 YOR225W_d YOR225W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.091 1.13E-7 YGR236C SPG1 hom Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.090 1.64E-7 YGR226C_d YGR226C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; overlaps significantly with a verified ORF, AMA1/YGR225W
0.089 2.22E-7 YMR127C SAS2 hom Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family
0.089 2.58E-7 YBR231C SWC5 hom Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress
0.087 4.68E-7 YKL221W MCH2 hom Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
0.084 9.55E-7 YDL029W ARP2 het Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity
0.084 1.06E-6 YNL328C MDJ2 hom Constituent of the mitochondrial import motor associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain
0.083 1.28E-6 YKL013C ARC19 het Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches