YOR190W / SPR1

Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR190W / SPR1

Click on Significant Values for Screen Details ID:SGTC_53|Compound:0973-0023|FD-Score:3.37|P-value:4.23E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.17|P-value:1.86E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:-3.60|P-value:1.85E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:-3.18|P-value:8.26E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:3.35|P-value:4.52E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:4.27|P-value:1.20E-5 ID:SGTC_424|Compound:splitomicin|FD-Score:4.24|P-value:1.37E-5 ID:SGTC_466|Compound:geldanamycin|FD-Score:-3.30|P-value:5.58E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.71|P-value:1.20E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:4.36|P-value:7.79E-6 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.92|P-value:5.22E-5 ID:SGTC_1039|Compound:k821-0043|FD-Score:-3.33|P-value:4.93E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:5.46|P-value:3.23E-8 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.22|P-value:7.11E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.73|P-value:1.08E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:-3.45|P-value:3.25E-4 ID:SGTC_1720|Compound:st037298|FD-Score:12.60|P-value:6.49E-36 ID:SGTC_2066|Compound:5222451|FD-Score:3.75|P-value:1.02E-4 ID:SGTC_2106|Compound:5357045|FD-Score:3.15|P-value:9.00E-4 ID:SGTC_2139|Compound:5578692|FD-Score:-3.34|P-value:4.87E-4 ID:SGTC_2166|Compound:5933061|FD-Score:-5.21|P-value:1.30E-7 ID:SGTC_2240|Compound:6690706|FD-Score:4.17|P-value:1.81E-5 ID:SGTC_2241|Compound:6772625|FD-Score:3.46|P-value:3.07E-4 ID:SGTC_2481|Compound:5478948|FD-Score:3.28|P-value:5.77E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-3.69|P-value:1.34E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.94|P-value:4.78E-5 ID:SGTC_2629|Compound:bisabolol|FD-Score:-3.47|P-value:3.04E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:6.37|P-value:1.39E-10 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-3.43|P-value:3.45E-4 ID:SGTC_2972|Compound:9093619|FD-Score:3.47|P-value:2.92E-4 ID:SGTC_3036|Compound:9090181|FD-Score:3.21|P-value:7.48E-4 ID:SGTC_3137|Compound:9097352|FD-Score:-3.27|P-value:6.20E-4 ID:SGTC_3212|Compound:9128307|FD-Score:4.30|P-value:1.05E-5 ID:SGTC_3332|Compound:9141069|FD-Score:4.16|P-value:1.93E-5 ID:SGTC_3352|Compound:9151559|FD-Score:3.63|P-value:1.62E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:3.37|P-value:4.23E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.17|P-value:1.86E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:-3.60|P-value:1.85E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:-3.18|P-value:8.26E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:3.35|P-value:4.52E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:4.27|P-value:1.20E-5 ID:SGTC_424|Compound:splitomicin|FD-Score:4.24|P-value:1.37E-5 ID:SGTC_466|Compound:geldanamycin|FD-Score:-3.30|P-value:5.58E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.71|P-value:1.20E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:4.36|P-value:7.79E-6 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.92|P-value:5.22E-5 ID:SGTC_1039|Compound:k821-0043|FD-Score:-3.33|P-value:4.93E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:5.46|P-value:3.23E-8 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.22|P-value:7.11E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.73|P-value:1.08E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:-3.45|P-value:3.25E-4 ID:SGTC_1720|Compound:st037298|FD-Score:12.60|P-value:6.49E-36 ID:SGTC_2066|Compound:5222451|FD-Score:3.75|P-value:1.02E-4 ID:SGTC_2106|Compound:5357045|FD-Score:3.15|P-value:9.00E-4 ID:SGTC_2139|Compound:5578692|FD-Score:-3.34|P-value:4.87E-4 ID:SGTC_2166|Compound:5933061|FD-Score:-5.21|P-value:1.30E-7 ID:SGTC_2240|Compound:6690706|FD-Score:4.17|P-value:1.81E-5 ID:SGTC_2241|Compound:6772625|FD-Score:3.46|P-value:3.07E-4 ID:SGTC_2481|Compound:5478948|FD-Score:3.28|P-value:5.77E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-3.69|P-value:1.34E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.94|P-value:4.78E-5 ID:SGTC_2629|Compound:bisabolol|FD-Score:-3.47|P-value:3.04E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:6.37|P-value:1.39E-10 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-3.43|P-value:3.45E-4 ID:SGTC_2972|Compound:9093619|FD-Score:3.47|P-value:2.92E-4 ID:SGTC_3036|Compound:9090181|FD-Score:3.21|P-value:7.48E-4 ID:SGTC_3137|Compound:9097352|FD-Score:-3.27|P-value:6.20E-4 ID:SGTC_3212|Compound:9128307|FD-Score:4.30|P-value:1.05E-5 ID:SGTC_3332|Compound:9141069|FD-Score:4.16|P-value:1.93E-5 ID:SGTC_3352|Compound:9151559|FD-Score:3.63|P-value:1.62E-4

Top fitness defect scores for YOR190W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1720 st037298 12.60 9.5 µM 6.49E-36 1 1.25E-36
2 SGTC_2634 4'-methoxyflavone 6.37 100.0 µM 1.39E-10 5 9.18E-11
3 SGTC_1051 3253-3903 5.46 78.0 µM 3.23E-8 4 2.38E-8
4 SGTC_701 4424-0219 4.36 185.0 µM 7.79E-6 calcium & mitochondrial duress 17 6.41E-6
5 SGTC_3212 9128307 4.30 49.5 µM 1.05E-5 36 8.65E-6
6 SGTC_423 5-fluorouracil 4.27 457.0 µM 1.20E-5 exosome 16 9.97E-6
7 SGTC_424 splitomicin 4.24 100.0 mM 1.37E-5 14 1.14E-5
8 SGTC_2240 6690706 4.17 185.9 µM 1.81E-5 15 1.52E-5
9 SGTC_3332 9141069 4.16 11.2 µM 1.93E-5 13 1.62E-5
10 SGTC_2604 4'-hydroxychalcone 3.94 11.3 µM 4.78E-5 38 4.07E-5
11 SGTC_1018 4259-0013 3.92 28.1 µM 5.22E-5 20 4.46E-5
12 SGTC_2066 5222451 3.75 176.0 µM 1.02E-4 heme biosynthesis & mitochondrial translocase 36 8.82E-5
13 SGTC_1287 0971-0001 3.73 34.6 µM 1.08E-4 sphingolipid biosynthesis & PDR1 51 9.40E-5
14 SGTC_474 dl-dihydrosphingosine 3.71 5.0 µM 1.20E-4 28 1.04E-4
15 SGTC_3352 9151559 3.63 45.6 µM 1.62E-4 19 1.41E-4
16 SGTC_2972 9093619 3.47 59.9 µM 2.92E-4 34 2.58E-4
17 SGTC_2241 6772625 3.46 37.8 µM 3.07E-4 43 2.72E-4
18 SGTC_53 0973-0023 3.37 40.0 µM 4.23E-4 RNA processing & uracil transport 23 3.77E-4
19 SGTC_123 0083-0120 3.35 66.7 µM 4.52E-4 66 4.03E-4
20 SGTC_2481 5478948 3.28 45.2 µM 5.77E-4 PDR1 70 5.17E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.178 3.51E-25 YJL127C SPT10 hom Putative histone acetylase with a role in transcriptional silencing, sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box
0.147 1.25E-17 YOL042W NGL1 hom Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.126 2.23E-13 YPL221W FLC1 hom Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance
0.125 3.12E-13 YPR093C ASR1 hom Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain similar to the mammalian rA9 protein
0.117 1.30E-11 YPL134C ODC1 hom Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation
0.110 1.55E-10 YJL162C JJJ2 hom Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.110 1.66E-10 YPL039W_p YPL039W_p hom Putative protein of unknown function; YPL039W is not an essential gene
0.110 2.00E-10 YDR044W HEM13 het Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
0.109 2.76E-10 YPL038W MET31 hom Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET31 has a paralog, MET32, that arose from the whole genome duplication
0.107 4.47E-10 YOR076C SKI7 hom Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotype
0.103 1.91E-9 YHL003C LAG1 hom Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress
0.103 1.98E-9 YKL095W YJU2 het Essential protein required for pre-mRNA splicing; associates transiently with the spliceosomal NTC (nineteen complex) and acts after Prp2p to promote the first catalytic reaction of splicing
0.099 1.07E-8 YHR126C_p ANS1_p hom Putative GPI protein; transcription dependent upon Azf1p
0.098 1.33E-8 YER079W_p YER079W_p hom Putative protein of unknown function
0.096 2.80E-8 YOL030W GAS5 hom 1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall