YOR111W_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR111W / YOR111W

Click on Significant Values for Screen Details ID:SGTC_398|Compound:bronopol|FD-Score:2.91|P-value:9.88E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:3.02|P-value:6.83E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.25|P-value:2.83E-4 ID:SGTC_458|Compound:nppb|FD-Score:3.00|P-value:7.14E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:3.69|P-value:4.63E-5 ID:SGTC_928|Compound:2764-0428|FD-Score:3.16|P-value:4.00E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.02|P-value:6.78E-4 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.37|P-value:1.73E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.13|P-value:4.42E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:3.99|P-value:1.20E-5 ID:SGTC_1403|Compound:3909-7815|FD-Score:-3.19|P-value:4.13E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:-3.30|P-value:2.74E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:-3.03|P-value:7.57E-4 ID:SGTC_1668|Compound:st014914|FD-Score:-3.10|P-value:5.78E-4 ID:SGTC_1889|Compound:st059080|FD-Score:5.42|P-value:4.71E-9 ID:SGTC_1904|Compound:st060225|FD-Score:3.37|P-value:1.73E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.24|P-value:3.48E-4 ID:SGTC_1952|Compound:st077036|FD-Score:-2.98|P-value:8.87E-4 ID:SGTC_2018|Compound:5133068|FD-Score:2.99|P-value:7.46E-4 ID:SGTC_2040|Compound:5100729|FD-Score:3.13|P-value:4.43E-4 ID:SGTC_2258|Compound:7960471|FD-Score:3.02|P-value:6.74E-4 ID:SGTC_2294|Compound:7971431|FD-Score:4.68|P-value:3.61E-7 ID:SGTC_2445|Compound:5742597|FD-Score:-3.18|P-value:4.30E-4 ID:SGTC_2448|Compound:5185112|FD-Score:3.30|P-value:2.36E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.38|P-value:1.67E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:-2.96|P-value:9.75E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.90|P-value:1.79E-5 ID:SGTC_2786|Compound:7743617|FD-Score:4.20|P-value:4.34E-6 ID:SGTC_3182|Compound:9108849|FD-Score:3.07|P-value:5.67E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-3.14|P-value:5.04E-4 ID:SGTC_3264|Compound:9137442|FD-Score:3.86|P-value:2.14E-5 ID:SGTC_3269|Compound:9137823|FD-Score:-3.53|P-value:1.08E-4 ID:SGTC_3298|Compound:9116858|FD-Score:3.19|P-value:3.52E-4 ID:SGTC_398|Compound:bronopol|FD-Score:2.91|P-value:9.88E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:3.02|P-value:6.83E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.25|P-value:2.83E-4 ID:SGTC_458|Compound:nppb|FD-Score:3.00|P-value:7.14E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:3.69|P-value:4.63E-5 ID:SGTC_928|Compound:2764-0428|FD-Score:3.16|P-value:4.00E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.02|P-value:6.78E-4 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.37|P-value:1.73E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.13|P-value:4.42E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:3.99|P-value:1.20E-5 ID:SGTC_1403|Compound:3909-7815|FD-Score:-3.19|P-value:4.13E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:-3.30|P-value:2.74E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:-3.03|P-value:7.57E-4 ID:SGTC_1668|Compound:st014914|FD-Score:-3.10|P-value:5.78E-4 ID:SGTC_1889|Compound:st059080|FD-Score:5.42|P-value:4.71E-9 ID:SGTC_1904|Compound:st060225|FD-Score:3.37|P-value:1.73E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.24|P-value:3.48E-4 ID:SGTC_1952|Compound:st077036|FD-Score:-2.98|P-value:8.87E-4 ID:SGTC_2018|Compound:5133068|FD-Score:2.99|P-value:7.46E-4 ID:SGTC_2040|Compound:5100729|FD-Score:3.13|P-value:4.43E-4 ID:SGTC_2258|Compound:7960471|FD-Score:3.02|P-value:6.74E-4 ID:SGTC_2294|Compound:7971431|FD-Score:4.68|P-value:3.61E-7 ID:SGTC_2445|Compound:5742597|FD-Score:-3.18|P-value:4.30E-4 ID:SGTC_2448|Compound:5185112|FD-Score:3.30|P-value:2.36E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.38|P-value:1.67E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:-2.96|P-value:9.75E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.90|P-value:1.79E-5 ID:SGTC_2786|Compound:7743617|FD-Score:4.20|P-value:4.34E-6 ID:SGTC_3182|Compound:9108849|FD-Score:3.07|P-value:5.67E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-3.14|P-value:5.04E-4 ID:SGTC_3264|Compound:9137442|FD-Score:3.86|P-value:2.14E-5 ID:SGTC_3269|Compound:9137823|FD-Score:-3.53|P-value:1.08E-4 ID:SGTC_3298|Compound:9116858|FD-Score:3.19|P-value:3.52E-4

Top fitness defect scores for YOR111W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1889 st059080 5.42 5.2 µM 4.71E-9 2 2.91E-8
2 SGTC_2294 7971431 4.68 200.0 µM 3.61E-7 6 1.44E-6
3 SGTC_2786 7743617 4.20 45.5 µM 4.34E-6 22 1.35E-5
4 SGTC_1320 1313-0481 3.99 95.3 µM 1.20E-5 21 3.35E-5
5 SGTC_2621 lithochol-11-enic acid 3.90 100.0 µM 1.79E-5 24 4.81E-5
6 SGTC_3264 9137442 3.86 49.5 µM 2.14E-5 16 5.65E-5
7 SGTC_927 2425-1185 3.69 123.0 µM 4.63E-5 34 1.13E-4
8 SGTC_2546 rhodinyl acetate 3.38 100.0 µM 1.67E-4 25 3.59E-4
9 SGTC_1289 0976-0073 3.37 69.1 µM 1.73E-4 23 3.71E-4
10 SGTC_1904 st060225 3.37 78.0 µM 1.73E-4 36 3.72E-4
11 SGTC_2448 5185112 3.30 27.2 µM 2.36E-4 25 4.91E-4
12 SGTC_410 α-linolenic acid 3.25 100.0 µM 2.83E-4 excess fatty acid 59 5.78E-4
13 SGTC_3298 9116858 3.19 71.4 µM 3.52E-4 33 7.05E-4
14 SGTC_928 2764-0428 3.16 58.7 µM 4.00E-4 cell wall 99 7.90E-4
15 SGTC_1308 1187-1617 3.13 41.4 µM 4.42E-4 fatty acid desaturase (OLE1) 88 8.65E-4
16 SGTC_2040 5100729 3.13 123.0 µM 4.43E-4 67 8.66E-4
17 SGTC_3182 9108849 3.07 49.5 µM 5.67E-4 RPP1 & pyrimidine depletion 39 0.00108
18 SGTC_2258 7960471 3.02 200.0 µM 6.74E-4 42 0.00126
19 SGTC_1287 0971-0001 3.02 34.6 µM 6.78E-4 sphingolipid biosynthesis & PDR1 91 0.00127
20 SGTC_403 arphamenine a 3.02 50.0 µM 6.83E-4 60S ribosome export 52 0.00128

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.114 3.48E-11 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.108 2.97E-10 YMR147W_p YMR147W_p hom Putative protein of unknown function
0.103 2.19E-9 YAR027W UIP3 hom Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family
0.101 5.12E-9 YOR301W RAX1 hom Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily
0.100 5.49E-9 YMR041C ARA2 hom NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase
0.099 9.82E-9 YGR097W ASK10 hom Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication
0.096 2.74E-8 YOR119C RIO1 het Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA
0.095 3.33E-8 YKL220C FRE2 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
0.093 6.23E-8 YGL115W SNF4 hom Activating gamma subunit of the AMP-activated Snf1p kinase complex; additional subunits of the complex are Snf1p and a Sip1p/Sip2p/Gal83p family member; activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis; protein abundance increases in response to DNA replication stress
0.090 1.72E-7 YOR315W SFG1 hom Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate
0.088 2.84E-7 YHR035W_p YHR035W_p hom Putative protein of unknown function; not an essential gene
0.087 4.48E-7 YER024W YAT2 hom Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane
0.086 5.62E-7 YJL211C_d YJL211C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL210W/PEX2
0.084 1.06E-6 YGR199W PMT6 hom Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases
0.080 3.86E-6 YBR216C YBP1 hom Protein involved in cellular response to oxidative stress; required for oxidation of specific cysteine residues of transcription factor Yap1p, resulting in nuclear localization of Yap1p in response to stress; YBP1 has a paralog, YBP2, that arose from the whole genome duplication