YOR154W_p / SLP1

Glycosylated integral ER membrane protein of unknown function; forms an ER-membrane associated protein complex with Emp65p; member of the SUN-like family of proteins; genetic interactions suggest a role in folding of ER membrane proteins; required for nuclear envelope localization of Mps3p

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR154W / SLP1

Click on Significant Values for Screen Details ID:SGTC_69|Compound:0096-0274|FD-Score:3.87|P-value:7.86E-6 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.86|P-value:1.03E-5 ID:SGTC_78|Compound:0336-0123|FD-Score:-4.16|P-value:2.18E-6 ID:SGTC_129|Compound:0088-0017|FD-Score:-3.57|P-value:4.13E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:2.89|P-value:6.19E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:3.83|P-value:9.58E-6 ID:SGTC_252|Compound:miconazole|FD-Score:-3.43|P-value:7.77E-5 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.27|P-value:1.53E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:2.81|P-value:8.14E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:3.98|P-value:4.36E-6 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:4.47|P-value:3.00E-7 ID:SGTC_445|Compound:e6 berbamine|FD-Score:-2.82|P-value:9.40E-4 ID:SGTC_446|Compound:go6976|FD-Score:3.40|P-value:7.24E-5 ID:SGTC_450|Compound:aminopyrene|FD-Score:4.02|P-value:3.58E-6 ID:SGTC_865|Compound:0488-0499|FD-Score:3.60|P-value:2.93E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:3.83|P-value:9.54E-6 ID:SGTC_911|Compound:3456-4043|FD-Score:2.78|P-value:9.43E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:3.05|P-value:3.25E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.91|P-value:6.22E-6 ID:SGTC_1326|Compound:1431-2094|FD-Score:-3.03|P-value:4.23E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:4.42|P-value:3.96E-7 ID:SGTC_1342|Compound:1486-1464|FD-Score:-4.57|P-value:2.15E-7 ID:SGTC_1343|Compound:1487-0095|FD-Score:3.49|P-value:4.81E-5 ID:SGTC_1396|Compound:3511-0007|FD-Score:-2.84|P-value:8.68E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:2.83|P-value:7.80E-4 ID:SGTC_1487|Compound:3970-0795|FD-Score:3.27|P-value:1.26E-4 ID:SGTC_1530|Compound:rhein|FD-Score:2.77|P-value:9.63E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.43|P-value:6.34E-5 ID:SGTC_1573|Compound:oleylamine|FD-Score:2.80|P-value:8.74E-4 ID:SGTC_1770|Compound:st043884|FD-Score:3.93|P-value:5.54E-6 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-2.84|P-value:8.91E-4 ID:SGTC_2087|Compound:5276107|FD-Score:-2.99|P-value:4.87E-4 ID:SGTC_2095|Compound:5432005|FD-Score:-2.86|P-value:8.05E-4 ID:SGTC_2096|Compound:5468907|FD-Score:2.79|P-value:8.97E-4 ID:SGTC_2235|Compound:salicylic acid|FD-Score:3.44|P-value:5.93E-5 ID:SGTC_2481|Compound:5478948|FD-Score:2.93|P-value:5.19E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-2.83|P-value:9.25E-4 ID:SGTC_2484|Compound:5809818|FD-Score:-4.04|P-value:4.15E-6 ID:SGTC_2581|Compound:avocatin a|FD-Score:4.93|P-value:1.88E-8 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.01|P-value:3.79E-4 ID:SGTC_2844|Compound:9010103|FD-Score:-3.21|P-value:2.02E-4 ID:SGTC_2946|Compound:9065502|FD-Score:3.47|P-value:5.31E-5 ID:SGTC_3214|Compound:9129694|FD-Score:3.41|P-value:6.98E-5 ID:SGTC_3216|Compound:9129716|FD-Score:3.10|P-value:2.64E-4 ID:SGTC_3339|Compound:9145883|FD-Score:3.19|P-value:1.77E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.87|P-value:7.86E-6 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.86|P-value:1.03E-5 ID:SGTC_78|Compound:0336-0123|FD-Score:-4.16|P-value:2.18E-6 ID:SGTC_129|Compound:0088-0017|FD-Score:-3.57|P-value:4.13E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:2.89|P-value:6.19E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:3.83|P-value:9.58E-6 ID:SGTC_252|Compound:miconazole|FD-Score:-3.43|P-value:7.77E-5 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.27|P-value:1.53E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:2.81|P-value:8.14E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:3.98|P-value:4.36E-6 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:4.47|P-value:3.00E-7 ID:SGTC_445|Compound:e6 berbamine|FD-Score:-2.82|P-value:9.40E-4 ID:SGTC_446|Compound:go6976|FD-Score:3.40|P-value:7.24E-5 ID:SGTC_450|Compound:aminopyrene|FD-Score:4.02|P-value:3.58E-6 ID:SGTC_865|Compound:0488-0499|FD-Score:3.60|P-value:2.93E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:3.83|P-value:9.54E-6 ID:SGTC_911|Compound:3456-4043|FD-Score:2.78|P-value:9.43E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:3.05|P-value:3.25E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.91|P-value:6.22E-6 ID:SGTC_1326|Compound:1431-2094|FD-Score:-3.03|P-value:4.23E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:4.42|P-value:3.96E-7 ID:SGTC_1342|Compound:1486-1464|FD-Score:-4.57|P-value:2.15E-7 ID:SGTC_1343|Compound:1487-0095|FD-Score:3.49|P-value:4.81E-5 ID:SGTC_1396|Compound:3511-0007|FD-Score:-2.84|P-value:8.68E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:2.83|P-value:7.80E-4 ID:SGTC_1487|Compound:3970-0795|FD-Score:3.27|P-value:1.26E-4 ID:SGTC_1530|Compound:rhein|FD-Score:2.77|P-value:9.63E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.43|P-value:6.34E-5 ID:SGTC_1573|Compound:oleylamine|FD-Score:2.80|P-value:8.74E-4 ID:SGTC_1770|Compound:st043884|FD-Score:3.93|P-value:5.54E-6 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-2.84|P-value:8.91E-4 ID:SGTC_2087|Compound:5276107|FD-Score:-2.99|P-value:4.87E-4 ID:SGTC_2095|Compound:5432005|FD-Score:-2.86|P-value:8.05E-4 ID:SGTC_2096|Compound:5468907|FD-Score:2.79|P-value:8.97E-4 ID:SGTC_2235|Compound:salicylic acid|FD-Score:3.44|P-value:5.93E-5 ID:SGTC_2481|Compound:5478948|FD-Score:2.93|P-value:5.19E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-2.83|P-value:9.25E-4 ID:SGTC_2484|Compound:5809818|FD-Score:-4.04|P-value:4.15E-6 ID:SGTC_2581|Compound:avocatin a|FD-Score:4.93|P-value:1.88E-8 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.01|P-value:3.79E-4 ID:SGTC_2844|Compound:9010103|FD-Score:-3.21|P-value:2.02E-4 ID:SGTC_2946|Compound:9065502|FD-Score:3.47|P-value:5.31E-5 ID:SGTC_3214|Compound:9129694|FD-Score:3.41|P-value:6.98E-5 ID:SGTC_3216|Compound:9129716|FD-Score:3.10|P-value:2.64E-4 ID:SGTC_3339|Compound:9145883|FD-Score:3.19|P-value:1.77E-4

Top fitness defect scores for YOR154W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2581 avocatin a 4.93 64.0 µM 1.88E-8 sphingolipid biosynthesis & PDR1 35 4.08E-7
2 SGTC_436 n,n-dimethylsphingosine 4.47 3.3 µM 3.00E-7 18 3.88E-6
3 SGTC_1331 1472-0049 4.42 76.2 µM 3.96E-7 10 4.87E-6
4 SGTC_450 aminopyrene 4.02 156.0 nM 3.58E-6 31 2.92E-5
5 SGTC_432 NS 1619 3.98 61.3 µM 4.36E-6 28 3.43E-5
6 SGTC_1770 st043884 3.93 66.3 µM 5.54E-6 13 4.16E-5
7 SGTC_1203 3992-3522 3.91 103.0 µM 6.22E-6 35 4.58E-5
8 SGTC_69 0096-0274 3.87 206.7 µM 7.86E-6 mitochondrial processes 44 5.54E-5
9 SGTC_910 3454-3003 3.83 490.0 µM 9.54E-6 18 6.48E-5
10 SGTC_167 3672-0051 3.83 66.2 µM 9.58E-6 45 6.51E-5
11 SGTC_865 0488-0499 3.60 301.0 µM 2.93E-5 23 1.62E-4
12 SGTC_1343 1487-0095 3.49 224.0 µM 4.81E-5 14 2.42E-4
13 SGTC_2946 9065502 3.47 71.4 µM 5.31E-5 14 2.63E-4
14 SGTC_2235 salicylic acid 3.44 500.0 µM 5.93E-5 9 2.88E-4
15 SGTC_1534 6-azauridine 3.43 81.6 µM 6.34E-5 RNA pol III & RNase P/MRP 46 3.04E-4
16 SGTC_3214 9129694 3.41 49.5 µM 6.98E-5 41 3.28E-4
17 SGTC_446 go6976 3.40 132.0 µM 7.24E-5 28 3.38E-4
18 SGTC_1487 3970-0795 3.27 2.8 µM 1.26E-4 DNA intercalators 33 5.32E-4
19 SGTC_3339 9145883 3.19 14.9 µM 1.77E-4 38 7.02E-4
20 SGTC_3216 9129716 3.10 49.5 µM 2.64E-4 RPP1 & pyrimidine depletion 68 9.73E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.154 3.06E-19 YJL125C GCD14 het Subunit of tRNA (1-methyladenosine) methyltransferase, with Gcd10p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression
0.119 5.79E-12 YNL303W_d YNL303W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.116 1.56E-11 YKL124W SSH4 hom Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases
0.113 5.75E-11 YNL324W_d YNL324W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.107 5.15E-10 YDR006C SOK1 hom Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13
0.107 5.83E-10 YNL014W HEF3 hom Translational elongation factor EF-3; member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells; HEF3 has a paralog, YEF3, that arose from the whole genome duplication
0.100 7.40E-9 YDR033W MRH1 hom Protein that localizes primarily to the plasma membrane; also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; MRH1 has a paralog, YRO2, that arose from the whole genome duplication
0.097 2.01E-8 YPL243W SRP68 het Core component of the signal recognition particle (SRP) complex; SRP complex functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress
0.096 2.55E-8 YPR106W ISR1 hom Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C
0.095 3.69E-8 YDR146C SWI5 hom Transcription factor that recruits Mediator and Swi/Snf complexes; activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; required for expression of the HO gene controlling mating type switching; localization to nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase; SWI5 has a paralog, ACE2, that arose from the whole genome duplication
0.091 1.31E-7 YGR017W_p YGR017W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
0.086 5.85E-7 YMR181C_p YMR181C_p hom Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); not an essential gene; YMR181C has a paralog, YPL229W, that arose from the whole genome duplication
0.086 6.75E-7 YIR044C YIR044C hom Possible pseudogene in strain S288C; YIR044C and the adjacent ORF, YIR043C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family
0.085 7.20E-7 YJR151W-A_p YJR151W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR; predicted to have a role in transcription based on computational guilt by association analysis
0.083 1.44E-6 YBR089C-A NHP6B hom High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; homologous to mammalian HMGB1 and HMGB2; NHP6B has a paralog, NHP6A, that arose from the whole genome duplication