HIPHOP chemogenomics database
YOR136W / IDH2 
Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YOR136W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.131 | 2.27E-14 | YDL140C | RPO21 | het | RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime |
| 0.120 | 3.68E-12 | YOL129W | VPS68 | hom | Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria |
| 0.104 | 1.65E-9 | YJL082W | IML2 | hom | Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; IML2 has a paralog, YKR018C, that arose from the whole genome duplication |
| 0.103 | 2.12E-9 | YOR329C | SCD5 | het | Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency |
| 0.100 | 5.99E-9 | YOR291W | YPK9 | hom | Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome |
| 0.098 | 1.37E-8 | YJR017C | ESS1 | het | Peptidylprolyl-cis/trans-isomerase (PPIase); specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNAP II large subunit (Rpo21p) C-terminal domain (CTD); associates with phospho-Ser5 form of RNAP II in vivo; regulates phosphorylation of Ser7 within CTD; present along entire coding length of genes; represses initiation of CUTs; required for efficient termination of mRNA transcription and trimethylation of histone H3 |
| 0.091 | 1.10E-7 | YDL163W_d | YDL163W_d | het | Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene CDC9/YDL164C encoding DNA ligase |
| 0.090 | 1.57E-7 | YHL032C | GUT1 | hom | Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p |
| 0.088 | 3.03E-7 | YMR229C | RRP5 | het | RNA binding protein involved in synthesis of both 18S and 5.8S rRNAs; component of both the ribosomal small subunit (SSU) processosome and the 90S preribosome; has binding preference for single stranded tracts of U's; relocalizes from nucleolus to nucleus upon DNA replication stress |
| 0.085 | 9.29E-7 | YJR115W_p | YJR115W_p | hom | Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication |
| 0.082 | 2.00E-6 | YML030W | RCF1 | hom | Cytochrome c oxidase subunit; required for assembly of the Complex III-Complex IV supercomplex, and for assembly of Cox13p and Rcf2p into cytochrome c oxidase; similar to Rcf2p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; required for growth under hypoxic conditions; member of the hypoxia induced gene family; C. elegans and human orthologs are functional in yeast |
| 0.080 | 3.31E-6 | YKL078W | DHR2 | het | Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis |
| 0.080 | 3.50E-6 | YOR373W | NUD1 | het | Component of the spindle pole body outer plaque; acts through the mitotic exit network to specify asymmetric spindle pole body inheritance |
| 0.080 | 3.82E-6 | YOR149C | SMP3 | het | Alpha 1,2-mannosyltransferase involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure |
| 0.080 | 3.88E-6 | YBR215W | HPC2 | hom | Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; mutants display synthetic defects with subunits of FACT, a complex that allows passage of RNA Pol II through nucleosomes |