YOR130C / ORT1

Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR130C / ORT1

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:3.10|P-value:3.63E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:6.70|P-value:1.35E-13 ID:SGTC_285|Compound:1486-1325|FD-Score:4.75|P-value:1.07E-7 ID:SGTC_296|Compound:1222-0039|FD-Score:-2.89|P-value:7.95E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:-3.12|P-value:3.18E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:-2.90|P-value:7.52E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:2.89|P-value:8.05E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:4.41|P-value:7.77E-7 ID:SGTC_370|Compound:0180-0345|FD-Score:6.05|P-value:2.05E-11 ID:SGTC_380|Compound:3970-0968|FD-Score:3.34|P-value:1.38E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.25|P-value:1.87E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.00|P-value:5.36E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:4.86|P-value:5.67E-8 ID:SGTC_522|Compound:1273-0010|FD-Score:3.36|P-value:1.26E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:4.78|P-value:9.38E-8 ID:SGTC_685|Compound:1278-0033|FD-Score:3.58|P-value:4.77E-5 ID:SGTC_799|Compound:1310-0557|FD-Score:-3.18|P-value:2.47E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.49|P-value:7.16E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:-2.86|P-value:8.60E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:2.90|P-value:7.93E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:-2.89|P-value:7.73E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:-4.33|P-value:1.11E-6 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.52|P-value:6.09E-5 ID:SGTC_1364|Compound:1653-0028|FD-Score:2.85|P-value:9.36E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.26|P-value:1.87E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:2.93|P-value:7.10E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:-4.12|P-value:3.35E-6 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.11|P-value:3.51E-4 ID:SGTC_1689|Compound:st020265|FD-Score:-3.20|P-value:2.36E-4 ID:SGTC_1708|Compound:st033234|FD-Score:3.20|P-value:2.45E-4 ID:SGTC_1710|Compound:st031758|FD-Score:2.89|P-value:8.07E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.54|P-value:5.67E-5 ID:SGTC_1750|Compound:st081859|FD-Score:3.72|P-value:2.44E-5 ID:SGTC_1751|Compound:st044839|FD-Score:3.49|P-value:7.23E-5 ID:SGTC_2034|Compound:5197015|FD-Score:3.07|P-value:4.03E-4 ID:SGTC_2084|Compound:5306078|FD-Score:3.25|P-value:1.98E-4 ID:SGTC_2114|Compound:5491910|FD-Score:3.07|P-value:4.03E-4 ID:SGTC_2290|Compound:7904846|FD-Score:-3.37|P-value:1.12E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.57|P-value:4.95E-5 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:2.86|P-value:9.15E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.95|P-value:8.11E-6 ID:SGTC_2815|Compound:7968870|FD-Score:-3.49|P-value:6.84E-5 ID:SGTC_2825|Compound:7998094|FD-Score:3.82|P-value:1.53E-5 ID:SGTC_2864|Compound:9034755|FD-Score:-4.30|P-value:1.30E-6 ID:SGTC_2893|Compound:9048488|FD-Score:3.05|P-value:4.48E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-4.06|P-value:4.52E-6 ID:SGTC_2988|Compound:9073640|FD-Score:-2.87|P-value:8.46E-4 ID:SGTC_2996|Compound:9066192|FD-Score:-4.62|P-value:2.22E-7 ID:SGTC_2999|Compound:9069765|FD-Score:-3.00|P-value:5.22E-4 ID:SGTC_3014|Compound:9081533|FD-Score:3.39|P-value:1.12E-4 ID:SGTC_3016|Compound:9080866|FD-Score:3.28|P-value:1.71E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.33|P-value:1.39E-4 ID:SGTC_3293|Compound:9120939|FD-Score:3.85|P-value:1.32E-5 ID:SGTC_38|Compound:0929-0051|FD-Score:3.10|P-value:3.63E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:6.70|P-value:1.35E-13 ID:SGTC_285|Compound:1486-1325|FD-Score:4.75|P-value:1.07E-7 ID:SGTC_296|Compound:1222-0039|FD-Score:-2.89|P-value:7.95E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:-3.12|P-value:3.18E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:-2.90|P-value:7.52E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:2.89|P-value:8.05E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:4.41|P-value:7.77E-7 ID:SGTC_370|Compound:0180-0345|FD-Score:6.05|P-value:2.05E-11 ID:SGTC_380|Compound:3970-0968|FD-Score:3.34|P-value:1.38E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.25|P-value:1.87E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.00|P-value:5.36E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:4.86|P-value:5.67E-8 ID:SGTC_522|Compound:1273-0010|FD-Score:3.36|P-value:1.26E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:4.78|P-value:9.38E-8 ID:SGTC_685|Compound:1278-0033|FD-Score:3.58|P-value:4.77E-5 ID:SGTC_799|Compound:1310-0557|FD-Score:-3.18|P-value:2.47E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.49|P-value:7.16E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:-2.86|P-value:8.60E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:2.90|P-value:7.93E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:-2.89|P-value:7.73E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:-4.33|P-value:1.11E-6 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.52|P-value:6.09E-5 ID:SGTC_1364|Compound:1653-0028|FD-Score:2.85|P-value:9.36E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.26|P-value:1.87E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:2.93|P-value:7.10E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:-4.12|P-value:3.35E-6 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.11|P-value:3.51E-4 ID:SGTC_1689|Compound:st020265|FD-Score:-3.20|P-value:2.36E-4 ID:SGTC_1708|Compound:st033234|FD-Score:3.20|P-value:2.45E-4 ID:SGTC_1710|Compound:st031758|FD-Score:2.89|P-value:8.07E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.54|P-value:5.67E-5 ID:SGTC_1750|Compound:st081859|FD-Score:3.72|P-value:2.44E-5 ID:SGTC_1751|Compound:st044839|FD-Score:3.49|P-value:7.23E-5 ID:SGTC_2034|Compound:5197015|FD-Score:3.07|P-value:4.03E-4 ID:SGTC_2084|Compound:5306078|FD-Score:3.25|P-value:1.98E-4 ID:SGTC_2114|Compound:5491910|FD-Score:3.07|P-value:4.03E-4 ID:SGTC_2290|Compound:7904846|FD-Score:-3.37|P-value:1.12E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.57|P-value:4.95E-5 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:2.86|P-value:9.15E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.95|P-value:8.11E-6 ID:SGTC_2815|Compound:7968870|FD-Score:-3.49|P-value:6.84E-5 ID:SGTC_2825|Compound:7998094|FD-Score:3.82|P-value:1.53E-5 ID:SGTC_2864|Compound:9034755|FD-Score:-4.30|P-value:1.30E-6 ID:SGTC_2893|Compound:9048488|FD-Score:3.05|P-value:4.48E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-4.06|P-value:4.52E-6 ID:SGTC_2988|Compound:9073640|FD-Score:-2.87|P-value:8.46E-4 ID:SGTC_2996|Compound:9066192|FD-Score:-4.62|P-value:2.22E-7 ID:SGTC_2999|Compound:9069765|FD-Score:-3.00|P-value:5.22E-4 ID:SGTC_3014|Compound:9081533|FD-Score:3.39|P-value:1.12E-4 ID:SGTC_3016|Compound:9080866|FD-Score:3.28|P-value:1.71E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.33|P-value:1.39E-4 ID:SGTC_3293|Compound:9120939|FD-Score:3.85|P-value:1.32E-5

Top fitness defect scores for YOR130C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_54 0159-0055 6.70 9.0 µM 1.35E-13 ERG2 18 1.06E-11
2 SGTC_370 0180-0345 6.05 38.7 µM 2.05E-11 DNA intercalators 3 7.24E-10
3 SGTC_516 3992-2719 4.86 87.3 µM 5.67E-8 9 5.79E-7
4 SGTC_530 4358-1714 4.78 28.0 µM 9.38E-8 21 8.87E-7
5 SGTC_285 1486-1325 4.75 46.0 µM 1.07E-7 15 9.94E-7
6 SGTC_369 0957-0393 4.41 4.5 µM 7.77E-7 cell wall signaling 15 5.29E-6
7 SGTC_2758 dehydroepiandrosterone 3.95 69.3 µM 8.11E-6 37 3.84E-5
8 SGTC_3293 9120939 3.85 62.0 µM 1.32E-5 23 5.80E-5
9 SGTC_2825 7998094 3.82 58.4 µM 1.53E-5 fatty acid desaturase (OLE1) 36 6.57E-5
10 SGTC_1750 st081859 3.72 2.4 µM 2.44E-5 endomembrane recycling 207 9.77E-5
11 SGTC_685 1278-0033 3.58 54.9 µM 4.77E-5 60S ribosome export 35 1.72E-4
12 SGTC_2393 9031399 3.57 185.9 µM 4.95E-5 RNA processing & uracil transport 42 1.78E-4
13 SGTC_1717 st033143 3.54 58.0 µM 5.67E-5 62 2.00E-4
14 SGTC_1175 0741-0056 3.52 27.6 µM 6.09E-5 37 2.12E-4
15 SGTC_913 3487-1245 3.49 167.0 µM 7.16E-5 48 2.43E-4
16 SGTC_1751 st044839 3.49 27.2 µM 7.23E-5 Golgi 18 2.45E-4
17 SGTC_3014 9081533 3.39 49.5 µM 1.12E-4 19 3.55E-4
18 SGTC_522 1273-0010 3.36 11.6 µM 1.26E-4 60S ribosome export 41 3.94E-4
19 SGTC_380 3970-0968 3.34 6.0 µM 1.38E-4 30 4.25E-4
20 SGTC_3211 9128781 3.33 49.5 µM 1.39E-4 98 4.27E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.242 6.43E-46 YOL140W ARG8 hom Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine
0.215 1.77E-36 YER069W ARG5,6 hom Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine
0.197 1.59E-30 YJL088W ARG3 hom Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine
0.158 3.54E-20 YOL058W ARG1 hom Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate
0.120 3.59E-12 YHR018C ARG4 hom Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway
0.117 1.23E-11 YOR303W CPA1 hom Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader
0.113 5.70E-11 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.108 3.34E-10 YEL009C GCN4 hom Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
0.101 4.60E-9 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.101 5.37E-9 YPR153W YPR153W hom Putative protein of unknown function
0.097 2.04E-8 YCL046W_d YCL046W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YCL045C
0.097 2.10E-8 YLR401C DUS3 hom Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress
0.093 6.51E-8 YGR153W_p YGR153W_p hom Putative protein of unknown function
0.093 6.64E-8 YIL145C PAN6 hom Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC
0.092 1.09E-7 YML072C TCB3 hom Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact