YOR144C / ELG1

Subunit of an alternative replication factor C complex important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis; required for PCNA (Pol30p) unloading during DNA replication

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR144C / ELG1

Click on Significant Values for Screen Details ID:SGTC_142|Compound:0335-0849|FD-Score:4.39|P-value:3.46E-6 ID:SGTC_158|Compound:k038-0087|FD-Score:4.69|P-value:7.66E-7 ID:SGTC_248|Compound:streptozotocin|FD-Score:3.22|P-value:4.82E-4 ID:SGTC_271|Compound:rotenone|FD-Score:3.31|P-value:3.41E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:3.57|P-value:1.23E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:3.29|P-value:3.74E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:3.15|P-value:6.19E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:3.13|P-value:6.54E-4 ID:SGTC_587|Compound:k089-0003|FD-Score:-3.09|P-value:8.16E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:3.08|P-value:7.99E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:-3.46|P-value:2.04E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:3.39|P-value:2.57E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:3.14|P-value:6.30E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:3.13|P-value:6.59E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:-3.57|P-value:1.34E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.25|P-value:4.34E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.40|P-value:2.41E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:4.47|P-value:2.29E-6 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.59|P-value:1.17E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.94|P-value:2.69E-5 ID:SGTC_1522|Compound:st012842|FD-Score:3.47|P-value:1.90E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:6.02|P-value:3.58E-10 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.53|P-value:1.50E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.60|P-value:1.10E-4 ID:SGTC_1854|Compound:st056233|FD-Score:-3.07|P-value:8.73E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.37|P-value:2.76E-4 ID:SGTC_1936|Compound:st074407|FD-Score:4.89|P-value:2.64E-7 ID:SGTC_1987|Compound:st072290|FD-Score:3.38|P-value:2.64E-4 ID:SGTC_2008|Compound:4012253|FD-Score:3.32|P-value:3.37E-4 ID:SGTC_2033|Compound:5192550|FD-Score:5.55|P-value:6.44E-9 ID:SGTC_2037|Compound:5169046|FD-Score:-4.21|P-value:8.34E-6 ID:SGTC_2038|Compound:4100038|FD-Score:3.16|P-value:5.92E-4 ID:SGTC_2040|Compound:5100729|FD-Score:4.53|P-value:1.74E-6 ID:SGTC_2116|Compound:5511452|FD-Score:3.45|P-value:2.04E-4 ID:SGTC_2241|Compound:6772625|FD-Score:4.02|P-value:1.89E-5 ID:SGTC_2268|Compound:7933382|FD-Score:3.36|P-value:2.83E-4 ID:SGTC_2299|Compound:7976368|FD-Score:-3.15|P-value:6.62E-4 ID:SGTC_2300|Compound:7976697|FD-Score:-3.05|P-value:9.22E-4 ID:SGTC_2322|Compound:7413319|FD-Score:-3.69|P-value:8.20E-5 ID:SGTC_2348|Compound:9022543|FD-Score:3.28|P-value:3.86E-4 ID:SGTC_2511|Compound:berberine|FD-Score:3.21|P-value:4.91E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:4.35|P-value:4.16E-6 ID:SGTC_2687|Compound:chenodiol|FD-Score:4.31|P-value:5.08E-6 ID:SGTC_2698|Compound:st077697|FD-Score:-3.20|P-value:5.41E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:-3.42|P-value:2.44E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:-3.44|P-value:2.18E-4 ID:SGTC_2784|Compound:7567673|FD-Score:3.98|P-value:2.27E-5 ID:SGTC_2862|Compound:9027634|FD-Score:3.86|P-value:3.84E-5 ID:SGTC_2884|Compound:9058502|FD-Score:3.90|P-value:3.20E-5 ID:SGTC_2888|Compound:9058547|FD-Score:3.67|P-value:8.30E-5 ID:SGTC_2908|Compound:7930301|FD-Score:3.38|P-value:2.68E-4 ID:SGTC_2936|Compound:9038235|FD-Score:3.69|P-value:7.72E-5 ID:SGTC_2941|Compound:9056145|FD-Score:-5.71|P-value:2.76E-9 ID:SGTC_2943|Compound:9068529|FD-Score:3.72|P-value:6.86E-5 ID:SGTC_2944|Compound:9067346|FD-Score:6.94|P-value:6.07E-13 ID:SGTC_2950|Compound:9072895|FD-Score:4.84|P-value:3.57E-7 ID:SGTC_2953|Compound:9074162|FD-Score:-5.34|P-value:2.39E-8 ID:SGTC_3153|Compound:9100258|FD-Score:5.16|P-value:6.34E-8 ID:SGTC_3154|Compound:9100113|FD-Score:3.23|P-value:4.65E-4 ID:SGTC_3155|Compound:9099265|FD-Score:3.09|P-value:7.71E-4 ID:SGTC_3221|Compound:9128209|FD-Score:3.17|P-value:5.68E-4 ID:SGTC_3254|Compound:9136651|FD-Score:3.02|P-value:9.83E-4 ID:SGTC_3348|Compound:9149464|FD-Score:3.97|P-value:2.39E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:4.39|P-value:3.46E-6 ID:SGTC_158|Compound:k038-0087|FD-Score:4.69|P-value:7.66E-7 ID:SGTC_248|Compound:streptozotocin|FD-Score:3.22|P-value:4.82E-4 ID:SGTC_271|Compound:rotenone|FD-Score:3.31|P-value:3.41E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:3.57|P-value:1.23E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:3.29|P-value:3.74E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:3.15|P-value:6.19E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:3.13|P-value:6.54E-4 ID:SGTC_587|Compound:k089-0003|FD-Score:-3.09|P-value:8.16E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:3.08|P-value:7.99E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:-3.46|P-value:2.04E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:3.39|P-value:2.57E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:3.14|P-value:6.30E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:3.13|P-value:6.59E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:-3.57|P-value:1.34E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.25|P-value:4.34E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.40|P-value:2.41E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:4.47|P-value:2.29E-6 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.59|P-value:1.17E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.94|P-value:2.69E-5 ID:SGTC_1522|Compound:st012842|FD-Score:3.47|P-value:1.90E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:6.02|P-value:3.58E-10 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.53|P-value:1.50E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.60|P-value:1.10E-4 ID:SGTC_1854|Compound:st056233|FD-Score:-3.07|P-value:8.73E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.37|P-value:2.76E-4 ID:SGTC_1936|Compound:st074407|FD-Score:4.89|P-value:2.64E-7 ID:SGTC_1987|Compound:st072290|FD-Score:3.38|P-value:2.64E-4 ID:SGTC_2008|Compound:4012253|FD-Score:3.32|P-value:3.37E-4 ID:SGTC_2033|Compound:5192550|FD-Score:5.55|P-value:6.44E-9 ID:SGTC_2037|Compound:5169046|FD-Score:-4.21|P-value:8.34E-6 ID:SGTC_2038|Compound:4100038|FD-Score:3.16|P-value:5.92E-4 ID:SGTC_2040|Compound:5100729|FD-Score:4.53|P-value:1.74E-6 ID:SGTC_2116|Compound:5511452|FD-Score:3.45|P-value:2.04E-4 ID:SGTC_2241|Compound:6772625|FD-Score:4.02|P-value:1.89E-5 ID:SGTC_2268|Compound:7933382|FD-Score:3.36|P-value:2.83E-4 ID:SGTC_2299|Compound:7976368|FD-Score:-3.15|P-value:6.62E-4 ID:SGTC_2300|Compound:7976697|FD-Score:-3.05|P-value:9.22E-4 ID:SGTC_2322|Compound:7413319|FD-Score:-3.69|P-value:8.20E-5 ID:SGTC_2348|Compound:9022543|FD-Score:3.28|P-value:3.86E-4 ID:SGTC_2511|Compound:berberine|FD-Score:3.21|P-value:4.91E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:4.35|P-value:4.16E-6 ID:SGTC_2687|Compound:chenodiol|FD-Score:4.31|P-value:5.08E-6 ID:SGTC_2698|Compound:st077697|FD-Score:-3.20|P-value:5.41E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:-3.42|P-value:2.44E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:-3.44|P-value:2.18E-4 ID:SGTC_2784|Compound:7567673|FD-Score:3.98|P-value:2.27E-5 ID:SGTC_2862|Compound:9027634|FD-Score:3.86|P-value:3.84E-5 ID:SGTC_2884|Compound:9058502|FD-Score:3.90|P-value:3.20E-5 ID:SGTC_2888|Compound:9058547|FD-Score:3.67|P-value:8.30E-5 ID:SGTC_2908|Compound:7930301|FD-Score:3.38|P-value:2.68E-4 ID:SGTC_2936|Compound:9038235|FD-Score:3.69|P-value:7.72E-5 ID:SGTC_2941|Compound:9056145|FD-Score:-5.71|P-value:2.76E-9 ID:SGTC_2943|Compound:9068529|FD-Score:3.72|P-value:6.86E-5 ID:SGTC_2944|Compound:9067346|FD-Score:6.94|P-value:6.07E-13 ID:SGTC_2950|Compound:9072895|FD-Score:4.84|P-value:3.57E-7 ID:SGTC_2953|Compound:9074162|FD-Score:-5.34|P-value:2.39E-8 ID:SGTC_3153|Compound:9100258|FD-Score:5.16|P-value:6.34E-8 ID:SGTC_3154|Compound:9100113|FD-Score:3.23|P-value:4.65E-4 ID:SGTC_3155|Compound:9099265|FD-Score:3.09|P-value:7.71E-4 ID:SGTC_3221|Compound:9128209|FD-Score:3.17|P-value:5.68E-4 ID:SGTC_3254|Compound:9136651|FD-Score:3.02|P-value:9.83E-4 ID:SGTC_3348|Compound:9149464|FD-Score:3.97|P-value:2.39E-5

Top fitness defect scores for YOR144C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2944 9067346 6.94 25.6 µM 6.07E-13 2 2.03E-12
2 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 6.02 66.5 µM 3.58E-10 3 8.98E-10
3 SGTC_2033 5192550 5.55 145.0 µM 6.44E-9 2 1.42E-8
4 SGTC_3153 9100258 5.16 49.5 µM 6.34E-8 4 1.26E-7
5 SGTC_1936 st074407 4.89 74.3 µM 2.64E-7 DNA damage response 14 4.92E-7
6 SGTC_2950 9072895 4.84 21.5 µM 3.57E-7 19 6.57E-7
7 SGTC_158 k038-0087 4.69 26.4 µM 7.66E-7 ubiquinone biosynthesis & proteasome 100 1.36E-6
8 SGTC_2040 5100729 4.53 123.0 µM 1.74E-6 30 2.98E-6
9 SGTC_1080 nisoldipine 4.47 24.4 µM 2.29E-6 TSC3-RPN4 16 3.88E-6
10 SGTC_142 0335-0849 4.39 62.7 µM 3.46E-6 ubiquinone biosynthesis & proteasome 105 5.75E-6
11 SGTC_2596 sinensetin 4.35 100.0 µM 4.16E-6 21 6.86E-6
12 SGTC_2687 chenodiol 4.31 100.0 µM 5.08E-6 16 8.31E-6
13 SGTC_2241 6772625 4.02 37.8 µM 1.89E-5 23 2.91E-5
14 SGTC_2784 7567673 3.98 72.7 µM 2.27E-5 iron homeostasis 29 3.48E-5
15 SGTC_3348 9149464 3.97 3.5 µM 2.39E-5 12 3.64E-5
16 SGTC_1271 0832-2808 3.94 169.0 µM 2.69E-5 12 4.08E-5
17 SGTC_2884 9058502 3.90 52.0 µM 3.20E-5 31 4.81E-5
18 SGTC_2862 9027634 3.86 71.4 µM 3.84E-5 ERG2 33 5.74E-5
19 SGTC_2943 9068529 3.72 45.3 µM 6.86E-5 23 9.99E-5
20 SGTC_2936 9038235 3.69 15.6 µM 7.72E-5 29 1.12E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.117 1.24E-11 YDL140C RPO21 het RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
0.113 4.57E-11 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.110 1.52E-10 YPL166W ATG29 hom Autophagy-specific protein; required for recruiting other ATG proteins to the pre-autophagosomal structure (PAS); interacts with Atg17p and localizas to the PAS in a manner interdependent with Atg17p and Cis1p; not conserved; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.098 1.38E-8 YNL311C SKP2 hom F-box protein of unknown function predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, based on co-purification experiments
0.096 2.37E-8 YBR270C_p BIT2_p hom Subunit of TORC2 membrane-associated complex; involved in regulation of actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; BIT2 has a paralog, BIT61, that arose from the whole genome duplication
0.093 6.02E-8 YMR017W SPO20 hom Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
0.093 7.40E-8 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.091 1.46E-7 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.090 1.70E-7 YLR262C-A TMA7 hom Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; protein abundance increases in response to DNA replication stress
0.089 2.16E-7 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.088 3.75E-7 YNR074C AIF1 hom Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase
0.087 4.25E-7 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.086 5.64E-7 YKL057C NUP120 hom Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP160
0.086 6.57E-7 YBR057C MUM2 hom Cytoplasmic protein essential for meiotic DNA replication and sporulation; interacts with Orc2p, which is a component of the origin recognition complex
0.084 1.12E-6 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data