YOR169C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GLN4/YOR168W

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR169C / YOR169C

Click on Significant Values for Screen Details ID:SGTC_140|Compound:0062-0056|FD-Score:-2.54|P-value:7.35E-4 ID:SGTC_225|Compound:nsc-122657|FD-Score:-3.00|P-value:8.94E-5 ID:SGTC_264|Compound:promethazine|FD-Score:-2.57|P-value:6.48E-4 ID:SGTC_276|Compound:colchicine|FD-Score:2.95|P-value:1.22E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:4.07|P-value:1.97E-7 ID:SGTC_536|Compound:3852-0578|FD-Score:-2.68|P-value:4.06E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:2.95|P-value:1.19E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:-3.09|P-value:5.52E-5 ID:SGTC_653|Compound:0203-0016|FD-Score:2.70|P-value:3.96E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:-2.52|P-value:8.17E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.01|P-value:8.98E-5 ID:SGTC_883|Compound:0850-0245|FD-Score:3.08|P-value:6.48E-5 ID:SGTC_895|Compound:0964-0006|FD-Score:2.50|P-value:9.40E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:2.54|P-value:7.98E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:2.62|P-value:5.55E-4 ID:SGTC_1606|Compound:st000094|FD-Score:2.97|P-value:1.08E-4 ID:SGTC_1896|Compound:st058441|FD-Score:-2.51|P-value:8.26E-4 ID:SGTC_1973|Compound:st070275|FD-Score:3.01|P-value:9.18E-5 ID:SGTC_2227|Compound:7312221|FD-Score:18.60|P-value:3.47E-119 ID:SGTC_2236|Compound:dapsone|FD-Score:-2.53|P-value:7.81E-4 ID:SGTC_2254|Compound:7938975|FD-Score:3.95|P-value:4.26E-7 ID:SGTC_2261|Compound:9010538|FD-Score:-2.60|P-value:5.74E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.80|P-value:1.10E-6 ID:SGTC_2355|Compound:9061122|FD-Score:3.03|P-value:8.06E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:3.15|P-value:4.43E-5 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:4.01|P-value:2.97E-7 ID:SGTC_2715|Compound:st079500|FD-Score:-2.88|P-value:1.60E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-4.14|P-value:1.14E-7 ID:SGTC_2955|Compound:9076254|FD-Score:3.44|P-value:9.30E-6 ID:SGTC_2989|Compound:9073649|FD-Score:2.65|P-value:4.79E-4 ID:SGTC_3081|Compound:9117243|FD-Score:3.60|P-value:3.67E-6 ID:SGTC_3094|Compound:9117742|FD-Score:-2.65|P-value:4.59E-4 ID:SGTC_3098|Compound:9119039|FD-Score:-2.65|P-value:4.50E-4 ID:SGTC_3099|Compound:9120367|FD-Score:-2.58|P-value:6.29E-4 ID:SGTC_3146|Compound:9095609|FD-Score:2.79|P-value:2.62E-4 ID:SGTC_3159|Compound:9100096|FD-Score:-3.39|P-value:1.15E-5 ID:SGTC_3328|Compound:9140624|FD-Score:3.53|P-value:5.56E-6 ID:SGTC_140|Compound:0062-0056|FD-Score:-2.54|P-value:7.35E-4 ID:SGTC_225|Compound:nsc-122657|FD-Score:-3.00|P-value:8.94E-5 ID:SGTC_264|Compound:promethazine|FD-Score:-2.57|P-value:6.48E-4 ID:SGTC_276|Compound:colchicine|FD-Score:2.95|P-value:1.22E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:4.07|P-value:1.97E-7 ID:SGTC_536|Compound:3852-0578|FD-Score:-2.68|P-value:4.06E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:2.95|P-value:1.19E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:-3.09|P-value:5.52E-5 ID:SGTC_653|Compound:0203-0016|FD-Score:2.70|P-value:3.96E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:-2.52|P-value:8.17E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.01|P-value:8.98E-5 ID:SGTC_883|Compound:0850-0245|FD-Score:3.08|P-value:6.48E-5 ID:SGTC_895|Compound:0964-0006|FD-Score:2.50|P-value:9.40E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:2.54|P-value:7.98E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:2.62|P-value:5.55E-4 ID:SGTC_1606|Compound:st000094|FD-Score:2.97|P-value:1.08E-4 ID:SGTC_1896|Compound:st058441|FD-Score:-2.51|P-value:8.26E-4 ID:SGTC_1973|Compound:st070275|FD-Score:3.01|P-value:9.18E-5 ID:SGTC_2227|Compound:7312221|FD-Score:18.60|P-value:3.47E-119 ID:SGTC_2236|Compound:dapsone|FD-Score:-2.53|P-value:7.81E-4 ID:SGTC_2254|Compound:7938975|FD-Score:3.95|P-value:4.26E-7 ID:SGTC_2261|Compound:9010538|FD-Score:-2.60|P-value:5.74E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.80|P-value:1.10E-6 ID:SGTC_2355|Compound:9061122|FD-Score:3.03|P-value:8.06E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:3.15|P-value:4.43E-5 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:4.01|P-value:2.97E-7 ID:SGTC_2715|Compound:st079500|FD-Score:-2.88|P-value:1.60E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-4.14|P-value:1.14E-7 ID:SGTC_2955|Compound:9076254|FD-Score:3.44|P-value:9.30E-6 ID:SGTC_2989|Compound:9073649|FD-Score:2.65|P-value:4.79E-4 ID:SGTC_3081|Compound:9117243|FD-Score:3.60|P-value:3.67E-6 ID:SGTC_3094|Compound:9117742|FD-Score:-2.65|P-value:4.59E-4 ID:SGTC_3098|Compound:9119039|FD-Score:-2.65|P-value:4.50E-4 ID:SGTC_3099|Compound:9120367|FD-Score:-2.58|P-value:6.29E-4 ID:SGTC_3146|Compound:9095609|FD-Score:2.79|P-value:2.62E-4 ID:SGTC_3159|Compound:9100096|FD-Score:-3.39|P-value:1.15E-5 ID:SGTC_3328|Compound:9140624|FD-Score:3.53|P-value:5.56E-6

Top fitness defect scores for YOR169C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2227 7312221 18.60 64.1 µM 3.47E-119 2 2.09E-77 15.50
2 SGTC_424 splitomicin 4.07 100.0 mM 1.97E-7 3 2.33E-5 0.25
3 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 4.01 100.0 µM 2.97E-7 6 3.04E-5 0.06
4 SGTC_2254 7938975 3.95 95.2 µM 4.26E-7 8 3.85E-5 0.06
5 SGTC_2288 7946289 3.80 167.3 µM 1.10E-6 6 7.16E-5 0.23
6 SGTC_3081 9117243 3.60 49.5 µM 3.67E-6 fatty acid desaturase (OLE1) 32 1.58E-4 0.01
7 SGTC_3328 9140624 3.53 29.0 µM 5.56E-6 6 2.08E-4 0.05
8 SGTC_2955 9076254 3.44 12.2 µM 9.30E-6 8 2.92E-4 0.07
9 SGTC_2620 irigenin 3.15 100.0 µM 4.43E-5 24 8.18E-4 0.03
10 SGTC_883 0850-0245 3.08 24.6 µM 6.48E-5 cell wall 21 0.00105 8.92E-4
11 SGTC_2355 9061122 3.03 103.1 µM 8.06E-5 6 0.00122 0.17
12 SGTC_874 0599-0792 3.01 117.0 µM 8.98E-5 22 0.00131 0.04
13 SGTC_1973 st070275 3.01 50.2 µM 9.18E-5 7 0.00132 0.03
14 SGTC_1606 st000094 2.97 49.2 µM 1.08E-4 60S ribosome export 19 0.00148 0.02
15 SGTC_631 k072-0230 2.95 41.5 µM 1.19E-4 60S ribosome export 16 0.00158 0.03
16 SGTC_276 colchicine 2.95 750.0 µM 1.22E-4 15 0.00160 0.01
17 SGTC_3146 9095609 2.79 49.5 µM 2.62E-4 14 0.00266 0.17
18 SGTC_653 0203-0016 2.70 55.2 µM 3.96E-4 15 0.00350 0.05
19 SGTC_2989 9073649 2.65 71.4 µM 4.79E-4 34 0.00397 0.02
20 SGTC_1307 1187-1599 2.62 12.2 µM 5.55E-4 PDR1 22 0.00438 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.462 2.00E-177 YOR168W GLN4 het Glutamine tRNA synthetase, monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Glu); N-terminal domain proposed to be involved in enzyme-tRNA interactions
0.131 2.59E-14 YGR021W_p YGR021W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.130 3.66E-14 YPL240C HSP82 hom Hsp90 chaperone; redundant in function with Hsc82p; required for pheromone signaling, negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding, nucleotide addition; protein abundance increases in response to DNA replication stress; contains two acid-rich unstructured regions that promote solubility of chaperone-substrate complexes; HSP82 has a paralog, HSC82, that arose from the whole genome duplication
0.130 4.63E-14 YMR251W GTO3 hom Omega class glutathione transferase; putative cytosolic localization
0.107 5.28E-10 YMR128W ECM16 het Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP, predominantly nucleolar in distribution, required for 18S rRNA synthesis
0.103 2.59E-9 YDR142C PEX7 hom Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP)
0.100 5.95E-9 YOL138C RTC1 hom Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; null mutation suppresses cdc13-1 temperature sensitivity; has N-terminal WD-40 repeats and a C-terminal RING motif
0.088 3.31E-7 YGL231C EMC4 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm ZK616.6/EMC-4, fly CG11137, human TMM85
0.084 9.60E-7 YPL263C KEL3 hom Cytoplasmic protein of unknown function
0.081 2.54E-6 YMR094W CTF13 het Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis
0.071 3.55E-5 YBR271W EFM2 hom S-adenosylmethionine-dependent methyltransferase; methylates translation elongation factors EF2 (Eft1p and Eft2p) and EF3A (Yef3p); belongs to the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; predicted to be involved in ribosome biogenesis
0.069 5.75E-5 YNL045W LAP2 hom Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.068 7.56E-5 YER057C HMF1 hom Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro
0.068 7.80E-5 YKL116C PRR1 hom Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
0.067 1.05E-4 YIL037C PRM2 hom Pheromone-regulated protein, predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p; required for efficient nuclear fusion