YOR229W / WTM2

Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; involved in response to replication stress; contains WD repeats

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR229W / WTM2

Click on Significant Values for Screen Details ID:SGTC_399|Compound:oxolinic acid|FD-Score:3.80|P-value:5.57E-5 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:4.29|P-value:6.31E-6 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.10|P-value:7.94E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:3.68|P-value:8.91E-5 ID:SGTC_541|Compound:4513-1321|FD-Score:-3.21|P-value:5.50E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:3.47|P-value:2.06E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:4.43|P-value:3.26E-6 ID:SGTC_691|Compound:1548-0686|FD-Score:3.10|P-value:7.90E-4 ID:SGTC_712|Compound:r015-0009|FD-Score:3.34|P-value:3.35E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:4.29|P-value:6.43E-6 ID:SGTC_741|Compound:4582-0002|FD-Score:3.34|P-value:3.34E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:5.74|P-value:2.58E-9 ID:SGTC_789|Compound:1309-1135|FD-Score:4.29|P-value:6.42E-6 ID:SGTC_878|Compound:0828-0289|FD-Score:3.05|P-value:9.69E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:-3.20|P-value:5.65E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.21|P-value:5.43E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:3.05|P-value:9.63E-4 ID:SGTC_1429|Compound:4049-0205|FD-Score:3.37|P-value:3.02E-4 ID:SGTC_1627|Compound:st003713|FD-Score:-3.22|P-value:5.31E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.83|P-value:4.88E-5 ID:SGTC_1860|Compound:st056228|FD-Score:3.84|P-value:4.63E-5 ID:SGTC_1902|Compound:st060212|FD-Score:3.19|P-value:5.84E-4 ID:SGTC_1924|Compound:st058459|FD-Score:3.17|P-value:6.23E-4 ID:SGTC_1934|Compound:st074720|FD-Score:3.95|P-value:2.90E-5 ID:SGTC_1939|Compound:st074455|FD-Score:-3.53|P-value:1.62E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-4.22|P-value:8.58E-6 ID:SGTC_1952|Compound:st077036|FD-Score:-4.15|P-value:1.19E-5 ID:SGTC_2123|Compound:5259487|FD-Score:4.42|P-value:3.36E-6 ID:SGTC_2306|Compound:7482397|FD-Score:3.73|P-value:7.23E-5 ID:SGTC_2322|Compound:7413319|FD-Score:3.22|P-value:5.18E-4 ID:SGTC_2466|Compound:5983409|FD-Score:3.25|P-value:4.69E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:4.52|P-value:2.11E-6 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.17|P-value:6.25E-4 ID:SGTC_2699|Compound:st077704|FD-Score:3.90|P-value:3.53E-5 ID:SGTC_2732|Compound:terfenadine|FD-Score:-3.42|P-value:2.51E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:3.26|P-value:4.55E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:3.22|P-value:5.26E-4 ID:SGTC_2909|Compound:7941780|FD-Score:4.18|P-value:1.05E-5 ID:SGTC_2991|Compound:9074669|FD-Score:3.74|P-value:6.93E-5 ID:SGTC_3055|Compound:9094636|FD-Score:3.78|P-value:5.94E-5 ID:SGTC_3083|Compound:9117465|FD-Score:3.10|P-value:8.00E-4 ID:SGTC_3131|Compound:9127911|FD-Score:3.08|P-value:8.64E-4 ID:SGTC_3148|Compound:9097893|FD-Score:3.56|P-value:1.45E-4 ID:SGTC_3259|Compound:9138485|FD-Score:-4.57|P-value:1.67E-6 ID:SGTC_3280|Compound:9140961|FD-Score:4.20|P-value:9.72E-6 ID:SGTC_399|Compound:oxolinic acid|FD-Score:3.80|P-value:5.57E-5 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:4.29|P-value:6.31E-6 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.10|P-value:7.94E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:3.68|P-value:8.91E-5 ID:SGTC_541|Compound:4513-1321|FD-Score:-3.21|P-value:5.50E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:3.47|P-value:2.06E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:4.43|P-value:3.26E-6 ID:SGTC_691|Compound:1548-0686|FD-Score:3.10|P-value:7.90E-4 ID:SGTC_712|Compound:r015-0009|FD-Score:3.34|P-value:3.35E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:4.29|P-value:6.43E-6 ID:SGTC_741|Compound:4582-0002|FD-Score:3.34|P-value:3.34E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:5.74|P-value:2.58E-9 ID:SGTC_789|Compound:1309-1135|FD-Score:4.29|P-value:6.42E-6 ID:SGTC_878|Compound:0828-0289|FD-Score:3.05|P-value:9.69E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:-3.20|P-value:5.65E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.21|P-value:5.43E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:3.05|P-value:9.63E-4 ID:SGTC_1429|Compound:4049-0205|FD-Score:3.37|P-value:3.02E-4 ID:SGTC_1627|Compound:st003713|FD-Score:-3.22|P-value:5.31E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.83|P-value:4.88E-5 ID:SGTC_1860|Compound:st056228|FD-Score:3.84|P-value:4.63E-5 ID:SGTC_1902|Compound:st060212|FD-Score:3.19|P-value:5.84E-4 ID:SGTC_1924|Compound:st058459|FD-Score:3.17|P-value:6.23E-4 ID:SGTC_1934|Compound:st074720|FD-Score:3.95|P-value:2.90E-5 ID:SGTC_1939|Compound:st074455|FD-Score:-3.53|P-value:1.62E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-4.22|P-value:8.58E-6 ID:SGTC_1952|Compound:st077036|FD-Score:-4.15|P-value:1.19E-5 ID:SGTC_2123|Compound:5259487|FD-Score:4.42|P-value:3.36E-6 ID:SGTC_2306|Compound:7482397|FD-Score:3.73|P-value:7.23E-5 ID:SGTC_2322|Compound:7413319|FD-Score:3.22|P-value:5.18E-4 ID:SGTC_2466|Compound:5983409|FD-Score:3.25|P-value:4.69E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:4.52|P-value:2.11E-6 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.17|P-value:6.25E-4 ID:SGTC_2699|Compound:st077704|FD-Score:3.90|P-value:3.53E-5 ID:SGTC_2732|Compound:terfenadine|FD-Score:-3.42|P-value:2.51E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:3.26|P-value:4.55E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:3.22|P-value:5.26E-4 ID:SGTC_2909|Compound:7941780|FD-Score:4.18|P-value:1.05E-5 ID:SGTC_2991|Compound:9074669|FD-Score:3.74|P-value:6.93E-5 ID:SGTC_3055|Compound:9094636|FD-Score:3.78|P-value:5.94E-5 ID:SGTC_3083|Compound:9117465|FD-Score:3.10|P-value:8.00E-4 ID:SGTC_3131|Compound:9127911|FD-Score:3.08|P-value:8.64E-4 ID:SGTC_3148|Compound:9097893|FD-Score:3.56|P-value:1.45E-4 ID:SGTC_3259|Compound:9138485|FD-Score:-4.57|P-value:1.67E-6 ID:SGTC_3280|Compound:9140961|FD-Score:4.20|P-value:9.72E-6

Top fitness defect scores for YOR229W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_788 1182-0090 5.74 188.0 µM 2.58E-9 endomembrane recycling 40 4.75E-9
2 SGTC_2595 hexamethylquercetagetin 4.52 100.0 µM 2.11E-6 14 3.11E-6
3 SGTC_579 4491-1009 4.43 110.0 µM 3.26E-6 60S ribosome export 15 4.71E-6
4 SGTC_2123 5259487 4.42 200.0 µM 3.36E-6 12 4.86E-6
5 SGTC_410 α-linolenic acid 4.29 100.0 µM 6.31E-6 excess fatty acid 27 8.94E-6
6 SGTC_789 1309-1135 4.29 70.6 µM 6.42E-6 ERG2 21 9.08E-6
7 SGTC_737 1950-0117 4.29 57.9 µM 6.43E-6 17 9.10E-6
8 SGTC_3280 9140961 4.20 49.5 µM 9.72E-6 60S ribosome export 10 1.36E-5
9 SGTC_2909 7941780 4.18 10.5 µM 1.05E-5 18 1.46E-5
10 SGTC_1934 st074720 3.95 32.6 µM 2.90E-5 56 3.90E-5
11 SGTC_2699 st077704 3.90 54.6 µM 3.53E-5 endomembrane recycling 50 4.73E-5
12 SGTC_1860 st056228 3.84 74.6 µM 4.63E-5 27 6.14E-5
13 SGTC_1727 st034309 3.83 9.9 µM 4.88E-5 46 6.46E-5
14 SGTC_399 oxolinic acid 3.80 75.0 µM 5.57E-5 10 7.34E-5
15 SGTC_3055 9094636 3.78 49.5 µM 5.94E-5 12 7.81E-5
16 SGTC_2991 9074669 3.74 71.4 µM 6.93E-5 azole & statin 75 9.06E-5
17 SGTC_2306 7482397 3.73 179.5 µM 7.23E-5 RPP1 & pyrimidine depletion 26 9.45E-5
18 SGTC_522 1273-0010 3.68 11.6 µM 8.91E-5 60S ribosome export 26 1.16E-4
19 SGTC_3148 9097893 3.56 49.5 µM 1.45E-4 47 1.86E-4
20 SGTC_542 3381-0244 3.47 89.3 µM 2.06E-4 59 2.60E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.089 2.09E-7 YMR234W RNH1 hom Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I; the homolog of mammalian RNAse HII (the S. cerevisiae homolog of mammalian RNAse HI is RNH201)
0.086 5.82E-7 YDR221W GTB1 hom Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p; involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER; relocalizes from ER to cytoplasm upon DNA replication stress
0.085 7.81E-7 YLR060W FRS1 het Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control
0.085 9.02E-7 YML007C-A_p YML007C-A_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria
0.080 3.59E-6 YMR271C URA10 hom Minor orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA10 has a paralog, URA5, that arose from the whole genome duplication
0.078 6.80E-6 YMR160W YMR160W hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; mutant has enhanced sensitivity to overexpression of mutant huntingtin; YMR160W is not an essential gene; relative distribution within the vacuolar membrane changes upon DNA replication stress
0.077 8.85E-6 YKL136W_d YKL136W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C
0.076 9.43E-6 YDR195W REF2 hom RNA-binding protein involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation, and in snoRNA maturation; part of holo-CPF subcomplex APT, which associates with 3'-ends of snoRNA- and mRNA-encoding genes
0.074 1.73E-5 YCL001W RER1 hom Protein involved in retention of membrane proteins, including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER
0.072 3.12E-5 YJL218W_p YJL218W_p hom Putative acetyltransferase; similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene
0.072 3.20E-5 YLR004C THI73 hom Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs
0.072 3.34E-5 YOL038C-A_p YOL038C-A_p hom Putative protein of unknown function; identified by SAGE analysis
0.071 3.38E-5 YLR360W VPS38 hom Part of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity; required for overflow degradation of misfolded proteins when ERAD is saturated
0.071 3.56E-5 YJL132W_p YJL132W_p hom Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene
0.071 3.78E-5 YJR048W CYC1 hom Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; CYC1 has a paralog, CYC7, that arose from the whole genome duplication