YOR161C-C_p

Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR161C-C / YOR161C-C

Click on Significant Values for Screen Details ID:SGTC_182|Compound:3448-4371|FD-Score:3.24|P-value:1.35E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:2.83|P-value:7.61E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.64|P-value:9.02E-8 ID:SGTC_264|Compound:promethazine|FD-Score:-3.74|P-value:1.15E-5 ID:SGTC_489|Compound:paxilline|FD-Score:3.28|P-value:1.16E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:3.82|P-value:8.94E-6 ID:SGTC_1170|Compound:0310-0127|FD-Score:2.78|P-value:8.93E-4 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.04|P-value:3.19E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:2.85|P-value:7.04E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:-3.41|P-value:5.74E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.74|P-value:9.51E-4 ID:SGTC_1633|Compound:st005664|FD-Score:-3.35|P-value:7.41E-5 ID:SGTC_1635|Compound:st007035|FD-Score:3.20|P-value:1.66E-4 ID:SGTC_1683|Compound:st010134|FD-Score:3.16|P-value:1.97E-4 ID:SGTC_1715|Compound:st032160|FD-Score:2.97|P-value:4.36E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.02|P-value:3.52E-4 ID:SGTC_1893|Compound:st059353|FD-Score:-3.16|P-value:1.70E-4 ID:SGTC_2105|Compound:5350118|FD-Score:3.32|P-value:9.84E-5 ID:SGTC_2126|Compound:5251174|FD-Score:3.87|P-value:7.00E-6 ID:SGTC_2336|Compound:9001819|FD-Score:2.93|P-value:5.06E-4 ID:SGTC_2337|Compound:9009472|FD-Score:2.82|P-value:7.83E-4 ID:SGTC_2373|Compound:9071805|FD-Score:3.86|P-value:7.42E-6 ID:SGTC_2379|Compound:9035213|FD-Score:3.18|P-value:1.82E-4 ID:SGTC_2391|Compound:6285546|FD-Score:-3.40|P-value:5.85E-5 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.76|P-value:1.02E-5 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-3.45|P-value:4.77E-5 ID:SGTC_2672|Compound:12a-hydroxy-5-deoxydehydromunduserone|FD-Score:-3.01|P-value:3.25E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:-3.18|P-value:1.58E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.85|P-value:7.62E-6 ID:SGTC_2853|Compound:9015042|FD-Score:-3.69|P-value:1.50E-5 ID:SGTC_3265|Compound:9137266|FD-Score:2.98|P-value:4.13E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:3.24|P-value:1.35E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:2.83|P-value:7.61E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.64|P-value:9.02E-8 ID:SGTC_264|Compound:promethazine|FD-Score:-3.74|P-value:1.15E-5 ID:SGTC_489|Compound:paxilline|FD-Score:3.28|P-value:1.16E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:3.82|P-value:8.94E-6 ID:SGTC_1170|Compound:0310-0127|FD-Score:2.78|P-value:8.93E-4 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.04|P-value:3.19E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:2.85|P-value:7.04E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:-3.41|P-value:5.74E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.74|P-value:9.51E-4 ID:SGTC_1633|Compound:st005664|FD-Score:-3.35|P-value:7.41E-5 ID:SGTC_1635|Compound:st007035|FD-Score:3.20|P-value:1.66E-4 ID:SGTC_1683|Compound:st010134|FD-Score:3.16|P-value:1.97E-4 ID:SGTC_1715|Compound:st032160|FD-Score:2.97|P-value:4.36E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.02|P-value:3.52E-4 ID:SGTC_1893|Compound:st059353|FD-Score:-3.16|P-value:1.70E-4 ID:SGTC_2105|Compound:5350118|FD-Score:3.32|P-value:9.84E-5 ID:SGTC_2126|Compound:5251174|FD-Score:3.87|P-value:7.00E-6 ID:SGTC_2336|Compound:9001819|FD-Score:2.93|P-value:5.06E-4 ID:SGTC_2337|Compound:9009472|FD-Score:2.82|P-value:7.83E-4 ID:SGTC_2373|Compound:9071805|FD-Score:3.86|P-value:7.42E-6 ID:SGTC_2379|Compound:9035213|FD-Score:3.18|P-value:1.82E-4 ID:SGTC_2391|Compound:6285546|FD-Score:-3.40|P-value:5.85E-5 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.76|P-value:1.02E-5 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-3.45|P-value:4.77E-5 ID:SGTC_2672|Compound:12a-hydroxy-5-deoxydehydromunduserone|FD-Score:-3.01|P-value:3.25E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:-3.18|P-value:1.58E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.85|P-value:7.62E-6 ID:SGTC_2853|Compound:9015042|FD-Score:-3.69|P-value:1.50E-5 ID:SGTC_3265|Compound:9137266|FD-Score:2.98|P-value:4.13E-4

Top fitness defect scores for YOR161C-C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 4.64 5.3 µM 9.02E-8 348 1.72E-6
2 SGTC_2126 5251174 3.87 33.9 µM 7.00E-6 35 5.52E-5
3 SGTC_2373 9071805 3.86 200.0 µM 7.42E-6 12 5.78E-5
4 SGTC_2752 diclazuril 3.85 33.1 µM 7.62E-6 126 5.90E-5
5 SGTC_556 4058-0063 3.82 51.5 µM 8.94E-6 31 6.70E-5
6 SGTC_2105 5350118 3.32 200.0 µM 9.84E-5 51 4.56E-4
7 SGTC_489 paxilline 3.28 115.0 µM 1.16E-4 PDR1 42 5.19E-4
8 SGTC_182 3448-4371 3.24 550.5 µM 1.35E-4 50 5.88E-4
9 SGTC_1635 st007035 3.20 42.4 µM 1.66E-4 273 6.95E-4
10 SGTC_2379 9035213 3.18 200.0 µM 1.82E-4 51 7.47E-4
11 SGTC_1683 st010134 3.16 710.0 nM 1.97E-4 70 7.95E-4
12 SGTC_1175 0741-0056 3.04 27.6 µM 3.19E-4 65 0.00117
13 SGTC_1717 st033143 3.02 58.0 µM 3.52E-4 93 0.00127
14 SGTC_3265 9137266 2.98 49.5 µM 4.13E-4 37 0.00144
15 SGTC_1715 st032160 2.97 10.2 µM 4.36E-4 91 0.00150
16 SGTC_2336 9001819 2.93 198.7 µM 5.06E-4 heme biosynthesis & mitochondrial translocase 111 0.00170
17 SGTC_1347 1493-0251 2.85 600.0 nM 7.04E-4 mitochondrial response to ROS 68 0.00221
18 SGTC_213 1246-0773 2.83 967.0 nM 7.61E-4 82 0.00236
19 SGTC_2337 9009472 2.82 200.0 µM 7.83E-4 98 0.00241
20 SGTC_1170 0310-0127 2.78 64.8 µM 8.93E-4 98 0.00268

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.321 2.90E-81 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.299 5.66E-70 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.297 3.60E-69 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.277 4.64E-60 YGR112W SHY1 hom Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome
0.274 8.21E-59 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.274 1.17E-58 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.271 2.71E-57 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.269 8.16E-57 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.264 2.01E-54 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.262 6.02E-54 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.259 1.16E-52 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.259 1.49E-52 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.259 1.71E-52 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.257 1.25E-51 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.256 1.75E-51 YKL087C CYT2 hom Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1